Article
Multidisciplinary Sciences
Tian Wang, Ezra Wiater, Xinmin Zhang, John B. Thomas, Marc Montminy
Summary: Fasting in mammals and Drosophila leads to metabolic changes, with Crtc gene involved in regulating glucagon and cAMP in fasting metabolism, promoting the expression of genes related to starvation response while inhibiting insulin secretion and signaling pathways, and enhancing activity in the one-carbon metabolism pathway.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Rui Zhou, Guodong Wang, Qi Li, Fanxi Meng, Can Liu, Rui Gan, Dapeng Ju, Meimei Liao, Junjie Xu, Di Sang, Xue Gao, Shuang Zhou, Kejia Wu, Quanzhi Sun, Ying Guo, Chongyang Wu, Zhiyu Chen, Lin Chen, Bihan Shi, Haiyan Wang, Xia Wang, Huaiye Li, Tao Cai, Bin Li, Fengchao Wang, Hiromasa Funato, Masashi Yanagisawa, Eric Erquan Zhang, Qinghua Liu
Summary: This study characterizes a major signaling pathway for the transcriptional regulation of sleep in mice, involving the LKB1-SIK3 pathway and phosphorylation of HDAC4/HDAC5. The findings provide insights into the molecular mechanisms that regulate sleep quantity and offer new potential targets for the treatment of sleep disorders.
Article
Biotechnology & Applied Microbiology
Chansik Yoon, Kyoung Eun Baek, Dongil Kim, Gyun Min Lee
Summary: This article investigates the challenge of achieving high-level expression of recombinant proteins in mammalian cells. The authors propose a method of introducing constitutively active transcription factors to overcome transcriptional limitations, which successfully increases the production of therapeutic proteins.
METABOLIC ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Rupesh Kumar, Maged Mostafa Mahmoud, Hanaa M. Tashkandi, Shafiul Haque, Steve Harakeh, Kalaiarasan Ponnusamy, Shazia Haider
Summary: This study aimed to identify key molecules in colorectal cancer using a computational systems biology approach. A protein-protein interaction network was constructed, and TP53, CTNBB1, AKT1, EGFR, HRAS, JUN, RHOA, and EGF were identified as key molecules. Regulatory networks of these key molecules were also constructed, revealing important regulatory factors. Biochemical investigation of these key regulators could provide further understanding of their role in the pathophysiology of colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biophysics
Ayana Yamagishi, Mei Mizusawa, Koki Uchida, Masumi Iijima, Shun'ichi Kuroda, Kyoko Fukazawa, Kazuhiko Ishihara, Chikashi Nakamura
Summary: This study developed a mechanical detection method using nanoneedles to measure protein-protein interactions in living cells and discovered the interaction between IF vimentin and transcription-related proteins.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Pharmacology & Pharmacy
Rongyin Gao, Ximei Zhang, Kun Zou, Duo Meng, Jinpeng Lv
Summary: Recent research indicates that clock proteins, specifically the protein CRY, play a role in regulating cutaneous pigmentation. The synthetic molecule modulator KL001 was found to inhibit melanin synthesis and reduce melanocyte dendrite elongation and melanosome transport. Activation of CRY1 led to the downregulation of MITF through the cAMP/PKA pathway, resulting in the inhibition of melanogenesis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jan N. Hansen, Fabian Kaiser, Philipp Leyendecker, Birthe Stueven, Jens-Henning Krause, Fatemeh Derakhshandeh, Jaazba Irfan, Tommy J. Sroka, Kenley M. Preval, Paurav B. Desai, Michael Kraut, Heidi Theis, Anna-Dorothee Drews, Elena De-Domenico, Kristian Haendler, Gregory J. Pazour, David J. P. Henderson, David U. Mick, Dagmar Wachten
Summary: This article investigates how the primary cilium controls cellular functions and tissue integrity through the ciliary cAMP signalosome, and reveals novel molecular components that may be involved in the development of polycystic kidney disease.
