Article
Cell Biology
Maria Stefania Brignone, Angela Lanciotti, Antonio Michelucci, Cinzia Mallozzi, Serena Camerini, Luigi Catacuzzeno, Luigi Sforna, Martino Caramia, Maria Cristina D'Adamo, Marina Ceccarini, Paola Molinari, Pompeo Macioce, Gianfranco Macchia, Tamara Corinna Petrucci, Mauro Pessia, Sergio Visentin, Elena Ambrosini
Summary: In astrocytes, MLC1 protein enhances volume-regulated anion channel-mediated chloride currents through phosphorylation by Ca2+/Calmodulin-dependent protein kinase II. This discovery reveals the mechanism by which MLC1 protein regulates volume regulation and Ca2+ signaling in astrocytes.
Article
Biochemistry & Molecular Biology
Daniel Gonzalez-Acosta, Elena Blanco-Romero, Patricia Ubieto-Capella, Karun Mutreja, Samuel Miguez, Susana Llanos, Fernando Garcia, Javier Munoz, Luis Blanco, Massimo Lopes, Juan Mendez
Summary: DNA interstrand crosslinks (ICLs) induced by endogenous aldehydes or chemotherapeutic agents interfere with essential processes such as replication and transcription. Recognition and repair require the formation of an X-shaped DNA structure that may arise from convergence of two replication forks at the crosslink or traversing of the lesion by a single replication fork. PrimPol is essential for ICL traverse downstream of the lesion, and targeting PrimPol activity may enhance the efficacy of chemotherapy based on DNA crosslinking agents.
Article
Medicine, General & Internal
Yali Du, Chuang Jin, Shengjie Yin, Geng Wang, Qian Ma, Yuancun Li, Binyao Chen, Hongxi Wang, Kunliang Qiu, Mingzhi Zhang
Summary: The study evaluated the accuracy and agreement of vault measurements using the IOLMaster700 compared to AS-OCT. The results showed that the IOLMaster700 provided highly reliable measurements of vault, C-ICL, and ACD, with good correlations and agreement with AS-OCT measurements.
FRONTIERS IN MEDICINE
(2022)
Article
Engineering, Electrical & Electronic
Xuyi Zhao, Chunfang Cao, Antian Du, Wenfu Yu, Shixian Han, Ruotao Liu, Yuanyu Chen, Jinyi Yan, Jin Yang, Hua Huang, Hailong Wang, Qian Gong
Summary: In this study, interband cascade lasers (ICLs) with a wavelength of 3.4 μm were developed using bulk AlGaAsSb as the cladding layers. The device performance parameters were found to be comparable to the best 5-stage ICLs using InAs/AlSb superlattice cladding layers. It was also observed that the threshold current density of the ICLs could be significantly reduced by using AlGaAsSb cladding layers.
IEEE PHOTONICS TECHNOLOGY LETTERS
(2022)
Article
Engineering, Marine
Xin Zhang, Kejian Wu, Rui Li, Dongze Li, Shuai Zhang, Ruyan Zhang, Shuo Li, Xianghui Dong
Summary: This paper investigates the interannual variability of Pacific swell pools and examines the factors contributing to their formation. The results show that swell propagation and wind fields interact to influence the formation and development of the swell pools. The size of the swell pools in the Pacific Ocean is largest in the northern hemisphere during winter and smallest during summer. There is a relationship between the swell pools and ENSO events.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2023)
Article
Ophthalmology
Tian Han, Xun Chen, Ye Xu, Lingling Niu, Xiaoying Wang, Xingtao Zhou
Summary: Implantable collamer lens (ICL) implantation can improve corrected distance vision acuity (CDVA) in eyes with preoperative suboptimal CDVA. This study provides postoperative outcomes of eyes with different preoperative CDVA, facilitating communication between surgeons and patients before surgery.
