Review
Medicine, General & Internal
Melanie Bailey, Dermot Linden, Hong Guo-Parke, Olivia Earley, Tunde Peto, Danny F. F. McAuley, Clifford Taggart, Joseph Kidney
Summary: SARS-CoV-2 binds to ACE2 receptors in the lungs, leading to endothelial pathology and activation of the contact-kinin pathway, resulting in clotting and inflammatory lung disease. Blood tests of hospitalized patients show prolonged APTT, decreased platelet counts, and lymphopenia, indicating consumption and emergence of lymphocytic pneumonitis. Bradykinin is involved in the development of edema and release of IL-6, contributing to thrombosis and lymphocytic pneumonitis. Measurements of platelets, lymphocytes, and APTT can help stratify the risk of developing ARDS.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Mahmoud E. Youssef, Mustafa A. Abdel-Reheim, Mohamed A. Morsy, Mahmoud El-Daly, Gamal M. K. Atwa, Galal Yahya, Simona Cavalu, Sameh Saber, Ahmed Gaafar Ahmed Gaafar
Summary: This study examined the effectiveness of the antithrombotic agent dabigatran in treating arthritis in rats. The results showed that dabigatran had anti-inflammatory and antioxidant effects, making it a potential novel therapeutic strategy for arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Ana Carolina Oliveira, Amanda Roberta Revoredo Vicentino, Daniele Andrade, Isabela Resende Pereira, Leonardo Saboia-Vahia, Otacilio da Cruz Moreira, Carla Eponina Carvalho-Pinto, Julia Barbalho da Mota, Leonardo Maciel, Glaucia Vilar-Pereira, Joao B. Pesquero, Joseli Lannes-Vieira, Pierre Sirois, Antonio Carlos Campos de Carvalho, Julio Scharfstein
Summary: We investigated the role of B1R receptor in the development of Chagas disease caused by Trypanosoma cruzi. Our findings suggest that blocking the B1R receptor can reduce heart parasitism and cardiac injury in acute and chronic Chagas disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Nicholas P. Giangreco, Guillaume Lebreton, Susan Restaino, Maryjane Farr, Emmanuel Zorn, Paolo C. Colombo, Jignesh Patel, Rajesh Kumar Soni, Pascal Leprince, Jon Kobashigawa, Nicholas P. Tatonetti, Barry M. Fine
Summary: This study utilized proteomics to identify potential biomarkers for predicting post-transplant survival in heart failure patients. The analysis identified six protein markers that have a predictive performance above AUROC of 0.6, including Prothrombin, anti-plasmin, Factor IX, carboxypeptidase 2, HGF activator, and low molecular weight kininogen. Additionally, the analysis revealed that upregulation of components of the kallikrein-kinin system and downregulation of kininogen prior to transplant were associated with improved survival after transplant.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Tanja Gangnus, Bjoern B. Burckhardt
Summary: The kallikrein-kinin system is involved in physiological and pathophysiological processes, but understanding of its in vivo role is limited. A sensitive LC-MS/MS platform has been developed to accurately determine kinin levels, successfully detecting low pg/mL levels in the plasma of healthy volunteers.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Orthopedics
Dino B. A. Tan, Chantalia Tedja, Lukas Kuster, Warren D. D. Raymond, Andreea Harsanyi, Priya V. V. Chowalloor, Neil L. Misso, Shashi Argawal, Kanti D. D. Bhoola, Helen I. I. Keen
Summary: This study examined the association between inflammation and the production of hormones in the blood of patients with arthritis. The researchers found that inflammatory biomarkers and the expression of the hormone B1R in blood were correlated with pain. Modulating the hormone system may be a new treatment approach for arthritis.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Hematology
Tanja Gangnus, Bjoern B. Burckhardt
Summary: The study aimed to develop and evaluate a standardized preanalytical procedure for reliable quantification of kinins. The researchers systematically investigated the impact of protease inhibitors and blood specimen collection and handling conditions on kinin levels. They found that nonstandardized settings led to rapid ex vivo rise of bradykinin and high interindividual variation. By screening 17 protease inhibitors, they developed a customized seven-component protease inhibitor that effectively stabilized kinin levels. Prolonged rest time until centrifugation, specific phlebotomy methodology, vacuum sampling technique, and time delays during venipuncture were identified as factors jeopardizing the reliability of kinin levels.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Aleksandr Shamanaev, Ivan Ivanov, Mao-Fu Sun, Maxim Litvak, Priyanka Srivastava, Bassem M. Mohammed, Rabia Shaban, Ashoka Maddur, Ingrid M. Verhamme, Owen J. T. McCarty, Ruby H. P. Law, David Gailani
Summary: Factor XII (FXII) is a plasma protease that contributes to bradykinin generation. Its conversion to FXIIa enhances when it binds to negatively charged surfaces. The heavy chain of FXII plays a key role in surface binding and activation, while also restricting activation when not bound to a surface. Different domains within the heavy chain have varying importance in FXII function, such as EGF1 being required for surface-dependent activation and KNG and FN2 influencing activation in the absence of a surface.
