Article
Engineering, Biomedical
Xiaohui Sun, Pengfei Yang
Summary: The study found that BRD4 expression was upregulated in psoriatic skin lesions and its inhibition could alleviate skin damage by suppressing inflammation and promoting keratinocyte apoptosis. Inhibition of BRD4 could suppress proliferation and inflammation of psoriatic keratinocytes, while promoting apoptosis.
BIOMEDICAL ENGINEERING ONLINE
(2021)
Article
Cell Biology
Guangbin Ye, Hongcheng Luo, Tingting Zhang, Tianshu Lan, Bo Ling, Zhongquan Qi
Summary: This study reveals that RNF183 regulates the proliferation, apoptosis, and cell cycle of LUAD cells by modulating the SHP2/STAT3 signaling pathway, and it can inhibit tumor growth in vivo.
Article
Biochemistry & Molecular Biology
Linyan Xu, Jun Jiao, Mengdi Liu, Yuanyuan Qin, Meng Zhang, Dongmei Yan, Kailin Xu, Wei Sang
Summary: Targeting BET may be an effective therapeutic strategy and potentiated by a combination with histone deacetylase inhibition in DLBCL.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Xiaohui Liang, Ping Wang, Chun Yang, Fei Huang, Hui Wu, Hailian Shi, Xiaojun Wu
Summary: Galangin inhibits the growth of MGC 803 cells by inducing apoptosis and decreasing cell proliferation, possibly mediated by modulating the STAT3/ROS axis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Hongli Mao, Jinlin Jia, Jinxiu Sheng, Shanfeng Zhang, Kaida Huang, Hongle Li, Fucheng He
Summary: The study found that Regenerating islet-derived protein 1-alpha (REG1A) was significantly increased in inflamed colorectal tissues of inflammatory bowel disease (IBD) patients, and it could inhibit inflammatory responses, promote cell proliferation, and suppress epithelial apoptosis. IL-6 and IL-22 activated REG1A transcription through the JAK/STAT3 signaling pathway. Overexpression of REG1A in mice alleviated DSS-induced inflammatory injury and maintained intestinal mucosal barrier integrity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Xiao-Ting Wu, Yu-Han Wang, Xiao-Yue Cai, Yun Dong, Qing Cui, Ya-Ning Zhou, Xi-Wen Yang, Wen-Feng Lu, Ming Zhang
Summary: Patients with lung adenocarcinoma (LUAD) have high mortality rate and poor prognosis. The overexpression of RNF115 in LUAD tissues is positively correlated with poor overall survival of LUAD patients. RNF115 plays oncogenic roles in LUAD by regulating the Wnt/beta-catenin pathway through ubiquitination of adenomatous polyposis coli (APC).
CANCER & METABOLISM
(2021)
Article
Oncology
Xinmu Zhang, Christina Nadolny, Qiwen Chen, Winifer Ali, Syed F. Hashmi, Ruitang Deng
Summary: This study found that the expression of USP2a is upregulated in hepatocellular carcinoma (HCC) patients and acts as a tumor suppressor gene in HCC pathogenesis. USP2a promotes tumor cell proliferation, resistance, and translation levels through multiple signaling pathways, leading to the occurrence and progression of HCC. The findings provide molecular and pathogenesis bases for developing interventions to treat HCC by targeting USP2a or its downstream pathways.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Cell Biology
Xuhui Fan, Haotian Fu, Ni Xie, Hangcheng Guo, Tiantian Fu, Yunfeng Shan
Summary: The study revealed that panaxadiol significantly inhibited proliferation and induced apoptosis in human pancreatic cancer cells, as well as suppressed the migration of pancreatic cancer cells, suggesting its potential as an anti-tumor agent for pancreatic cancer treatment.
Article
Biochemistry & Molecular Biology
Joo-Young Im, Bo-Kyung Kim, Sung-Hoon Yoon, Byoung Chul Cho, Yu Mi Baek, Mi-Jung Kang, Nayeon Kim, Young-Dae Gong, Misun Won
Summary: The study demonstrated that DGG-100629 inhibited lung cancer cell growth by suppressing DDIAS expression and affecting JNK and STAT3 signaling pathways.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Oncology
Huailin Wang, Yan Fu
Summary: Up-regulation of NR1D1 in ovarian cancer cells inhibits cell proliferation, induces cell cycle arrest and apoptosis, suppresses the JAK/STAT3 signaling pathway through up-regulation of SOCS3, and delays the growth of ovarian cancer cells.
