Article
Biochemistry & Molecular Biology
Hyeyoon Lee, Rui Sun, Christof Niehrs
Summary: Bone morphogenetic proteins (BMPs) play important roles in various biological processes, including embryogenesis and disease. Recent studies have found that R-spondin 2 (RSPO2) acts as a BMP receptor antagonist, and a peptide derived from RSPO2 can uncouple BMP antagonist function from WNT agonist function, showing potential for therapeutic development in diseases like acute myeloid leukemia (AML). By using a dendrimer based on this peptide, it is possible to selectively target BMP receptor signaling, reduce cell growth, and induce differentiation in AML cells, as well as modulate embryonic patterning in Xenopus embryos.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Fen Ji, Chao Feng, Jie Qin, Chong Wang, Dongming Zhang, Libo Su, Wenwen Wang, Mengtian Zhang, Hong Li, Longbing Ma, Weicheng Lu, Changmei Liu, Zhaoqian Teng, Baoyang Hu, Fengzeng Jian, Jingdun Xie, Jianwei Jiao
Summary: The deletion of Pd1 in the brain leads to abnormal cortical neurogenesis and depressive-like behaviors. Pd1 regulates neurogenesis by targeting Pax3 through the β-catenin signaling pathway. Furthermore, Pd1 also plays a similar role in the proliferation and differentiation of human neural progenitor cells (hNPCs).
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Environmental Sciences
Han Song, Junjun Qiu, Keqin Hua
Summary: USP14 is overexpressed in cervical cancer and is associated with clinical stage and prognosis of patients. It promotes the proliferation, migration, and invasion of cervical cancer cells by upregulating the expression of beta-catenin.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Chengming Zhang, Zhiyi Liu, Xiaotian Wang, Bin Zhang, Licheng Cui, Qinghe Hu, Bin Hu, Kuan Cao, Wengang Shan, Hengliang Shi, Renhao Wang
Summary: In this study, it was found that CTSK interacts with SIAH1 and inhibits its protein level, leading to increased proliferation of hepatocellular carcinoma (HCC) cells. CTSK mediates SIAH1 ubiquitination and degradation by promoting SIAH1 autoubiquitination and recruiting NEDD4 as an upstream ubiquitin ligase. These findings highlight the oncogenic role of CTSK in HCC progression.
Article
Oncology
Nicolas Penel, Sylvie Bonvalot, Andre-Michel Bimbai, Alexandra Meurgey, Francois Le Loarer, Sebastien Salas, Sophie Piperno-Neumann, Christine Chevreau, Pascaline Boudou-Rouquette, Pascale Dubray-Longeras, Jean-Emmanuel Kurtz, Cecile Guillemet, Emmanuelle Bompas, Antoine Italiano, Axel Le Cesne, Daniel Orbach, Julien Thery, Marie-Cecile Le Deley, Jean-Yves Blay, Olivier Mir
Summary: This prospective nationwide cohort study aimed to investigate the outcomes of desmoid-type fibromatosis (DF), focusing on the prognostic value of CTNNB1 mutations. The results showed that CTNNB1 mutation profile was associated with unfavorable prognostic factors but was not a prognostic factor for event-free survival (EFS).
CLINICAL CANCER RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Zhaoxuan Li, Xue Song, Yan Fan, Yuming Bao, Hu Hou
Summary: A collagen-hyaluronate composite gradient membrane was prepared and shown to effectively guide the growth of bone tissue. The membrane displayed excellent biocompatibility and cytocompatibility, making it a promising material for guided tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Juan He, Zhen Zeng, Yuelong Wang, Jiaojiao Deng, Xin Tang, Fujun Liu, Jianhan Huang, Hongxu Chen, Ruichao Liang, Xin Zan, Zhiyong Liu, Aiping Tong, Gang Guo, Jianguo Xu, Xiaofeng Zhu, Liangxue Zhou, Yong Peng
Summary: The study revealed that craniopharyngioma (CP) has fewer somatic mutations compared to malignant tumors, and mutations in CTNNB1 in adamantinomatous-type CP (ACP) and BRAF V600E in papillary-type CP (PCP) are mutually exclusive. A novel mutation in exon 3 of CTNNB1 was identified, showing that it can activate the Wnt-signaling pathway by increasing beta-catenin stability and promoting cell proliferation through experimental validation.
