Article
Engineering, Biomedical
Han-Seop Kim, Jae Yun Kim, Binna Seol, Cho Lok Song, Ji Eun Jeong, Yee Sook Cho
Summary: Human natural killer cells with potent anticancer activity can be directly reprogrammed from somatic cells using pluripotency transcription factors and an optimized reprogramming medium. These reprogrammed NK cells show strong innate-adaptive immunomodulatory activity and are highly effective against a wide range of cancer cells, including solid cancers and cancer stem cells. Reprogrammed NK cells, either bearing cancer-specific chimeric antigen receptors or combined with antibodies for antibody-dependent cell-mediated cytotoxicity, demonstrate selective anticancer effects with enhanced potency.
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Thalita Alves Zanetti, Bruna Isabela Biazi, Giuliana Castello Coatti, Adrivanio Baranoski, Lilian Areal Marques, Amanda Cristina Corveloni, Mario Sergio Mantovani
Summary: This study compared the effects of curcumin and its two analogs on human renal adenocarcinoma cells, revealing that they induce cell death through different mechanisms, with DiMC showing the highest cytotoxicity and apoptosis-inducing effects.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Clinical Neurology
Angelika Goertzen, Abdul Kareem Altawashi, Julian Rieck, Ruediger W. Veh
Summary: Autoimmune encephalitis is a rare disease and its true rarity is still unknown. The low incidence and difficulties in diagnosis may hinder neurologists' efforts to identify patients with unclear symptoms as having autoimmune encephalitis. This study aims to obtain a better estimate of autoimmune disorders among 100 inpatients in a neurological department.
JOURNAL OF NEUROLOGY
(2023)
Article
Hematology
Annkristin Heine, Anna Maria Wolf, Sebastian Schlaweck, Solveig Nora Daecke, Peter Brossart, Dominik Wolf
Summary: Targeting JAK has revolutionized the treatment of myeloproliferative neoplasms, with the JAK inhibitor ruxolitinib significantly improving patient outcomes at the cost of increased infection risk. The novel JAK inhibitor pacritinib exhibits less pronounced immunosuppressive effects on dendritic cells compared to ruxolitinib, providing a potentially promising treatment option for patients with myelofibrosis.
EXPERIMENTAL HEMATOLOGY
(2021)
Editorial Material
Biology
Auden Cote-L'Heureux, Yogesh N. K. Maithania, Melissa Franco, Konstantin Khrapko
Summary: A large-scale study on mitochondrial DNA mutations has identified a subset that does not accumulate with age.
Letter
Gastroenterology & Hepatology
Peter R. Gibson
Summary: The article is related to papers by Wang et al. Visit the link to view the article.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Chemistry, Multidisciplinary
H. Chen, L. Liang, Z. Lin, Y. Zhang, S. Mi, L. Rao, T. Xu
Summary: In this study, it was found that 3D bioprinted cancer cells are more tolerant to serum starvation compared to 2D cells, and autophagy may play an important role in this process.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Peter J. Schuette, Juliane M. Ikebara, Sandra Maesta-Pereira, Anita Torossian, Ekayana Sethi, Alexandre H. Kihara, Jonathan C. Kao, Fernando M. C. Reis, Avishek Adhikari
Summary: This study investigates the neural activity of glutamatergic and GABAergic neurons in the CA1 region of the hippocampus during environmental changes. The results show that GABAergic neurons have decreased remapping compared to glutamatergic neurons, while the spatial encoding of glutamatergic neurons remains stable across multiple days. However, GABAergic neurons are less likely to remain active and exhibit consistent place coding across recording days.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Marta Serra-Garcia, Uri Gneezy
Summary: Research shows that papers that fail to replicate in top psychology, economics, and general interest journals are cited more than those that replicate, even after the failure is published. Only 12% of post-replication citations of non-replicable findings acknowledge the replication failure. Experts are able to predict which papers will be replicated, raising the question of why non-replicable papers are accepted for publication in the first place. One possible explanation is that review teams face a trade-off and lower standards regarding reproducibility when the results are more interesting.
Article
Chemistry, Physical
Liangliang Zhang, Kai Wang, Luying Yu, Kaijie Luo, Shaopeng Guo, Hong Chen, Xiang Li, Yonghang Chen, Xin Yu, Yajie Qian, Yanbiao Liu, Gang Xue
Summary: The study found that sludge-derived hydrochar and pyrochar have different effects on atrazine removal under PDS activation. Hydrochar has a more significant enhancement on ATZ removal in the PDS system compared to pyrochar. This is because humic substances in HC play a crucial role in ATZ degradation, providing more O-1(2).
