Article
Ecology
Michael Briga, Simon Verhulst
Summary: The study found that basal metabolic rate decreases linearly with age while standard metabolic rate increases linearly with age. The absolute standardized change with age was faster for basal metabolic rate compared to standard metabolic rate, and the within-individual correlation of age related change was negligible. Sex did not show specific differences in metabolic rate or metabolic ageing rate.
FUNCTIONAL ECOLOGY
(2021)
Review
Endocrinology & Metabolism
Ramy M. Hanna, Rebecca S. Ahdoot, Kamyar Kalantar-Zadeh, Lena Ghobry, Ira Kurtz
Summary: Calcium is an essential ion involved in various physiological processes, and the kidney plays a crucial role in maintaining whole-body calcium balance. Dysregulation of calcium handling can lead to several diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Transplantation
Yasuhiro Ichida, Shuichi Ohtomo, Tessai Yamamoto, Naoaki Murao, Yoshinori Tsuboi, Yoshiki Kawabe, Hiroko Segawa, Naoshi Horiba, Ken-ichi Miyamoto, Juergen Floege
Summary: The study suggests that in rats with CKD, the contribution of NaPi-IIb to intestinal phosphate absorption significantly decreases and a low-affinity alternative, particularly PiT-1, is upregulated in a compensatory manner.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Cell Biology
Mandy Mun Yee Kwong, Jee Whu Lee, Mohammed Razip Samian, Habibah A. Wahab, Nobumoto Watanabe, Eugene Boon Beng Ong
Summary: Certain plant extracts have been found to extend chronological lifespan in budding yeast by enhancing stress resistance and modulating longevity-defined signaling pathways. These extracts also confer oxidative stress tolerance, potentially extending yeast chronological lifespan through the upregulation of stress response pathways.
Article
Cell Biology
Alexander Richard Mendenhall
Summary: The Mediterranean diet, which includes foods with high levels of cis-monounsaturated fatty acids (MUFAs) such as olive oil, is associated with increased human lifespan. A recent study demonstrates that MUFAs stimulate a lipid droplet-peroxisome organelle network, reducing lipid oxidation and protecting cell membranes during ageing.
NATURE CELL BIOLOGY
(2023)
Article
Sport Sciences
Eric Lichtenstein, Jonathan Wagner, Raphael Knaier, Denis Infanger, Ralf Roth, Timo Hinrichs, Arno Schmidt-Trucksaess, Oliver Faude
Summary: Handgrip maximum rate of force development (GRFD) is closely related to lower body power compared to handgrip maximum strength (GF(max)), and its trajectories over the lifespan are more similar to lower body power. GF(max) tests are more economical and equally good at predicting lower body explosive strength in older age.
SPORTS HEALTH-A MULTIDISCIPLINARY APPROACH
(2023)
Article
Multidisciplinary Sciences
James W. Vaupel, Francisco Villavicencio, Marie-Pier Bergeron-Boucher
Summary: This article reviews key strands of demographic research on past trends in human longevity and explores possible future trends in life expectancy at birth. Life expectancy has been increasing at a steady pace, leading to a more equal distribution of individual life spans, but there is considerable uncertainty in forecasting future trends.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Cell Biology
Luana Toniolo, Giuseppe Sirago, Emiliana Giacomello
Summary: Ageing is a complex process involving multiple cellular mechanisms and can lead to the development of various pathologies. The investigation of ageing processes and the search for countermeasures are challenging, requiring the use of experimental models ranging from unicellular organisms to more complex systems. However, these models have their limitations and potential obstacles that need to be considered in ageing research.
HISTOLOGY AND HISTOPATHOLOGY
(2023)
Article
Multidisciplinary Sciences
Ren Dodge, Eric W. Jones, Haolong Zhu, Benjamin Obadia, Daniel J. Martinez, Chenhui Wang, Andres Aranda-Diaz, Kevin Aumiller, Zhexian Liu, Marco Voltolini, Eoin L. Brodie, Kerwyn Casey Huang, Jean M. Carlson, David A. Sivak, Allan C. Spradling, William B. Ludington
Summary: The gut is exposed to various bacteria from the diet and environment, but the composition of the gut microbiome remains stable over time in different host species. This study used gnotobiotic Drosophila to investigate the stability of different strains of bacteria in the fly gut. The researchers found that a physical niche in the foregut selectively binds bacteria with strain-specificity, stabilizing their colonization. Initial colonization by Lactobacillus species remodels the niche to favor secondary colonization by unrelated commensals. These findings provide insights into the establishment and stability of a multi-species intestinal microbiome.
