Article
Chemistry, Medicinal
Mengge Ma, Lin Chen, Zhishu Tang, Zhongxing Song, Xin Kong
Summary: This study evaluated the hepatoprotective effect of Carthamus tinctorius L. leaf extract on chronic liver injury and found that it may exert its effects through antioxidation, anti-inflammation, and modulation of TLRs/NF-kappa B and PI3K/AKT pathways.
Article
Biochemistry & Molecular Biology
Su Cheol Baek, Sang Ah Yi, Bum Soo Lee, Jae Sik Yu, Jin-Chul Kim, Changhyun Pang, Tae Su Jang, Jaecheol Lee, Ki Hyun Kim
Summary: Safflower, a herb in the Compositae family with a history of use in oriental countries, contains polyacetylene glycosides. Among these compounds, 2, 3, and 4 were found to inhibit adipogenesis, prevent lipid accumulation, and activate AMPK to facilitate lipid metabolism, suggesting their potential as therapeutic agents against obesity.
Article
Multidisciplinary Sciences
Chaoxiang Ren, Chao Chen, Shuai Dong, Rui Wang, Bin Xian, Tianlei Liu, Ziqing Xi, Jin Pei, Jiang Chen
Summary: In this study, widely targeted metabolomics and transcriptomics were used to investigate the changes in flavonoid biosynthesis during flower development in safflower. A total of 212 flavonoid metabolites were detected and screened for candidate genes involved in flavonoid glycoside biosynthesis. The study revealed a significant correlation between the UGT9 gene and flavonoid glycosides in safflower, suggesting its important role in flavonoid glycoside biosynthesis during color transition.
Article
Polymer Science
Dan Lin, Cheng-Jian Xu, Yang Liu, Yu Zhou, Shuang-Li Xiong, Hua-Chang Wu, Jing Deng, Yu-Wen Yi, Ming-Feng Qiao, Hang Xiao, Sook-Wah Chan, Yi Lu
Summary: The structures of two polysaccharides (CTLP-1 and CTLP-2) from Carthamus tinctorius L. were analyzed. Both polysaccharides exhibited high antioxidant activities, indicating their potential as antioxidants.
Review
Medicine, Research & Experimental
Bin Xian, Rui Wang, Huajuan Jiang, Yongfeng Zhou, Jie Yan, Xulong Huang, Jiang Chen, Qinghua Wu, Chao Chen, Ziqing Xi, Chaoxiang Ren, Jin Pei
Summary: This study provides an overview of the application and chemical structure information of flavonoid compounds in safflower, as well as detailed descriptions of their mechanisms in treating cardiovascular and cerebrovascular diseases. It also summarizes their pharmacological mechanisms in protecting the liver, lungs, bones, and their anti-cancer and anti-inflammatory effects. Additionally, the study updates the latest information on the molecular biology of safflower flavonoids, highlighting the significant differences in their applications, chemical structures, and pharmacological properties.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Plant Sciences
Yuanyuan Liang, Lin Wang
Summary: AD is a progressive and complex neurodegenerative disease characterized by dementia. Current treatment strategies for AD are not meeting clinical expectations and more treatment options need to be explored. This review investigates the potential mechanisms of C. tinctorius L. and its active constituents in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Genetics & Heredity
Zhihua Wu, Tiange Yang, Rui Qin, Hong Liu
Summary: In this study, the mitogenome of safflower (Carthamus tinctorius) was analyzed and reported. The safflower mitogenome consisted of two circular chromosomes, with a total length of 321,872 bp, and encoded 55 unique genes. The phylogenetic tree based on mitogenome PCGs revealed a closer relationship between safflower and three Cardueae species, similar to the phylogeny constructed from plastid genomes.
Article
Chemistry, Applied
Liuwei Zhao, Caijun Ren, Xiaofeng Xue, Huanxian Lu, Kai Wang, Liming Wu
Summary: This study characterized monofloral safflower honey (MSH) from a metabolomic perspective and proposed safflomin A as a reliable chemical marker for its authentication. Commercial non-safflower honeys did not test positive for safflomin A, indicating its potential as a fingerprinting chemical marker for safflower honey authentication.