CURRENT EYE RESEARCH
(2022)
Article
Computer Science, Software Engineering
Wenjuan Hou, Chen Zong, Pengfei Wang, Shiqing Xin, Shuangmin Chen, Guozhu Liu, Changhe Tu, Wenping Wang
Summary: Signed distance fields (SDFs) are a powerful surface representation that can be easily transformed into various other surface representations. In this study, the focus is on defining and computing Restricted Voronoi Diagrams (RVDs) based on SDF, named SDF-RVD. The authors show that SDF-RVD works well on different surface representations and can be combined with Centroidal Voronoi Tessellation (CVT) to generate high-quality triangulated meshes.
COMPUTER-AIDED DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Daiqin Chen, Shuai Liu, Dinghao Chen, Jinhao Liu, Jerry Wu, Han Wang, Yun Su, Gijung Kwak, Xinyuan Zuo, Divya Rao, Honggang Cui, Chunying Shu, Jung Soo Suk
Summary: This study introduces a simple approach to enhance gene transfer efficacy in the lung by modifying nanoparticles surface and using a hypotonic vehicle to overcome biological delivery barriers. It demonstrates a two-pronged delivery strategy that provides safe, wide-spread and high-level transgene expression in both healthy mice and mice with chronic lung diseases characterized by reinforced delivery barriers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Multidisciplinary Sciences
Bernhard A. Kramer, Jacobo Sarabia Del Castillo, Lucas Pelkmans
Summary: Individual cells can make decisions based on their internal state and surroundings, but it is still unclear how they can do this reliably. To investigate the information processing capacity of human cells, the researchers conducted a study on signaling responses and cellular state markers. The results showed that signaling nodes in the network displayed adaptive information processing, leading to heterogeneous growth factor responses and enabling cells to capture partially nonredundant information about their state. This demonstrates that individual cells have a large information processing capacity to accurately interpret growth factor concentration in the context of their cellular state and make decisions accordingly. The heterogeneity and complexity in signaling networks may have coevolved to facilitate specific and context-aware decision-making in multicellular settings.
Article
Oceanography
Behnam Shabani, Peter Ware, Tom E. Baldock
Summary: Laboratory measurements were conducted to study the interaction between high-frequency wind-waves and low-frequency paddle waves. The results indicate that the suppression of wind-waves is mainly due to enhanced dissipation of high-frequency waves near the crests of low-frequency waves, rather than reduced wind-input.
JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS
(2022)
Article
Plant Sciences
Moli Chu, Yuan Wang, Baicong Mu, Haiman Ge, Chi Zhang, Fugeng Zhao, Aigen Fu, Sheng Luan, Legong Li, Wenzhi Lan
Summary: In this study, the AtICln gene in Arabidopsis was found to play a role in response to osmotic and low-NO3 stress, contributing to plant tolerance under stress conditions. Disruption of AtICln gene led to decreased plant tolerance to osmotic stress and growth defects under low-NO3 conditions. The findings suggest that AtICln is involved in cellular NO3- accumulation, influencing osmotic adjustment and low-NO3 tolerance in plants.
PLANT CELL AND ENVIRONMENT
(2021)
Article
Multidisciplinary Sciences
Yan Hu, Yan Hou, Shijie Zhou, Yingzhi Wang, Congcong Shen, Li Mu, Dan Su, Rundong Zhang
Summary: This study reconstituted the chaperone machinery using recombinant proteins and investigated their roles systematically. The findings reveal differences in the spliceosomal assembly between Schizosaccharomyces pombe and humans.
Article
Ophthalmology
Fathy Fawzy Morkos, Nader F. Fawzy, Mohamed El Bahrawy, Nada Fathy, Rania Serag Elkitkat
Summary: The study evaluated the long-term efficacy, safety, and stability of Posterior Chamber Phakic Intraocular Lenses (PC-pIOLs) for correcting myopic anisometropic amblyopia in pediatrics, showing significant improvement in visual and refractive outcomes postoperatively.
Article
Engineering, Environmental
B. Sharmila, S. Bhuvaneshwari, G. Landlin
Summary: The study explores the use of calcium lignosulphonate in stabilizing expansive soil, showing improved strength and reduced swell potential compared to untreated soil. The findings highlight the potential of using unconventional materials to reduce environmental impact and dependence on traditional additives.