Article
Endocrinology & Metabolism
Lorna I. F. Smith, Zidong Zhao, Jamie Walker, Stafford Lightman, Francesca Spiga
Summary: This study investigated the activation and expression of CRTC isoforms in rat adrenal glands under different stress conditions. The results showed that CRTC2 and CRTC3 play important roles in the transcriptional regulation of StAR, with their activation and nuclear localization associated with changes in plasma ACTH levels. Both isoforms were found to bind to the Star promoter, with CRTC3 binding dynamics corresponding to changes in nuclear protein levels. While little variation was observed in CRTC isoform expression over a 24-hour period, long-term down-regulation was observed following endotoxic stress.
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Qin Li, Yunqin Shen, Xingyue Guo, Yixuan Xu, Yuheng Mao, Yinfan Wu, Fang He, Caixia Wang, Yanqiu Chen, Yan Yang
Summary: Betanin can dose-dependently alleviate allergic asthma and upregulate the cAMP-PKA-CREB pathway. This study provides a novel nutritional strategy for the treatment of allergic asthma.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yan-Yan Zhao, Li-Jun Zhang, Xiang-Yan Liang, Xiao-Chun Zhang, Jin-Rui Chang, Man Shi, Huan Liu, Ying Zhou, Zhuo Sun, Yu-Feng Zhao
Summary: Pyruvate activates PDEs to reduce cAMP levels and inhibits the cAMP-Epac-CREB signaling pathway, resulting in upregulation of FGF21 expression in hepatocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hye Yeon Lim, Eunji Kim, Sang Hee Park, Kyung Hwan Hwang, Donghyun Kim, You-Jung Jung, Spandana Rajendra Kopalli, Yong Deog Hong, Gi-Ho Sung, Jae Youl Cho
Summary: Theasinensin A (TSA) has been shown to inhibit melanin formation and secretion, as well as down-regulate the expression of genes related to melanin formation. TSA can also suppress the activities of proteins in the melanocortin 1 receptor (MC1R) signaling pathway associated with melanin synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Avijit Mallick, Shane K. B. Taylor, Sakshi Mehta, Bhagwati P. Gupta
Summary: The Axin family of proteins plays a crucial role in controlling various cellular processes and providing specificity to signaling pathways. This study focused on the Caenorhabditis elegans Axin homolog pry-1 and its interacting gene picd-1. The findings showed that picd-1 is involved in stress response and lifespan maintenance, and its expression overlaps with pry-1 in multiple tissues. Furthermore, pry-1 and picd-1 inhibit the activity of CRTC-1, a transcriptional coactivator promoting longevity. This study highlights the importance of picd-1 in mediating pry-1 function and suggests a potential role for Cabin-1 domain-containing protein in Axin signaling in other systems.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Medicinal
Mingqiang Wang, Yanzhen Li, Jianhui Su, Jingyan Bai, Zhongxiang Zhao, Zhanghua Sun
Summary: This study found that 4-GDB can alleviate colonic injury, reduce inflammation, and improve colonic barrier function by regulating cAMP/PKA/CREB and NF-kappa B pathways. This suggests that 4-GDB may be a potential agent for treating ulcerative colitis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Cell Biology
Jelena Ostojic, Young-Sil Yoon, Tim Sonntag, Billy Nguyen, Joan M. Vaughan, Maxim Shokhirev, Marc Montminy
Summary: The cyclic AMP pathway promotes melanocyte differentiation by activating CREB and CRTC1-3. In melanoma cells, CRTC3 deficiency leads to impaired differentiation and melanosome maturation. CRTC3 interacts with CREB to stimulate OCA2 expression, affecting pigmentation and melanoma risk, and is activated by ERK1/2 signaling.
Review
Plant Sciences
Liyang Su, Siqi Wan, Junmei Zhou, Qing Song Shao, Bingcong Xing
Summary: This review discusses the roles of transcription factors (TFs) in regulating plant seed development, noting that different TFs or TF families may have similar functions in this process, and some members of the same TF family may have opposite roles.
