Review
Biology
Michel Belyk, Nicole Eichert, Carolyn McGettigan
Summary: Humans have a unique ability for voice modulation, which is supported by close connections between multiple brain regions and the existence of somatotopic maps. Understanding how this unique human phenotype evolved in brain networks is crucial for a deeper understanding of the evolutionary process of human speech ability.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Neurosciences
Amanda S. Therrien, Matthew A. Statton, Amy J. Bastian
Summary: Damage to the cerebellum causes movement disorders like ataxia, but patients can significantly improve reaching movements through binary reinforcement training, suggesting benefits beyond mere repetition or reduced visual control.
Article
Multidisciplinary Sciences
Lauren N. Miterko, Tao Lin, Joy Zhou, Meike E. van der Heijden, Jaclyn Beckinghausen, Joshua J. White, Roy Sillitoe
Summary: Deep brain stimulation (DBS) shows potential in improving motor function in a mouse model of ataxia, with the combination of cerebellar nuclei DBS and physical activity being particularly effective.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Antonello Baldassarre, Maria Serena Filardi, Sara Spadone, Stefania Della Penna, Giorgia Committeri
Summary: The study found that rates of early and late post-training motor skill learning were positively correlated with the strength of functional connections among regions within the brain. Early learning was associated with connections within cerebellar regions, while late learning was related to connections between cortical and subcortical motor areas. This suggests that spontaneous brain activity carries behaviorally relevant information for experience-dependent cognitive operations over time.
Article
Genetics & Heredity
Robert Lalonde, Catherine Strazielle
Summary: The function of the Agtpbp1 gene has been mainly studied through the analysis of Agtpbp1(pcd) mutant mice, which exhibit cerebellar degeneration and changes in neurotransmitter concentrations, leading to cerebellar ataxia and other behavioral deficits. Similar neuropathogical and behavioral profiles have been observed in human subjects with biallelic variants of AGTPBP1.
Article
Genetics & Heredity
Robert Lalonde, Catherine Strazielle
Summary: The function of the HERC1 gene, mainly studied through mutant mice and subjects with variants, includes regulating cerebellar Purkinje cells, synaptic vesicles, climbing fiber projections, and alpha-motoneuron projections. The resulting phenotypes involve cerebellar ataxia, motor coordination loss, muscle weakness, and spatial deficits.
Article
Multidisciplinary Sciences
Junko Ota, Kensuke Umehara, Jeff Kershaw, Riwa Kishimoto, Yoshiyuki Hirano, Yasuhiko Tachibana, Hisateru Ohba, Takayuki Obata
Summary: Static T2*WI-based Subject-Specific Super Resolution fMRI (STSS-SRfMRI) is a novel scheme that enhances the spatial resolution of fMRI using super-resolution generative adversarial networks (SRGAN) and a T2*-weighted image (T2*WI) dataset for training. Experimental results show that the STSS-SRfMRI scheme achieves higher functional resolution.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Owen P. Morgan, Mitchell B. Slapik, Katherine G. Iannuzzelli, Stephen M. LaConte, Jonathan M. Lisinski, Peg C. Nopoulos, Ashley M. Cochran, Sharif Kronemer, Liana S. Rosenthal, Cherie L. Marvel
Summary: The cerebellum is crucial for sequencing within the implicit domain, while it may not be critical for cognitive sequencing that could be accomplished using explicit strategies. Individuals with cerebellar ataxia are able to compensate for cognitive sequencing by utilizing extra-cerebellar mechanisms, preserving resources for motor function. This highlights the complex role of the cerebellum in different types of sequencing tasks.