Article
Biochemistry & Molecular Biology
Debanjan Bhattacharjee, Sreeram Kaveti, Nishant Jain
Summary: STAT3, an oncogene associated with poor prognosis, can be ubiquitinated by APC/C CDH1 during mitosis, resulting in long-lasting anti-tumor responses. Inhibiting phosphatases can decrease STAT3 ubiquitination. Targeting mitosis may be a potential therapeutic window for treating STAT3-activated cancers.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Article
Environmental Sciences
Vimala Karuppaiya, Asaikkutti Annamalai, Shanthi Krishnamurthy, Kannan Soundarapandian
Summary: This study found that the natural substance DCL can inhibit the proliferation and migration of prostate cancer cells by blocking the JAK/STAT3 signaling pathway. The results showed that DCL has significant cytotoxic effects on PC-3 cells and can increase ROS production and apoptotic signals. Additionally, DCL suppresses the expression of proteins that control cell proliferation.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Cell Biology
Tong-bing Wang, Mei Geng, Hua Jin, Ai-guo Tang, Hao Sun, Liu-zheng Zhou, Bin-hai Chen, Gang Shen, Qiang Sun
Summary: The inhibitor PF-429242 targeting S1P showed potent inhibition of RCC cell growth both in vitro and in vivo, inducing apoptosis in the cells. Silencing or knockout of S1P had similar inhibitory effects, while overexpression of SREBP1 and S1P enhanced RCC cell proliferation and migration.
CELL DEATH & DISEASE
(2021)
Article
Endocrinology & Metabolism
Songnian Zou, Shouxi Cui, Bin Liang
Summary: This study revealed that overexpressed PLAGL2 and OLFM4 were observed in bladder cancer cells. Silencing of PLAGL2 or OLFM4 suppressed proliferation, promoted apoptosis, and alleviated stemness of bladder cancer cells. PLAGL2 could transcriptionally activate OLFM4 and regulate the STAT3 signaling pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Oncology
Yafei Jiang, Gangyang Wang, Haoran Mu, Xiaojun Ma, Zhuoying Wang, Yu Lv, Tao Zhang, Jing Xu, Jinzeng Wang, Yunqi Li, Jing Han, Mengkai Yang, Zongyi Wang, Ke Zeng, Xinmeng Jin, Song Xue, Mingzhu Yin, Wei Sun, Yingqi Hua, Zhengdong Cai
Summary: The study revealed that NHWD-870, as an effective BET inhibitor, showed significant inhibition of tumor proliferation and promotion of cell apoptosis in osteosarcoma by disrupting the JAK/STAT3 signaling pathway. Additionally, NHWD-870 inhibited osteoclast differentiation and bone loss, and demonstrated synthetic lethal effects with cisplatin against osteosarcoma in a preclinical model.
FRONTIERS IN ONCOLOGY
(2021)
Article
Virology
Morgan Mann, David S. Roberts, Yanlong Zhu, Yi Li, Jia Zhou, Ying Ge, Allan R. Brasier
Summary: The study reveals that RSV infection alters the interaction proteins of BRD4, with 101 proteins significantly enriched in the BRD4 complex responsive to both RSV infection and BRD4 inhibition. These proteins are mainly transcription factors and transcriptional coactivators, including members of the AP1 transcription factor complex.
Article
Virology
Xiaofang Xu, Morgan Mann, Dianhua Qiao, Allan R. Brasier
Summary: The research utilized SMRT sequencing and short-read mRNA sequencing to characterize changes in mRNA processing in epithelial cells in response to RSV infection, revealing differential splicing and polyadenylation, particularly involving cell cycle control and the innate immune response pathway.
Article
Physiology
Dianhua Qiao, Melissa Skibba, Xiaofang Xu, Roberto P. Garofalo, Yingxin Zhao, Allan R. Brasier
Summary: Paramyxoviridae, respiratory syncytial virus (RSV), and murine respirovirus are enveloped, negative-sense RNA viruses that cause vertebrate lower respiratory tract infections (LRTIs). RSV infection induces the activation of the hexosamine biosynthetic pathway (HBP), as well as mesenchymal transition (EMT) and ECM remodeling through the IRE1 alpha-XBP1 arm of the unfolded protein response (UPR). Murine respirovirus induces similar effects in a host-dependent manner, suggesting a role for the IRE1 alpha-XBP1s arm in paramyxovirus-induced metabolic adaptation and mucosal remodeling.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Genetics & Heredity
Kishor K. Bhakat, Sutapa Ray
Summary: Genomic DNA in the nucleus is wrapped around nucleosomes, consisting of core histones. The histone chaperone complex FACT is involved in nucleosome remodeling during processes like transcription and DNA repair, playing a crucial role in various repair pathways. Overexpression of FACT in cancer is associated with drug resistance and poor prognosis, while inhibitors like curaxins show promise in sensitizing cancer to chemotherapy and radiation.