Article
Biochemistry & Molecular Biology
Shotaro Isozaki, Hiroki Tanaka, Kie Horioka, Hiroaki Konishi, Shin Kashima, Shuhei Takauji, Mikihiro Fujiya, Henrik Druid
Summary: This study elucidates the molecular dynamics of frostbite using a mouse frostbite model and keratinocyte cell culture. The activation of beta-catenin signaling and its nuclear translocation are observed in frostbite, and this process is associated with hypoxia. Beta-catenin promotes keratinocyte motility and tissue repair, as shown by the suppression of epithelial-mesenchymal transition and in vitro wound healing activity when beta-catenin is inhibited.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Andrew C. Hedman, Zhigang Li, Laetitia Gorisse, Swetha Parvathaneni, Chase J. Morgan, David B. Sacks
Summary: AMP-activated protein kinase (AMPK) is crucial in maintaining cellular energy homeostasis through regulating catabolic and anabolic pathways, with IQGAP1 identified as a novel regulator of AMPK signaling. Lack of IQGAP1 leads to impaired AMPK activation and metabolic dysregulation, highlighting the importance of the functional interplay between IQGAP1 and AMPK.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biology
Santina Quarta, Andrea Cappon, Cristian Turato, Mariagrazia Ruvoletto, Stefania Cannito, Gianmarco Villano, Alessandra Biasiolo, Maristella Maggi, Francesca Protopapa, Loris Bertazza, Silvano Fasolato, Maurizio Parola, Patrizia Pontisso
Summary: This study investigates the ability of SerpinB3 to modulate the Wnt pathway in liver cancer and monocytic cells, finding that SerpinB3 activates the Wnt signaling pathway and increases cell survival and invasiveness through the upregulation of Wnt co-receptors and LRP family members.
Review
Biotechnology & Applied Microbiology
Arundhathi Dev, Meenakshi Vachher, Chandra Prakash Prasad
Summary: beta-catenin is a crucial protein involved in various cellular processes, including cellular homeostasis, embryonic development, and cancer. It functions as a signaling molecule and also plays a role in cell adhesion. Aberrant expression of beta-catenin promotes the transcription of oncogenes and contributes to tumorigenesis. Understanding the regulation of beta-catenin is important for understanding the mechanisms of cancer progression.
Article
Biophysics
V. Siddartha Yerramilli, Alonzo H. Ross, Suzanne Scarlata, Arne Gericke
Summary: IQGAP1 is a scaffold protein that coordinates multiple signaling pathways, and its spatial and temporal resolution remains unclear. Through fluorescence imaging and correlation methods, the study reveals the interaction of IQGAP1 and PIPKI gamma on both the plasma membrane and in cytosol. Epidermal growth factor (EGF) stimulation drives the movement of cytosolic IQGAP1 towards the plasma membrane, promoting cytoskeletal changes. The study also uncovers the association of cytosolic IQGAP1-PIPKI gamma complexes with early endosomes and their aggregation upon EGF stimulation. The findings highlight the role of IQGAP1 in regulating cell migration through linking phosphoinositide lipid signaling with cytoskeletal reorganization.
BIOPHYSICAL JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Ilandarage Menu Neelaka Molagoda, Chang-Hee Kang, Mi-Hwa Lee, Yung Hyun Choi, Chang-Min Lee, Seungheon Lee, Gi-Young Kim
Summary: Fisetin enhances osteogenic activity, promotes vertebral formation in zebrafish larvae, inhibits anti-osteoblastic genes induced by prednisolone, and activates the GSK-3 beta/beta-catenin signaling pathway to stimulate osteogenesis.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Oncology
Chun Tang, Xuehui Wang, Changle Ji, Wenfang Zheng, Yunhe Yu, Xiaochong Deng, Xiqian Zhou, Lin Fang
Summary: The study demonstrated that miR-640 suppresses the tumorigenesis of breast cancer cells by regulating the Wnt/β-catenin signaling pathway, making it a potential novel target for targeted therapy in breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Developmental Biology
Bo Wang, Xiaozhi Rong, Yumei Zhou, Yunzhang Liu, Jiqin Sun, Beibei Zhao, Bei Deng, Lei Lu, Ling Lu, Yun Li, Jianfeng Zhou
Summary: This study reveals that EIF4A3 acts as a Wnt inhibitor by interfering with the formation of beta-catenin/Tcf transcription activation complex, playing a crucial role in regulating embryonic development in zebrafish.
