Review
Oncology
Aneri Shah, Jonathan A. Lindquist, Lars Rosendahl, Ingo Schmitz, Peter R. Mertens
Summary: YB-1 is a RNA binding protein involved in various cellular processes, its activation is associated with NF-kappa B and can affect the inflammatory response and cell survival mechanisms.
Article
Biochemistry & Molecular Biology
Maria Feoktistova, Roman Makarov, Amir S. Yazdi, Diana Panayotova-Dimitrova
Summary: TNF-induced cell death is regulated by RIPK1 and TRADD, with RIPK1 playing a critical role in apoptosis and necroptosis in the absence of IAPs, while TRADD functions as a negative regulator of NIK stabilization and ripoptosome formation. Additionally, MAPK signaling activation does not require RIPK1 and TRADD, and partial repression of NF-kappa B activation in these cells does not sensitize them to TNF due to the lack of NIK stabilization. RIPK1 is essential for preventing TRADD ubiquitination and degradation during TNF signaling, highlighting the intricate balance between cell death and survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Olena Zaitseva, Annett Hoffmann, Christoph Otto, Harald Wajant
Summary: The article describes the biology and signaling of fibroblast growth factor-inducible 14 (Fn14), a member of the tumor necrosis factor receptor superfamily. It discusses the features and preclinical data of Fn14-targeting biologicals, as well as the problems and limitations encountered in these studies. The potential of targeting Fn14 in tumor therapy is highlighted, including directing cytotoxic activities to the tumor, blocking protumoral activities of the TWEAK/Fn14 system, and stimulating Fn14 for cell death.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Hang Liu, Xueyan Dai, Shiwen Xu, Huiling Guo, Jiamei Zhu, Sunan Wang, Yuning Wu, Caiying Zhang
Summary: This study investigated the effects of molybdenum (Mo) and cadmium (Cd) on myocardium injury in ducks and the function of NF-κB/TNF-α axis. The findings showed that the accumulation of Mo and/or Cd caused elements imbalance and necroptosis in myocardial tissue. Mo and/or Cd induced necroptosis via the NF-κB/TNF-α axis and decreased death receptor-mediated apoptosis in duck myocardium, with different effects on mitochondrial-mediated apoptosis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Oncology
Pierina Cetraro, Julio Plaza-Diaz, Alex MacKenzie, Francisco Abadia-Molina
Summary: The Inhibitor of Apoptosis (IAP) family plays a crucial role in inhibiting programmed cell death and regulating the immune response. Abnormal expression of IAPs can lead to the development of various pathologies, with several cancer types showing overexpression of IAPs.
Article
Environmental Sciences
Lihui Xuan, Jinming Guo, Dexin Xia, Lu Li, Daining Wang, Ying Chang
Summary: This study found that profenofos (PFF) as an environmental pollutant can harm human health through the food chain. Albicanol, a sesquiterpene compound, has been shown to antagonize the toxicity caused by PFF exposure. However, the mechanism of PFF toxicity and the role of Albicanol in regulating immune function, apoptosis, and necroptosis have not been reported. The study revealed that PFF exposure led to mitochondrial damage, increased expression of innate immunity-related factors, and activated TNF/NF-kappa B pathway, while Albicanol countered these effects.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemical Research Methods
Leonie K. Amstein, Joerg Ackermann, Jennifer Hannig, Ivan Ikic, Simone Fulda, Ina Koch
Summary: This paper presents a mathematical model that describes the molecular switches in cell survival, apoptosis, and necroptosis in cellular signaling pathways. The model is verified and analyzed using Petri net techniques, and important checkpoints and pathways are identified in the TNFR1 signaling pathway.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Environmental Sciences
Jun Bai, Siwei Deng, Xinyu Zhang, Zhaolai Dai, Yun Ji, Shenming Zeng, Fazheng Ren, Ying Yang, Zhenlong Wu
Summary: As a natural aldehyde organic compound, cinnamaldehyde (CA) showed protective effects against zearalenone (ZEA)-induced apoptosis, barrier dysfunction, and mucin reduction in LS174T cells. CA significantly prevented the decline in cell viability, reversed the increase of the LDH level, cell cycle disruption, and apoptosis induced by ZEA. It also alleviated the reduction of mucin secretion and the expression of mucin 2 and tight junction proteins in LS174T cells caused by ZEA exposure. CA protects cells against ZEA-induced damage through the JNK/NF-kappa B signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Pharmacology & Pharmacy
Yang Yang, Wei Zhou, Xiuqi Xu, Xianxiu Ge, Fei Wang, Guang-Qin Zhang, Lin Miao, Xueting Deng
Summary: This study suggests that Aprepitant alleviates inflammatory pain in mice by inhibiting the phosphorylation of JNK and p38, as well as the NF-kappa B signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chunji Ma, Xiujing Hao, Liyang Gao, Yongyu Wang, Juan Shi, Haixia Luo, Min Li
Summary: We established a cell model of M. pneumoniae-infected macrophages to investigate the role and functional mechanisms of extracellular vesicles (EVs) as intercellular messengers. We found that EVs derived from infected macrophages were pure and had a diameter of 30-200 nm. These EVs were taken up by uninfected macrophages and induced the production of inflammatory cytokines through the NF-κB and MAPK signaling pathways. Furthermore, the expression of inflammatory cytokines induced by EVs relied on the TLR2-NF-κB/JNK signaling pathway. These findings provide insights into the persistent inflammatory response and cell-to-cell immune modulation during M. pneumoniae infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Yuyan Bai, Jin Zhou, Han Zhu, Yanlin Tao, Lupeng Wang, Liu Yang, Hui Wu, Fei Huang, Hailian Shi, Xiaojun Wu
Summary: This study found that Isoliquiritigenin (ISL) can inhibit microglia-mediated neuroinflammation in Parkinson's disease (PD) by deactivating JNK/AKT/NFκB signaling pathways. These findings suggest the therapeutic potential of ISL for microglia-mediated neuroinflammation in PD.
