Article
Clinical Neurology
Carsten M. Klingner, Fabian Kattlun, Lena Krolopp, Elisabeth Jochmann, Gerd F. Volk, Stefan Brodoehl, Orlando Guntinas-Lichius, Otto W. Witte, Christian Dobel
Summary: Learning from errors is a fundamental mechanism for motor adaptation. Long-term mismatches in motor actions can lead to changes in brain processing that optimize motor learning potential. This study investigates whether short-term mismatches can induce similar effects and suggests that short-term mismatch interventions may be used as a therapeutic strategy to enhance motor learning potential.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Charlene Truong, Celia Ruffino, Alexandre Crognier, Christos Paizis, Lionel Crognier, Charalambos Papaxanthis
Summary: This study examines the effects of error-based and reinforcement training on the acquisition and long-term retention of free throw accuracy in basketball. The error-based group demonstrated immediate improvement in accuracy, while the reinforcement group showed improvement over time. The mixed group exhibited advantages in both acquisition and retention. These findings highlight the importance of combining error-based and reinforcement learning for efficient skill acquisition and retention.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Matthew Weightman, John-Stuart Brittain, Alison Hall, R. Chris Miall, Ned Jenkinson
Summary: The study found that short-duration stimulation applied to the cerebellum enhanced movements performed simultaneously with stimulation, while M1 stimulation did not improve adaptation. This suggests that the coupling of cerebellar stimulation and movement plays a crucial role in facilitating enhanced learning in the stimulated context.
Article
Multidisciplinary Sciences
Ehsan Sedaghat-Nejad, Jay S. Pi, Paul Hage, Mohammad Amin Fakharian, Reza Shadmehr
Summary: The ability of the brain to control movement accurately relies on the cerebellum. Recent research has found that cerebellar P cells transmit information by synchronizing their spikes and utilizing disinhibition to convey important signals for movement control.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Psychology, Multidisciplinary
Lisa Fleury, Francesco Panico, Alexandre Foncelle, Patrice Revol, Ludovic Delporte, Sophie Jacquin-Courtois, Christian Collet, Yves Rossetti
Summary: Prism adaptation is a useful method to study sensorimotor adaptation, and the cerebellum plays an important role in the transfer of after-effects. This study aimed to explore whether anodal stimulation of the cerebellum could enhance after-effects transfer from throwing to pointing in novice participants. The results showed that active stimulation did not have significant beneficial effects on error reduction or throwing after-effects, but it had an effect on the longitudinal evolution of pointing errors and on pointing kinematic parameters during transfer assessment.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Food Science & Technology
Ayane Ninomiya, Abdallah Mshaty, Asahi Haijima, Hiroyuki Yajima, Michifumi Kokubo, Miski Aghnia Khairinisa, Winda Ariyani, Yuki Fujiwara, Sumiyasu Ishii, Nobutake Hosoi, Hirokazu Hirai, Izuki Amano, Noriyuki Koibuchi
Summary: Recent studies have suggested a possible link between perfluorooctane sulfonate (PFOS) and developmental disabilities. In this study, researchers examined the effects of early lactational PFOS exposure on motor coordination, social activity, and anxiety in male mice. The results showed impaired motor coordination and altered synaptic plasticity in the cerebellum of PFOS-exposed mice. These findings highlight the potential long-lasting effects of lactational PFOS exposure on cerebellar function.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Neurosciences
Takuma Inoshita, Tomoo Hirano
Summary: The cerebellum is involved in motor learning, with LTD at PF-PC synapses considered a primary mechanism. NE's contribution to cerebellum-dependent learning has been reported separately. Studies have found that NE facilitates LTD induction at PF-PC synapses in the cerebellar flocculus through activation of PKA via p-AR.
Article
Multidisciplinary Sciences
Manasi Wali, Trevor Lee-Miller, Reshma Babu, Hannah J. Block
Summary: The brain estimates hand position by combining visual and proprioceptive cues, and spatial mismatches between these cues elicit recalibration. It is unclear how long this recalibration is retained. This study investigates whether direct vision and/or active movement of the hand can undo visuo-proprioceptive recalibration, and whether recalibration is still evident 24 hours later.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Lynea B. Kaethler, Katlyn E. Brown, Sean K. Meehan, W. Richard Staines
Summary: Enhancing cerebellar activity improves motor adaptation rates and increases beta-ERD during motor planning. This study enhances our understanding of cerebellum-motor connections and may inform future skill training and rehabilitation protocols.
