Article
Multidisciplinary Sciences
Lauren N. Miterko, Tao Lin, Joy Zhou, Meike E. van der Heijden, Jaclyn Beckinghausen, Joshua J. White, Roy Sillitoe
Summary: Deep brain stimulation (DBS) shows potential in improving motor function in a mouse model of ataxia, with the combination of cerebellar nuclei DBS and physical activity being particularly effective.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Mauro Giuffre, Silvia Gazzin, Caterina Zoratti, John Paul Llido, Giuseppe Lanza, Claudio Tiribelli, Rita Moretti
Summary: Celiac disease is a complex multi-organ disease that can involve the neurological and psychiatric systems. Recent evidence suggests that the gut microbiota and the gut-liver-brain axis play important roles in the neurological manifestations of celiac disease. There is still debate on the use of serological and neurophysiological findings for the early diagnosis and monitoring of celiac disease-related neurological involvement, but most symptoms can be reversed with a strict gluten-free diet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Bara Aljada, Ahmed Zohni, Wael El-Matary
Summary: The gluten-free diet is popular for treating immune-mediated disorders caused by gluten, but it has disadvantages like high costs, nutritional deficiencies, and social and psychological barriers. Close follow-up with patients following the diet is recommended, and more data is needed to assess its effectiveness in managing mental and cognitive disorders.
Review
Food Science & Technology
Xiaoxue Zhu, Xin-Huai Zhao, Qiang Zhang, Na Zhang, Olugbenga P. Soladoye, Rotimi E. Aluko, Yuhao Zhang, Yu Fu
Summary: This article reviews the latest research progress on the relationship between celiac disease (CD) and gluten. It emphasizes the structure and function of gluten peptides related to CD, gluten detection methods, the effects of processing on gluten, and gluten-free diets. The limitations in current CD research are also discussed. This study facilitates a comprehensive understanding of CD and gluten, providing a theoretical reference for future research.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Gastroenterology & Hepatology
Benjamin Lebwohl, Alberto Rubio-Tapia
Summary: The incidence of celiac disease is increasing due to both improved recognition and a real increase of the disorder. The reasons for this true rise are unclear, but may be related to environmental factors. Early-life gluten exposure is a major focus of prevention efforts.
Article
Biology
Harvey Perez, May F. Abdallah, Jose Chavira, Angelina S. Norris, Martin T. Egeland, Karen L. Vo, Callan L. Buechsenschuetz, Valentina Sanghez, Jeannie L. Kim, Molly Pind, Kotoka Nakamura, Geoffrey G. Hicks, Richard A. Gatti, Joaquin Madrenas, Michelina Iacovino, Peter J. McKinnon, Paul J. Mathews
Summary: By introducing null mutations in both the Atm and Aptx genes in mice, researchers have created a novel mouse model that exhibits progressively severe ataxic phenotype and cerebellar molecular layer atrophy. The perturbations significantly alter the biophysical properties of cerebellar Purkinje neurons and their neural activity, correlating with cerebellar atrophy and ataxia over the animal's first year of life. Additionally, the double mutant mice also show a predisposition to cancer and immune abnormalities, resembling symptoms of A-T.
Review
Nutrition & Dietetics
Fardowsa Abdi, Saania Zuberi, Jedid-Jah Blom, David Armstrong, Maria Ines Pinto-Sanchez
Summary: A gluten-free diet is essential for treating celiac disease and may improve symptoms in non-celiac gluten/wheat sensitivity. However, adopting a gluten-free diet or a gluten-restricted diet may increase the risk of malnutrition and nutrient deficiencies. Therefore, patients with these conditions should undergo nutritional assessment and monitoring, and receive multidisciplinary care for long-term nutrition management.
Review
Immunology
Renata Auricchio, Riccardo Troncone
Summary: Celiac disease is an autoimmune disorder triggered by gluten, with prevention strategies focusing on identifying at-risk individuals and eliminating risk factors. Research has shown that both genetic and environmental factors play a role in the development of the disease, suggesting that future interventions could involve protection from infections, manipulation of microbiota, and modulation of T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Xingxing Wu, Lin Qian, Kexin Liu, Jing Wu, Zhaowei Shan
Summary: Coeliac disease is an autoimmune intestinal disease induced by gluten, and adherence to gluten-free diet is an effective treatment. The gut microbiota plays a crucial role in maintaining health, which is regulated by diet. There is a need for alternative treatments to GFD due to the increasing prevalence of coeliac disease.
