Article
Biochemistry & Molecular Biology
Asmaa A. Zidan, Mohammed Al-Hawwas, Griffith B. Perkins, Ghada M. Mourad, Catherine J. M. Stapledon, Larisa Bobrovskaya, Xin-Fu Zhou, Plinio R. Hurtado
Summary: The study reveals that USC-derived extracellular vesicles (EVs) are a heterogeneous population ranging in size, with immunomodulatory functions that can promote B cell proliferation and IgM antibody secretion. Additionally, the EVs carry a variety of substances that play important roles in stimulating, differentiating, and immune functions of B cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Catherine Karbasiafshar, Frank W. Sellke, M. Ruhul Abid
Summary: Cardiovascular disease is the leading cause of death globally. Current treatment options are limited, and stem-cell-derived extracellular vesicles (EVs) therapy shows promise but also faces several challenges.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Chemistry, Analytical
Xiaowei Wei, Lijun Cai, Hanxu Chen, Luoran Shang, Yuanjin Zhao, Weijian Sun
Summary: This study proposes a novel system for multiplexed analysis of bladder cancer-derived urine exosomes using magnetic microspheres as barcoded microcarriers. The unique structure of the microcarriers allows for controllable movement and high sensitivity detection of exosomes. The noninvasive nature of the platform, combined with its good sensitivity, specificity, low sample consumption, and ease of use, indicates its great potential for bladder cancer diagnosis in clinical applications.
ANALYTICAL CHEMISTRY
(2022)
Review
Cell & Tissue Engineering
Yuling Huang, Lina Yang
Summary: This review summarizes the preclinical research status of MSC-EVs in treating fibrotic diseases, highlighting their potential superiority over MSCs. However, there is still a significant knowledge gap in treating fibrosis of other tissues and organs, which requires further exploration.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Lu Yu, Siying Liu, Chen Wang, Chuanyu Zhang, Yajie Wen, Kaiyue Zhang, Shang Chen, Haoyan Huang, Yue Liu, Lingling Wu, Zhongchao Han, Xiangmei Chen, Zongjin Li, Na Liu
Summary: The study found that ESC-EVs can promote the recovery of the structure and function of damaged kidneys by increasing cell proliferation, promoting angiogenesis, inhibiting fibrosis progression, and rescuing DNA damage. ESC-EVs exert therapeutic effects by activating Sox9(+) cells.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Polymer Science
Anna Ulldemolins, Alicia Jurado, Carolina Herranz-Diez, Nuria Gavara, Jorge Otero, Ramon Farre, Isaac Almendros
Summary: Physiomimetic decellularized extracellular matrix-derived hydrogels are an important source of bioactive vesicles that can modulate lung repair. EVs and ECM-vesicles derived from MSCs and L-HG have similar therapeutic capacity in lung repair, but MSCs-derived EVs show higher therapeutic potential.
Review
Medicine, General & Internal
Jia-Yi Ding, Min-Jiang Chen, Ling-Feng Wu, Gao-Feng Shu, Shi-Ji Fang, Zhao-Yu Li, Xu-Ran Chu, Xiao-Kun Li, Zhou-Guang Wang, Jian-Song Ji
Summary: Skin wounds result from trauma, tearing, cuts, or contusions, and can impose a significant socioeconomic burden. Recent studies have focused on the use of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) for wound repair. MSC-derived EVs offer a more stable and safer alternative to cell therapy, and can promote the repair of damaged substructures and inhibit scar formation. Furthermore, they can be used as a scaffold and developed into bioengineered EVs for trauma repair. Understanding the detailed mechanism of EVs will allow for their effective use in clinical treatments for wound repair.
