Article
Clinical Neurology
Anna P. Andreou, Charlotte Leese, Rosaria Greco, Chiara Demartini, Eve Corrie, Deniz Simsek, Anna Zanaboni, Ksenia Koroleva, Joseph O. Lloyd, Giorgio Lambru, Ciara Doran, Oleg Gafurov, Elizabeth Seward, Rashid Giniatullin, Cristina Tassorelli, Bazbek Davletov
Summary: Migraine, with a prevalence of 15%, is the most common and disabling neurological disorder. Current oral medications have variable effects and intolerable side effects, leading to dissatisfaction. Injectable therapeutics provide a new treatment paradigm for chronic migraine but are effective in only around 50% of subjects.
Article
Anesthesiology
Toru Yamamoto, Yatendra Mulpuri, Mikhail Izraylev, Qianyi Li, Menooa Simonian, Christian Kramme, Brian L. Schmidt, Herbert H. Seltzman, Igor Spigelman
Summary: Migraine affects a significant portion of the global population, with current treatments only effective in a subset of patients. Peripherally restricted cannabinoids (PRCBs) show promise in alleviating chronic pain symptoms, offering a potential therapeutic target for migraine and medication overuse headache.
Article
Neuroimaging
Gerrit L. J. Onderwater, Jannie P. Wijnen, Chloe Najac, Robin M. van Dongen, Itamar Ronen, Andrew Webb, Ronald Zielman, Erik W. van Zwet, Michel D. Ferrari, Hermien E. Kan, Mark C. Kruit, Gisela M. Terwindt
Summary: Enhanced activity of the glutamatergic system may be involved in the pathophysiology of migraines. This study used high- resolution 7T MR spectroscopy to show changes in the glutamatergic system during a migraine attack, with an increase in GABA concentration observed in migraine patients compared to healthy controls.
NEUROIMAGE-CLINICAL
(2021)
Article
Clinical Neurology
Chunxiao Yang, Zihua Gong, Xiaochen Zhang, Shuai Miao, Bozhi Li, Wei Xie, Tao Wang, Xun Han, Liang Wang, Zhao Dong, Shengyuan Yu
Summary: This study aimed to investigate the role of neuropeptide Y (NPY) in migraine. The study found that the NPY signaling pathway was altered in patients with migraine, and injection of NPY in a mouse model could alleviate migraine symptoms. These findings may provide new insights into novel therapeutic targets for the treatment of migraine.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Multidisciplinary Sciences
Alexey Y. Sokolov, Maxim A. Volynsky, Anastasiia V. Potapenko, Polina M. Iurkova, Valeriy V. Zaytsev, Ervin Nippolainen, Alexei A. Kamshilin
Summary: This study aims to evaluate the effects of nitroglycerin (NTG) on meningeal vessel blood-flow parameters using imaging photoplethysmography (iPPG) in animal experiments. The results showed that NTG caused a steady decrease in blood pressure and had a dual effect on meningeal vasomotor activity. Additionally, sumatriptan acted as a synergist of the NTG vasodilating action. These findings contribute to understanding the interaction of vasoactive drugs in the study of headache pathophysiology and methods of therapy.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Chenhao Li, Yang Li, Wenwen Zhang, Zhenjie Ma, Shaobo Xiao, Wei Xie, Shuai Miao, Bozhi Li, Guangshuang Lu, Yingyuan Liu, Wenhao Bai, Shengyuan Yu
Summary: Clinical imaging studies have shown that the hypothalamus is activated in migraine patients before and during headache, and has increased functional connectivity with the spinal trigeminal nucleus. The dopaminergic system in the hypothalamus, particularly the A11 nucleus, may play a crucial role in the pathogenesis of migraine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Bianca N. Mason, Shayne N. Hassler, Kathryn DeFea, Scott Boitano, Josef Vagner, Theodore J. Price, Greg Dussor
Summary: Research has found that activation of PAR2 in the meninges can cause acute headache behavioral responses and increase sensitivity to glyceryl trinitrate (GTN) for migraines. However, control groups did not show this reaction. Therefore, this study suggests that PAR2 may be a novel therapeutic target for migraines.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Clinical Neurology
Jr-Wei Wu, Pi-Yi Lai, Yung-Lin Chen, Yen-Feng Wang, Jiing-Feng Lirng, Shu-Ting Chen, Kuan-Lin Lai, Wei-Ta Chen, Yu-Te Wu, Shuu-Jiun Wang
Summary: The study identified that left hippocampal volume is helpful in identifying sumatriptan non-responders, suggesting that left hippocampal volume could be used to predict the treatment response to sumatriptan in migraine patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Shouyi Wu, Xiao Ren, Chenlu Zhu, Wei Wang, Kaibo Zhang, Zhilei Li, Xuejiao Liu, Yonggang Wang
Summary: Chronic migraine is a common and highly disabling disorder, and functional MRI has shown that abnormal brain region activation is associated with chronic migraine. Drugs targeting CGRP have been effective in treating chronic migraine. In this study, two types of chronic migraine models were established in mice using NTG and LEV, and olcegepant was shown to alleviate mechanical hyperalgesia by attenuating brain activation in these models.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Dentistry, Oral Surgery & Medicine
Matteo Cotta Ramusino, Giulia Perini, Marco Capelli, Gloria Vaghi, Roberto Fogari, Daniele Bosone, Alfredo Costa
Summary: This study suggests that hypertension may contribute to the chronic evolution of headache by affecting vascular tone and autonomic regulation.