APPLIED CATALYSIS B-ENVIRONMENTAL
(2021)
Review
Biochemistry & Molecular Biology
Tuoxian Tang, Mahmudul Hasan, Daniel G. S. Capelluto
Summary: Phafin proteins are a family of proteins that contain PH and FYVE domains. They are classified into two groups, Phafin1 and Phafin2, and both groups bind to phosphatidylinositol 3-phosphate [PtdIns(3)P]. Phafin proteins are involved in cellular pathways such as apoptosis, endocytic cargo trafficking, and autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Le Xiong, Stephen L. L. Nutt, Cyril Seillet
Summary: Innate lymphoid cells (ILCs) serve as a link between sensory cells and effector cells, contributing to tissue homeostasis and adaptation to changing environmental conditions. Studying the non-canonical functions of these cells provides insights into their regulation and adaptability.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ilaria Campesi, Giampiero Capobianco, Antonella Cano, Valeria Lodde, Sara Cruciani, Margherita Maioli, Giovanni Sotgiu, Maria Laura Idda, Mariangela Valentina Puci, Margherita Ruoppolo, Michele Costanzo, Marianna Caterino, Francesca Cambosu, Andrea Montella, Flavia Franconi
Summary: This study found sex-related differences in amniotic fluid and amniotic fluid cells. Inflammation markers and certain metabolites were higher in female amniotic fluid, while other metabolites were higher in male amniotic fluid. Female amniotic fluid cells expressed more estrogen receptors and proteins associated with autophagy, while male amniotic fluid cells expressed more proteins associated with lysosomes.
Article
Multidisciplinary Sciences
Dorian Leger, Silvio Matassa, Elad Noor, Alon Shepon, Ron Milo, Arren Bar-Even
Summary: The translation discusses the increasing pressure on the environment due to population growth and changes in dietary patterns, emphasizing the need for a revolution in the way natural resources are harnessed. It also highlights the potential of cultivating microbial biomass to produce single-cell protein (SCP) for protein-rich feed and food supplements, and the lack of quantitative comparison between traditional agriculture and photovoltaic-driven SCP systems.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Environmental Sciences
Monique T. Binet, Amanda Reichelt-Brushett, Kitty McKnight, Lisa A. Golding, Craig Humphrey, Jenny L. Stauber
Summary: Manganese (Mn) is considered one of the least toxic metals to aquatic organisms, but elevated concentrations in tropical marine waters have been found. This study shows that adult scleractinian corals are uniquely sensitive to acute exposures of Mn at concentrations much lower than those affecting early life stages, challenging the traditional notion that early life stages are more sensitive. The toxicity was observed in the coral host, not the algal symbionts.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Alberto Cecconi, Jean Paul Vilchez-Tschischke, Jesus Mateo, Javier Sanchez-Gonzalez, Samuel Espana, Rodrigo Fernandez-Jimenez, Beatriz Lopez-Melgar, Leticia Fernandez Friera, Gonzalo J. Lopez-Martin, Valentin Fuster, Jesus Ruiz-Cabello, Borja Ibanez
Summary: The study found that colchicine may stabilize atherosclerotic plaque by reducing inflammatory activity and plaque burden, particularly in animals with high cholesterol levels.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Tomasz J. Guzik, Valentin Fuster
CARDIOVASCULAR RESEARCH
(2020)
Article
Cardiac & Cardiovascular Systems
Carlos Galan-Arriola, Rocio Villena-Gutierrez, Maria Higuero-Verdejo, Ivan A. Diaz-Rengifo, Gonzalo Pizarro, Gonzalo J. Lopez, Antonio de Molina-Iracheta, Claudia Perez-Martinez, Rodrigo D. Garcia, David Gonzalez-Calle, Manuel Lobo, Pedro L. Sanchez, Eduardo Oliver, Raul Cordoba, Valentin Fuster, Javier Sanchez-Gonzalez, Borja Ibanez
Summary: This study demonstrates that RIPC applied immediately before each doxorubicin injection can preserve cardiac contractility, result in significantly higher long-term left ventricular ejection fraction, and less cardiac fibrosis in a translatable large-animal model of AIC. RIPC is able to prevent mitochondrial fragmentation and dysregulated autophagy from AIC early stages, suggesting it as a promising intervention for testing in clinical trials for AIC.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Yuan Zhang, Ioannis Karakikes
Summary: The growing recognition of human genetics and genomics in cardiovascular disease, coupled with the advancement of genome editing technologies like CRISPR-Cas9, has opened up new possibilities for applying genome editing in cardiovascular medicine. Recent developments in CRISPR-based tools have enhanced efficiency, precision, flexibility, and targeting capabilities, allowing for deeper insights into genotype-phenotype associations through large-scale genotyping and GWAS studies. The combination of genetic insights and cutting-edge technologies holds promise for uncovering novel disease mechanisms and potentially transforming genes into medicines, although challenges remain in translating genetic findings into therapeutic applications for cardiovascular diseases.