Review
Biology
Jonathan S. Tsay, Hyosub Kim, Adrian M. Haith, Richard B. Ivry
Summary: Multiple learning processes contribute to successful goal-directed actions. Among these processes, implicit sensorimotor adaptation plays a primary role in ensuring well-calibrated and accurate movements. Traditionally, adaptation is thought to minimize visual errors through an iterative process. However, the role of proprioception has been neglected, with the assumption that it passively responds to visual errors without directly contributing to adaptation. This study proposes an alternative model, the proprioceptive re-alignment model (PReMo), which suggests that implicit adaptation aims to minimize proprioceptive errors. The PReMo model is consistent with previous findings and provides a parsimonious explanation for unexplained phenomena.
Article
Neurosciences
Ilja Wagner, Alexander C. Schuetz
Summary: Motor adaptation relies on an error signal generated by the movement target to evaluate movement accuracy and suppresses error signals from irrelevant objects. In dynamic environments, the availability of conflicting error signals varies over time, and properties of the visual environment determine how movement errors are corrected.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Engineering, Biomedical
Aamir Abbasi, Nathan P. Danielsen, Jennifer Leung, A. K. M. G. Muhammad, Saahil Patel, Tanuj Gulati
Summary: The study demonstrates that cerebellar stimulation can significantly and long-lastingly alter the activity patterns of M1 neurons by changing firing rates, enhancing neural synchrony, and increasing the activation strength of neuronal ensembles. These changes were not accompanied by significant alterations in the overall spectral power of LFPs post-stimulation.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2021)
Article
Health Care Sciences & Services
Dieter F. Kutz, Stephanie Froehlich, Julian Rudisch, Katrin Mueller, Claudia Voelcker-Rehage
Summary: This study found an association between finger tapping and cognitive function. The results showed significant differences in parameters between groups, sex, and group x sex interaction under two tapping conditions. Linear discriminant analysis indicated that finger tapping parameters were only partially useful for early stage dementia classification. The findings were discussed in relation to the age-related degeneration of motor areas in the brain.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Neurosciences
Abhimanyu Mahajan, Palak Gupta, Jonathan Jacobs, Luca Marsili, Andrea Sturchio, H. A. Jinnah, Alberto J. Espay, Aasef G. Shaikh
Summary: The study examined the role of the cerebellum in tremor-dominant cervical dystonia patients by measuring the adaptive capacity of rapid reflexive eye movements. It found that patients lacked both fast and slow timescales in saccade adaptation, indicating maladaptive cerebellar outflow as a potential pathophysiological basis for the disorder.
Article
Clinical Neurology
Hang Yu, Manli Wang, Qiu Yang, Xiaojiao Xu, Rong Zhang, Xi Chen, Weidong Le
Summary: We propose that there may be alterations in the cerebellar electrophysiology and sleep-wake cycles at the early stage of Alzheimer's disease (AD), before the appearance of amyloid-beta neuropathological hallmarks. The characteristics of cerebellar electrophysiology could potentially serve as a biomarker for the prepathological detection of AD. Sleep disturbances are common in preclinical AD patients, and the structure and function of the cerebellum may be altered early on in the disease, suggesting its possible involvement in the progression of AD.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Elodie Nerrant, Lucie Abouaf, Frederic Pollet-Villard, Anne-Laure Vie, Sandra Vukusic, Julien Berthiller, Bettina Colombet, Alain Vighetto, Caroline Tilikete
JOURNAL OF NEURO-OPHTHALMOLOGY
(2020)
Article
Multidisciplinary Sciences
Judith Nicolas, Aurelie Bidet-Caulet, Denis Pelisson
SCIENTIFIC REPORTS
(2019)
Article
Behavioral Sciences
Leslie Tricoche, Johan Ferrand-Verdejo, Denis Pelisson, Martine Meunier
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2020)
Letter
Clinical Neurology
M. Cescutti, C. Davenas, C. Tilikete, F. Durand-Dubief, R. Marignier, S. Vukusic
REVUE NEUROLOGIQUE
(2020)
Article
Neurosciences
Aasef G. Shaikh, Adolfo Bronstein, Sergio Carmona, Yoon-Hee Cha, Catherine Cho, Fatema F. Ghasia, Daniel Gold, Kemar E. Green, Christoph Helmchen, Richard T. Ibitoye, Jorge Kattah, Ji-Soo Kim, Sudhir Kothari, Mario Manto, Barry M. Seemungal, Dominik Straumann, Michael Strupp, David Szmulewicz, Alexander Tarnutzer, Ali Tehrani, Caroline Tilikete, Miriam Welgampola, Guillermo Zalazar, Amir Kheradmand
Summary: Virtual healthcare practices have seen significant growth in the modern era, especially accelerated by the challenges posed by the COVID-19 pandemic. Guidelines on remote examination methods in neurotology have become crucial, aiming to diagnose inner-ear, brainstem, and cerebellum diseases effectively. The focus has been on determining urgent medical care needs for patients with vestibular disorders versus those who can be managed on an expedited outpatient basis.