JOURNAL OF ORAL & FACIAL PAIN AND HEADACHE
(2022)
Article
Pharmacology & Pharmacy
Qi Xu, Lihong Sun, Wenxin Zhang, Hui Wu, Cuicui Jiao, Lili Xu, Xiaowei Qian, Huaqi Yao, Qing Chen, Fang Xu, Feng Fu, Ying Feng, Luyang Wang, Xinzhong Chen
Summary: This study established a rat model of pain induced by uterine cervix inflammation, with a novel pain score derived from specific behaviors and c-Fos expression in the spinal cord. The highest pain score and c-Fos expression were found in the 0.9 mg capsaicin group. Intrathecal morphine significantly reduced both the pain score and c-Fos expression in the spinal cord.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Emergency Medicine
Bronwyn Tunnage, Lisa J. Woodhouse, Mark Dixon, Craig Anderson, Sandeep Ankolekar, Jason Appleton, Lesley Cala, Timothy England, Kailash Krishnan, Diane Havard, Grant Mair, Keith Muir, Steve Phillips, John Potter, Christopher Price, Marc Randall, Thompson G. Robinson, Christine Roffe, Else Sandset, Niro Siriwardena, Polly Scutt, Joanna M. Wardlaw, Nikola Sprigg, Philip M. Bath
Summary: This study analyzed the outcomes of stroke mimic patients in the RIGHT-2 trial and found that the use of transdermal glyceryl trinitrate (GTN) may improve functional outcomes at 90 days and one year, but the specific reasons remain unclear.
BMC EMERGENCY MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Shuding Sun, Guo Zheng, Decui Zhou, Lili Zhu, Xin He, Chunfeng Zhang, Chongzhi Wang, Chunsu Yuan
Summary: This research demonstrated that emodin can alleviate nitroglycerin-induced migraine in rats by reducing levels of nitric oxide, calcitonin gene-related peptide, substance P, tumor necrosis factor, and cyclic guanosine monophosphate, as well as inhibiting the expression of c-Fos positive cells. Emodin may act through the cGMP-PKG pathway to relieve migraine.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Colombe Otis, Emilie Bouet, Sokhna Keita-Alassane, Marilyn Frezier, Alienor Delsart, Martin Guillot, Agathe Bedard, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Bertrand Lussier, Francis Beaudry, Eric Troncy
Summary: Validating animal pain models is crucial for enhancing translational research and pharmacological treatment response. This study found that a calibrated slight exercise protocol combined with multimodal analgesia had positive effects on the MI-RAT model, particularly when used in conjunction with positive analgesics, reducing sensitivity to pain and improving joint structure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Julio Cesar Morales-Medina, Mario Alberto Bautista-Carro, Gilberto Serrano-Bello, Patricia Sanchez-Teoyotl, Ana Gloria Vasquez-Ramirez, Tommaso Iannitti
Summary: Pain is a global public health concern and often coexists with anxiety and depression. The marker c-Fos can be used as a brain marker of pain by identifying activated cells. In this study, we investigated the effects of peripheral inflammation on mechanical allodynia, anxiety, and depression-related behaviors in male rats. The results showed that peripheral inflammation activated c-Fos in specific supraspinal brain nuclei and was associated with mechanical allodynia, providing new insights into the brain regions involved in pain control. The findings suggest that this model can be used to study resistance to pain development.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Deepak Kumar Bhatt, Aanchal Mehrotra, Andrea Gaedigk, Revathi Chapa, Abdul Basit, Haeyoung Zhang, Prachi Choudhari, Mikael Boberg, Robin E. Pearce, Roger Gaedigk, Ulrich Broeckel, J. Steven Leeder, Bhagwat Prasad
