Article
Polymer Science
Yulia Kuznetsova, Ksenya Gushchina, Karina Sustaeva, Alexander Mitin, Marfa Egorikhina, Victoria Chasova, Lyudmila Semenycheva
Summary: Graft gelatin and poly(methyl methacrylate) copolymers with cross-linked structure were successfully synthesized in the presence of the tributylborane-2,5-di-tert-butyl-p-benzoquinone system. Compared with other initiating systems, this system exhibited a better cross-linking structure and showed high regenerative potential.
Article
Engineering, Environmental
Runzeng Liu, Scott A. Mabury
Summary: This study identified prevalent human exposure to 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate antioxidants, with fenozan acid being detected in urine samples as a potential biomarker. This is the first report of fenozan acid as a biomarker in urine, providing a basis for further research on human exposure to these compounds.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Applied
Viyana Movahed, Leila Arshadi, Mehrnaz Ghanavati, Ehsan Mahdavi Nejad, Zahra Mohagheghzadeh, Mosayeb Rezaei
Summary: A sensing layer containing ZnO@MnO2-rGO nanocomposite was used to modify a glassy carbon electrode for monitoring some antioxidant molecules. The resulting nanocomposite-modified electrode exhibited significant electrocatalytic activities, with low detection limits and satisfactory analytical performance.
Article
Chemistry, Applied
Jule-Philipp Dietz, Dorota Ferenc, Timothy F. Jamison, B. Frank Gupton, Till Opatz
Summary: A new method for synthesizing the active pharmaceutical ingredients tenofovir and adefovir was developed, showing high efficiency and relatively high yields.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2021)
Article
Thermodynamics
Min Jia, Song Guo, Sining Chen, Shang Gao, Huiming Sun
Summary: In this study, the decomposition mechanism of DBAD was analyzed using C80 Micro-calorimeter and STA-FTIR-MS instrument, and the thermal hazard was evaluated by the key index on self-accelerating decomposition temperature (SADT). The results showed that the heat release per unit mass of DBAD was 699.85 +/- 52.88 kJ kg(-1), and the activation energy calculated by Friedman method ranged from 28.58 to 52.03 kJ mol(-1). The thermal decomposition reaction of DBAD can be described by the Zhuralev-Lesokin-Tempelman equation. The calculated SADT of DBAD under 25 kg standard package was 63.95 degrees C.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Vaibhav Bedi, Dipendu Mandal, Zahid Hussain, Shi-Ming Chen, Yile Wu, Zheng-Wang Qu, Stefan Grimme, Douglas W. Stephan
Summary: The reaction of (tBuO(2)CN)(2) with 9-BBN leads to the formation of a bicyclic heterocyclic compound, while its reactions with BF3 or [Et3Si][B(C6F5)(4)] result in the isolation of different compounds. Computational studies reveal that the steric and electronic properties of the Lewis acid are important in the formation of one of the compounds.
DALTON TRANSACTIONS
(2024)
Article
Chemistry, Inorganic & Nuclear
Yun-Kun Hong, Yoonsu Park, Hyeri Kang, Hyungbin Son, Don-Hyung Ha
Summary: This study demonstrates the chemical transformation from zinc oxide (ZnO) to zinc sulphide (ZnS) using di-tert-butyl disulphide (TBDS) as a highly reactive sulphur precursor. The shape and phase of NPs undergo significant changes, while the Zn oxidation state remains stable. Trioctylphosphine (TOP) accelerates the reaction rate with TBDS, compared to elemental sulphur which requires a longer reaction time.
DALTON TRANSACTIONS
(2021)
Article
Thermodynamics
Huimin Yan, Nan Yin, Jipeng Luo, Bing Wu, Zhicheng Tan, Quan Shi
Summary: Thermal safety assessment is an effective means to prevent frequent chemical accidents. In this study, the adiabatic calorimetry technique was used for the first time to investigate the thermal runaway reaction. The results demonstrated that adiabatic calorimetry is suitable for determining and assessing the thermal risk of adiabatic runaway reactions. The findings also provide an important reference for the broader application of adiabatic calorimetry.
THERMOCHIMICA ACTA
(2023)
Article
Chemistry, Physical
Ying Luo, Yuxi Yang, Linyu Wang, Li Wang, Shouhui Chen
Summary: An electrochemical sensor based on ultrafine ZnO/ZnNi2O4 @porous carbon@covalent-organic framework (COF) was constructed for the detection of paracetamol (PA) and tert-butylhydroquinone (TBHQ). The sensor exhibited wide linear ranges and good stability, selectivity, and sensitivity.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Food Science & Technology
Hang Yu, Yaxin He, Mengru Wang, Fangwei Yang, Yunfei Xie, Yahui Guo, Yuliang Cheng, Weirong Yao
Summary: The study demonstrated that DHA can be regenerated to AA in the presence of TBHQ, significantly increasing the regeneration rate of AA. The extent of regeneration is influenced by factors such as the surface area of the PE film, TBHQ content, reaction time, and temperature. Adding TBHQ to chocolate improves the antioxidant capacity of AA and may extend the shelf-life of liqueur chocolate.