MILITARY MEDICAL RESEARCH
(2023)
Review
Cell & Tissue Engineering
Davod Pashoutan Sarvar, Hosein Effatpanah, Parvin Akbarzadehlaleh, Karim Shamsasenjan
Summary: The study highlights the important role of MSC-derived extracellular vesicles (MSC-EVs) in hematopoietic regulation and immune response after transplantation. MSC-EVs directly fuse with hematopoietic stem cell membranes, affecting their fate, and regulate the proliferation and differentiation of hematopoietic stem cells through the release of various bioactive factors.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell Biology
Victor Lu, Maria Tennyson, James Zhang, Wasim Khan
Summary: This systematic review explored the use of MSC-EVs for tendon/ligament repair, showing that MSC-EV therapy can facilitate tendon/ligament healing. However, not all studies found improvements in every parameter, with weak evidence linking biomechanical alterations to functional improvement.
Review
Nanoscience & Nanotechnology
Zhiwei Jia, Shunxin Zhang, Wei Li
Summary: Degenerative bone disorders such as IVDD, OA, and OP present significant challenges for aging populations with no effective treatments available. The use of stem cell-derived EVs as a novel therapeutic approach holds promise in addressing these disorders. However, a comprehensive assessment of EV-based therapies in degenerative bone disorders is currently lacking. This review aims to fill this gap by summarizing the current state of the field and discussing the potential of EV-based treatments for IVDD, OA, and OP.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Medicine, Research & Experimental
Tian Tian, Lei Cao, Chuan He, Qing Ye, Ruyu Liang, Weiyan You, Huixin Zhang, Jiahuan Wu, Jinhai Ye, Bakhos A. Tannous, Jun Gao
Summary: Ischemic stroke is a major cause of death and anti-inflammatory strategies are promising for reducing brain injury during reperfusion. Stem cell-derived extracellular vesicles (EVs) have emerged as therapeutic agents for immune modulation. By attaching targeting ligands onto EVs using a recombinant fusion protein, researchers were able to deliver anti-inflammatory EVs to the ischemic brain, showing promising results in suppressing inflammation.
Review
Biochemistry & Molecular Biology
Anna Trzyna, Agnieszka Banas-Zabczyk
Summary: The secretome of ASCs, including exosomes, contains a variety of cytokines and non-coding RNAs that have therapeutic potential in a wide range of diseases. Utilizing ASC secretome as a cell-free therapy shows promise in overcoming limitations of cell-based therapies and improving treatment efficacy.
Article
Chemistry, Multidisciplinary
Wanrong Meng, Linlin Wang, Xueyu Du, Mingzhe Xie, Fan Yang, Fei Li, Zhanxuan E. Wu, Jianguo Gan, Hongxuan Wei, Chang Cao, Shun Lu, Bangrong Cao, Longjiang Li, Ling Li, Guiquan Zhu
Summary: Extracellular vesicles (EVs) are potential therapeutic carriers, but they have limited targeting ability. To address this issue, researchers genetically engineered natural free streptavidin (SA) on the cellular surface of bone marrow mesenchymal stem cells (BMSCs) to obtain BMSC-derived EVs (BMSC-EVs) with enhanced targetability. The study demonstrated that these BMSC-EVs could be modified with different molecules to achieve specific delivery of drugs to different types of tumors, making them a versatile platform for targeted drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Biotechnology & Applied Microbiology
Yuanliang Xia, Ruohan Yang, Yulin Hou, Hengyi Wang, Yuehong Li, Jianshu Zhu, Changfeng Fu
Summary: Intervertebral disc degeneration is a major cause of lower back pain, and current treatments have limitations. Cell therapy using extracellular vesicles shows potential for treating this condition.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cell & Tissue Engineering
Si-Jia Sun, Rui Wei, Fei Li, Song-Yan Liao, Hung-Fat Tse
Summary: MSC-derived exosomes show promising potential in cardiac regeneration and repair due to their trophic and immunomodulatory effects. Compared to parent stem cells, they offer lower tumorigenic risk and superior stability.
