期刊
CERAMICS INTERNATIONAL
卷 37, 期 4, 页码 1377-1391出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceramint.2011.01.005
关键词
Hydroxyapatite; beta-Tri calcium phosphate; Microplasma spraying; In vivo animal trial; Intramedullar pinning; Bone defects healing
资金
- Department of Science and Technology, New Delhi
- Council of Scientific and Industrial Research, New Delhi
Here we report a comparative study of the healing kinetics of surgically created artificial defects in the tibia of New Zealand white rabbits. Comparison of the healing kinetics was made for uncoated conventional SS316L intramedullary pins, and the same pins with microplasma sprayed (MIPS) pure hydroxyapatite (HAp) and beta-tri calcium phosphate (beta-TCP) coatings. After thorough material characterizations including XRD, FTIR, SEM, etc., MIPS coated pins were implanted to such animals. Serum biochemistry, radiology and fluorochrome labelling were used to evaluate the comparative healing kinetics of these implants in vivo. In comparison to those of the uncoated pins, the pins coated with both MIPS HAp and beta-TCP showed significant increment of alkaline phosphatase up to 15th postoperative day, insignificant changes in serum phosphorus and calcium with uneventful healing of bone defect. There was development of Havarsian canals and well-defined peripherally placed osteoblasts along with evidence of angiogenesis and comparatively more new bone formation in the defect site. On a comparative scale, the performance of the beta-TCP coated intramedullary pins was much better than that of the pure HAp coated pins than the uncoated intramedullary pins. (C) 2011 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
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