Article
Biochemistry & Molecular Biology
Zoe Tasma, Andrew Siow, Paul W. R. Harris, Margaret A. Brimble, Simon J. O'Carroll, Debbie L. Hay, Christopher S. Walker
Summary: This study validated commercially available antibodies and used them to detect PACAP-responsive receptors in the trigeminal ganglia. Antibodies that could differentiate between receptor splice variants were identified, and expression of multiple receptors in neuronal and glial-like cells was observed. These findings suggest that these receptors are potential targets for migraine treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Atsuko Hayata-Takano, Yusuke Shintani, Keita Moriguchi, Naoki Encho, Kohei Kitagawa, Takanobu Nakazawa, Hitoshi Hashimoto
Summary: The study showed that PACAP increased internalization of 5-HT2A receptors, leading to attenuation of 5-HT2A-mediated signaling and suppression of head twitch responses induced by 5-HT2A agonists. This suggests a potential role for PACAP-PAC1 signaling in regulating serotonin receptor activity and behavior in mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Zachariah Bertels, Elizaveta Mangutov, Kendra Siegersma, Haley C. Cropper, Alycia Tipton, Amynah A. Pradhan
Summary: Research suggests that chronic use of opioids can lead to opioid-induced hyperalgesia (OIH) and medication overuse headache (MOH), and pituitary adenylate cyclase activating polypeptide (PACAP) is upregulated in both conditions. This study investigates whether PACAP acts as a bridge between opioids and pain chronification through blocking PACAP-PAC1 receptor. Results show that the PAC1 antagonist, M65, reverses chronic allodynia induced by combining morphine with the migraine trigger, nitroglycerin; and inhibits the exacerbation of cortical spreading depression, a correlate of migraine aura, caused by chronic opioids. In situ hybridization reveals co-expression of µ-opioid receptor (MOR) and PACAP in trigeminal ganglia, and near complete overlap between MOR and PAC1 in the trigeminal nucleus caudalis and periaqueductal gray. PACAPergic mechanisms may play a role in facilitating the transition to chronic headache following opioid use, and interventions targeting this system may be particularly beneficial for OIH and MOH.
Article
Clinical Neurology
Fatma Hanci, Yasemin Baranoglu Kilinc, Erkan Kilinc, Sevim Turay, Mustafa Dilek, Nimet Kabakus
Summary: The study found that plasma levels of PACAP-38 and vasoactive intestinal peptide were higher in pediatric migraine patients compared to controls, while levels of calcitonin gene-related peptide and substance P remained unchanged. No significant difference in neuropeptide levels was found between attack and attack-free periods.
Article
Biochemistry & Molecular Biology
Evelin Patko, Edina Szabo, Denes Toth, Tamas Tornoczky, Inez Bosnyak, Alexandra Vaczy, Tamas Atlasz, Dora Reglodi
Summary: This study found widespread immunoreactivity of PACAP and its specific receptor PAC1-R in the human eye, indicating the translational value of in vitro and animal studies and suggesting their presence in the human eye. This is important for understanding the distribution and function of PACAP in the human eye.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Chemistry, Medicinal
Ichiro Takasaki, Ai Watanabe, Takuya Okada, Daisuke Kanayama, Ryota Nagashima, Miyu Shudo, Ayaka Shimodaira, Kazuto Nunomura, Bangzhong Lin, Yurie Watanabe, Hiroaki Gouda, Atsuro Miyata, Takashi Kurihara, Naoki Toyooka
Summary: A series of pyrido[2,3-d]pyrimidine derivatives based on PA-8 were synthesized and evaluated, and compound 2o showed more potent antagonistic activities than PA-8. It could block PACAP-induced aversive behaviors and mechanical allodynia, and potentially become an analgesic for neuropathic pain treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Neurosciences
Keerthana Sureshkumar, Andrea Saenz, Syed M. Ahmad, Kabirullah Lutfy
Summary: PACAP and its receptors play a role in the regulation of food intake in the central and peripheral nervous systems. This article reviews the literature on the role of PACAP in food intake regulation and synthesizes the mechanisms by which PACAP exerts its anorexic effects in different brain regions.