Article
Food Science & Technology
Kai-Zhong Xu, Xiao-Juan Tan, Zeng-Yan Chang, Jun-Jian Li, Ai-Qun Jia
Summary: The oxidant TBQ has the potential to be a Quorum Sensing Inhibitor (QSI) and anti-biofilm agent against Chromobacterium violaceum. It can reduce the synthesis of virulence factors and inhibit biofilm formation, improving susceptibility to antibiotics in this multi-drug resistant bacteria.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ewa Wagner-Wysiecka, Paulina Szulc, Elzbieta Luboch, Jaroslaw Chojnacki, Pawel Sowinski, Katarzyna Szwarc-Karabyka
Summary: This study presents the preparation and characterization of products resulting from the photochemical and thermochemical rearrangements of certain azoxybenzocrown compounds. The structures of these compounds were determined using various spectroscopic methods, and their ability to bind and recognize metal cations was also investigated.
Article
Chemistry, Organic
Shaoqun Zhu, Jiawei Wang, Bing Zhou, Hong Hou
Summary: The regioselective hydroxyphosphorylation of 1,3-enynes catalyzed by copper/di-tert-butyl peroxide is described in this study. The advantages of this radical reaction include excellent functional group tolerance, the use of a catalytic amount of copper and di- tert-butyl peroxide as a radical initiator, and mild reaction conditions. The desired products are obtained in moderate to excellent yields after purification.
SYNTHESIS-STUTTGART
(2021)
Article
Chemistry, Inorganic & Nuclear
Lisa-Marie Frenzel, Clemens Bruhn, Rudolf Pietschnig
Summary: The ligand properties of a stereochemically confined hydrotriphosphane have been explored in relation to diamagnetic group 10 transition metal centers, Ni(II) and Pt(0). Metal insertion into the H - P(P < )(2) bond is observed, resulting in a remarkably stable platinum hydride unit that is less reactive towards oxidation with molecular oxygen compared to the adjacent polyphosphorus scaffold.
INORGANICA CHIMICA ACTA
(2021)
Article
Thermodynamics
M. Preussker, M. Doentgen, D. Firaha, K. Leonhard, K. A. Heufer
Summary: In this study, the reaction rate constants for the dissociation reactions of di-tert butyl peroxide were determined using an independent approach of theory and pyrolysis experiments. The experimental and theoretical results showed good agreement, with the experimental rate coefficients falling within the estimated uncertainty of the theoretically obtained reaction constants. The comparison of Transition State Theory (TST) and Phase Space Theory (PST) revealed the limitations of TST for certain dissociation reactions and demonstrated the predictivity of PST. Additional studies on the oxidation of DTBP products highlighted the need for further research on key reactions within the methyl and acetone sub mechanisms.
PROCEEDINGS OF THE COMBUSTION INSTITUTE
(2021)
Review
Cell Biology
Isaac Jardin, Jose J. Lopez, Jose Sanchez-Collado, Luis J. Gomez, Gines M. Salido, Juan A. Rosado
Summary: Cancer stem cells exhibit stemness features and their behavior is influenced by Ca2+ homeostasis and store-operated Ca2+ entry. Understanding the key components of store-operated Ca2+ entry is important for the understanding of cancer stem cell biology and tumorigenesis.
Article
Biochemistry & Molecular Biology
Matias Estaras, Candido Ortiz-Placin, Alba Castillejo-Rufo, Miguel Fernandez-Bermejo, Gerardo Blanco, Jose M. Mateos, Daniel Vara, Pedro L. Gonzalez-Cordero, Sandra Chamizo, Diego Lopez, Adela Rojas, Isabel Jaen, Noelia de Armas, Gines M. Salido, Juan L. Iovanna, Patricia Santofimia-Castano, Antonio Gonzalez
Summary: The effects of melatonin on cellular proliferation and energetic metabolism in pancreatic stellate cells were investigated. Melatonin was found to affect the phosphorylation levels of key kinases and proteins involved in cell proliferation and energy metabolism. It also induced mitochondrial oxidative stress and affected mitochondrial function, leading to changes in cell respiration and ATP production. These findings suggest that melatonin can modulate pancreatic stellate cell physiology and energy metabolism.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Oncology
Jose Sanchez-Collado, Joel Nieto-Felipe, Isaac Jardin, Rajesh Bhardwaj, Alejandro Berna-Erro, Gines M. Salido, Tarik Smani, Matthias A. Hediger, Jose J. Lopez, Juan A. Rosado
Summary: Breast cancer cells exhibit altered expression and post-translational modification of STIM proteins and Orai channels, resulting in differences in store-operated Ca2+ entry (SOCE) compared to non-tumoral breast epithelial cells. This study showed that N-linked glycosylation of Orai1 and STIM1 is not essential for SOCE in breast cancer cells and may contribute to apoptosis resistance. Additionally, impairment of STIM1 N-linked glycosylation attenuated caspase-3 activation in non-tumoral cells, while breast cancer cells displayed smaller caspase-3 activity and were unaffected by the non-glycosylable STIM1 mutant. Abnormal SOCE and alterations in glycosylation are associated with cancer development and invasion.
