Review
Medicine, General & Internal
Masao Saitoh
Summary: Epithelial-mesenchymal transition (EMT) plays a crucial role in cancer progression, associated with invasion, metastasis, generation of tumor stem cells, and resistance to therapy. Transforming growth factor (TGF)-beta acts as a key mediator in the EMT process, initiating and maintaining EMT through signaling pathways and transcription factors.
Article
Cell Biology
Ha Young Jang, Soo-Jin Kim, Kyu-Sang Park, Jeong Hun Kim
Summary: Degenerative changes of RPE triggered by TGF-beta 2 and oxidative stress play a critical role in AMD progression. The expression of antiaging protein alpha-klotho declines with age, increasing the risk of age-related diseases. Alpha-klotho protects against TGF-beta 2-induced RPE degeneration and EMT both in vitro and in vivo. It inhibits TGF-beta 2 signaling, EMT, oxidative stress, and senescence-associated signaling.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Wonchul Lim, Bu-Nam Jeon, Young-Joo Kim, Ki-Hwan Kim, Hyeonseok Ko
Summary: The study found that FBI-1 plays a negative role in epithelial-to-mesenchymal transition in lung cancer, suggesting it as a potential therapeutic target and diagnostic indicator for early stage of lung cancer metastasis.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Ning Zhao, Minwei He, Wei Chen, Peng Jin, Lulu Cao, Jinhai Deng, Xu Cheng, Lu Wang
Summary: Our study identified FAM96A as a crucial regulator of tumor metastasis and epithelial-mesenchymal transition (EMT) by inhibiting the TGF-beta signaling pathway.
Article
Multidisciplinary Sciences
Abhilasha Srivastava, Harshita Sharma, Shibasish Chowdhury, Rajdeep Chowdhury, Sudeshna Mukherjee
Summary: Hepatocellular carcinoma (HCC) often develops under inflammatory conditions with various cytokines present. Transforming growth factor-beta (TGF-beta) is a major cytokine in the tumor environment and is involved in promoting epithelial to mesenchymal transition (EMT) in tumor cells. However, the cellular events and molecular regulation of TGF-beta-induced EMT are still unclear. In this study, HCC cells were treated with TGF-beta and it was found that EMT induced by TGF-beta is associated with cytostasis and altered cellular metabolism. TGF-beta down-regulates cell cycle-associated transcripts and metabolic genes through epigenetic silencing, and this process is mediated by TGF-beta downstream signaling mediator-SMAD and chromatin repressive complex member-EZH2.
Review
Oncology
Valeria Ramundo, Giuliana Giribaldi, Elisabetta Aldieri
Summary: Metabolic changes in the tumor microenvironment play a critical role in cancer by affecting signaling pathways that control cellular metabolism. The deregulation of cancer metabolism is closely related to oxidative stress control and the involvement of cytokines like transforming growth factor beta (TGF-beta) in tumorigenesis and cancer progression. The crosstalk between TGF-beta and oxidative stress contributes significantly to tumorigenesis and cancer invasiveness by affecting redox imbalance and cellular metabolism.
Article
Biochemistry & Molecular Biology
Long Xu, Jian Wang, Buhan Liu, Jiaying Fu, Yuanxin Zhao, Sihang Yu, Luyan Shen, Xiaoyu Yan, Jing Su
Summary: Epithelial ovarian cancer has the highest mortality rate among gynecological malignant tumors, largely due to metastasis. This study found that HDAC9 plays different roles in different histological subtypes of ovarian cancer and may be a potential target for personalized treatment.