NATURE COMMUNICATIONS
(2023)
Article
Physiology
Jianxiang Xue, Linto Thomas, Sathish Kumar Murali, Moshe Levi, Robert A. Fenton, Jessica A. Dominguez Rieg, Timo Rieg
Summary: Intestinal NHE3 has a significant contribution to P-i homeostasis. In contrast to effects described for tenapanor on P-i homeostasis, NHE3(IEC-KO) mice show enhanced, rather than reduced, intestinal P-i uptake.
Article
Biochemistry & Molecular Biology
Qi Chen, Qinjun Zhang, Amel Thanina Amrouche, Weisu Huang, Baiyi Lu
Summary: This study found that the male flowers of Eucommia ulmoides Oliv. and its active compound asperuloside can improve muscle aging and muscle hypofunction, reduce lipid accumulation, and activate mitophagy. These findings provide potential evidence for the preventive application and functional food development of Eucommia ulmoides male flowers and asperuloside against muscle aging.
Editorial Material
Multidisciplinary Sciences
Shaunak Deota, Satchidananda Panda
Summary: By combining calorie restriction, fasting, and regulating circadian rhythms, mice can achieve a long and healthy life.
Article
Microbiology
Alisa Kazarina, Jevgenija Kuzmicka, Santa Bortkevica, Pawel Zayakin, Janis Kimsis, Viktorija Igumnova, Darja Sadovska, Lauma Freimane, Agnija Kivrane, Agne Namina, Valentina Capligina, Alise Poksane, Renate Ranka
Summary: The global population is aging due to longer life expectancy and declining birth rates. Evidence suggests that oral microbiota composition may play a significant role in aging. A study in Latvia investigated the age-related variations in oral microbiome of supragingival plaque and buccal mucosa samples in the general population. The results showed significant differences in bacterial profiles of supragingival plaque among different age groups. The diversity of bacteria in supragingival plaque was highest in the 20-40 age group, declined during the 40-60 age period, and increased again after the age of 60. The prevalence of certain opportunistic pathogens also increased with age.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Viktoria Wagner, Fabian Kern, Oliver Hahn, Nicholas Schaum, Nicole Ludwig, Tobias Fehlmann, Annika Engel, Dominic Henn, Shusruto Rishik, Alina Isakova, Michelle Tan, Rene Sit, Norma Neff, Martin Hart, Eckart Meese, Steve Quake, Tony Wyss-Coray, Andreas Keller
Summary: By studying the expression of noncoding RNA (ncRNA) in aging and rejuvenated mice, we found that the molecular aging trajectories are mostly tissue-specific, except for eight broadly deregulated microRNAs (miRNAs). These miRNAs were also found in circulating plasma and extracellular vesicles (EVs), while tissue-specific ncRNAs were less present. MiR-29c-3p had the strongest correlation with aging in solid organs, plasma, and EVs. In mice rejuvenated by heterochronic parabiosis, the level of miR-29c-3p was restored to a similar level as in young liver. MiR-29c-3p targets pathways related to the extracellular matrix and secretion, which are known to be involved in aging.
NATURE BIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Joao Pedro de Magalhaes
Summary: With a globally aging population, longevity has become a promising market in the biotech industry. The potential to slow down human aging has led to a race in discovering promising longevity drugs and translating them to humans. Investment in longevity biotech is booming, with several clinical trials expected to reveal drugs that extend healthy lives.