ANNALS OF MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Mariana Verdelho Machado
Summary: Celiac disease (CD) is a common autoimmune disease, affecting approximately 1% of the population. Regardless of symptoms, all CD patients must adhere to a lifelong gluten-free diet (GFD). However, this can be challenging due to a lack of gluten awareness in foods and the widespread use of gluten in processed foods. Research has been conducted to find pharmacological treatment for CD, but achieving full histological recovery on a GFD remains difficult.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Veronica Segura, Angela Ruiz-Carnicer, Carolina Sousa, Maria de Lourdes Moreno
Summary: The only current treatment for celiac disease is a strict gluten-free diet, but there is a need for non-dietary alternatives to prevent damage from dietary transgressions. Recent therapies for CD focus on degrading gluten, regulating the immune response, and inducing immunological tolerance, with promising results seen in some phase III and II clinical trials.
Article
Food Science & Technology
Maria Purificacion Gonzalez, Catalina Ballestero-Fernandez, Violeta Fajardo, Maria Achon, Angela Garcia-Gonzalez, Elena Alonso-Aperte, Natalia Ubeda
Summary: The study assessed the contribution of GFP to the diets of children and adolescents with CD, finding that GFP accounted for a high percentage of total energy, carbohydrates, fiber, and salt intake, but a lower percentage of fat, sugar, and protein intake. It is important to reduce fat, saturated fat, and salt intake, and increase fiber content in processed GFP.
Review
Nutrition & Dietetics
Aner Cardo, Itziar Churruca, Arrate Lasa, Virginia Navarro, Maialen Vazquez-Polo, Gesala Perez-Junkera, Idoia Larretxi
Summary: Celiac disease (CD) is an autoimmune disorder of the small intestine that requires a gluten-free diet (GFD) for effective treatment. Nutritional imbalances may occur in adults with CD following GFD, but deficiencies can improve as intestinal mucosa recovers over time. Monitoring nutrient intake, especially plant proteins and essential nutrients, is important to prevent nutritional deficiencies in the long term.
Article
Nutrition & Dietetics
Juan Manuel Rodriguez, Virginia Estevez, Karla Bascunan, Jimena Ayala, Magdalena Araya
Summary: This study assessed gluten contamination in oat-based gluten-free products and found that they are currently highly contaminated. It is urgent to regulate and implement protocols to ensure safe consumption of these products.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Alberto Raiteri, Alessandro Granito, Chiara Faggiano, Alice Giamperoli, Teresa Catenaro, Giulia Negrini, Francesco Tovoli
Summary: The dietary habits of celiac disease (CD) patients adhering to a gluten-free diet (GFD) are correlated with the risk of nonalcoholic fatty liver disease (NAFLD). A questionnaire-based study found that specific patterns of packaged gluten-free food consumption are significantly associated with NAFLD. The information obtained through this study can be used in clinical practice for personalized treatment and further research.
Article
Cell Biology
Simeng Li, Volga Tarlac, Roberto B. I. Christanto, Shauna L. French, Justin R. Hamilton
Summary: The number of PAR4 receptors expressed on platelets does not vary across different genotypes, and therefore cannot explain the altered pharmacology of the rs773902 PAR4 sequence variant.
Article
Immunology
R. P. Anderson, G. Goel, M. Y. Hardy, A. R. Russell, S. Wang, E. Szymczak, R. Zhang, K. E. Goldstein, M. Neff, K. E. Truitt, L. J. Williams, J. L. Dzuris, J. A. Tye-Din
Summary: The study found that whole blood IL-2 release assay is effective in detecting immune responses to gliadin peptides, aiding in the diagnosis and monitoring of coeliac disease. Results showed that GC caused an increase in IL-2 release, indicating the dominant role of IL-2 in whole blood cytokine release assays.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Clinical Neurology
Alexander Fidao, Alysha De Livera, Nupur Nag, Sandra Neate, George A. Jelinek, Steve Simpson-Yap
Summary: Depression plays a major mediating role in the relationship between fatigue and mental quality of life in people with multiple sclerosis, while physical activity has a minor role. These findings may contribute to the development of treatments to reduce the impacts of fatigue and improve mental quality of life in pwMS.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Health Care Sciences & Services
Nupur Nag, Xin Lin, Maggie Yu, Steve Simpson-Yap, George A. Jelinek, Sandra L. Neate, Michele Levin
Summary: The study found that physical activity was inversely associated with most neurological disorders, while smoking was positively associated with MND and stroke. Additionally, cognitive engagement, face-to-face social interaction, and stress-reducing activities were significantly linked to AD and stroke, while online social interaction and stress reduction activities were associated with MS.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Editorial Material
Clinical Neurology
W. Bevens, K. Gray, S. L. Neate, N. Nag, T. J. Weiland, G. A. Jelinek, S. Simpson-Yap
Summary: The management of multiple sclerosis (MS) has seen significant advancements with the rise of mHealth technologies, but the uptake of mHealth apps among MS patients outside of North America remains unclear. This study, based on the HOLISM cohort, provides insights into mHealth app usage and the characteristics of adopters within a global MS population. Overall, 3.1% of respondents reported using mHealth apps, mainly concentrated in Australasia and North America.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Review
Immunology
Robert P. Anderson
Summary: Recent studies have shown that a gluten-free diet is not as effective in treating celiac disease as previously believed, and patients still experience acute symptoms and cytokine release from gluten exposure. Pharmacological adjuncts to the diet are being developed. Understanding the pathogenesis of celiac disease is crucial for identifying drug targets and developing noninvasive biomarkers.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Sandra L. Neate, Angela Donald, George A. Jelinek, Nupur Nag
Summary: This study explored the perspectives of people with multiple sclerosis (pwMS) on lifestyle modification for disease management. Participants faced practical challenges and psychological barriers, but also experienced positive outcomes and personal transformations through engagement in healthy lifestyle behaviors. These findings may lead to more focused qualitative explorations of lifestyle modification experiences and outcomes in MS in the future.