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Pharmacology & Pharmacy
Cindy Yanfei Li, Joseph L. Dempsey, Dongfang Wang, SooWan Lee, Kris M. Weigel, Qiang Fei, Deepak Kumar Bhatt, Bhagwat Prasad, Daniel Raftery, Haiwei Gu, Julia Yue Cui
DRUG METABOLISM AND DISPOSITION
(2018)
Article
Pharmacology & Pharmacy
Bhagwat Prasad, Deepak Kumar Bhatt, Katherine Johnson, Revathi Chapa, Xiaoyan Chu, Laurent Salphati, Guangqing Xiao, Caroline Lee, Cornelis E. C. A. Hop, Anita Mathias, Yurong Lai, Mingxiang Liao, William G. Humphreys, Sean C. Kumer, Jashvant D. Unadkat
DRUG METABOLISM AND DISPOSITION
(2018)
Article
Pharmacology & Pharmacy
Deepak Kumar Bhatt, Abdul Basit, Haeyoung Zhang, Andrea Gaedigk, Seung-been Lee, Katrina G. Claw, Aanchal Mehrotra, Amarjit Singh Chaudhry, Robin E. Pearce, Roger Gaedigk, Ulrich Broeckel, Timothy A. Thornton, Deborah A. Nickerson, Erin G. Schuetz, John K. Amory, J. Steven Leeder, Bhagwat Prasad
DRUG METABOLISM AND DISPOSITION
(2018)
Meeting Abstract
Pharmacology & Pharmacy
Abdul Basit, Hay Young Zhang, Deepak Kumar Bhatt, John K. Amory, Bhagwat Prasad
DRUG METABOLISM AND PHARMACOKINETICS
(2018)
Review
Clinical Neurology
Inger Jansen-Olesen, Sara Hougaard Pedersen
JOURNAL OF HEADACHE AND PAIN
(2018)
Article
Pharmacology & Pharmacy
Haeyoung Zhang, Abdul Basit, Diana Busch, King Yabut, Deepak Kumar Bhatt, Marek Drozdzik, Marek Ostrowski, Albert Li, Carol Collins, Stefan Oswald, Bhagwat Prasad
BIOCHEMICAL PHARMACOLOGY
(2018)
Meeting Abstract
Pharmacology & Pharmacy
Bhagwat Prasad, Haeyoung Zhang, Deepak Bhatt, Abdul Basit, Maureen Bunger
DRUG METABOLISM AND PHARMACOKINETICS
(2019)
Meeting Abstract
Pharmacology & Pharmacy
Mayurbhai Kathadbhai Ladumor, Deepak Kumar Bhatt, Saranjit Singh, Bhagwat Prasad
DRUG METABOLISM AND PHARMACOKINETICS
(2019)
Article
Clinical Neurology
Jacob Worm, Katrine Falkenberg, Jes Olesen
JOURNAL OF HEADACHE AND PAIN
(2019)
Article
Pharmacology & Pharmacy
Anna Koldbro Hansted, Deepak Kumar Bhatt, Jes Olesen, Lars Jorn Jensen, Inger Jansen-Olesen
PHARMACOLOGICAL REPORTS
(2019)
Article
Pharmacology & Pharmacy
Mayur K. Ladumor, Deepak Kumar Bhatt, Andrea Gaedigk, Sheena Sharma, Aarzoo Thakur, Robin E. Pearce, J. Steven Leeder, Michael B. Bolger, Saranjit Singh, Bhagwat Prasad
DRUG METABOLISM AND DISPOSITION
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Letizia Satriano, Monika Lewinska, Colm O. Rourke, Douglas V. N. P. Oliveira, Deepak Kumar Bhatt, Andrzej Taranta, Monika Herr, Beate Straub, Elizabeth A. Conner, Anuradha Budhu, Yotsawat Pomyen, Tao Ma, Zach Gerhart-Hines, Claus Sivertsen Stjernegaard, Matthias Matter, Christoph Crocoll, Xin W. Wang, Jens Marquardt, Jesper Andersen
JOURNAL OF HEPATOLOGY
(2019)
Editorial Material
Clinical Neurology
Jes Olesen, Messoud Ashina
NATURE REVIEWS NEUROLOGY
(2019)