PHYSIOLOGIA PLANTARUM
(2021)
Article
Pharmacology & Pharmacy
Ole Jensen, Muhammad Rafehi, Mladen Tzvetkov, Juergen Brockmoeller
BIOCHEMICAL PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Manuela Vay, Marleen Julia Meyer, Antje Blank, Gisela Skopp, Peter Rose, Mladen Vassilev Tzvetkov, Gerd Mikus
CLINICAL PHARMACOKINETICS
(2020)
Article
Pharmacology & Pharmacy
Sarah Romer, Marleen J. Meyer, Kathrin Klein, Lennart V. Schneider, Johannes Matthaei, Ana Tzvetkova, Joanna Lapczuk-Romanska, Jochen Gaedcke, Marek Drozdzik, Jurgen Brockmoeller, Anne T. Nies, Mladen V. Tzvetkov
Summary: rs35854239 variant partially affects OCT1 splicing, leading to moderate changes in OCT1 expression in the human liver. The alternative spliced OCT1 transcript is not correctly localized in the plasma membrane and unable to transport substrates. However, this variant does not significantly impact the pharmacokinetics of drugs like sumatriptan and fenoterol.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ole Jensen, Johannes Matthaei, Henry G. Klemp, Marleen J. Meyer, Jurgen Brockmoller, Mladen V. Tzvetkov
Summary: This study confirmed IBC as an endogenous biomarker of OCT1 activity in humans, with OCT1 potentially regulating cellular concentrations of specific regulators or co-substrates in lipid and energy metabolism. Unlike in mice, OCT1 in humans may not directly mediate the efflux of IBC, suggesting a different mechanism for the association between blood concentrations of carnitine derivatives and OCT1 genotype in humans.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Pharmacology & Pharmacy
Marleen J. Meyer, Mladen V. Tzvetkov
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Johannes Matthaei, Juergen Brockmoeller, Werner Steimer, Konstanze Pischa, Stefan Leucht, Maria Kullmann, Ole Jensen, Typhaine Ouethy, Mladen Vassilev Tzvetkov, Muhammad Rafehi
Summary: The pharmacokinetics of the tricyclic antidepressant amitriptyline is primarily influenced by the genotypes of CYP2D6 and CYP2C19, with OCT1 genetic variation playing a minor role. Inhibition of OCT1 by amitriptyline and nortriptyline in vitro was observed, but significant effects of OCT1 genetic polymorphism on drug pharmacokinetics were not found in clinical studies with healthy volunteers and depressive disorder patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Saskia Floerl, Annett Kuehne, Joachim Geyer, Juergen Brockmoeller, Mladen V. Tzvetkov, Yohannes Hagos
Summary: The study revealed a strong correlation in transport kinetics and inhibition pattern between human NTCP and mouse Ntcp, but specific compounds like benzbromarone showed significant species differences. Such differences need to be taken into consideration when transferring pharmacokinetic data from rodents to humans.