Article
Hematology
Aleksandr Shamanaev, Ivan Ivanov, Mao-Fu Sun, Maxim Litvak, Priyanka Srivastava, Bassem M. Mohammed, Rabia Shaban, Ashoka Maddur, Ingrid M. Verhamme, Owen J. T. McCarty, Ruby H. P. Law, David Gailani
Summary: Factor XII (FXII) is a plasma zymogen that contributes to bradykinin production. The activation of FXII is enhanced when it binds to negatively charged surfaces such as polymeric orthophosphate. The heavy chain of FXII promotes surface-binding and activation, while restricting activation in the absence of a surface. EGF1, KNG, and FN2 domains play important roles in FXII function.
Article
Immunology
Miklos Lipcsey, Barbro Persson, Oskar Eriksson, Anna M. Blom, Karin Fromell, Michael Hultstrom, Markus Huber-Lang, Kristina N. Ekdahl, Robert Frithiof, Bo Nilsson
Summary: Severe COVID-19 can lead to ARDS-like lung injury associated with vascular inflammation, thrombosis, and angiogenesis, in which the intravascular innate immune system (IIIS) plays a crucial role. Activation of blood cascade systems in critically ill COVID-19 patients is linked to organ damage, illness severity scores, and survival, suggesting potential prognostic markers and therapeutic targets for the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhiye Zhang, Chuanbin Shen, Mingqian Fang, Yajun Han, Chengbo Long, Weihui Liu, Min Yang, Ming Liu, Dengdeng Zhang, Qiqi Cao, Xue Chen, Yaqun Fang, Qiumin Lu, Zongliu Hou, Yaxiong Li, Zhenze Liu, Xi Lei, Heyu Ni, Ren Lai
Summary: Ischemic stroke is a major cause of death and disability worldwide. This study identifies a promising inhibitor called sylvestin which can protect against ischemic stroke without increasing the risk of bleeding.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Cell Biology
Carola E. Matus, Pamela Ehrenfeld, Carlos D. Figueroa
Summary: The human skin is a complex organ composed of the epidermis and dermis layers. The epidermis serves as a protective barrier against harmful agents, while the dermis provides support and various structures. The kallikrein family and kinins play crucial roles in maintaining skin homeostasis and regulating inflammation and cell differentiation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Biology
Ahmed S. Gouda, Fatima G. Adbelruhman, Reham N. Elbendary, Fadiyah Ahmed Alharbi, Sultan Qalit Alhamrani, Bruno Megarbane
Summary: Zinc deficiency in COVID-19 may lead to abnormal activation of the renin-angiotensin and kinin-kallikrein systems, resulting in exaggerated inflammatory manifestations.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Immunology
Enrique Alfaro, Elena Diaz-Garcia, Sara Garcia-Tovar, Ester Zamarron, Alberto Mangas, Raul Galera, Kapil Nanwani-Nanwani, Rebeca Perez-de-Diego, Eduardo Lopez-Collazo, Francisco Garcia-Rio, Carolina Cubillos-Zapata
Summary: COVID-19 has caused devastating effects worldwide. This study focuses on the bradykinin cascade and its impact on disease severity in COVID-19 patients. The researchers found dysregulation of the kallikrein-kinin system in COVID-19 patients, associated with inflammation, hypercoagulation, and lymphopenia. BK1-8/BK plasma concentration combined with D-dimer levels may serve as independent predictors for ICU admission in COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medical Laboratory Technology
Dorsa Sohaei, Morley Hollenberg, Sok-Ja Janket, Eleftherios P. Diamandis, Gennady Poda, Ioannis Prassas
Summary: COVID-19 initially presents as a respiratory infection but can progress to a systemic disease involving multiple organs and microthromboses. The SARS-CoV-2 virus enters host cells by binding to the ACE2 receptor. ACE2 is expressed in various tissues, including the lung, heart, intestine, kidney, testis, gallbladder, vasculature, and immune cells. Interference with ACE2 signaling can lead to systemic pathologies such as endothelial dysfunction, microthromboses, and systemic inflammation. Understanding these targets may be valuable for the treatment of COVID-19 and other virus-induced coagulopathies in the future.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2023)
Editorial Material
Cell Biology
Liliana Schaefer
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Timon Eckes, Sammy Patyna, Alexander Koch, Anke Oftring, Stefan Gauer, Nicholas Obermueller, Stephanie Schwalm, Liliana Schaefer, Jerold Chun, Hermann-Josef Groene, Josef Pfeilschifter
Summary: This study found that S1P(5) deficiency can improve tubular damage and tubulointerstitial fibrosis in a mouse model of adenine-induced nephropathy, and reduce inflammation. Therefore, targeting S1P(5) may be a promising therapeutic target for kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Fabian Schramm, Liliana Schaefer, Malgorzata Wygrecka
Summary: This review article provides an overview of the ErbB receptor-ligand system and its importance in developmental and physiological processes. It focuses on the role of ErbB receptors and their ligands in maladaptive remodeling of lung tissue, specifically in idiopathic pulmonary fibrosis (IPF). The article discusses the pathways and cellular processes contributing to miscommunication between epithelial and mesenchymal cells in IPF, and reviews in vivo studies on the efficacy of ErbB signaling inhibitors in lung injury models. Additionally, it discusses lessons learned from clinical applications of ErbB1 signaling inhibitors in cancer to inform clinical trials in IPF.