Review
Critical Care Medicine
Pascal Seve, Yvan Jamilloux, Caroline Tilikete, Mathieu Gerfaud-Valentin, Laurent Kodjikian, Thomas El Jammal
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Multidisciplinary Sciences
Judith Nicolas, Aurelie Bidet-Caulet, Denis Pelisson
SCIENTIFIC REPORTS
(2020)
Article
Behavioral Sciences
Elvio Blini, Caroline Tilikete, Leonardo Chelazzi, Alessandro Farne, Fadila Hadj-Bouziane
Article
Clinical Neurology
Celine Louapre, Elisabeth Maillart, Caroline Papeix, Sinead Zeidan, Damien Biotti, Zoe Lepine, Abir Wahab, Mickael Zedet, Pierre Labauge, Caroline Tilikete, Julie Pique, Ayman Tourbah, Guillaume Mathey, Dalia Dimitri Boulos, Pierre Branger, Laurent Daniel Kremer, Romain Marignier, Nicolas Collongues, Jerome De Seze
Summary: The outcomes of COVID-19 in patients with NMOSD or MOGAD treated with immunosuppressive therapies were generally favorable in this cohort study. Hospitalized patients tended to be older with shorter disease duration, while outpatients were younger with longer disease duration. Larger international studies are needed to identify risk factors for severe COVID-19 in this immunocompromised population.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Behavioral Sciences
Alexis Cheviet, Laure Pisella, Denis Pelisson
Summary: This study investigated the contribution of the posterior parietal cortex (PPC) to saccadic remapping mechanisms in visual constancy. A patient with a PPC lesion and optic ataxia in the left hemifield was studied in transsaccadic visual localization tasks, showing specific patterns of perceptual deficits. The findings support the crucial role of the PPC in saccadic remapping processes for perceptual visual constancy.
Article
Biology
Leslie Tricoche, Elisabetta Monfardini, Amelie J. Reynaud, Justine Epinat-Duclos, Denis Pelisson, Jerome Prado, Martine Meunier
Summary: The presence of peers can help children perform more like adults, with better response strategies and faster response times. Peer presence influences educational skills and lays the groundwork for understanding how brain mechanisms mediating this social influence evolve during development.
Article
Endocrinology & Metabolism
Claire Marx, Muriel Rabilloud, Francoise Borson Chazot, Caroline Tilikete, Emmanuel Jouanneau, Gerald Raverot
Summary: The study compared the outcomes of patients with pituitary apoplexy managed by conservative or surgical approaches, finding no significant differences at 1 year in terms of visual field defects and visual acuity impairment. The Pituitary Apoplexy Score (PAS) may be a reliable parameter for guiding therapeutic strategy, with surgery recommended for patients with a PAS score >= 4.
Meeting Abstract
Clinical Neurology
C. Louapre, E. Maillart, C. Papeix, S. Zeidan, D. Biotti, Z. Lepine, A. Wahab, M. Zedet, P. Labauge, C. Tilikete, J. Pique, A. Tourbah, G. Mathey, D. Dimitri Boulos, P. Branger, L. Kremer, R. Marignier, N. Collongues, J. De Seze
MULTIPLE SCLEROSIS JOURNAL
(2020)
Meeting Abstract
Clinical Neurology
C. Tilikete
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2019)
Article
Medicine, General & Internal
Svenja Specovius, Hanna G. Zimmermann, Frederike Cosima Oertel, Claudia Chien, Charlotte Bereuter, Lawrence J. Cook, Marco Aurelio Lana Peixoto, Mariana Andrade Fontenelle, Ho Jin Kim, Jae-Won Hyun, Su-Kyung Jung, Jacqueline Palace, Adriana Roca-Fernandez, Alejandro Rubio Diaz, Maria Isabel Leite, Srilakshmi M. Sharma, Fereshte Ashtari, Rahele Kafieh, Alireza Dehghani, Mohsen Pourazizi, Lekha Pandit, Anitha Dcunha, Orhan Aktas, Marius Ringelstein, Philipp Albrecht, Eugene May, Caryl Tongco, Letizia Leocani, Marco Pisa, Marta Radaelli, Elena H. Martinez-Lapiscina, Hadas Stiebel-Kalish, Mark Hellmann, Itay Lotan, Sasitorn Siritho, Jerome de Seze, Thomas Senger, Joachim Havla, Romain Marignier, Caroline Tilikete, Alvaro Cobo Calvo, Denis Bernardi Bichuetti, Ivan Maynart Tavares, Nasrin Asgari, Kerstin Soelberg, Ayse Altintas, Rengin Yildirim, Uygur Tanriverdi, Anu Jacob, Saif Huda, Zoe Rimler, Allyson Reid, Yang Mao-Draayer, Ibis Soto de Castillo, Michael R. Yeaman, Terry J. Smith, Alexander U. Brandt, Friedemann Paul