HEALTH EXPECTATIONS
(2022)
Article
Clinical Neurology
Nupur Nag, Xirun Yang, George Jelinek, Sandra Neate, Steve Simpson-Yap
Summary: Undertaking stress-reducing activities or meditation may help reduce depression, fatigue, and enhance mastery in patients with multiple sclerosis. Physical and relaxation activities are associated with lower frequencies of depression, while meditation is associated with lower frequency of depression and higher mastery.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Review
Gastroenterology & Hepatology
Robert P. Anderson
Summary: Diagnostics are crucial in addressing the global prevalence of coeliac disease and promoting new non-dietary treatments. Non-biopsy diagnosis is gaining acceptance due to the better understanding of the immunopathogenesis of coeliac disease and the use of serology. Research methods for measuring gluten-specific CD4+ T cells and the acute recall response to gluten ingestion may further expand non-biopsy diagnosis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Nutrition & Dietetics
Vivienne Guan, Steve Simpson-Yap, Nupur Nag, George Jelinek, Sandra Neate, Yasmine Probst
Summary: Understanding the dietary characteristics of people living with multiple sclerosis (plwMS) is important for planning nutrition interventions. This study validated the psychometric properties of the Dietary Habits Questionnaire (DHQ) and compared it with repeated 24-hour recall assessments. The DHQ was found to be appropriate for screening participants with relapsing-remitting MS, and five dietary patterns were identified.
Editorial Material
Gastroenterology & Hepatology
Robert P. Anderson
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Clinical Neurology
Alexander Fidao, George Jelinek, Steve Simpson-Yap, Sandra Neate, Nupur Nag
Summary: People with multiple sclerosis (pwMS) have reduced quality of life, and engaging in healthy lifestyle behaviors such as a healthy diet and regular physical activity can improve their quality of life. This study aims to assess the benefits of individual lifestyle behaviors on quality of life, and whether engaging in multiple healthy behaviors concurrently has additive benefits.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Jeanette C. Reece, Sandra L. Neate, Rebekah A. Davenport, Elasma Milanzi, Nupur Nag, William Bevens, Maggie Yu, George A. Jelinek, Steve Simpson-Yap
Summary: This study aims to investigate the relationship between stressful life events and fatigue and depressive symptoms in people living with multiple sclerosis (plwMS). The findings suggest that the number and load of stressful life events are not associated with higher prevalence of fatigue or depressive symptoms, except for those events with a perceived negative emotional impact.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Clinical Neurology
Steve Simpson-Yap, Sandra L. Neate, Nupur Nag, Yasmine C. Probst, Maggie Yu, George A. Jelinek, Jeanette C. Reece
Summary: This study aimed to examine the relationship between diet quality and subsequent disability in people with MS. The results showed that higher diet quality was associated with lower disability risk, while meat and dairy consumption was associated with increased disability risk.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Muskan Yadav, Sandra Neate, Craig Hassed, Richard Chambers, Sherelle Connaughton, Nupur Nag
Summary: The goal of this research was to identify elements that aided in course completion and implementation of teachings in a digital mindfulness course. The study found that benefits from a virtual community, appeal of content, enablers to participation and implementation, and personal benefits were key themes. Some novel findings include growing together, repeating the course, evidence-based teaching, and immediate benefits on physical and mental well-being.
JMIR FORMATIVE RESEARCH
(2022)