Article
Hematology
Alejandro Berna-Erro, Girish Ramesh, Elena Delgado, Antonio J. Corbacho, Francisca Ferrer-Marin, Raul Teruel, Maria P. Granados, Juan A. Rosado, Pedro C. Redondo
Summary: This study investigated the changes in Ca2+ entry through the store-operated calcium entry (SOCE) mechanism in neonatal platelets. The results showed altered TG-evoked SOCE, different molecular weight forms of STIM1, and overexpression of SARAF in neonatal platelets compared to maternal and control women platelets. It was also found that CAPN1 may cleave STIM1 in neonatal platelets, impairing SARAF coupling after SOCE activation.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Cell Biology
Joel Nieto-Felipe, Alvaro Macias-Diaz, Jose Sanchez-Collado, Alejandro Berna-Erro, Isaac Jardin, Gines M. Salido, Jose J. Lopez, Juan A. Rosado
Summary: Store operated Ca2+ entry (SOCE) is essential for maintaining intracellular Ca2+ homeostasis and regulating cellular functions. STIM and Orai proteins mediate SOCE, which is initiated by activation of inositol 1,4,5-trisphosphate receptors. STIM proteins sense the decrease in endoplasmic reticulum Ca2+ concentration and activate plasma membrane Ca2+ channels formed by Orai proteins. STIM1/Orai-mediated Ca2+ signals finely regulate the activity of various transcription factors and influence multiple signaling events and cellular functions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Correction
Oncology
Jose Sanchez-Collado, Jose J. Lopez, Carlos Cantonero, Isaac Jardin, Sergio Regodon, Pedro C. Redondo, Juan Gordillo, Tarik Smani, Gines M. Salido, Juan A. Rosado
Article
Pharmacology & Pharmacy
Elena Fernandez-Delgado, Samuel Estirado, Ana B. Rodriguez, Francisco Luna-Giles, Emilio Vinuelas-Zahinos, Javier Espino, Jose Antonio Pariente
Summary: Six squared-planar Pd(II) complexes with thiazine and thiazoline ligands were synthesized and characterized. Cytotoxicity assay showed that complexes with phenyl substitutions had the lowest IC50 values and induced apoptosis. The presence of bulky substitutions on the ligands, such as phenyl groups, may influence the cytotoxicity of the synthesized chemotherapeutic agents.
Review
Biochemistry & Molecular Biology
Marta Martin-Bornez, Debora Falcon, Rosario Morrugares, Geraldine Siegfried, Abdel-Majid Khatib, Juan A. A. Rosado, Isabel Galeano-Otero, Tarik Smani
Summary: Myocardial infarction (MI) leads to the loss of cardiac myocytes and damage to the coronary microcirculation, which exceeds the regenerative capacity of the heart. The repair process after MI involves angiogenesis, fibroblast proliferation, and scar formation. Various signaling pathways, including Notch, Wnt, PI3K, and modulation of intracellular Ca2+ concentration, regulate angiogenesis in the infarcted heart. Additionally, cell-to-cell communication through extracellular vesicles containing pro-angiogenic proteins and miRNAs plays a role in cardiac repair after MI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Alejandro Berna-Erro, Maria Purificacion Granados, Juan Antonio Rosado, Pedro Cosme Redondo
Summary: Hypoxia is a stressful physiological condition that may occur during labor and pregnancy. Newborns adapt to temporary hypoxic conditions through changes in organ functions and intracellular molecular pathways. This review analyzes the main platelet modifications at the protein level during hypoxia and provides updates on research related to platelet markers and regulation of platelet function in response to hypoxia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Blanca Calle-Ciborro, Teresa Espin-Jaime, Francisco J. Santos, Ana Gomez-Martin, Isaac Jardin, Maria J. Pozo, Juan A. Rosado, Pedro J. Camello, Cristina Camello-Almaraz
Summary: Skeletal muscle releases hormones called myokines, which interact with other organs and mediate the effects of physical activity. The release of interleukin 6 (IL-6), a myokine involved in inflammation, immunity, and metabolism, from muscle cells is not well understood. This study investigated the role of calcium ions in the release of IL-6 from human muscle cells and found that proteins responsible for calcium increase during stimulation induce IL-6 release. These findings could provide insights into the release of IL-6 and other myokines in pathological conditions.
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)