PHYTOTHERAPY RESEARCH
(2023)
Article
Cell Biology
Rania Alaaeldin, Sally M. Bakkar, Reham H. Mohyeldin, Fares E. M. Ali, Nehad M. Reda Abdel-Maqsoud, Moustafa Fathy
Summary: The study aimed to investigate the nephroprotective activity of azilsartan on renal ischemia/reperfusion injury in rats. The results showed that azilsartan exhibited nephroprotective effects by exerting antioxidant, anti-inflammatory, anti-apoptotic activities, and inhibiting the HMGB1/NF-kappa B/p38/ERK1/2/JNK signaling pathway in rats with renal IR injury.
Article
Immunology
Zhijun Liu, Himani Nailwal, Jonah Rector, Masmudur M. Rahman, Richard Sam, Grant McFadden, Francis Ka-Ming Chan
Summary: The study identified a viral inducer (vIRD) found in orthopoxviruses that can regulate the host's necroptosis kinase. Introduction of vIRD into vaccinia virus enhanced viral replication, while deletion of vIRD reduced virus-induced inflammation and replication.
Article
Immunology
Rong Hu, Libo Chen, Xiaolong Chen, Zhong Xie, Chao Xia, Yong Chen
Summary: Aloperine has been shown to inhibit osteoclast activity and formation mediated by RANKL, indicating its potential as a new drug for the prevention and treatment of postmenopausal osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Oncology
Olivia A. Diaz Arguello, Hidde J. Haisma
Summary: Cancer, a complex disease marked by evasion of apoptosis, can potentially be treated by inducing apoptosis in cancerous cells. Among the tumor necrosis factor (TNF) protein family, certain ligands possess apoptosis-inducing capabilities. Various recombinant TNF apoptosis-inducing ligands have been developed over time to improve their effectiveness in cancer treatment.
Article
Biochemistry & Molecular Biology
Julia M. Fraile, Diana Campos-Iglesias, Francisco Rodriguez, Aurora Astudillo, Roser Vilarrasa-Blasi, Nuria Verdaguer-Dot, Miguel A. Prado, Joao A. Paulo, Steven P. Gygi, Jose I. Martin-Subero, Jose M. P. Freije, Carlos Lopez-Otin
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Hematology
Gabriel Bretones, Miguel G. Alvarez, Javier R. Arango, David Rodriguez, Ferran Nadeu, Miguel A. Prado, Rafael Valdes-Mas, Diana A. Puente, Joao A. Paulo, Julio Delgado, Neus Villamor, Armando Lopez-Guillermo, Daniel J. Finley, Steven P. Gygi, Elias Campo, Victor Quesada, Carlos Lopez-Otin
Article
Biochemistry & Molecular Biology
Filomena Massa, Roberta Tammaro, Miguel A. Prado, Marcella Cesana, Byung-Hoon Lee, Daniel Finley, Brunella Franco, Manuela Morleo
HUMAN MOLECULAR GENETICS
(2019)
Article
Cell Biology
Daniel Finley, Miguel A. Prado
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Angel Guerra-Moreno, Miguel A. Prado, Jessie Ang, Helena M. Schnell, Yagmur Micoogullari, Joao A. Paulo, Daniel Finley, Steven P. Gygi, John Hanna
Article
Multidisciplinary Sciences
Lucia Cabal-Hierro, Peter van Galen, Miguel A. Prado, Kelly J. Higby, Katsuhiro Togami, Cody T. Mowery, Joao A. Paulo, Yingtian Xie, Paloma Cejas, Takashi Furusawa, Michael Bustin, Henry W. Long, David B. Sykes, Steven P. Gygi, Daniel Finley, Bradley E. Bernstein, Andrew A. Lane
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Josephine J. Wu, Ashley Cai, Jessie E. Greenslade, Nicole R. Higgins, Cong Fan, Nhat T. T. Le, Micaela Tatman, Alexandra M. Whiteley, Miguel A. Prado, Birger Dieriks, Maurice A. Curtis, Christopher E. Shaw, Teepu Siddique, Richard L. M. Faull, Emma L. Scotter, Daniel Finley, Mervyn J. Monteiro
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Hematology
Yijie Liu, Yang Mei, Xu Han, Farida V. Korobova, Miguel A. Prado, Jing Yang, Zhangli Peng, Joao A. Paulo, Steven P. Gygi, Daniel Finley, Peng Ji
Summary: The membrane skeleton plays an important role in modulating proteome remodeling and organelle clearance during final stages of erythropoiesis, with mDia2 acting as a key regulator in this process through polymerization of actin protofilament. Disruption of the skeleton leads to defects in detaching the extruded nucleus and in activating the ESCRT-III complex, resulting in global defects in proteome remodeling, endolysosomal trafficking, and autophagic organelle clearance. Chmp5, regulated by mDia2, is essential for membrane remodeling and autophagosome-lysosome fusion, highlighting a formin-regulated signaling pathway connecting the membrane skeleton to key processes in terminal erythropoiesis.