TRENDS IN CARDIOVASCULAR MEDICINE
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Samin K. Sharma, Valentin Fuster, Leonard Hofstra, Annapoorna S. Kini, Arthur Gianelli, Jagat Narula
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Mohit K. Turagam, Daniel Musikantow, Martin E. Goldman, Adel Bassily-Marcus, Edward Chu, Poojita Shivamurthy, Joshua Lampert, Iwanari Kawamura, Mahmoud Bokhari, William Whang, Benjamin Aaron Bier, Waqas Malick, Helen Hashemi, Marc A. Miller, Subbarao Choudry, Christopher Pumill, Tania Ruiz-Maya, Michael Hadley, Gennaro Giustino, Jacob S. Koruth, Noelle Langan, Aamir Sofi, Srinivas R. Dukkipati, Jonathan L. Halperin, Valentin Fuster, Roopa Kohli-Seth, Vivek Y. Reddy
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2020)
Article
Urology & Nephrology
Lili Chan, Kumardeep Chaudhary, Aparna Saha, Kinsuk Chauhan, Akhil Vaid, Shan Zhao, Ishan Paranjpe, Sulaiman Somani, Felix Richter, Riccardo Miotto, Anuradha Lala, Arash Kia, Prem Timsina, Li Li, Robert Freeman, Rong Chen, Jagat Narula, Allan C. Just, Carol Horowitz, Zahi Fayad, Carlos Cordon-Cardo, Eric Schadt, Matthew A. Levin, David L. Reich, Valentin Fuster, Barbara Murphy, John C. He, Alexander W. Charney, Erwin P. Boettinger, Benjamin S. Glicksberg, Steven G. Coca, Girish N. Nadkarni
Summary: The study found that AKI is common among hospitalized COVID-19 patients in the United States, with a 46% occurrence rate and 19% of patients requiring dialysis. Independently predicting severe AKI were chronic kidney disease, male gender, and higher serum potassium levels at admission. In-hospital mortality was significantly higher in patients with AKI compared to those without AKI, with only 30% of AKI patients recovering kidney function by the time of discharge.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Cell Biology
Donal MacGrogan, Beatriz Martinez-Poveda, Jean-Pierre Desvignes, Leticia Fernandez-Friera, Manuel Jose Gomez, Eduardo Gil Vilarino, Sergio Callejas Alejano, Pablo Garcia-Pavia, Jorge Solis, Joaquin Lucena, David Salgado, Gwenaelle Collod-Beroud, Emilie Faure, Alexis Theron, Julia Torrents, Jean-Francois Avierinos, Lorena Montes, Ana Dopazo, Valentin Fuster, Borja Ibanez, Fatima Sanchez-Cabo, Stephane Zaffran, Jose Luis de la Pompa
PHYSIOLOGICAL GENOMICS
(2020)
Article
Cardiac & Cardiovascular Systems
Rebeca Lorca, Marta Jimenez-Blanco, Jose Manuel Garcia-Ruiz, Gonzalo Pizarro, Rodrigo Fernandez-Jimenez, Ana Garcia-Alvarez, Leticia Fernandez-Friera, Manuel Lobo-Gonzalez, Valentin Fuster, Xavier Rossello, Borja Ibanez
Summary: This study assessed the transmural and lateral spread of myocardial damage in patients with acute myocardial infarction. It found that myocardial scarring decreased significantly in both the transmural and lateral dimensions 6 months after the event, indicating infarct resorption. The study also showed that myocardial salvage occurs in both transmural and lateral directions.
