Article
Cell Biology
Bahareh Tabanifar, Anbalagan Moorthy, Heng Hang Tsai, Srinivasaraghavan Kannan, Chandra S. Verma, Kanaga Sabapathy
Summary: This study reveals a mechanism of cell death mediated by JNK, involving the degradation of the anti-apoptotic protein APE1. Upon exposure to genotoxic stress, JNK interacts with APE1, leading to its ubiquitination and degradation, which ultimately triggers cell death.
Article
Biochemistry & Molecular Biology
Juying Jiao, Linjie Ruan, Chien-shan Cheng, Fengjiao Wang, Peiwen Yang, Zhen Chen
Summary: In this study, aberrantly expressed kinases in pancreatic cancer (PC) were identified, and the role of RIPK2 kinase was validated in promoting cancer cell proliferation, migration, and invasion. RIPK2 knockout inhibited tumor growth and metastasis in PC, and also affected autophagosome formation, ROS production, and cell apoptosis. Additionally, the interaction between oncogenic kinase PRKCI and RIPK2 was found to enhance the downstream phosphorylation of NF-κB, JNK, and ERK.
MOLECULAR MEDICINE
(2023)
Review
Endocrinology & Metabolism
Ruben Nogueiras, Guadalupe Sabio
Summary: The article highlights the role of hypothalamic stress induced by nutrient overload as a major contributor to obesity and related diseases, with a particular focus on the importance of the JNK kinases in the brain. Recent research suggests opposing roles for JNK1 and JNK3 in AgRP neurons of the hypothalamus, demonstrating the complexity of JNK biology.
Article
Biochemistry & Molecular Biology
Andrew M. Kidger, Mark K. Saville, Linda K. Rushworth, Jane Davidson, Julia Stellzig, Motoharu Ono, Ludwig A. Kuebelsbeck, Klaus-Peter Janssen, Bernhard Holzmann, Jennifer P. Morton, Owen J. Sansom, Christopher J. Caunt, Stephen M. Keyse
Summary: DUSP5 and DUSP6 are negative regulators of RAS/ERK signaling pathway. Deletion of either Dusp5 or Dusp6 promotes pancreatic hyperplasia, acinar to ductal metaplasia, and pre-neoplastic pancreatic intraepithelial neoplasia in a mouse model of KRAS-driven pancreatic cancer. However, as time progresses, pancreatic hyperplasia is reversed with atrophy of pancreatic tissue and weight loss observed in animals lacking either DUSP5 or DUSP6. These findings suggest that DUSP5 and DUSP6 have partially non-redundant roles in suppressing oncogenic KRAS signaling, thereby retarding tumor progression.
Article
Cell Biology
Maria Chatzifrangkeskou, Panayiotis Kouis, Paris A. Skourides
Summary: Chatzifrangkeskou et al. discovered that c-Jun N-terminal kinase (JNK) plays an important role in ciliogenesis and ciliary function by regulating the actin networks in multiciliated cells. JNK signaling is critical for maintaining the actin networks and ciliary function in mature multiciliated cells. Additionally, JNK is implicated in the development of diseases such as diabetes, neurodegeneration, and liver disease, which are associated with ciliary dysfunction.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Cell Biology
Lang Shi, Hongchu Zha, Zhou Pan, Jiayi Wang, Yao Xia, Huimin Li, Hua Huang, Ruchi Yue, Zhixia Song, Jiefu Zhu
Summary: The study suggests that DUSP1 plays a critical role in maintaining mitochondrial function and structural integrity. DUSP1 protects against AKI by preventing BAX-induced mtDNA leakage and blocking excessive activation of the cGAS-STING signaling axis through JNK dephosphorylation.
CELL DEATH & DISEASE
(2023)
Article
Neurosciences
Qi Hou, Shuai Li, Bo Zhang, Huaqing Chu, Cheng Ni, Xuejie Fei, Hui Zheng
Summary: The study found that lncRNA Riken attenuates anesthesia-induced neuroinflammation by interacting with microRNA-101a, thereby alleviating the neurotoxic effects induced by sevoflurane.