Article
Immunology
Eileen Moritz, Gabriele Jedlitschky, Josefine Negnal, Mladen Tzvetkov, Guenter Daum, Marcus Doerr, Stephan B. Felix, Henry Voelzke, Matthias Nauck, Edzard Schwedhelm, Peter Meisel, Thomas Kocher, Bernhard H. Rauch, Birte Holtfreter
Summary: The study found that S1P serum concentrations were significantly increased in patients with periodontitis and were correlated with high-sensitivity C-reactive protein levels. There was no significant association with caries variables, but the expression of the S1P-generating enzyme was elevated in inflamed gingival tissue compared to normal tissue.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Carolin Seifert, Ellen Balz, Susann Herzog, Anna Korolev, Sebastian Gassmann, Heiko Paland, Matthias A. Fink, Markus Grube, Sascha Marx, Gabriele Jedlitschky, Mladen Tzvetkov, Bernhard H. Rauch, Henry W. S. Schroeder, Sandra Bien-Moeller
Summary: Research has shown that PIM1 kinase plays a significant role in the behavior of glioblastoma stem cells, and its inhibition can lead to the death of these stem-like cells, suggesting a potential approach for glioblastoma therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Caspar Mewes, Tessa Alexander, Benedikt Buttner, Jose Hinz, Ayelet Alpert, Aron-F Popov, Tim Beissbarth, Mladen Tzvetkov, Marian Grade, Michael Quintel, Ingo Bergmann, Ashham Mansur
Summary: The study investigated the impact of the rs951818 SNP of the LAG-3 gene on sepsis mortality and disease severity. AA-homozygote patients had lower 28-day mortality and more often required invasive mechanical ventilation compared to C-allele carriers. The findings suggest genetic profiling of LAG-3 variants could be a promising approach for risk stratification in sepsis patients and personalized therapeutic targeting of immune checkpoints may be a future component of sepsis therapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Adrian Rump, Franziska N. Weiss, Louisa Schulz, Marie-Luise Kromrey, Eberhard Scheuch, Mladen V. Tzvetkov, Tyler White, Shane Durkee, Kevin W. Judge, Vincent Jannin, Aouatef Bellamine, Werner Weitschies, Michael Grimm
Summary: Controlling the timing and location of release of active ingredients in the gastrointestinal tract after oral administration remains a challenge. This study used MRI and salivary tracing techniques to investigate the impact of different combinations of capsule sizes and materials on the disintegration site and time. Results suggested that variability in the gastrointestinal localization of disintegration was lowest for the DUOCAP(R) capsule-in-capsule configuration using DRcaps(R) designed release capsules, enabling targeted delivery to the distal small intestine.
Article
Biochemistry & Molecular Biology
Marleen Julia Meyer, Simon Falk, Sarah Roemer, Clarissa Prinzinger, Sabine Tacke, Joachim Geyer, Stefan Simm, Mladen Vassilev Tzvetkov
Summary: In this study, the cloned dog OCT1 and OCT2 were compared to their human and mouse orthologs, revealing significant differences in transport kinetics. The functional characterization of dog OCT1 and OCT2 provides valuable insights for the use of dogs as pre-clinical models and for drug therapy in dogs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marleen J. Meyer, Pascale C. F. Schreier, Mert Basaran, Stefaniia Vlasova, Tina Seitz, Juergen Brockmoeller, Barbara Zdrazil, Mladen V. Tzvetkov
Summary: This study analyzed the differences between human and mouse OCT1 orthologs and identified nonconserved amino acids Cys36 and Phe32 as determinants of OCT1 polyspecificity. It also found that the second phenol ring in Cys36 is essential for the affinity of fenoterol. This is the first study to report single amino acids as determinants of OCT1 polyspecificity.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Eik Schaefer, Christian Scheer, Karen Salje, Anja Fritz, Thomas Kohlmann, Nils-Olaf Huebner, Matthias Napp, Lizon Fiedler-Lacombe, Dana Stahl, Bernhard Rauch, Matthias Nauck, Uwe Voelker, Stephan Felix, Guglielmo Lucchese, Agnes Floeel, Stefan Engeli, Wolfgang Hoffmann, Klaus Hahnenkamp, Mladen Tzvetkov
Summary: In this study, we analyzed the symptoms and comorbidities of COVID-19 patients in North-East Germany and found that ageusia without anosmia was associated with the highest risk of hospitalization. Other symptoms such as dyspnea, vomiting, and fever were also significantly associated with increased hospitalization risk. Age > 60 years and comorbidities such as COPD, prior stroke, diabetes, kidney, and cardiac diseases were further identified as risk factors for hospitalization. These findings highlight the importance of considering both symptoms and comorbidities in identifying patients at high risk of hospitalization.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Angelique Kragl, Anke Hannemann, Matthias Nauck, Uwe Voelker, Heide Siggelkow, Alexander Teumer, Mladen V. Tzvetkov
Summary: Osteporosis is a chronic disease characterized by reduced bone mineral density and increased fracture risk. This study found significant associations between certain genetic variants and bone properties, supporting the role of genetic disposition in osteoporosis development. The study also identified a novel causal role of SCD expression in adipose tissue on bone integrity.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)