REVISTA ESPANOLA DE CARDIOLOGIA
(2021)
Article
Cardiac & Cardiovascular Systems
Carlos G. Santos-Gallego, Ariana P. Vargas-Delgado, Juan Antonio Requena-Ibanez, Alvaro Garcia-Ropero, Donna Mancini, Sean Pinney, Frank Macaluso, Samantha Sartori, Merce Roque, Fernando Sabatel-Perez, Anderly Rodriguez-Cordero, M. Urooj Zafar, Icilma Fergus, Farah Atallah-Lajam, Johanna P. Contreras, Cathleen Varley, Pedro R. Moreno, Vivian M. Abascal, Anuradha Lala, Ronald Tamler, Javier Sanz, Valentin Fuster, Juan J. Badimon
Summary: This study found that empagliflozin significantly improved left ventricular function and volumes, functional capacity, and quality of life in nondiabetic HFrEF patients, compared to placebo. The observations strongly support the role of sodium-glucose cotransporter 2 inhibitors in the treatment of HFrEF patients regardless of their glycemic status.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Carlos G. Santos-Gallego, Juan Antonio Requena-Ibanez, Rodolfo San Antonio, Alvaro Garcia-Ropero, Kiyotake Ishikawa, Shin Watanabe, Belen Picatoste, Ariana P. Vargas-Delgado, Eduardo J. Flores-Umanzor, Javier Sanz, Valentin Fuster, Juan J. Badimon
Summary: The study aimed to investigate the effect of empagliflozin on diastolic function in non-diabetic heart failure patients and the pathways causing diastolic dysfunction. Empagliflozin was found to improve diastolic function in non-diabetic HF patients, mitigates histological and molecular remodeling, and reduces both left ventricle and cardiomyocyte stiffness.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Dries A. M. Feyen, Isaac Perea-Gil, Renee G. C. Maas, Magdalena Harakalova, Alexandra A. Gavidia, Jennifer Arthur Ataam, Ting-Hsuan Wu, Aryan Vink, Jiayi Pei, Nirmal Vadgama, Albert J. Suurmeijer, Wouter P. te Rijdt, Michelle Vu, Prashila L. Amatya, Maricela Prado, Yuan Zhang, Logan Dunkenberger, Joost P. G. Sluijter, Karim Sallam, Folkert W. Asselbergs, Mark Mercola, Ioannis Karakikes
Summary: This study uncovered the mechanisms of PLN R14del cardiomyopathy using single-cell RNA sequencing, revealing a protective effect of the unfolded protein response (UPR). The findings suggest that modulating the UPR could be a potential therapeutic strategy for treating PLN R14del cardiomyopathy.
Article
Cardiac & Cardiovascular Systems
Francois Haddad, Jennifer Arthur Ataam, Myriam Amsallem, Nicholas Cauwenberghs, Tatiana Kuznetsova, Yael Rosenberg-Hasson, Roham T. Zamanian, Ioannis Karakikes, Benjamin D. Horne, Joseph B. Muhlestein, Lydia Kwee, Svati Shah, Holden Maecker, Stacey Knight, Kirk Knowlton
Summary: This study identified the importance of the insulin-like growth factor (IGF) axis in heart failure with preserved ejection fraction (HFpEF). Through proteomic profiling, a set of IGF phenotypes associated with pulmonary hypertension and mortality in HFpEF were identified.
JOURNAL OF CARDIAC FAILURE
(2022)
Article
Cell & Tissue Engineering
Nike Bharucha, Alexandra A. Gavidia, Ioannis Karakikes, Jennifer Arthur Ataam
Summary: Prime editing involves using a fused Cas9 nickase and reverse transcriptase to copy a DNA sequence into a specific locus without the need for double-stranded DNA breaks or donor DNA templates. By integrating a doxycycline-inducible Prime Editor protein into safe harbor genomic loci, precise nucleotide insertions can be achieved in human induced pluripotent stem cells with high efficiency, showing promise for disease modeling and functional genetics studies.
STEM CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jiongjia Cheng, Masanao Tsuda, Karl Okolotowicz, Mary Dwyer, Paul J. Bushway, Alexandre R. Colas, Joseph J. Lancman, Dennis Schade, Isaac Perea-Gil, Arne A. N. Bruyneel, Jaechol Lee, Nirmal Vadgama, Justine Quach, Wesley L. McKeithan, Travis L. Biechele, Joseph C. Wu, Randall T. Moon, P. Duc Si Dong, Ioannis Karakikes, John R. Cashman, Mark Mercola
Summary: The study revealed a molecular cascade linking stress signaling to the regulation of TCF/LEF transcriptional activity, providing insights into how stress can control cell shape and renewal. These findings have implications for understanding tissue morphogenesis and anticancer therapeutics.
CELL CHEMICAL BIOLOGY
(2021)