Editorial Material
Cell Biology
Elie El Agha, Malgorzata Wygrecka
Article
Cell Biology
Vahid Kheirollahi, Ali Khadim, Georgios Kiliaris, Martina Korfei, Margarida Maria Barroso, Ioannis Alexopoulos, Ana Ivonne Vazquez-Armendariz, Malgorzata Wygrecka, Clemens Ruppert, Andreas Guenther, Werner Seeger, Susanne Herold, Elie El Agha
Summary: This study provides a comprehensive transcriptional profile of IGF signaling components in mice during embryonic lung development, bleomycin-induced pulmonary fibrosis, and human IPF lung explants. The findings suggest that Igf1 is upregulated in the lung mesenchyme during late gestation, while Igf1r is downregulated. In lung fibrosis, IGF1 is upregulated while IGF1R is downregulated, and several IGF binding proteins are upregulated. Treatment of IPF lung fibroblasts with recombinant IGF1 leads to myogenic differentiation.
Editorial Material
Cell Biology
Eric Delpire, Thomas J. Hawke, Mythreye Karthikeyan, Wei Kong, Alexander Nystroem, Shizuka Uchida, Liliana Schaefer
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Cell Biology
Malgorzata Wygrecka, Ioannis Alexopoulos, Daniel P. Potaczek, Liliana Schaefer
Summary: ApoA-I plays an important role in reverse cholesterol transport and also possesses anti-inflammatory and antioxidative functions. Dysfunctional apoA-I or its low abundance can lead to the formation of foam cells in alveolar macrophages. Increased numbers of foam cells have been observed in the lungs of mice exposed to certain substances and in patients with lung fibrosis. Understanding the role of apoA-I in lung fibrosis provides potential avenues for therapeutic development.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wei Peng, Artem Kepsch, Till O. Kracht, Hiba Hasan, Rukmali Wijayarathna, Eva Wahle, Christiane Pleuger, Sudhanshu Bhushan, Stefan Guenther, A. Christine Kauerhof, Ana Planinic, Daniela Fietz, Hans-Christian Schuppe, Malgorzata Wygrecka, Kate L. Loveland, Davor Jezek, Andreas Meinhardt, Mark P. Hedger, Monika Fijak
Summary: Experimental autoimmune-orchitis (EAO), a rodent model of chronic testicular inflammation and fibrosis, replicates pathogenic changes seen in some cases of human spermatogenic disturbances. CCR2 and activin A promote fibrosis during testicular inflammation by regulating macrophage function.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Editorial Material
Cell Biology
Liliana Schaefer, Sandrine V. Pierre
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Cell Biology
Sarah Miethe, Daniel P. Potaczek, Stanislawa Bazan-Socha, Melanie Bachl, Liliana Schaefer, Malgorzata Wygrecka, Holger Garn
Summary: Extracellular vesicles (EVs) have gained attention for their role in intercellular signaling, particularly in the connection between adipose tissue (AT) and the lung in diseases such as obesity-associated asthma and lung cancer-associated cachexia. Studies have shown both pathogenic and protective effects of EVs in these diseases, with AT-derived EVs playing a potential therapeutic role. Further research is needed to better understand the role of EVs in disease development and organ interconnectivity.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Immunology
Katharina Jandl, Johannes Lorenz Berg, Anna Birnhuber, Elisabeth Fliesser, Izabela Borek, Benjamin Seeliger, Sascha David, Julius J. Schmidt, Gregor Gorkiewicz, Martin Zacharias, Tobias Welte, Horst Olschewski, Akos Heinemann, Malgorzata Wygrecka, Grazyna Kwapiszewska
Summary: Immune cell recruitment, endothelial cell barrier disruption, and platelet activation are common in lung injuries like COVID-19-induced ARDS. In this study, we investigated the role of endostatin, a bioactive fragment of the basement membrane protein collagen XVIII alpha 1, on cellular functions associated with ARDS. Our results showed that endostatin enhanced neutrophil and platelet activity, as well as induced microvascular barrier disruption.
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Critical Care Medicine
Malgorzata Wygrecka, Lukasz Wujak, Philipp Markart, Djuro Kosanovic, Holger C. Mueller-Redetzky, Martin Witzenrath, Ingrid Henneke, Ralph T. Schermuly, Werner Seeger, Liliana Schaefer, Grazyna Kwapiszewska, Leigh M. Marsh, Nelli Baal, Holger Hackstein, Steven de Maat, Coen Maas
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)