期刊
CELLULAR SIGNALLING
卷 26, 期 6, 页码 1226-1234出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2014.02.006
关键词
RGS protein; Cardiac hypertrophy; G protein; GPCR; Protein synthesis
类别
资金
- Canadian Institutes of Health Research
- Heart and Stroke Foundation of Ontario
- Heart and Stroke Foundation of Canada
The protective effect of Regulator of G protein Signaling 2 (RGS2) in cardiac hypertrophy is thought to occur through its ability to inhibit the chronic GPCR signaling that promotes pathogenic growth both in vivo and in cultured cardiomyocytes. However, RGS2 is known to have additional functions beyond its activity as a GTPase accelerating protein, such as the ability to bind to eukaryotic initiation factor, elF2B, and inhibit protein synthesis. The RGS2 eIF2B-interacting domain (RGS2(eb)) was examined for its ability to regulate hypertrophy in neonatal ventricular myocytes. Both full-length RGS2 and RGS2(eb) were able to inhibit agonist-induced cardiomyocyte hypertrophy, but RGS2eb had no effect on receptor-mediated inositol phosphate production, cAMP production, or ERK 1/2 activation. These results suggest that the protective effects of RGS2 in cardiac hypertrophy may derive at least in part from its ability to govern protein synthesis. (C) 2014 Elsevier Inc. All rights reserved.
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