DRUG DISCOVERY TODAY
(2021)
Article
Cell Biology
Ioana Alesutan, Jakob Voelkl, Florian Stoeckigt, Sobuj Mia, Martina Feger, Uwe Primessnig, Mentor Sopjani, Carlos Munoz, Oliver Borst, Meinrad Gawaz, Burkert Pieske, Bernhard Metzler, Frank Heinzel, Jan Wilko Schrickel, Florian Lang
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2015)
Article
Medicine, Research & Experimental
M. Sopjani, M. Rinnerthaler, J. Kruja, M. Dermaku-Sopjani
CURRENT MOLECULAR MEDICINE
(2015)
Article
Biochemistry & Molecular Biology
Mentor Sopjani, Vjollca Konjufca, Mark Rinnerthaler, Rexhep Rexhepaj, Miribane Dermaku-Sopjani
CURRENT MEDICINAL CHEMISTRY
(2016)
Article
Oncology
Simon Auer, Mark Rinnerthaler, Johannes Bischof, Maria Karolin Streubel, Hannelore Breitenbach-Koller, Roland Geisberger, Elmar Aigner, Janne Cadamuro, Klaus Richter, Mentor Sopjani, Elisabeth Haschke-Becher, Thomas Klaus Felder, Michael Breitenbach
FRONTIERS IN ONCOLOGY
(2017)
Review
Biochemistry & Molecular Biology
Miribane Dermaku-Sopjani, Sokol Abazi, Caterina Faggio, Jehona Kolgeci, Mentor Sopjani
JOURNAL OF BIOCHEMISTRY
(2014)
Review
Biochemistry & Molecular Biology
Mentor Sopjani, Lulzim Millaku, Dashnor Nebija, Merita Emini, Arleta Rifati-Nixha, Miribane Dermaku-Sopjani
CURRENT MEDICINAL CHEMISTRY
(2019)
Article
Integrative & Complementary Medicine
Berat Krasniqi, Shpetim Thaci, Miribane Dermaku-Sopjani, Arleta Rifati-Nixha, Sokol Abazi, Mentor Sopjani
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Review
Medicine, Research & Experimental
Miribane Dermaku-Sopjani, Mentor Sopjani
Summary: COVID-19 is a new public health crisis caused by SARS-CoV-2 virus originating from bats and spreading to humans through intermediary animals in China. The virus has resulted in over 43.4 million confirmed cases and approximately 1.16 million deaths worldwide, posing a serious threat to global public health. The disease is transmitted through inhalation or direct contact, with an incubation period of 1 to 14 days and symptoms including cough and fatigue, potentially leading to multi-organ dysfunction in severe cases.
CURRENT MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Miribane Dermaku-Sopjani, Mentor Sopjani
Summary: ACE2 and ACE share some homologies, but they are inhibited by different inhibitors. ACE2 metabolizes Ang II into vasodilatory Ang-(1-7). COVID-19 Pandemic highlights the importance of ACE2, and the differences in ACE2 among patients may lead to different responses to the virus.
CURRENT PROTEIN & PEPTIDE SCIENCE
(2021)
Article
Integrative & Complementary Medicine
Shpetim Thaci, Berat Krasniqi, Miribane Dermaku-Sopjani, Arleta Rifati-Nixha, Sokol Abazi, Mentor Sopjani
Summary: This study describes the relaxing effects of Vitex agnus-castus extract on isolated rabbit arterial rings. The extract demonstrated calcium channel blocking activities and its vasodilator effect was mainly endothelium-dependent and mediated by NO/cGMP and prostaglandins synthesis. These findings suggest that Vitex agnus-castus extract may have potential therapeutic benefits for cardiovascular disorders.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Fatemeh Gharanjik, Manzar Banoo Shojaeifard, Narges Karbalaei, Marzieh Nemati
Summary: This study investigated the effect of Calendula officinalis hydroalcoholic extract on PCOS in rats. The results showed that high doses of the extract had a positive effect on improving PCOS symptoms.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Neurosciences
Mohammad Adloo, Mehrzad Bahadori, Manzar Banoo Shojaeifard
Summary: The study evaluated the protective effect of hydroalcoholic extract of Anacyclus pyrethrum root (APE) against pentylenetetrazole (PTZ) drug-induced epileptic seizures in an animal model. The results showed that APE increased the latency time of seizures and reduced the number and severity of seizure attacks.
EGYPTIAN JOURNAL OF NEUROLOGY PSYCHIATRY AND NEUROSURGERY
(2022)
Article
Otorhinolaryngology
Faton Sermaxhaj, Besim Latifaj, Besim Sermaxhaj, Mentor Sopjani
Summary: We present a case of malignant melanoma in the middle ear in a 63-year-old woman with severe pain, tinnitus, photophobia, and hemorrhagic discharge from the right ear. After conservative treatment, a metastatic lymph node was found in the neck, and further examination confirmed melanoma. Surgery revealed a tumoral lesion in the middle ear with bone infiltration, and the patient responded well to Nivolumab treatment.
ENT-EAR NOSE & THROAT JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Mentor Sopjani, Shpetim Thaci, Berat Krasniqi, Miranda Selmonaj, Mark Rinnerthaler, Miribane Dermaku-Sopjani
CURRENT MEDICINAL CHEMISTRY
(2017)
Article
Cell Biology
Johannes Bischof, Manuel Salzmann, Maria Karolin Streubel, Jiri Hasek, Florian Geltinger, Jutta Duschl, Nikolaus Bresgen, Peter Briza, Danusa Haskova, Renata Lejskovas, Mentor Sopjani, Klaus Richter, Mark Rinnerthaler
CELL DEATH DISCOVERY
(2017)