BULLETIN OF ENGINEERING GEOLOGY AND THE ENVIRONMENT
(2021)
Article
Ophthalmology
Christoph Lwowski, Karel Van Keer, Tim Ruscher, Luisa Van Keer, Mehdi Shajari, Thomas Kohnen
Summary: The study aimed to evaluate the intermediate and long-term visual outcomes and safety of phakic intraocular posterior chamber lens with a central hole (ICL V4c) for myopic eyes. The retrospective case study included 45 eyes with a 5-year postoperative follow-up. The results showed that ICL V4c had good intermediate and long-term stability, efficacy, and safety in myopic eyes, comparable to other literature.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Review
Cell Biology
Grazia Tamma, Giovanna Valenti, Elena Grossini, Sandra Donnini, Angela Marino, Raul A. Marinelli, Giuseppe Calamita
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Physiology
Nandu Goswami, Johannes Reichmuth, Annarita Di Mise, Bianca Brix, Andreas Roessler, Mariangela Centrone, Marianna Ranieri, Annamaria Russo, Natale Gaspare De Santo, Grazia Tamma, Ferdinando Carlo Sasso, Giovanna Valenti
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2019)
Article
Multidisciplinary Sciences
Marianna Ranieri, Annarita Di Mise, Graziana Difonzo, Mariangela Centrone, Maria Venneri, Tommaso Pellegrino, Annamaria Russo, Maria Mastrodonato, Francesco Caponio, Giovanna Valenti, Grazia Tamma
Article
Cell Biology
Marianna Ranieri, Maria Venneri, Tommaso Pellegrino, Mariangela Centrone, Annarita Di Mise, Susanna Cotecchia, Grazia Tamma, Giovanna Valenti
Article
Biochemistry & Molecular Biology
Mariangela Centrone, Patrizia Gena, Marianna Ranieri, Annarita Di Mise, Mariagrazia D'Agostino, Maria Mastrodonato, Maria Venneri, Davide De Angelis, Stefano Pavan, Antonella Pasqualone, Carmine Summo, Valentina Fanelli, Giovanna Valenti, Giuseppe Calamita, Grazia Tamma
Article
Food Science & Technology
Mariangela Centrone, Mariagrazia D'Agostino, Graziana Difonzo, Alessandra De Bruno, Annarita Di Mise, Marianna Ranieri, Cinzia Montemurro, Giovanna Valenti, Marco Poiana, Francesco Caponio, Grazia Tamma
Summary: The production of olive oil leads to the generation of a significant amount of waste and by-products. Research shows that extracts from olive wastewater exhibit higher antioxidant ability compared to those from olive pomace and olive leaf, likely due to differences in phenolic composition. These findings suggest that phenols in the by-product extracts may have health benefits through interfering with signaling molecules in cells.
Article
Food Science & Technology
Michela Costantini, Carmine Summo, Mariangela Centrone, Iga Rybicka, Mariagrazia D'Agostino, Paolo Annicchiarico, Francesco Caponio, Stefano Pavan, Grazia Tamma, Antonella Pasqualone
Summary: Epidemiological studies have shown a negative correlation between legume consumption and age-related diseases, likely due to the presence of antioxidant compounds such as phenolic and flavonoid compounds. Different pea and chickpea accessions exhibited varying antioxidant activity, with chickpeas having higher DPPH scavenging activity and peas showing higher antioxidant activity as evaluated using the ABTS assay. Chemical composition was found to influence antioxidant activity, with pea accessions having higher content of total phenolic compounds, Zn, and Cu, while black and brown chickpeas had higher levels of anthocyanins, Mn, Mg, and Ca.
POLISH JOURNAL OF FOOD AND NUTRITION SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Bianca Maria Rotoli, Rossana Visigalli, Francesca Ferrari, Marianna Ranieri, Grazia Tamma, Valeria Dall'Asta, Amelia Barilli
Summary: This study evaluated the effects of desmopressin on human pulmonary microvascular endothelial cells and found that it had no cytotoxic effect on the endothelium, but significantly stimulated the production of nitric oxide.