Article
Neurosciences
Rossitza Draganova, Viktor Pfaffenrot, Katharina M. Steiner, Sophia L. Goericke, Naveen Elangovan, Dagmar Timmann, Juergen Konczak
Summary: Neurodegeneration of the cerebellum primarily affects cerebellar cortex and leads to a loss of control and coordination of movement. However, compensatory changes in gray matter volume in the cerebellar output nuclei and secondary motor cortex may play a role in addressing this motor deficit.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Roderick P. P. W. M. Maas, Dennis J. L. G. Schutter, Ivan Toni, Dagmar Timmann, Bart P. C. van de Warrenburg
Summary: This study investigated whether repeated sessions of cerebellar transcranial direct current stimulation (tDCS) can modify the acquisition and/or timing of conditioned eyeblink responses (CRs) in patients with spinocerebellar ataxia type 3 (SCA3). The results showed that cerebellar tDCS had a significant treatment effect on the timing parameters of CRs, but did not affect CR acquisition. It was also found that the severity of disease measures and the duration of the disease were associated with the timing of CRs.
Article
Neurosciences
Jonathan Nicholas, Christian Amlang, Chi-Ying R. Lin, Leila Montaser-Kouhsari, Natasha Desai, Ming-Kai Pan, Sheng-Han Kuo, Daphna Shohamy
Summary: Recent studies have shown that individuals with cerebellar ataxia are impaired in learning reward associations through trial-and-error feedback, while retaining the ability to predict reward based on episodic memory. This suggests a specific and necessary role for the cerebellum in incremental learning of reward associations based on reinforcement, in addition to its role in motor learning.
Article
Neurosciences
Jasmine L. Mirdamadi, Courtney R. Seigel, Stephen D. Husch, Hannah J. Block
Summary: When there is a mismatch between visual and proprioceptive estimates of hand position, the brain realigns them to reduce the discrepancy. This realignment affects not only the representation of the finger itself, but also extends to other parts of the limb.
Article
Biology
Harvey Perez, May F. Abdallah, Jose Chavira, Angelina S. Norris, Martin T. Egeland, Karen L. Vo, Callan L. Buechsenschuetz, Valentina Sanghez, Jeannie L. Kim, Molly Pind, Kotoka Nakamura, Geoffrey G. Hicks, Richard A. Gatti, Joaquin Madrenas, Michelina Iacovino, Peter J. McKinnon, Paul J. Mathews
Summary: By introducing null mutations in both the Atm and Aptx genes in mice, researchers have created a novel mouse model that exhibits progressively severe ataxic phenotype and cerebellar molecular layer atrophy. The perturbations significantly alter the biophysical properties of cerebellar Purkinje neurons and their neural activity, correlating with cerebellar atrophy and ataxia over the animal's first year of life. Additionally, the double mutant mice also show a predisposition to cancer and immune abnormalities, resembling symptoms of A-T.
Article
Clinical Neurology
Erin M. Edwards, Nora E. Fritz, Amanda S. Therrien
Summary: Cerebellar pathology is common in persons with multiple sclerosis, leading to enhanced motor impairment and disability progression. However, the differential effects of cerebellar dysfunction on rehabilitation outcomes in this population are still unknown. Future research should focus on rehabilitation interventions targeting cerebellar dysfunction in persons with multiple sclerosis.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)
Article
Behavioral Sciences
Evelyn M. Guilherme, Anna Carolyna L. Gianlorenco
Summary: This study investigated the effects of intracerebellar microinjection of dopaminergic agents on motor and emotional memory in mice. The results suggest that cerebellar dopaminergic D2 receptors may participate in the modulation of aversive memory processes without influencing motor performance.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Neurosciences
Jinseok Oh, Arash Mahnan, Jiapeng Xu, Hannah J. Block, Jurgen Konczak
Summary: The typical development of finger position sense from late childhood to adulthood is characterized by an age-dependent increase in proprioceptive precision, rather than a decrease in bias.