NEUROTOXICITY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hyun-Young Lee, Seon-Hee Oh
Summary: Arsenic induces cytotoxicity in non-small-cell lung cancer cells through the coordinated action of p62 and Nix signaling, affecting mitochondrial membrane potential and caspase protein cleavage. The modulation of p62 and Nix by MAPK pathways regulates arsenic-induced cytotoxicity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Jinrun Zhou, Yujuan Yao, Jiaojiao Zhang, Zhaohui Wang, Tianshu Zheng, Yao Lu, Weihua Kong, Jing Zhao
Summary: Myocardial apoptosis induced by myocardial ischemia and hyperlipemia are the main causes of high mortality of cardiovascular diseases. This study found that early growth response protein 1 (EGR-1) is involved in both types of apoptosis and identified the mechanism of EGR-1 entering the nucleus.
Article
Pharmacology & Pharmacy
Sholeh Akbari, Fereshteh Talebpour Amiri, Maloos Naderi, Fatemeh Shaki, Mohammad Seyedabadi
Summary: This study elucidated the accelerating role of sodium arsenite on D-galactose-induced reproductive aging in male rats. The findings suggest that sodium arsenite exacerbates the aging process in testis tissue, leading to decreased sperm motility and count, histopathological changes, increased oxidative stress, and altered gene expression.
Editorial Material
Cell Biology
Jeffrey R. Allen, Lucia C. Strader
Summary: This study identifies two RNA-binding proteins that regulate heat stress tolerance in plants.
DEVELOPMENTAL CELL
(2022)
Article
Biochemical Research Methods
Shihu Jiao, Xiucai Ye, Chunyan Ao, Tetsuya Sakurai, Quan Zou, Lei Xu
Summary: The rapid and extensive transmission of SARS-CoV-2 has caused a global health emergency, and identifying phosphorylation sites plays a crucial role in understanding the molecular mechanisms of infection. However, current prediction tools lack accuracy and efficiency. This study presents a comprehensive analysis of SARS-CoV-2 infection in human lung cells and introduces a deep learning predictor, PSPred-ALE, designed to identify phosphorylation sites. The predictor utilizes a self-adaptive learning embedding algorithm and a multihead attention module to improve prediction accuracy. Comparative analysis shows that PSPred-ALE outperforms existing prediction tools. The proposed model can assist biomedical scientists in understanding phosphorylation mechanisms in SARS-CoV-2 infection.
Article
Nutrition & Dietetics
Savanie Fernando, Jacob Sellers, Shauri Smith, Sarayu Bhogoju, Sadie Junkins, Morgan Welch, Orion Willoughby, Nabin Ghimire, Cassandra Secunda, Marina Barmanova, Sean C. Kumer, Kisuk Min, Ahmed Lawan
Summary: This study reveals the upregulation of MKP-2 in liver tissue of obese and fatty liver disease patients and in insulin-responsive tissues of obese mice. MKP-2 deficiency in mice protects against diet-induced obesity and hepatic steatosis and is accompanied by improved glucose homeostasis and insulin sensitivity.
Article
Multidisciplinary Sciences
Fabin Dang, Li Nie, Jin Zhou, Kouhei Shimizu, Chen Chu, Zhong Wu, Anne Fassl, Shizhong Ke, Yuangao Wang, Jinfang Zhang, Tao Zhang, Zhenbo Tu, Hiroyuki Inuzuka, Piotr Sicinski, Adam J. Bass, Wenyi Wei
Summary: Inhibition of CK1 epsilon can prevent acquisition of CDK4/6i resistance, enhancing the therapeutic efficacy of CDK4/6i in human breast cancer.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Wei Siang Lee, Daniel C. S. Tan, Yuanyuan Deng, Annika van Hummel, Stefania Ippati, Claire Stevens, Paulina Carmona-Mora, Daryl Ariawan, Liming Hou, Holly Stefen, Tamara Tomanic, Mian Bi, Florence Tomasetig, Adam Martin, Thomas Fath, Stephen Palmer, Yazi D. Ke, Lars M. Ittner
Summary: The study identified syntaxin 8 and syntaxin 6 as mediators of tau release from cells in Alzheimer's disease and progressive supranuclear palsy, providing insights into the underlying molecular mechanisms of tau pathology spreading. These findings suggest a differential role of syntaxins in alternative secretory pathways, contributing to the pathogenesis of AD and PSP.
BIOCHEMICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Ioannis Temponeras, George Stamatakis, Martina Samiotaki, Dimitris Georgiadis, Harris Pratsinis, George Panayotou, Efstratios Stratikos
Summary: Recent studies have found that pharmacological inhibition of ER aminopeptidase 2 (ERAP2) could potentially improve the efficacy of cancer immunotherapy. In this study, MOLT-4 T lymphoblast leukemia cells were treated with a selective ERAP2 inhibitor, resulting in significant shifts in the immunopeptidome. The newly generated peptides induced by the inhibitor could trigger cytotoxic responses against cancer cells and enhance the therapeutic effect of immune-checkpoint inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Vasiliki-Dimitra C. Tsolaki, Sofia K. Georgiou-Siafis, Athina Tsamadou, Stefanos A. Tsiftsoglou, Martina Samiotaki, George Panayotou, Asterios S. Tsiftsoglou
Summary: The study investigated the kinetics of intracellular accumulation of hemin in human transformed proerythroid K562 cells, revealing that the process is time and temperature-dependent and affected by the properties of hemin. Hemin-uptake exhibited saturation kinetics and involved a carrier-cell surface receptor-mediated process, with most hemin accumulating in the cytoplasm and a portion entering the nucleus. Analysis identified a variety of hemin-binding proteins (HeBPs) in different cellular compartments, suggesting their role in the homeostatic regulation of heme.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemical Research Methods
Vasiliki-Iris Perivolidi, Foteini Violitzi, Elisavet Ioannidou, Vagelis Rinotas, George Stamatakis, Martina Samiotaki, George Panayotou, Eleni Douni
Summary: This study identified the interactome of SLC2SA46, a mitochondrial protein, and found that it interacts with multiple proteins involved in mitochondrial architecture, energy production, and inter-organellar contacts. Tissue-specific enrichment of interactors was observed.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Plant Sciences
Aliki Xanthopoulou, Theodoros Moysiadis, Christos Bazakos, Evangelos Karagiannis, Ioanna Karamichali, George Stamatakis, Martina Samiotaki, Maria Manioudaki, Michail Michailidis, Panagiotis Madesis, Ioannis Ganopoulos, Athanassios Molassiotis, Georgia Tanou
Summary: The study provides new insights into plant biology through the integration of genomics and proteomics, identifying a large number of genes and proteins in sweet cherries. Analysis reveals differences between gene and protein quantities, key regulators of fruit development, and novel cherry proteins. Additionally, a new protein-level annotation and database were developed for further research in Prunus species.
Article
Cell Biology
Konstantina Katsarou, Charith Raj Adkar-Purushothama, Emilios Tassios, Martina Samiotaki, Christos Andronis, Purificacion Lison, Christoforos Nikolaou, Jean-Pierre Perreault, Kriton Kalantidis
Summary: In this study, advanced bioinformatic analysis, in vitro experiments, and LC-MS/MS were used to search for small viroid peptides of the PSTVd. Results suggest that under the experimental conditions, no produced peptides were identified, indicating that the presence of PSTVd in ribosomes is most likely not related to peptide production but rather to another unknown function that requires further study.
Article
Neurosciences
Nasia Antoniou, Kanella Prodromidou, Georgia Kouroupi, Ioanna Boumpoureka, Martina Samiotaki, George Panayotou, Maria Xilouri, Ismini Kloukina, Leonidas Stefanis, Regis Grailhe, Era Taoufik, Rebecca Matsas
Summary: Combining high throughput screening with iPSC-based disease modeling, a small molecule with neuroprotective actions for Parkinson's disease has been identified.
NPJ PARKINSONS DISEASE
(2022)
Article
Biochemical Research Methods
Aikaterini G. Karra, Aikaterini Sioutopoulou, Vyron Gorgogietas, Martina Samiotaki, George Panayotou, Anna-Maria G. Psarra
Summary: This study characterized mitochondrial glucocorticoid receptor interacting proteins, revealing potentially new regulatory roles of the receptor in mitochondria. The interactions between mtGR and PDH, as well as mtGR and HSP60, suggest involvement of mtGR in energy production regulation and mitochondrial import processes. These findings uncover potential novel regulatory roles of mtGR in coordinating nuclear and mitochondrial functions.