Article
Biochemistry & Molecular Biology
Guangchun Fan, Zhengxin Tao, Shang Chen, Huahua Zhang, Rongjie Yu
Summary: In this study, it was found that the positive allosteric modulators PACAP(28-38) and TAT significantly trigger the nuclear translocation of PAC1-R, and the nuclearly translocated PAC1-R binds with the promoter regions of PAC1-R and PACAP. This translocation is positively correlated with the increase of PAC1-R and PACAP expression levels as well as the neuroprotective activities.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Neurosciences
Abha K. Rajbhandari, Christopher J. Octeau, Sarah Gonzalez, Zachary T. Pennington, Farzanna Mohamed, Jeremy Trott, Jasmine Chavez, Erin Ngyuen, Natasha Keces, Weizhe Z. Hong, Rachael L. Neve, James Waschek, Baljit S. Khakh, Michael S. Fanselow
Summary: Trauma can lead to dysfunctional fear regulation and development of disorders like PTSD. Research in mice showed that the PACAPergic pathway can modulate fear and fear extinction. Selective deletion of PAC1 receptors in mICCs in females may affect fear acquisition, generalization, and extinction, with modulation dependent on behavioral state.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Jessica Lu, Sarah J. Piper, Peishen Zhao, Laurence J. Miller, Denise Wootten, Patrick M. Sexton
Summary: Pituitary Adenylate Cyclase-Activating Peptide (PACAP) and Vasoactive Intestinal Peptide (VIP) are neuropeptides that play important roles in various physiological and pathological processes by activating specific receptors. The structural similarities between these peptides and their receptors present challenges in designing selective therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Irene Soles-Tarres, Nuria Cabezas-Llobet, Benjamin Lefranc, Jerome Leprince, Jordi Alberch, David Vaudry, Xavier Xifro
Summary: This study found that PACAP can exert antiapoptotic and neurotrophic effects on neuronal cells in Huntington's disease (HD) through the PAC1R receptor. In a mouse model, intranasal administration of PACAP restored motor function and increased levels of PAC1R, CBP, and BDNF in the striatum.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Charlotte Ernstsen, Sarah L. Christensen, Rikke H. Rasmussen, Brian S. Nielsen, Inger Jansen-Olesen, Jes Olesen, David M. Kristensen
Summary: Using in vivo and ex vivo models, the study shows that PACAP-38 can provoke migraine-like changes independently of CGRP and partially through K-ATP channels. The findings suggest that PACAP-38 antagonism could be a potential alternative therapeutic approach for patients non-responsive to CGRP-targeting therapies.