Article
Agricultural Engineering
Mahdiyeh Poodineh, Nafiseh Mahdi Nezhad, Ghasem Mohammadi-Nejad, Barat Ali Fakheri, Fatemeh Ebrahimi
Summary: This study aimed to determine the importance of QTL monitoring and QTL inter loci interaction in safflower under normal and drought stress conditions. A new linkage map with 69 polymorphic AFLP markers was constructed, identifying 17 major QTL and 66 epistatic QTL for ten agronomic traits. These QTL accounted for 3.04%-24.71% and 8.31%-56.5% of the phenotypic variations of traits, respectively. Seven main genomic regions on linkage group (LG) 4 and LG5 were found to co-localize QTL for various traits, providing valuable information for future breeding programs to enhance drought tolerance.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Agronomy
Jania Claudia Camilo dos Santos, Dayane Mercia Ribeiro da Silva, Deoclecio Jardim Amorim, Mariana Peduti Vicentini Sab, Marcelo de Almeida Silva
Summary: The study concludes that low doses of glyphosate can mitigate water deficit effects on safflower plants, allowing them to maintain their metabolism and reach levels close to those without water stress in terms of plant height and leaf area.
PEST MANAGEMENT SCIENCE
(2021)
Article
Food Science & Technology
Arzu Yalcin Melikoglu, Idil Tekin, Nergiz Hayatioglu, Seda Ersus
Summary: This study focused on the production and characterization of environmentally friendly biocomposite and nano-biocomposite packaging films using safflower head waste. The use of cellulose and cellulose nanocrystals as fillers in the packaging films was investigated. It was found that cellulose nanocrystals exhibited higher crystallinity and smaller particle size compared to cellulose. The incorporation of these fillers in low-density polyethylene based films showed improved mechanical properties and increased crystallinity and gas permeability.
Article
Agriculture, Multidisciplinary
Songyang Sui, Kebo Xie, Ruimingqian Guo, Jungui Dai, Lin Yang
Summary: In this study, a flavanone 3-hydroxylase (F3H) enzyme, CtF3H1, was characterized from Carthamus tinctorius, a plant commonly used in traditional Chinese medicine. CtF3H1 exhibited high stereoselectivity and substrate promiscuity towards structurally diverse (2S)-flavanones. Isothermal titration calorimetry revealed distinct binding behaviors of CtF3H1 with (2S)-flavanone and (2R)-flavanone, which governed its stereoselectivity. Structure-activity relationship analysis identified the necessary hydroxyl groups for regio- and stereoselective 3-hydroxylation of (2S)-flavanones. Homology modeling and site-directed mutagenesis identified the crucial amino acid residues for hydroxylation. These findings expand our understanding of the catalytic mechanism of F3H and provide potential for further enzyme engineering.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Qiongqiong Wang, Shiqi Liu, Long Xu, Bin Du, Lijun Song
Summary: Polysaccharides were extracted from safflower using ultrasound and four purified fractions were obtained. The physicochemical properties and in vitro physiological activities of these fractions were investigated. SSP3 showed higher antioxidant and antiproliferative activities. These findings provide a theoretical framework for the use of safflower polysaccharides in functional foods and medications.
Article
Food Science & Technology
Yang-Gyu Park, Jeong-Hwi Cho, Jinyoung Choi, Eun-Myeong Ju, Gareeballah Osman Adam, Dae-Il Hwang, Ji-Hye Lee, So-Yul An, Ha-Kyoung Choi, Chung-Berm Park, Hong-Geun Oh
Summary: The study demonstrated that the combination treatment of Curcuma longa and Carthamus tinctorius extracts has significant anti-inflammatory and immunomodulatory effects, inhibiting nitric oxide production, regulating macrophage and NK cell activity, and boosting immune response in the body.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Chemistry, Multidisciplinary
Shameenii A. P. P. Thanebal, Senty Vun-Sang, Mohammad Iqbal
Summary: The study demonstrated that Pandanus amaryllifolius has antioxidant properties and can protect rats from acute hepatic damage caused by carbon tetrachloride. The extract contains various phytochemical constituents, showing significant antioxidant enzyme activity and reducing the extent of liver damage.
ARABIAN JOURNAL OF CHEMISTRY
(2021)