Article
Biochemistry & Molecular Biology
Aditi, Aaron C. Mason, Manisha Sharma, T. Renee Dawson, Susan R. Wente
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Gastroenterology & Hepatology
Man Liu, Jingying Zhou, Xiaoyu Liu, Yu Feng, Weiqin Yang, Feng Wu, Otto Ka-Wing Cheung, Hanyong Sun, Xuezhen Zeng, Wenshu Tang, Myth T. S. Mok, John Wong, Philip Chun Yeung, Paul Bo San Lai, Zhiwei Chen, Hongchuan Jin, Jie Chen, Stephen Lam Chan, Anthony W. H. Chan, Ka Fai To, Joseph J. Y. Sung, Minhu Chen, Alfred Sze-Lok Cheng
Article
Cell Biology
Manisha Sharma, Susan R. Wente
MOLECULAR BIOLOGY OF THE CELL
(2020)
Article
Immunology
Xuezhen Zeng, Jingying Zhou, Zhewen Xiong, Hanyong Sun, Weiqin Yang, Myth T. S. Mok, Jing Wang, Jingqing Li, Man Liu, Wenshu Tang, Yu Feng, Hector Kwong-Sang Wang, Shun-Wa Tsang, King-Lau Chow, Philip Chun Yeung, John Wong, Paul Bo-San Lai, Anthony Wing-Hung Chan, Ka Fai To, Stephen Lam Chan, Qiang Xia, Jing Xue, Xiao Chen, Jun Yu, Sui Peng, Joseph Jao-Yiu Sung, Ming Kuang, Alfred Sze-Lok Cheng
Summary: This study demonstrates that aberrantly activated CCRK signaling in chronic liver diseases can reprogram the immunosuppressive microenvironment to promote cancer metastasis to the liver. Overexpression of CCRK increases the metastasis of melanoma and colorectal cancer to the liver, while depletion of these signals reduces the risk of metastasis.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Genetics & Heredity
Shirley S. W. Cheng, Pui Kwan Joyce Chan, Ho-Ming Luk, Myth Tsz-Shun Mok, Ivan F. M. Lo
Summary: KCS type 2 is a rare genetic disorder characterized by short stature, eye abnormalities, dental problems, and other features. Some patients may exhibit unique spinal manifestations, while male patients may also have micro-orchidism. A multidisciplinary management approach is recommended for this rare syndrome.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2021)
Article
Genetics & Heredity
Pui Tak Yu, Ho-Ming Luk, Myth T. Mok, F. M. Ivan Lo
Summary: Mandibular hypoplasia, deafness, progeroid feature, and lipodystrophy syndrome (MDPL) is a rare condition characterized by features such as lipodystrophy, dysmorphic features, and early onset hearing loss. This case report highlights the evolving manifestations of MDPL from childhood to adulthood in a 31-year-old Chinese woman with a specific pathogenic variant in the POLD1 gene.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2021)
Article
Genetics & Heredity
Shirley S. W. Cheng, Ho-Ming Luk, Myth Tsz-Shun Mok, Sha-Sha Leung, Ivan F. M. Lo
Summary: Coffin-Siris syndrome is a genetically heterogeneous disorder characterized by coarse facial features, hypoplasia of the fifth digits and nails, and intellectual disability. This case series discussed 18 Chinese individuals with molecularly confirmed variants, highlighting age-dependent phenotypic presentation and ethnicity-related effects on the syndrome. Additionally, the report included the first family with maternal somatic mosaicism of ARID1B variant leading to familial recurrence of the syndrome.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2021)
Article
Oncology
Feng Wu, Liangliang Xu, Yalin Tu, Otto K. W. Cheung, Lemuel L. M. Szeto, Myth T. S. Mok, Weiqin Yang, Wei Kang, Qin Cao, Paul B. S. Lai, Stephen L. Chan, Patrick Tan, Joseph J. Y. Sung, Kevin Y. Yip, Alfred S. L. Cheng, Ka F. To
Summary: This study identified an average of about 500 somatically-acquired super-enhancers per patient in non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinomas (HCCs), which were functionally enriched for aberrant metabolism and cancer phenotypes. Particularly, SIRT7 played a crucial role in HCC, affecting chromatin regulatory network and potentially serving as a druggable vulnerability.