JOURNAL OF MOTOR BEHAVIOR
(2023)
Article
Oncology
Valentin Karl Ladenhauf, Malik Galijasevic, Johannes Kerschbaumer, Christian Franz Freyschlag, Martha Nowosielski, Anna Maria Birkl-Toeglhofer, Johannes Haybaeck, Elke Ruth Gizewski, Stephanie Mangesius, Astrid Ellen Grams
Summary: MGMT-methylated glioblastomas have lower ADC values compared to glioblastomas without MGMT methylation in peritumoral white matter. There were no differences in enhancing tumor areas. These findings could improve predictions of MGMT status in glioblastomas.
Article
Oncology
Sarah Iglseder, Anna Iglseder, Vincent Beliveau, Johanna Heugenhauser, Elke R. Gizewski, Johannes Kerschbaumer, Guenther Stockhammer, Christian Uprimny, Irene Virgolini, Jozsef Dudas, Meinhard Nevinny-Stickel, Martha Nowosielski, Christoph Scherfler
Summary: This retrospective study aimed to analyze the correlation between somatostatin receptor subtypes (SSTR 1-5) and maximum standardized uptake value (SUVmax) in meningioma patients using Gallium-68 DOTA-D-Phe1-Tyr3-octreotide Positron Emission Tomography ([68Ga]Ga-DOTATOC PET). The study also developed a radiomic model based on apparent diffusion coefficient (ADC) maps derived from diffusion weighted magnetic resonance images (DWI MRI) to reproduce SUVmax. Results showed that SSTR subtypes 2A, 2B, and 5 correlated significantly with SUVmax in meningioma patients.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Engineering, Biomedical
Christian Lassmann, Winfried Ilg, Tim W. Rattay, Ludger Schoels, Martin Giese, Daniel F. B. Haeufle
Summary: In Hereditary Spastic Paraplegia type 4 (SPG4), gait changes in prodromal and early-to-moderate manifest participants can be predicted and evaluated by comparing neuro-muscular simulations and patient gait changes, linking them to neuro-muscular dysfunction for early therapeutic interventions.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2023)
Letter
Clinical Neurology
Jens Seemann, Andreas Traschuetz, Winfried Ilg, Matthis Synofzik
JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Martin Bendszus, Jens Fiehler, Fabien Subtil, Susanne Bonekamp, Anne Hege Aamodt, Blanca Fuentes, Elke R. Gizewski, Michael D. Hill, Antonin Krajina, Laurent Pierot, Claus Z. Simonsen, Kamil Zelenak, Rolf A. Blauenfeldt, Bastian Cheng, Angelique Denis, Hannes Deutschmann, Franziska Dorn, Fabian Flottmann, Susanne Gellissen, Johannes C. Gerber, Mayank Goyal, Jozef Haring, Christian Herweh, Silke Hopf-Jensen, Vi Tuan Hua, Maerit Jensen, Andreas Kastrup, Christiane Fee Keil, Andrej Klepanec, Egon Kurca, Ronni Mikkelsen, Markus Moehlenbruch, Stefan Mueller-Huelsbeck, Nico Muennich, Paolo Pagano, Panagiotis Papanagiotou, Gabor C. Petzold, Mirko Pham, Volker Puetz, Jan Raupach, Gernot Reimann, Peter Arthur Ringleb, Maximilian Schell, Eckhard Schlemm, Silvia Schoenenberger, Bjorn Tennoe, Christian Ulfert, Katerina Valis, Eva Vitkova, Dominik F. Vollherbst, Wolfgang Wick, Goetz Thomalla
Summary: Endovascular thrombectomy is associated with improved functional outcome and lower mortality in patients with acute ischemic stroke from large vessel occlusion using non-contrast CT as the primary imaging modality for patient selection.
Article
Pediatrics
Maria Sappler, Nina Volleritsch, Marlene Hammerl, Yasmin Pellkofer, Elke Griesmaier, Elke Ruth Gizewski, Susanne Kaser, Ursula Kiechl-Kohlendorfer, Vera Neubauer
Summary: This study found that there was no impairment of brain development in GDM-exposed preterm infants compared to matched controls, but there were differences in white matter microstructure in specific regions indicating an enhanced maturation. However, neurodevelopmental outcome did not differ between the groups.
