期刊
CERAMICS INTERNATIONAL
卷 39, 期 7, 页码 8401-8410出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceramint.2013.04.021
关键词
Tissue engineering; Microenvironment; Capillary action; Bone marrow ingress and retention
资金
- National Agenda Project (NAP)
- Korea Research Council of Fundamental Science Technology [P-09-JC-LU63-C01]
We have developed a hydroxyapatite-based scaffold with micro-channels and nano-pores (MCNP) using a polyurethane template coating method to overcome some of the limitations by addressing fluid absorbance and retention via capillary action. The novel scaffold has 3 basic structures. First, the scaffold has a porous trabecular network similar to that of human trabecular bones (300-400 um) which are mechanically matched to the strength of native trabecular bone (2-12 MPa). Second, it has micro-sized channels (25-70 um) within each trabecular septum which exhibit highly effective fluid absorption via capillary action. Third, the surface of each septum has nano-sized pores (100-400 nm) that allow immobilized cells to anchor. The surface area of the scaffold with micro-channels was significantly (+42.0%) higher than the scaffold without micro-channels as calculated using computer aided design (CAD) software, while overall porosity did not change significantly (+8.8%). Combinatorial effects of these internal structures result in a host-adapting construct that enhances cell ingress and retention from the host bone marrow throughout the entire scaffold. (C) 2013 Elsevier Ltd and Techna Group S.r.l. All tights reserved.
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