Article
Genetics & Heredity
Stephanie K. L. Ho, Ho-ming Luk, Samuel Y. L. Ng, Kris P. T. Yu, Shirley S. W. Cheng, Phoebe P. Y. Ng, Myth T. S. Mok, Edgar W. L. Hau, Ivan F. M. Lo
Summary: This article summarizes the clinical and molecular characteristics of 832 NF1 patients from a single center in Hong Kong over a 16-year period, providing insights into the clinical manifestations and molecular variations of NF1.
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2022)
Article
Genetics & Heredity
Samuel Y. L. Ng, Ho-Ming Luk, Edgar W. L. Hau, Shirley S. W. Cheng, Kris P. T. Yu, Stephanie Ho, Myth T. S. Mok, Ivan F. M. Lo
Summary: This study analyzed mutations in 123 Chinese patients with TSC and found that most patients had pathogenic/likely-pathogenic variants, with some phenotypic differences between TSC1 and TSC2. Subependymal nodules were more common in males, while renal angiomyolipoma occurred predominantly in females. Sporadic cases showed a higher frequency of renal angiomyolipoma and other symptoms. The study also found that TSC2 variants were associated with mental retardation and other phenotypic features.
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2022)
Article
Immunology
Wenshu Tang, Jingying Zhou, Weiqin Yang, Yu Feng, Haoran Wu, Myth T. S. Mok, Lingyun Zhang, Zhixian Liang, Xiaoyu Liu, Zhewen Xiong, Xuezhen Zeng, Jing Wang, Jiahuan Lu, Jingqing Li, Hanyong Sun, Xiaoyu Tian, Philip Chun Yeung, Yong Hou, Heung Man Lee, Candice C. H. Lam, Howard H. W. Leung, Anthony W. H. Chan, Ka Fai To, John Wong, Paul B. S. Lai, Kelvin K. C. Ng, Simon K. H. Wong, Vincent W. S. Wong, Alice P. S. Kong, Joseph J. Y. Sung, Alfred S. L. Cheng
Summary: Obesity and hypercholesterolemia are major risk factors for hepatocellular carcinoma. This study found that obesity leads to hepatic cholesterol accumulation, which suppresses natural killer T (NKT) cell-mediated antitumor immunosurveillance. By lowering cholesterol and inhibiting cholesterol biosynthesis, the function of NKT cells can be restored to prevent HCC development promoted by obesity.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Min Ou, Henry Chi-Ming Leung, Amy Wing-Sze Leung, Ho-Ming Luk, Bin Yan, Chi-Man Liu, Tony Ming-For Tong, Myth Tsz-Shun Mok, Wallace Ming-Yuen Ko, Wai-Chun Law, Tak-Wah Lam, Ivan Fai-Man Lo, Ruibang Luo
Summary: HKG is the first fully accessible variant database for Hong Kong Cantonese, constructed from 205 novel whole-exome sequencing data. It fills the research gap in understanding the genetic architecture of southern Chinese subgroups, particularly Hong Kong Cantonese. HKG has identified numerous unique variants, annotated their clinical significance and putative loss-of-function, providing important population characteristics for future medical development.
NAR GENOMICS AND BIOINFORMATICS
(2022)
Meeting Abstract
Oncology
Wenshu Tang, Jingying Zhou, Weiqin Yang, Yu Feng, Myth Mok, Alfred Sze Cheng
Meeting Abstract
Oncology
Liangliang Xu, Feng Wu, Otto K. W. Cheung, Lemuel L. M. Szeto, Myth T. S. Mok, Kevin Y. L. Yip, Ka F. To, Alfred S. L. Cheng
Meeting Abstract
Gastroenterology & Hepatology
Wenshu Tang, Jingying Zhou, Weiqin Yang, Yu Feng, Myth T. S. Mok, Alfred S. L. Cheng
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)