Article
Oncology
Xiaowu Liu, Guannan Zhao, Xueyun Huo, Yaohong Wang, Gabor Tigyi, Bing-Mei Zhu, Junming Yue, Wenjing Zhang
Summary: Adipose-derived stem cells (ADSC) play a promoting role in ovarian cancer metastasis by inducing epithelial to mesenchymal transition (EMT) in OC cells, leading to proliferation, survival, migration, and invasion. Experimental evidence shows that ADSC contributes to ovarian tumor growth and metastasis by activating the TGF-beta pathway. Targeting ADSC with TGF-beta inhibitor has therapeutic potential in blocking EMT and OC metastasis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Haichuan Wang, Pan Wang, Meng Xu, Xinhua Song, Hong Wu, Matthias Evert, Diego F. Calvisi, Yong Zeng, Xin Chen
Summary: The dysregulation of TGF beta signaling has been implicated in both tumor promoting and inhibiting activities in liver carcinogenesis. Activation of c-MYC is critical in hepatocellular carcinoma (HCC). The interactions between c-MYC and TGF beta signaling pathways are complex and play divergent roles in HCC initiation and progression.
CELL DEATH & DISEASE
(2021)
Article
Ophthalmology
Yi Chen, Binxin Wu, Jian Feng He, Jingyao Chen, Zi Wei Kang, Dandan Liu, Junjie Luo, Kexin Fang, Xiaoxu Leng, Haibin Tian, Jingying Xu, Caixia Jin, Jieping Zhang, Juan Wang, Jingfa Zhang, Qingjian Ou, Lixia Lu, Furong Gao, Guo-Tong Xu
Summary: This study successfully induced EMT in RPE cells through prolonged low-density culture, and found that the combination of the ROCK inhibitor Y27632 and the TGF-beta receptor inhibitor RepSox effectively suppressed and reversed the EMT process, maintaining the morphology and function of RPE cells and the retina. This combined therapy could be a new strategy for treating proliferative retinal diseases involving EMT of RPE cells.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Tsugumasa Toma, Hiroshi Tateishi, Kensaku Kawakami, Taha F. S. Ali, Masahiro Kamo, Kazuaki Monde, Yuta Nakashima, Mikako Fujita, Masami Otsuka
Summary: Metastasis is the main cause of mortality in solid tumors, but there are no available antimetastatic drugs on the market. This study focused on a synthetic compound called HPH-15, which showed anti-EMT and anti-cell migration activities in non-small-cell lung cancer cells. HPH-15 was found to inhibit downstream TGF-beta signaling and could potentially lead to the development of new antimetastatic drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Qiuju Liang, Zhijie Xu, Yuanhong Liu, Bi Peng, Yuan Cai, Wei Liu, Yuanliang Yan
Summary: NR2F1 regulates platinum sensitivity and immune response in ovarian cancer by modulating TGF-beta 1-mediated EMT.
Article
Immunology
Danxue Qin, Peiqiang Liu, Huiqin Zhou, Jing Jin, Wanyang Gong, Kunyu Liu, Siyuan Chen, Jingyu Huang, Wenjun Fan, Zezhang Tao, Yu Xu
Summary: Chronic rhinosinusitis with nasal polyps (CRSwNP) is caused by prolonged inflammation of the paranasal sinus mucosa. In this study, TIM-4 was found to be increased in the sinonasal mucosa of CRSwNP patients, especially in macrophages. TIM-4 was positively correlated with clinical scores and inhibition of TIM-4 reduced polyp formation and EMT.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yu Liu, Mingxu Da
Summary: This study found that WTAP is significantly overexpressed in gastric carcinoma tissue, and its high expression is closely associated with poor prognosis in gastric cancer patients. Overexpression of WTAP can promote migration and EMT of GC cells, as well as the expression of TGF-beta and mRNA stability. Knockdown of WTAP inhibits migration of GC cells, decreases TGF-beta expression, and reduces mRNA stability. In addition, WTAP also promotes multiple chemotherapy and radiotherapy resistance in GC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Mi Zhou, Yuanjun Zhao, Sarah R. Weber, Christopher Gates, Nicholas J. Carruthers, Han Chen, Xiaoming Liu, Hong-Gang Wang, Michael Ford, Matthew T. Swulius, Alistair J. Barber, Stephanie L. Grillo, Jeffrey M. Sundstrom
Summary: The expression of R345W-Fibulin-3 alters the size and cargo of extracellular vesicles (EVs), which are sufficient to enhance cell migration and induce epithelial-mesenchymal transition (EMT) in recipient cells. Transforming growth factor beta (TGF beta) plays a critical role in EV-mediated EMT induction.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)