Article
Biochemistry & Molecular Biology
Shiqiang Zhang, Xuan Zhang, Xin Guan, Xiaoli Ma, Hong Chen, Bingren Huang, Deng Chen
Summary: Phosphorylated YAF2 exhibits anti-apoptotic activity in human tumor cells by targeting FANK1 expression and inhibiting its degradation, leading to increased stability.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Evgeniya S. Grigoryeva, Liubov A. Tashireva, Vladimir V. Alifanov, Olga E. Savelieva, Sergey V. Vtorushin, Marina V. Zavyalova, Nadezhda V. Cherdyntseva, Vladimir M. Perelmuter
Summary: This study investigated the association between different apoptotic states of circulating tumor cells (CTCs) in breast cancer patients and treatment outcomes. The results showed that the proportion of CTCs with early apoptosis features can serve as a prognostic indicator for metastasis-free survival and is associated with the response to neoadjuvant chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Sandra Ferreira, Nuno Saraiva, Patricia Rijo, Ana S. Fernandes
Summary: LOX and LOXL2 are amine oxidases that catalyze cross-linking reactions of elastin and collagen in connective tissue, with LOXL2 showing high expression in certain tumors. Inhibition of LOX and LOXL2 is considered a promising strategy for preventing metastasis and invasion of breast cancer. Novel synthetic compounds acting as selective inhibitors for LOX/LOXL2 or dual LOX/LOXL inhibitors have been developed, showing potential for effective therapeutic approaches in breast cancer treatment.
Article
Engineering, Biomedical
Luo Zhong, Yang Xia, Tan He, Shi Wenjie, An Jinxia, Yang Lijun, Gao Hui
Summary: Metastasis-induced breast cancer mortality is a critical issue that requires attention. Aquaporin 3 (AQP3), a transmembrane transport channel for H2O2 molecules, has been found to accelerate breast cancer cell migration. Therefore, a flexible crosslinked polymeric nanoplatform with AQP3 inhibition was designed to inhibit the metastasis of breast cancer cells. Additionally, suppression of tumor growth was combined with photothermal therapy to enhance the efficacy of anticancer therapy.
ACTA BIOMATERIALIA
(2022)
Article
Medicine, Research & Experimental
Negar Deldadeh, Shahpar Haghighat, Zahra Omidi, Ramin Sarrami-Foroushani, Alireza Madjid Ansari, Hassan Sanati, Azadeh Azizi, Farid Zayeri, Flora Forouzesh, Teunis B. H. Geijtenbeek, Mohammad Amin Javidi
Summary: This study is one of the first in vivo studies to investigate the impact of Sinopharm (S) and AstraZeneca (A) vaccines on breast cancer. The results suggest that COVID-19 vaccines can decrease tumor growth and metastasis.
Article
Oncology
Simion C. Dinca, Daniel Greiner, Keren Weidenfeld, Laura Bond, Dalit Barkan, Cheryl L. Jorcyk
Summary: High co-expression of LOXL2 and OSM in IDC patients is associated with worse metastasis-free survival rates, while high levels of either individually are less impactful; LOXL2 expression is positively correlated with OSM/OSM receptor (OSMR) expression in IDC patients. Additionally, OSM-induced LOXL2 promotes an increase in ECM collagen I fiber crosslinking, leading to significant fiber alignment between cells and increased IDC cell invasion.
BREAST CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Ana Luisa Correia, Joao C. Guimaraes, Priska Auf Der Maur, Duvini De Silva, Marcel P. Trefny, Ryoko Okamoto, Sandro Bruno, Alexander Schmidt, Kirsten Mertz, Katrin Volkmann, Luigi Terracciano, Alfred Zippelius, Marcus Vetter, Christian Kurzeder, Walter Paul Weber, Mohamed Bentires-Alj
Summary: The study investigates how different tissue-specific microenvironments can either inhibit or support the progression of breast cancer in the liver. It identifies the interplay between natural killer (NK) cells and activated hepatic stellate cells (aHSCs) as a master switch of cancer dormancy, suggesting that therapies aimed at normalizing the NK cell pool may be successful in preventing metastatic outgrowth.
Article
Pharmacology & Pharmacy
Gustavo H. Marin, Samuel Murail, Laura Andrini, Marcela Garcia, Severine Loisel, Pierre Tuffery, Angelita Rebollo
Summary: The combination of a tumor-penetrating peptide (TPP) with a peptide able to interfere with a given protein-protein interaction (IP) is a promising strategy for clinical application. This study analyzes the internalization and functional effect of the TPP-IP combination in the context of breast cancer, specifically targeting the PP2A/SET interaction.
