Article
Neurosciences
Xiao Wang, Yutong Zhang, Wenchuan Qi, Tao Xu, Ziwen Wang, Huaqiang Liao, Yanan Wang, Jie Liu, Yang Yu, Zhenxi He, Shan Gao, Dehua Li, Guilin Zhang, Ling Zhao
Summary: This study aimed to assess the altered patterns of brain activity dynamics over different time scales and the potential pathophysiological mechanisms of alterations in patients with MWoA. The findings provide new evidence for the hypothesis of abnormal dynamic brain activity in migraine.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Clinical Neurology
Karissa N. Arca, Juliana H. VanderPluym, Rashmi B. Halker Singh
Summary: Neuroimaging plays an important role in evaluating migraine aura (MA) and hemiplegic migraine, especially in cases with atypical features or first-time presentation. Unique imaging findings such as reversible cortical diffusion restriction and biphasic transition from hypoperfusion to hyperperfusion are associated with acute MA. Research imaging modalities have shown distinct findings in migraine with aura, aiding in interpretation of imaging results and improvement of patient care.
Article
Clinical Neurology
Katarina Mitrovic, Igor Petrusic, Aleksandra Radojicic, Marko Dakovic, Andrej Savic
Summary: This study used machine learning techniques to differentiate healthy individuals from those with migraines and classify different types of migraines. The results show that an algorithm based on MRI data can accurately identify migraine patients and distinguish between simple and complex migraines. This method has significant implications for the diagnosis and classification of migraines.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
[Anonymous]
Summary: This study used SWI-MinIP images to observe changes in venous continuity in children with primary headache. The results showed that patients with migraine had increased cerebral venous perfusion in the most involved region of the headache, which can be used as a diagnostic indicator for primary headache.
Article
Clinical Neurology
Jasem Yousef Al-Hashel, Raed Alroughani, Khaled Gad, Lamiaa Al-Sarraf, Samar Farouk Ahmed
Summary: WMHs are more frequent in migraine patients, especially in those with chronic migraine. Older age, longer disease duration, frequent attacks, and high serum homocysteine level are the main risk factors for WMHs.
Article
Clinical Neurology
Byung-Kun Kim, Soohyun Cho, Ha Yan Kim, Min Kyung Chu
Summary: The study investigated the validity and reliability of the self-administered Visual Aura Rating Scale (VARS) questionnaire in screening visual aura in patients with migraine. The conclusion demonstrated that the questionnaire is a valid and reliable instrument for this purpose.
Article
Neurosciences
Alvaro Planchuelo-Gomez, David Garcia-Azorin, Angel L. Guerrero, Santiago Aja-Fernandez, Margarita Rodriguez, Rodrigo de Luis-Garcia
Summary: No specific migraine biomarkers have been identified in single-modality MRI studies, but a multimodal MRI analysis revealed structural connectivity abnormalities in chronic and episodic migraine patients. Differences in connectivity patterns between cortical and subcortical regions were observed, shedding new light on the association between brain structure and connectivity in migraine.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Seongho Park, Dong Ah Lee, Ho-Joon Lee, Kyong Jin Shin, Kang Min Park
Summary: This exploratory study aimed to investigate the underlying pathomechanisms of migraine with aura (MA) and migraine without aura (MO) during the interictal phase using connectivity analysis. While there were no differences in global structural connectivity, differences in global functional connectivity were found between patients with MA and MO. Further studies are needed to confirm these findings and explore the potential of using functional connectivity as novel biomarkers in migraine.
ACTA NEUROLOGICA SCANDINAVICA
(2022)
Article
Medicine, Research & Experimental
Wen-Qiang Cui, Si-Shuo Zhang, Fei Xu, Hai-Tao Li, Hong-Wei Zhi, Ya-Han Wang, Yong-Jun Huo, Xiang-Qing Xu, Hong-Yun Wu
Summary: This study found that abnormal frontoparietal network (FPN) function was correlated with attention, anxiety, depression, and sleep status in participants with migraine without aura (MwoA). These results provide further insights into the evaluation and treatment of MwoA.
MEDICAL SCIENCE MONITOR
(2022)
Article
Clinical Neurology
Shirui Cheng, Xinyue Zhang, Huabin Zheng, Nannan Jiang, Jun Zhou, Xinling Li, Yu Fang, Xiaopeng Huang, Jingtao Liang, Tao Yin, Fanrong Liang, Fang Zeng, Zhengjie Li
Summary: This study aims to predict analgesia response in patients with MwoA receiving acupuncture treatment based on brain structural and functional characteristics. Machine learning methods will be used to classify patients and predict response or non-response to acupuncture treatment using multimodal MRI parameters.
