期刊
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
卷 31, 期 2-3, 页码 219-229出版社
KARGER
DOI: 10.1159/000343363
关键词
Heat shock proteins; Mitogen-activated protein kinases; miRNA; Insulin resistance; Muscle overload
资金
- Department of Energy [DE-PS02-09ER-01]
Background: Insulin resistance (IR) may decrease muscle adaptability. Heat shock proteins (HSPs), mitogen-activated protein kinases (MAPKs), and miRNA are thought to play a role in muscle hypertrophy but it is unclear if IR may affect their regulation. Methods: Soleus muscles of lean Zucker (LZ) and insulin resistant obese Zucker (OZ) rats were overloaded for 7 or 21 days and subjected to immunoblotting and RT-PCR. Results: IR was associated with decreased muscle hypertrophy. Overload increased HSP27 phosphorylation in both the LZ and OZ rats at day 7 but only in the LZ at day 21. IR was associated with diminished overload induced MAPK phosphorylation and decreased expression of miR-1 and miR133. Overload decreased mir-1 levels in both the LZ and OZ but to a greater extent in the LZ animals. Conclusion: These results suggest that alterations in the regulation of HSPs, MAPKs and miRNA may be associated with the diminished hypertrophy of IR muscle. Copyright (C) 2013 S. Karger AG, Basel
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