Article
Engineering, Biomedical
Qiyin Huang, Bin Zhong, Naveen Elangovan, Mingming Zhang, Jurgen Konczak
Summary: This study presents a fast and accurate method to assess human ankle motion sense acuity using a robotic device. The results show that the perception of ankle motion velocity has a bias, which increases with the reference velocity.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Meeting Abstract
Hospitality, Leisure, Sport & Tourism
Leoni Viola Winter, Stefan Panzer, Jurgen Konczak
JOURNAL OF SPORT & EXERCISE PSYCHOLOGY
(2023)
Article
Neurosciences
Jacquelyn V. L. Sertic, Nicole Fall, Juergen Konczak
Summary: This study investigated whether physically active middle-aged and older adults demonstrate age-related decline in ankle proprioception and found that active aging adults may be spared from this decline, especially for small ankle displacements.
JOURNAL OF MOTOR BEHAVIOR
(2023)
Article
Neurosciences
Andrea H. Nemeth, Chrystalina A. Antoniades, Juergen Dukart, Martina Minnerop, Clara Rentz, Bart-Jan Schuman, Bart van de Warrenburg, Ilse Willemse, Enrico Bertini, Anoopum S. Gupta, Carlos Bandeira de Mello Monteiro, Hajar Almoajil, Lori Quinn, Susan B. Perlman, Fay Horak, Winfried Ilg, Andreas Traschuetz, Adam P. Vogel, Helen Dawes
Summary: This article provides consensus guidance for using internal smartphone sensors to assess key domains in ataxia. The guidance emphasizes the importance of consensus, identifies priority measures and standard criteria, and encourages further research in this field.
Article
Otorhinolaryngology
Stephanie Misono, Jiapeng Xu, Jinseok Oh, Anna Sombrio, Ali Stockness, Arash Mahnan, Jurgen Konczak
Summary: Unexplained chronic cough is a common condition with significant negative impact on quality of life. This study aimed to investigate whether individuals with chronic cough exhibit abnormal neural processing during voluntary laryngeal motor activity. The findings suggest that chronic cough affects sensorimotor cortical activity during vocalization.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2023)
Article
Neurosciences
Pierre Cabaraux, Sunil K. Agrawal, Huaying Cai, Rocco Salvatore Calabro, Casali Carlo, Damm Loic, Doss Sarah, Christophe Habas, Anja K. E. Horn, Winfried Ilg, Elan D. Louis, Hiroshi Mitoma, Vito Monaco, Maria Petracca, Alberto Ranavolo, Ashwini K. Rao, Serena Ruggieri, Tommaso Schirinzi, Mariano Serrao, Susanna Summa, Michael Strupp, Olivia Surgent, Matthis Synofzik, Shuai Tao, Hiroo Terasi, Diego Torres-Russotto, Brittany Travers, Jaimie A. Roper, Mario Manto
Summary: This consensus paper discusses the roles of the cerebellum in human gait, its assessment and therapy. The cerebellum is critical for postural control and mapping sensory information into motor commands. Various cerebellar disorders can lead to impaired gait and balance, with ataxia being a common symptom. Different techniques, such as wearable devices and deep learning methods, are being developed for the evaluation and treatment of cerebellar disorders.
Meeting Abstract
Hospitality, Leisure, Sport & Tourism
Jacquelyn Sertic, Jurgen Konczak
JOURNAL OF SPORT & EXERCISE PSYCHOLOGY
(2022)
Review
Rehabilitation
Leoni Winter, Qiyin Huang, Jacquelyn V. L. Sertic, Jurgen Konczak
Summary: This study systematically reviewed recent empirical evidence on proprioceptive training and found that it can lead to significant improvements in proprioceptive and motor function, especially in clinical populations. Joint position sense error was identified as a reliable and feasible measure for clinical use.
FRONTIERS IN REHABILITATION SCIENCES
(2022)