Nucleophilic difluoroalkylation of benzophenones, benzaldehydes and Schiff s bases by tetrafluoroethyl ether and difluoroacetamide

From gem-difluoromethyl group of 1,1,2,2-tetrafluoroethyl ether and 2,2-difluoroalkylamide, proton can be removed by potassium bis(trimethylsilyl)amide in DMF, THF or toluene. The generated nucleophiles are then condensed with benzophenones, benzaldehydes or Schiffs bases to provide new fluorinated alcohols and amines. Some interesting solvent effects are also observed., (C) 2014 Elsevier B.V. All rights reserved.