Article
Biochemistry & Molecular Biology
Alexandra M. Whiteley, Miguel A. Prado, Stefanie A. H. de Poot, Joao A. Paulo, Marissa Ashton, Sara Dominguez, Martin Weber, Hai Ngu, John Szpyt, Mark P. Jedrychowski, Amy Easton, Steven P. Gygi, Thimo Kurz, Mervyn J. Monteiro, Eric J. Brown, Daniel Finley
Summary: This study provides an unbiased and global analysis of Ubqln2's role in controlling the proteome composition, showing impacts on various physiological pathways and identifying specific proteins linked to UBQLN2 function. The research also reveals candidate client proteins whose degradation is promoted by UBQLN2 in disease models.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Chang Cao, Miguel A. Prado, Liang Sun, Shira Rockowitz, Piotr Sliz, Joao A. Paulo, Daniel Finley, Mark D. Fleming
Summary: Maternal iron deficiency has limited impact on placental gene expression in mice during mid-gestation, mainly mediated by IRE coordination of iron gene expression. Interestingly, sexually dimorphic effects of maternal iron deficiency on placental gene expression were observed, with more alterations in male mouse placentas.
JOURNAL OF NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Helena M. Schnell, Richard M. Walsh, Shaun Rawson, Mandeep Kaur, Meera K. Bhanu, Geng Tian, Miguel A. Prado, Angel Guerra-Moreno, Joao A. Paulo, Steven P. Gygi, Jeroen Roelofs, Daniel Finley, John Hanna
Summary: The study on the assembly intermediates of the proteasome 20S core particle using cryo-EM structures reveals how chaperones coordinate early steps in proteasome biogenesis. The high-resolution structures show the importance of the coordinated activity of chaperones in orchestrating key aspects of CP assembly. Through these structures, the architecture and positions of certain subunits are identified, providing insight into their functions in proteasome biogenesis.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Xu Han, Yang Mei, Rama K. Mishra, Honghao Bi, Atul D. Jain, Gary E. Schiltz, Baobing Zhao, Madina Sukhanova, Pan Wang, Arabela A. Grigorescu, Patricia C. Weber, John J. Piwinski, Miguel A. Prado, Joao A. Paulo, Len Stephens, Karen E. Anderson, Charles S. Abrams, Jing Yang, Peng Ji
Summary: Myeloproliferative neoplasms (MPNs) are characterized by the activated JAK2/STAT pathway. Pleckstrin-2 (Plek2) is a downstream target of the JAK2/STAT5 pathway and is overexpressed in patients with MPNs. Plek2-specific small molecule inhibitors show potent inhibitory effects on cell proliferation.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Helen A. B. Paterson, Sijia Yu, Natalia Artigas, Miguel A. Prado, Nejc Haberman, Yi-Fang Wang, Andrew M. Jobbins, Elena Pahita, Joao Mokochinski, Zoe Hall, Maryse Guerin, Joao A. Paulo, Soon Seng Ng, Francesc Villarroya, Sheikh Tamir Rashid, Wilfried Le Goff, Boris Lenhard, Ines Cebola, Daniel Finley, Steven P. Gygi, Christopher R. Sibley, Santiago Vernia
Summary: RBFOX2 plays a key role in maintaining cholesterol homeostasis in the liver, and dysregulation of this process can lead to hepatocyte lipid imbalance and the development of metabolic diseases.
Article
Biochemistry & Molecular Biology
Brian C. Lin, Trong H. Phung, Nicole R. Higgins, Jessie E. Greenslade, Miguel A. Prado, Daniel Finley, Mariusz Karbowski, Brian M. Polster, Mervyn J. Monteiro
Summary: Mutations in UBQLN2 can lead to ALS with FTD, affecting mitochondrial proteins in the spinal cord and causing functional decline and structural abnormalities in mitochondria. The deficits in oxidative phosphorylation and mitochondrial import factor processing may contribute to the pathogenic mechanisms associated with UBQLN2 mutations.
HUMAN MOLECULAR GENETICS
(2021)
Meeting Abstract
Critical Care Medicine
A. Gonzalez-Lopez, P. Pickerodt, I. Lopez-Alonso, C. von Haefen, M. A. Prado, H. M. Reimann, G. Albaiceta, R. Francis, C. Spies
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)