Article
Biochemistry & Molecular Biology
Kirsteen J. Campbell, Susan M. Mason, Matthew L. Winder, Rosalie B. E. Willemsen, Catherine Cloix, Hannah Lawson, Nicholas Rooney, Sandeep Dhayade, Andrew H. Sims, Karen Blyth, Stephen W. G. Tait
Summary: MCL-1 plays a crucial role in breast cancer, with its anti-apoptotic function being key. Deletion or inhibition of MCL-1 relies on pro-apoptotic proteins BAX/BAK for its anti-tumor effects, and it also influences stem cell activity in breast cancer cells.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Biochemistry & Molecular Biology
Ruey-Herng Lee, Yu-Jen Wang, Ting-Yen Lai, Tsui-Ling Hsu, Po-Kai Chuang, Han-Chung Wu, Chi-Huey Wong
Summary: The combination of anti-SSEA4 and anti-Globo H antibodies can suppress tumor growth in breast cancer cells. SSEA4 is identified as a major target in breast cancer due to higher expression levels compared to Globo H. An antibody designed to maximize ADCC activity can enhance the killing efficiency of NK cells.
ACS CHEMICAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Vincenzo Salemme, Mauro Vedelago, Alessandro Sarcinella, Federico Moietta, Alessio Piccolantonio, Enrico Moiso, Giorgia Centonze, Marta Manco, Andrea Guala, Alessia Lamolinara, Costanza Angelini, Alessandro Morellato, Dora Natalini, Raffaele Calogero, Danny Incarnato, Salvatore Oliviero, Laura Conti, Manuela Iezzi, Daniela Tosoni, Giovanni Bertalot, Stefano Freddi, Francesco A. Tucci, Francesco De Sanctis, Cristina Frusteri, Stefano Ugel, Vincenzo Bronte, Federica Cavallo, Paolo Provero, Marta Gai, Daniela Taverna, Emilia Turco, Salvatore Pece, Paola Defilippi
Summary: The p140Cap adaptor protein is a tumor suppressor associated with improved prognosis in breast cancer. It inhibits the tumor-promoting function of polymorphonuclear myeloid-derived suppressor cells by downregulating the beta-Catenin/Tumor Initiating Cells/G-CSF axis. Low expression of p140Cap is correlated with more aggressive tumor types and reduced tumor-infiltrating lymphocytes.
NATURE COMMUNICATIONS
(2023)
Article
Plant Sciences
Yong-Jin Kwon, Eun-Bi Seo, Seul-Ki Kim, Hyun-Seung Lee, Haeri Lee, Young-Ah Jang, Yu Mi Kim, Yong-Nyun Kim, Jin-Tae Lee, Sang-Kyu Ye
Summary: The study confirmed the anti-cancer effects of Chamaecyparis obtusa leaf extracts through cell and animal experiments. The extracts inhibited the growth and metastasis of breast cancer, induced cell apoptosis, and regulated signal transduction pathways. The findings suggest that Chamaecyparis obtusa leaf extracts have potential applications in the treatment and prevention of breast cancer.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Cell Biology
Rongkun Li, Hengchao Li, Lili Zhu, Xiaoxin Zhang, Dejun Liu, Qing Li, Bo Ni, Lipeng Hu, Zhigang Zhang, Yanli Zhang, Xu Wang, Shu-Heng Jiang
Summary: This study identifies a previously unknown hypoxia-LOXL2-HIF1α axis that regulates the Warburg effect in PDAC, providing a potential drug target for therapy. LOXL2 plays a crucial role in stabilizing HIF1α and promoting glycolytic metabolism under hypoxia, linking the Warburg effect to tumor growth and metastasis in PDAC. Hijacking glycolysis compromises LOXL2-induced oncogenic activities in this context.
CELL DEATH & DISEASE
(2021)
Review
Biology
Khulood M. Al-Khater, Sarah Almofty, Vijaya Ravinayagam, Noor Alrushaid, Suriya Rehman
Summary: Breast cancer is the most common cancer in females globally and metastasis, resistance to current drugs, and the role of metastatic suppressors like KAI1 are key challenges in managing the disease. Understanding the molecular events of genes like KAI1 is crucial for developing prognostic biomarkers and specific therapies for breast cancer patients.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Oncology
Lucas E. L. Terceiro, Chidalu A. Edechi, Nnamdi M. Ikeogu, Barbara E. Nickel, Sabine Hombach-Klonisch, Tanveer Sharif, Etienne Leygue, Yvonne Myal
Summary: The tumor microenvironment is crucial in the development and metastasis of various cancers, including breast cancer. Interactions between breast cancer cells and neighboring cells regulate metastasis through cell-to-cell contact or the release of signaling factors. Exosomes and circulating tumor cells also play roles in breast cancer metastasis. Markers associated with stromal cells in the breast tumor environment have potential to predict patient survival and guide treatment, while advancements in technology may lead to more effective therapies for breast cancer patients.
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)