期刊
CEREBELLUM
卷 12, 期 5, 页码 738-757出版社
SPRINGER
DOI: 10.1007/s12311-013-0464-0
关键词
Cerebellum; Interpositus nucleus; Motor control; Classical conditioning; Emotions
资金
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- NIH [R01-NS-036210]
- Italian Ministry of Health [RC11.G]
- Santa Lucia Foundation
- [MICINN-BFU2008-0899]
- [P07-CVI-2487]
- [JA-BIO-122]
- [MICINN-BFU2008-03390]
- [P07-CVI-02686]
In the present paper, we examine the role of the cerebellar interpositus nucleus (IN) in motor and non-motor domains. Recent findings are considered, and we share the following conclusions: IN as part of the olivo-cortico-nuclear microcircuit is involved in providing powerful timing signals important in coordinating limb movements; IN could participate in the timing and performance of ongoing conditioned responses rather than the generation and/or initiation of such responses; IN is involved in the control of reflexive and voluntary movements in a task- and effector system-dependent fashion, including hand movements and associated upper limb adjustments, for quick effective actions; IN develops internal models for dynamic interactions of the motor system with the external environment for anticipatory control of movement; and IN plays a significant role in the modulation of autonomic and emotional functions.
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