Article
Immunology
Caijie Zhou, Meihua Li, Yu Liu, Xinxin Wang, Shuang Zhang, Li Guan, Jingyi Hong, Wei Zhou, Gaohui Wu, Weiliang Diao, Qinmiao Huang, Pingchang Yang
Summary: TAFA4 can suppress the expression of FcεRI in mast cells to attenuate experimental AR. It is negatively correlated with tryptase levels in nasal secretions and modulates the transcription of Fcer1g gene.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Behavioral Sciences
Margaret A. Minnig, Tayun Park, Maria Echeveste Sanchez, Pietro Cottone, Valentina Sabino
Summary: This study found that a decrease in PAC1R levels in the NAcc Shell leads to excessive alcohol drinking, increased preference for ethanol, and higher motivation to drink in rats, but did not comparably increase self-administration of saccharin, suggesting selectivity of action.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Mafalda S. L. Aresta Branco, Alejandro Gutierrez Cruz, Mahsa Borhani Peikani, Violeta N. Mutafova-Yambolieva
Summary: The urinary bladder requires proper concentrations of extracellular ATP and other purines at receptor sites for normal functioning. Ectonucleotidases play a crucial role in dephosphorylation of ATP to ADP, AMP and ADO. The activation of metabolic pathways can restrict the release of ectonucleotidases and prevent excessive hydrolysis of ATP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Ann-Louise Esserlind, Anne Francke Christensen, Stacy Steinberg, Niels Grarup, Oluf Pedersen, Torben Hansen, Thomas Werge, Thomas Folkmann Hansen, Lise Lotte N. Husemoen, Allan Linneberg, Esben Budtz-Jorgensen, Maria Lurenda Westergaard, Hreinn Stefansson, Jes Olesen
Review
Biology
Michael K. Borregaard, Isabel R. Amorim, Paulo A. V. Borges, Juliano S. Cabral, Jose M. Fernandez-Palacios, Richard Field, Lawrence R. Heaney, Holger Kreft, Thomas J. Matthews, Jens M. Olesen, Jonathan Price, Francois Rigal, Manuel J. Steinbauer, Konstantinos A. Triantis, Luis Valente, Patrick Weigelt, Robert J. Whittaker
BIOLOGICAL REVIEWS
(2017)
Article
Clinical Neurology
Song Guo, Anne Luise Haulund Vollesen, Rikke Dyhr Hansen, Ann-Louise Esserlind, Faisal Mohammed Amin, Anne Francke Christensen, Jes Olesen, Messoud Ashina
Article
Clinical Neurology
Song Guo, Anne Luise Haulund Vollesen, Young Bae Lee Hansen, Erik Frandsen, Malene Rohr Andersen, Faisal Mohammad Amin, Jan Fahrenkrug, Jes Olesen, Messoud Ashina
Article
Clinical Neurology
Emma Katrine Hansen, Jes Olesen
Article
Clinical Neurology
Elena R. Lebedeva, Natalia R. Kobzeva, Denis V. Gilev, Jes Olesen
Article
Clinical Neurology
Song Guo, Anne Francke Christensen, Marie Louise Liu, Benjamin Naveed Janjooa, Jes Olesen, Messoud Ashina
Article
Pharmacology & Pharmacy
Aysegul Sekeroglu, Julie Mie Jacobse, Inger Jansen-Olesen, Saurabh Gupta, Majid Sheykhzade, Jes Olesen, Deepak K. Bhatt
PHARMACOLOGICAL REPORTS
(2017)
Correction
Endocrinology & Metabolism
Susanne W. Bruun, Knud Josefsen, Julia T. Tanassi, Ales Marek, Martin H. F. Pedersen, Ulrik Sidenius, Martin Haupt-Jorgensen, Julie C. Antvorskov, Jesper Larsen, Niels H. Heegaard, Karsten Buschard
JOURNAL OF DIABETES RESEARCH
(2017)
Review
Clinical Neurology
Inger Jansen-Olesen, Sara Hougaard Pedersen
JOURNAL OF HEADACHE AND PAIN
(2018)
Article
Multidisciplinary Sciences
Gordon Munro, Steffen Petersen, Inger Jansen-Olesen, Jes Olesen
SCIENTIFIC REPORTS
(2018)
Article
Clinical Neurology
Katrine Falkenberg, Jes Olesen
JOURNAL OF HEADACHE AND PAIN
(2018)
Article
Clinical Neurology
Jacob Worm, Katrine Falkenberg, Jes Olesen
JOURNAL OF HEADACHE AND PAIN
(2019)
Article
Pharmacology & Pharmacy
Anna Koldbro Hansted, Deepak Kumar Bhatt, Jes Olesen, Lars Jorn Jensen, Inger Jansen-Olesen
PHARMACOLOGICAL REPORTS
(2019)
Editorial Material
Clinical Neurology
Jes Olesen, Messoud Ashina
NATURE REVIEWS NEUROLOGY
(2019)