FRONTIERS IN NEUROLOGY
(2022)
Article
Rehabilitation
Yoo Jin Choo, Mathieu Boudier-Reveret, Min Cheol Chang
Summary: Detailed knowledge of brain anatomy is essential for treating patients with brain disorders. This study reviewed essential parts of human brain anatomy using magnetic resonance imaging, focusing on structures in each brain lobe, limbic system, language-related structures, and important neural tracts related to motor and sensory functions. This review aims to assist physiatrists in accurately identifying functional damage from brain disorders and planning appropriate rehabilitative treatment.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Paul D. Griffiths, Mariasavina Severino, Deborah Jarvis, Laura Mandefield, Cecilia Parazzini, Lorenzo Pinelli, Marco Di Maurizio, Fabio Triulzi, Elisa Scola, Giorgio Conte, Giovanni Palumbo, Maurilio Genovese, Andrea Rossi, Renzo Guerrini, Andrea Righini
Summary: The study included 64 foetuses with cortical formation abnormalities (CFA) who underwent two in utero magnetic resonance (iuMR) exams, with 62% showing consistent CFA description between the two studies. In 38% of cases, there was a category change, including cases without CFA initially detected, changes in laterality/symmetry, and re-classification within the same group. Brain abnormalities other than CFA were present in around half of the cases on both first and second studies. Prognosis was predicted to have changed in 8% of cases based on the second study, with all indicating a worse prognosis.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tong Fu, Yujia Gao, Xiaobin Huang, Di Zhang, Lindong Liu, Peng Wang, Xindao Yin, Hai Lin, Jianmin Yuan, Shuyue Ai, Xinying Wu
Summary: This study identified whole-brain connectivity features as imaging markers for MwA identification, showing significant differences in structural and functional connectivity between MwA and MwoA patients. The identified features were correlated with clinical rating scales and demonstrated high accuracy in predicting MwA using random forest classifiers.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Neuroimaging
Hao Liu, Ruiping Zheng, Yong Zhang, Beibei Zhang, Haiman Hou, Jingliang Cheng, Shaoqiang Han
Summary: This study used a new method based on gray matter volumes (GMVs) to investigate the neuroanatomical subtypes of migraine. The results showed that migraine patients without aura have high interindividual variability in GMVs, and two distinct and reproducible neuroanatomical subtypes of migraine were revealed.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Feifei Qu, Taotao Sun, Yongsheng Chen, Brijesh Kumar Yadav, Ling Jiang, Zhaoxia Qian, E. Mark Haacke
Summary: The study utilized STAGE imaging to estimate tissue properties in the fetal brain, finding that the ratios of T-1app and PDapp in different regions varied, indicating the potential utility of STAGE imaging for assessing fetal brain properties.
EUROPEAN RADIOLOGY
(2021)
Article
Anesthesiology
Janu Thuraiaiyah, Mohammad Al-Mahdi Al-Karagholi, Fatima Azzahra Elbahi, Zixuan Alice Zhuang, Messoud Ashina
Summary: In a randomized, double-blinded, placebo-controlled, crossover study, researchers found that adenosine does not significantly induce migraine attacks but does cause headache. Adenosine increases heart rate, facial skin blood flow, and superficial temporal artery diameter, while decreasing middle cerebral artery blood flow.
Article
Clinical Neurology
C. Tsagkas, A. Horvath-Huck, T. Haas, M. Amann, A. Todea, A. Altermatt, J. Mueller, A. Cagol, M. Leimbacher, M. Barakovic, M. Weigel, S. Pezold, T. Sprenger, L. Kappos, O. Bieri, C. Granziera, P. Cattin, K. Parmar
Summary: This study proposes a novel automatic segmentation method for spinal cord compartments in patients with multiple sclerosis (MS) and compares it with manual segmentation. The results demonstrate that the automatic method shows higher reproducibility and accuracy compared to manual segmentation, and reveal that patients with MS have reduced areas in specific spinal cord tissue compartments.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Review
Clinical Neurology
Irene de Boer, Iris Elsa Verhagen, Marcio Nattan Portes Souza, Messoud Ashina
Summary: New acute therapies such as ditans and gepants may be effective alternatives for patients who cannot use or do not respond to triptans. However, further studies are needed to determine their place and safety in migraine treatment.
Review
Clinical Neurology
Mohammad Al-Mahdi Al-Karagholi, Veberka Kalatharan, Hashmat Ghanizada, Christian Gram, Gregory Dussor, Messoud Ashina
Summary: This systematic review examined clinical studies on the role of prolactin and its receptors in headache and migraine. The findings suggest that prolactin and its receptors play a key role in migraine pathophysiology. Further randomized and placebo-controlled clinical studies are needed to clarify the influence of prolactin in migraine attack initiation.
Article
Clinical Neurology
Messoud Ashina, Stewart J. Tepper, Uwe Reuter, Andrew M. Blumenfeld, Susan Hutchinson, Jing Xia, Rosa Miceli, Lawrence Severt, Michelle Finnegan, Joel M. Trugman
Summary: This study assessed the long-term safety, tolerability, and efficacy of once-daily oral atogepant 60 mg in adults with migraine. The results showed that daily use of atogepant for preventive treatment of migraine during this 1-year trial was safe, well tolerated, and efficacious.
Review
Clinical Neurology
Lionesa Bahtiri, Andreas Vinther Thomsen, Messoud Ashina, Anders Hougaard
Summary: This systematic review summarizes and evaluates cases of migraine aura-like episodes triggered by sclerotherapy of veins of the lower extremities, and explores possible underlying mechanisms.