Article
Neurosciences
Maria Venneri, Vanessa Vezzi, Annarita Di Mise, Marianna Ranieri, Mariangela Centrone, Grazia Tamma, Lene N. Nejsum, Giovanna Valenti
Summary: Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a rare X-linked disease caused by gain-of-function mutations of arginine vasopressin receptor 2 (V2R). The constitutive AQP2 trafficking associated with the gain-of-function V2R-R137L/C mutants causing NSIAD is protein kinase A independent and requires an intact Ser269 in AQP2 under the control of ROCK phosphorylation.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Review
Green & Sustainable Science & Technology
Giusy Rita Caponio, Fabio Minervini, Grazia Tamma, Giuseppe Gambacorta, Maria De Angelis
Summary: Grapes, especially Vitis vinifera L., are widely cultivated and winemaking produces a large amount of waste. These residues are causing environmental and economic sustainability issues. To combat this, researchers are exploring ways to create high-value products from these waste materials. Grape pomace, a byproduct of winemaking, contains compounds like polyphenols, phenolic acids, resveratrol, and fiber that have antioxidant properties. Traditional uses of grape pomace include producing distillates and extracting tartaric acid and coloring substances, but newer applications include extracting antioxidants, using it as fermentation substrates and biomass for energy production, and extracting fiber for high-value bioactive product development. This article discusses the involvement of bioactive molecules from grape pomace in human biological functions and their applications in the agri-food sector.
Article
Cell Biology
Stine Julie Tingskov, Mariagrazia D'Agostino, Frederic H. Login, Grazia Tamma, Lene N. Nejsum, Rikke Norregaard
Summary: In this study, the effect of tamoxifen (TAM) on the expression and localization of aquaporin 3 (AQP3) in collecting ducts was investigated. TAM attenuated the downregulation of AQP3 in a unilateral ureteral obstruction (UUO) model and a lithium-induced nephrogenic diabetes insipidus (NDI) model, and affected the intracellular localization in the collecting ducts. TAM also influenced the expression profile of other basolateral proteins.
Article
Biochemistry & Molecular Biology
Aurelia Lamanuzzi, Ilaria Saltarella, Antonia Reale, Assunta Melaccio, Antonio Giovanni Solimando, Concetta Altamura, Grazia Tamma, Clelia Tiziana Storlazzi, Doron Tolomeo, Vanessa Desantis, Maria Addolorata Mariggio, Jean-Francois Desaphy, Andrew Spencer, Angelo Vacca, Benedetta Apollonio, Maria Antonia Frassanito
Summary: Extracellular vesicles (EVs) derived from fibroblasts play an important role in promoting angiogenesis in the bone marrow of multiple myeloma patients. The cargo of these EVs contains angiogenic cytokines that mediate this process. The uptake-independent and uptake-dependent mechanisms of FBEVs contribute to different stages of angiogenesis.
Article
Cell Biology
Caterina Allegretta, Graziana Difonzo, Francesco Caponio, Grazia Tamma, Onofrio Laselva
Summary: The deletion of phenylalanine at position 508 (F508del) causes misfolded CFTR protein, leading to its retention in the ER and degradation. This dysfunction of CFTR channel activity is associated with chronic infection and inflammation, primary causes of lung function decline in CF patients. Additionally, LPS-dependent oxidative stress further reduces CFTR function in airway epithelial cells. Olive leaf extract (OLE) has been found to decrease ROS levels and attenuate inflammatory response in CFBE and HNE cells, mimicking the infection and inflammatory status of CF patients. OLE also restores the decrease in F508del-CFTR function caused by LPS, suggesting its potential for preventing chronic lung damage in CF patients.
Review
Biochemistry & Molecular Biology
Angela Tesse, Elena Grossini, Grazia Tamma, Catherine Brenner, Piero Portincasa, Raul A. Marinelli, Giuseppe Calamita
FRONTIERS IN MOLECULAR BIOSCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Annarita Di Mise, Marianna Ranieri, Mariangela Centrone, Maria Venneri, Grazia Tamma, Daniela Valenti, Giovanna Valenti
FRONTIERS IN MOLECULAR BIOSCIENCES
(2018)