Article
Geosciences, Multidisciplinary
Yongsheng Gai, Liang Liu, Guowei Zhang, Chao Wang, Xiaoying Liao, Wenqiang Yang, Lei Kang, Tuo Ma, Yuting Cao
Summary: A study of HP-UHP rocks in South Altyn Tagh reveals a differential exhumation process for the eastern and western segments, with the rocks in the eastern segment experiencing distinct metamorphism and rapid exhumation compared to the western segment.
Article
Computer Science, Artificial Intelligence
Penghai Zhao, Weilan Wang, Guowei Zhang, Yuqi Lu
Summary: This study focuses on the binarization problem in degraded historical Tibetan document images and proposes an improved approach. By rescaling the input and output of the attention U-Net and accelerating the construction of the training set, the issue of pseudo-touching is successfully addressed, leading to better performance across several metrics.
NEURAL COMPUTING & APPLICATIONS
(2023)
Article
Computer Science, Information Systems
Ce Zhang, Weilan Wang, Huaming Liu, Guowei Zhang, Qiang Lin
Summary: This paper proposes a character segmentation method based on key feature information for historical Tibetan documents, which can effectively solve the challenges in character segmentation and achieve good results.
Article
Materials Science, Multidisciplinary
Guowei Zhang, Yuanyuan Kang, Yijun Liu, Zhaojie Wang, Hong Xu
Summary: The research on the CuPb20Sn5/Carbon steel bimetallic sample revealed that the friction properties vary under different loads, with the friction coefficient first increasing and then decreasing as the load increases, leading to an increase in wear rate. At lower loads, the CuPb20Sn5 surface experiences minimal wear, while at higher loads, significant wear occurs.
MATERIALS RESEARCH EXPRESS
(2022)
Article
Management
Guowei Zhang, Ning Jia, Ning Zhu, Yossiri Adulyasak, Shoufeng Ma
Summary: Assessing a humanitarian transportation network early after a disaster is crucial for reducing casualties. Drones are considered for the assessment operations due to their potential. However, a novel challenge arises in the drone arc routing problem where drones can travel off the road network. To address this challenge, a graph transformation technique and a robust team orienteering problem with uncertain assessment time are proposed. The problem is solved efficiently using path-based reformulation and Lagrangian decomposition, and an exact branch-and-price framework is applied.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2023)
Article
Optics
Guowei Zhang, Ying Bai, Caiyan Yu, Tongtong Xuan
Summary: This study provides a new approach to effectively attach carbon nanodots to mesoporous silica nanospheres, solving the aggregation-induced luminescence quenching problem. The obtained hybrid phosphor exhibits excellent thermal stability and photostability. Based on this hybrid phosphor, a white light-emitting diode with high luminous efficiency and good color rendering index is fabricated.
JOURNAL OF LUMINESCENCE
(2022)
Article
Chemistry, Organic
Yuxiao Duan, Guowei Zhang, Xinyue Liu, Fenghui Shi, Tingting Wang, Hongchen Yan, Hu Xu, Lei Zhang
Summary: In this study, three acene-extended triptycenes containing TIPS-ethynyl functionalized anthracene, tetracene, and pentacene as subunits were synthesized and characterized. The optoelectronic properties and crystal packing motifs of these compounds could be modulated by changing the subunits. The excited-state behavior of these molecules was investigated, showing that two of them exhibited intramolecular singlet fission (iSF).
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Engineering, Multidisciplinary
Baokun Han, Lei Guo, Jinrui Wang, Zongzhen Zhang, Guowei Zhang, Sixiang Jia
Summary: This paper proposes a fast general normalized convolutional sparse filtering (FGNC-SF) method based on the L-1-L-2 mixed norm for intelligent fault diagnosis. By adjusting different normalization parameters, the proposed method demonstrates good diagnostic accuracy, efficiency, and robustness in mechanical condition monitoring.
