期刊
JOURNAL OF FOOD AND DRUG ANALYSIS
卷 23, 期 1, 页码 49-56出版社
FOOD & DRUG ADMINSTRATION
DOI: 10.1016/j.jfda.2014.05.004
关键词
animal model; anti-inflammation; cytokines; myeloperoxidase; Sargassum hemiphyllum
资金
- Council of Agriculture, Executive Yuan, Taiwan, R.O.C
Sargassum hemiphyllum is a common plant found on the coasts of Taiwan; it has been used as an anti-inflammatory agent in traditional herbal medicine. This study aimed to evaluate the anti-inflammatory effects of S. hemiphyllum sulfated polysaccharide (SHSP) using two different mouse models. In both arachidonic acid-induced ear inflammatory gavage and paint models, SHSP decreased ear swelling and erythema. In addition, SHSP decreased the production of myeloperoxidase, nitric oxide, interleukin-1 beta (IL-1 beta), IL-6, and tumor necrosis factor-cc in a dose-dependent manner. Histological examination results showed that SHSP reduced the area of neutrophilic infiltration in inflamed ears. The anti-inflammatory activity of SHSP has already been demonstrated in vitro. In this study, SHSP extracted from the same species of brown seaweed exhibited anti-inflammatory activity in both oral and topical applications in vivo. Therefore, SHSP may play a role in the treatment of inflammatory diseases. Copyright (C) 2014, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC. All rights reserved.
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