Review
Medicine, General & Internal
Sutapa Ray, Nagendra K. Chaturvedi, Kishor K. Bhakat, Angie Rizzino, Sidharth Mahapatra
Summary: Medulloblastoma is the most common malignant central nervous system tumor in pediatric patients. Tumors can be divided into average and high-risk status based on age, metastasis at diagnosis, and extent of surgical resection. High-throughput screening has allowed for the identification of four primary subgroups, each with further subdivisions based on cytogenetic and epigenetic events. Exploiting these genetic aberrations may lead to novel targeted therapeutics.
Article
Biochemistry & Molecular Biology
Suravi Pramanik, Yingling Chen, Heyu Song, Irine Khutsishvili, Luis A. Marky, Sutapa Ray, Amarnath Natarajan, Pankaj K. Singh, Kishor K. Bhakat
Summary: This study identifies a novel role for the protein APE1 in regulating stable G4 formation and KRAS expression in PDAC, suggesting that G4 structures could be potential prognostic markers and therapeutic targets for PDAC.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemical Research Methods
Yanlong Zhu, Stephane Esnault, Ying Ge, Nizar N. Jarjour, Allan R. Brasier
Summary: Airway remodeling in patients with asthma is associated with leukocyte numbers and remodeling markers. Patients with lower FEV1 have distinct dynamic responses to allergens.
CLINICAL PROTEOMICS
(2022)
Article
Biochemistry & Molecular Biology
Yanlong Zhu, Stephane Esnault, Ying Ge, Nizar N. Jarjour, Allan R. Brasier
Summary: This study analyzed metabolites in bronchoalveolar fluid (BALF) during a bronchial antigen challenge and identified distinct metabolic responses, providing insight into pathogenic and protective subtypes in allergic asthma.
Editorial Material
Virology
Allan R. Brasier
Article
Biochemistry & Molecular Biology
Dianhua Qiao, Melissa Skibba, Xiaofang Xu, Allan R. Brasier
Summary: Epithelial mesenchymal plasticity (EMP) is a complex cellular reprogramming event that plays a major role in tissue homeostasis. Recently, the unfolded protein response (UPR) was found to trigger EMP through the IRE1 alpha-XBP1s axis, enhancing glucose shunting to protein N glycosylation. By identifying the genomic targets of XBP1s using CUT&RUN, it was discovered that XBP1s peaks were located near various promoters of genes controlling Rho-GTPase signaling, N-linked glycosylation, and ER-Golgi transport. Moreover, the IRE1 alpha-XBP1s pathway was shown to regulate mesenchymal transcription factors and hexosamine biosynthesis in EMP by recruiting activated RNA Pol II to GC-rich promoters.
NUCLEIC ACIDS RESEARCH
(2023)
Editorial Material
Medicine, Research & Experimental
Allan R. Brasier
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Oncology
Kyle A. Rohrer, Heyu Song, Anum Akbar, Yingling Chen, Suravi Pramanik, Phillip J. Wilder, Erin M. McIntyre, Nagendra K. Chaturvedi, Kishor K. Bhakat, Angie Rizzino, Don W. Coulter, Sutapa Ray
Summary: Medulloblastoma (MB) is a common childhood malignant brain tumor that accounts for a significant percentage of pediatric central nervous system tumors. This study reveals the functional role of activated STAT3 in promoting MB tumorigenesis and chemoresistance by inducing the oncogene MYC. Inhibiting STAT3 can reduce the growth and survival of MB cells and improve treatment efficacy, especially in high-risk MYC-amplified tumors.
Review
Medicine, Research & Experimental
Allan. R. R. Brasier, Shannon. L. L. Casey, Peggy Hatfield, Patrick. W. W. Kelly, Whitney. A. A. Sweeney, Marin Schweizer, Bo Liu, Elizabeth. S. S. Burnside
Summary: This study proposes a model for developing leadership in translational teams (TTs) from team formation to dissemination and implementation. It identifies the stable impact of leadership behaviors on team development and emphasizes the importance of ongoing reflection, evaluation, and practice to enhance leadership skills. The study also provides a comprehensive multi-level evaluation framework to track the growth of TT leadership skills.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Review
Medicine, Research & Experimental
Allan R. Brasier, Shannon L. Casey, Felice Resnik, Betsy Rolland, Elizabeth S. Burnside
Summary: Successful translation involves the application of research and product development to advance healthcare interventions. Training in team skills and attitudes can enhance translational team performance. Interdisciplinary teams undergo developmental phases, with each phase promoting knowledge generation and translation. Antecedents of stage-dependent competencies and assessment rubrics can guide training interventions for improving performance in the clinical context.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Review
Medicine, Research & Experimental
Allan R. Brasier, Elizabeth S. Burnside, Betsy Rolland
Summary: A translational team is a type of interdisciplinary team that aims to improve human health. Understanding how to promote team performance in the areas of affect, communication, management, collaborative problem-solving, and leadership is essential. This study conducted a literature review to identify key competencies that enhance team performance and develop strategies for training interventions.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)