Article
Clinical Neurology
Alessandro Cagol, Nuria Cerda Fuertes, Marc Stoessel, Muhamed Barakovic, Sabine Schaedelin, Marcus D'Souza, Jens Wurfel, Alexander U. Brandt, Ludwig Kappos, Till Sprenger, Yvonne Naegelin, Jens Kuhle, Cristina Granziera, Athina Papadopoulou
Summary: This study investigated the associations among OCT changes, MRI measurements of brain volume loss, and physical and cognitive impairment in patients with multiple sclerosis. The results showed that OCT measures of pRNFL and GCIPL were associated with volumes of gray matter structures, and inversely correlated with T2-lesion volume. These findings highlight the value of OCT as markers of neurodegeneration and disability in multiple sclerosis.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Charidimos Tsagkas, Antal Huck-Horvath, Alessandro Cagol, Tanja Haas, Muhamed Barakovic, Michael Amann, Esther Ruberte, Lester Melie-Garcia, Matthias Weigel, Simon Pezold, Regina Schlaeger, Jens Kuhle, Till Sprenger, Ludwig Kappos, Oliver Bieri, Philippe Cattin, Cristina Granziera, Katrin Parmar
Summary: Spinal cord atrophy of the cervical anterior horn is clinically relevant in multiple sclerosis (MS) patients, particularly in progressive MS (PMS) patients and at the level of cervical SC enlargement.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Charidimos Tsagkas, Antal Huck-Horvath, Alessandro Cagol, Tanja Haas, Michael Amann, Muhamed Barakovic, Esther Ruberte, Lester Melie-Garcia, Matthias Weigel, Simon Pezold, Regina Schlaeger, Jens Kuhle, Till Sprenger, Ludwig Kappos, Oliver Bieri, Philippe Cattin, Cristina Granziera, Katrin Parmar
Summary: This study investigated longitudinal changes of cervical spinal cord (cSC) gray and white matter areas in multiple sclerosis (MS) patients. The results showed that patients with clinical progression had a faster reduction of cSC areas over time compared to stable patients. Additionally, compared to patients without clinical progression and healthy controls, only patients with clinical progression demonstrated a preferential reduction of cSC and white matter areas at the level of cSC enlargement.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Messoud Ashina, Caroline Roos, Lily Qian Li, Mika Komori, David Ayer, Dustin Ruff, John Henry Krege
Summary: During the 12-month extension study, patients treated with lasmiditan showed significant improvements in migraine-related disability and quality of life. No new safety concerns were identified.
Article
Clinical Neurology
Stewart J. Tepper, Richard B. Lipton, Stephen D. Silberstein, David Kudrow, Messoud Ashina, Uwe Reuter, David W. Dodick, Andrea Wang, Sunfa Cheng, Jan Klatt, Daniel D. Mikol
Summary: This study evaluated the long-term efficacy and safety of erenumab in patients with chronic migraine. The results showed that long-term treatment with erenumab could consistently reduce monthly migraine days and the efficacy was similar in patients with and without acute medication overuse.
Review
Clinical Neurology
Mohammad Al-Mahdi Al-Karagholi, Veberka Kalatharan, Hashmat Ghanizada, Gregory Dussor, Messoud Ashina
Summary: The review aimed to investigate the role of prolactin signaling in the pathophysiology of headache and migraine. Sex-dependent features of migraines suggest the involvement of the hypothalamus-pituitary-gonadal axis. Prolactin signaling has been implicated in sex-related differences in pain perception.
Article
Clinical Neurology
Lili Kokoti, Mohammad Al-Mahdi Al-Karagholi, Cherie Amalie Waldorff Nielsen, Messoud Ashina
Summary: This study investigated the effect of the K-ATP channel blocker glibenclamide on levcromakalim-induced headache in healthy volunteers and found that glibenclamide did not attenuate levcromakalim-induced headache. Future studies should further explore the role of different isoforms of sulfonylurea receptor subunits of K-ATP channels in the pathogenesis of headache and migraine.
Article
Clinical Neurology
Messoud Ashina, Richard B. Lipton, Jessica Ailani, Jan Versijpt, Simona Sacco, Dimos D. Mitsikostas, Cecilie Laurberg Christoffersen, Bjorn Sperling, Anders Ettrup
Summary: This post hoc analysis suggests that eptinezumab can reduce monthly migraine days in patients with difficult-to-treat migraines. The majority of patients who responded to eptinezumab during the initial weeks maintained or improved their response during the later weeks. Additionally, a significant number of initial non-responders showed a response after the second infusion.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Messoud Ashina, Dimos D. Mitsikostas, Verena Ramirez Campos, Steve Barash, Xiaoping Ning, Hans-Christoph Diener
Summary: This study aimed to determine the number needed to treat (NNT), number needed to harm (NNH), and likelihood of being helped or harmed (LHH) in a post hoc analysis of the phase 3b FOCUS trial. The results showed that the NNT, NNH, and LHH for quarterly and monthly fremanezumab compare favorably with those for traditional oral preventive medications, including topiramate, valproate, and propranolol.