Article
Materials Science, Multidisciplinary
Dongya Yang, Jiajun Li, Gengrui Zhao, Honggang Wang, Zhenyu Li, Shengsheng Chen, Gui Gao, Guowei Zhang, Hong Xu
Summary: This study investigated the effects of molybdenum disilicide and ferrophosphorus particles on the tribological properties of copper-tin bismuth bimetallic bearing materials. The addition of these particles was found to improve the mechanical and wear resistance properties of the alloys.
MATERIALS SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Yu Li, Guowei Zhang, Jingwei Niu, Hong Xu
Summary: The effects of Al-5Ti-0.8C and La on ZL205A alloy were investigated. It was found that adding 0.1%La + 0.3%Al-5Ti-0.8C alloy resulted in fine grains, fragmented Al2Cu phase, and fine precipitated phase after T5 treatment. The high-temperature mechanical properties of the alloy were significantly improved, attributed to the refinement of grains by Al-La phase and TiC particles and reduced tendency for intergranular fracture. The high-temperature strengthening mechanism was achieved through the introduction of TiC by Al-5Ti-0.8C alloy and Al11La3 formed by the addition of La, which refined the grains, promoted the precipitation of theta'(Al2Cu) phase, and hindered dislocation and grain boundary motion.
Article
Chemistry, Physical
Huan Yu, Guowei Zhang, Weize Lv, Hong Xu, Changjun Xu
Summary: An Al-7Si-Cu-Mg-Mn/steel bimetal was prepared by compound casting, and the effect of a coupled traveling and rotating magnetic field on the interface microstructure and shear strength was investigated. The magnetic field resulted in changes in the interface layer thickness, element concentration gradient, and dissolution rate of intermetallic compounds, leading to an increase in shear strength.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Chemistry, Physical
Guowei Zhang, Zhaojie Wang, Changjun Xu, Hong Xu, Cong Wang
Summary: The age-hardening behavior of the Al-7Si-0.5Mg alloy was studied with different sizes and distributions of Si phase. The specimen with fine and homogeneous Si exhibited accelerated age-hardening kinetics and higher hardness compared to the specimen with coarse and clustered Si, attributed to the higher dislocation density caused by thermal contraction mismatch. The overlapping of the plastically-affected zone of adjacent Si in the specimen with large and clustered Si resulted in reduced volume fraction of the plastically-affected zone, lower dislocation density, and slower age-hardening kinetics. The relationship between Si radius and critical inter-particle spacing for minimizing interaction and maximizing dislocation density and age-hardening kinetics was established.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Engineering, Multidisciplinary
Xiao Wang, Guowei Zhang, Yongqiang Li, Na Qu
Summary: This paper investigates the maintenance policy for a 2M1B assembly line system. By using an SMDP model and the HAMRL method, the learning process is accelerated and the maintenance strategy for the system is obtained. Empirical results show that the HAMRL algorithm has advantages in larger space and practical problems.
JOURNAL OF INDUSTRIAL AND MANAGEMENT OPTIMIZATION
(2023)
Article
Ophthalmology
Lihua Kang, Jiawei Luo, Pengfei Li, Guowei Zhang, Miao Wei, Min Ji, Huaijin Guan
Summary: This study discovered that miR-125a-3p regulates apoptosis in LECs by suppressing TMBIM4, offering a new therapeutic target for cataract.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Article
Integrative & Complementary Medicine
Zhang Li-Hui, Zhang Wan-Ying, Xiong Jia-Ming, Duan Xiu-Mei, Hai Li-Na, Zhang Yu-Liang, Zhang Miao-Miao, Qin Gui-Fang, Zhang Guo-Wei
Summary: This study combined network pharmacology and bioinformatics to investigate the mechanism of Compound Kushen Injection (CKI) in the treatment of bladder cancer. The results demonstrated that CKI inhibited the proliferation and migration of bladder cancer cells and induced apoptosis through the regulation of multiple genes, proteins, and biological pathways.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