JOURNAL OF PROTEOMICS
(2022)
Article
Neurosciences
Engie Prifti, Eleni N. Tsakiri, Ergina Vourkou, George Stamatakis, Martina Samiotaki, Efthimios M. C. Skoulakis, Katerina Papanikolopoulou
Summary: Tau accumulation is associated with Alzheimer's disease and other Tauopathies. This study identifies Mical as a novel protein that interacts with human Tau and alters its interactions with microtubules and the Actin cytoskeleton. Mical's redox activity, specifically the oxidation of Cys322, is shown to play a crucial role in Tau aggregation propensity and toxicity.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Theodora Manolakou, Dionysis Nikolopoulos, Dimitrios Gkikas, Anastasia Filia, Martina Samiotaki, George Stamatakis, Antonis Fanouriakis, Panagiotis Politis, Aggelos Banos, Themis Alissafi, Panayotis Verginis, Dimitrios T. Boumpas
Summary: Enhanced activation of the ATR/Chk1 pathway of the DNA damage response was observed in B cells of patients with active SLE, driven by type I IFN. Pharmacologic targeting of ATR in B cells attenuated their immunogenic profile, suggesting ATR as a potential novel therapeutic target in SLE.
Article
Biochemistry & Molecular Biology
Sofia K. Georgiou-Siafis, Martina K. Samiotaki, Vassilis J. Demopoulos, George Panayotou, Asterios S. Tsiftsoglou
Summary: This study reveals the molecular mechanism by which GSH inhibits hemin-induced cytotoxicity by affecting hemin's structural integrity. GSH prevents HIC and reduces intracellular hemin levels in K562 cells. Additionally, GSH-hematin adducts are identified as novel entities in the human metabolome of RBCs in hemolytic disorders.
Article
Plant Sciences
Christina Skodra, Michail Michailidis, Theodoros Moysiadis, George Stamatakis, Maria Ganopoulou, Ioannis-Dimosthenis S. Adamakis, Lefteris Angelis, Ioannis Ganopoulos, Georgia Tanou, Martina Samiotaki, Christos Bazakos, Athanassios Molassiotis
Summary: This study reveals the protective role of low-salt pre-exposure in olive trees under high salinity stress, and identifies the sugar regulation mechanisms and hormone signaling pathways involved. Additionally, proteogenomic analysis uncovers the differences between the transcriptome and proteome in response to salinity, as well as key protein post-translational modifications and interaction networks related to salt priming.
Article
Cell Biology
Patricia A. Gomes, Cristian Bodo, Carlos Nogueras-Ortiz, Martina Samiotaki, Minghao Chen, Carina Soares-Cunha, Joana M. Silva, Barbara Coimbra, George Stamatakis, Liliana Santos, George Panayotou, Foteini Tzouanou, Clarissa L. Waites, Christos Gatsogiannis, Nuno Sousa, Dimitrios Kapogiannis, Bruno Costa-Silva, Ioannis Sotiropoulos
Summary: Background: Extracellular vesicles (EVs) have great potential in the diagnosis and treatment of brain disorders, and are a valuable tool for precision medicine. However, the collection and characterization of physiologically relevant EVs are of utmost importance.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Nikolaos Bekas, Martina Samiotaki, Maria Papathanasiou, Panagiotis Mokos, Athanasios Pseftogas, Konstantinos Xanthopoulos, Dimitris Thanos, George Mosialos, Dimitra Dafou
Summary: This study reveals the important regulatory role of CYLD in the early stages of somatic cell reprogramming. CYLD DUB deficiency reduces reprogramming efficiency and hinders the mesenchymal-to-epithelial transition (MET) process. These findings expand our understanding of early reprogramming mechanics and highlight the significance of CYLD as an extracellular matrix regulator.
Article
Genetics & Heredity
Paraskevi Karousi, Martina Samiotaki, Manousos Makridakis, Jerome Zoidakis, Diamantis C. Sideris, Andreas Scorilas, Thomas Carell, Christos K. Kontos
Summary: This study investigates the role of 3'-tRF-Cys(GCA) in gene expression regulation in HEK-293 cells and finds that it can regulate gene expression by affecting multiple cellular pathways. Additionally, the study identifies the direct interaction between 3'-tRF-Cys(GCA) and thymopoietin and its modulation of the protein's levels.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Biochemistry & Molecular Biology
Athanasios Armakolas, Vasiliki Dimopoulou, Adrianos Nezos, George Stamatakis, Martina Samiotaki, George Panayotou, Maria Tampaki, Martha Stathaki, Spyridon Dourakis, John Koskinas
Summary: This study investigated diagnostic markers for the early detection of hepatocellular carcinoma (HCC) based on proteome analysis, microRNAs, and circulating tumor cells (CTCs). The results showed that miR-200b, APOA2, and APOC3 proteins are sensitive markers and can potentially be used for the early diagnosis of HCC.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)