Humanised monoclonal antibodies neutralise pertussis toxin by receptor blockade and reduced retrograde trafficking

Characterization of Individual Human Antibodies That Bind Pertussis Toxin Stimulated by Acellular Immunization

(2018) Edith Acquaye-Seedah et al.   INFECTION AND IMMUNITY

Engineering therapeutic antibodies to combat infectious diseases

(2018) Ellen K Wagner et al.   Current Opinion in Chemical Engineering

Synergistic Neutralization of Pertussis Toxin by a Bispecific AntibodyIn VitroandIn Vivo

(2016) Ellen K. Wagner et al.   Clinical and Vaccine Immunology

Neutralizing Monoclonal Antibodies against Disparate Epitopes on Ricin Toxin’s Enzymatic Subunit Interfere with Intracellular Toxin Transport

(2016) Anastasiya Yermakova et al.   Scientific Reports

Pertussis leukocytosis: mechanisms, clinical relevance and treatment

(2016) Nicholas H. Carbonetti   Pathogens and Disease

Intracellular disassembly and activity of pertussis toxin require interaction with ATP

(2016) Roger D. Plaut et al.   Pathogens and Disease

Rapid Fine Conformational Epitope Mapping Using Comprehensive Mutagenesis and Deep Sequencing

(2015) Caitlin A. Kowalsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of Fc–FcγR interactions in IgG-mediated microbial neutralization

(2015) Stylianos Bournazos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A cocktail of humanized anti–pertussis toxin antibodies limits disease in murine and baboon models of whooping cough

(2015) Annalee W. Nguyen et al.   Science Translational Medicine

Mechanism of Action and Epitopes ofClostridium difficileToxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography

(2014) Peter Orth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Neutralization of a Human Anti-α-toxin Antibody

(2014) Vaheh Oganesyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antibody-Mediated Inhibition of Ricin Toxin Retrograde Transport

(2014) A. Yermakova et al.   mBio

Emerging roles of recycling endosomes

(2013) T. Taguchi   JOURNAL OF BIOCHEMISTRY

Neutralizing monoclonal antibodies against ricin's enzymatic subunit interfere with protein disulfide isomerase-mediated reduction of ricin holotoxin in vitro

(2013) Joanne M. O'Hara et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Retrograde trafficking of AB5 toxins: mechanisms to therapeutics

(2013) Somshuvra Mukhopadhyay et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Shiga toxin–binding site for host cell receptor GPP130 reveals unexpected divergence in toxin-trafficking mechanisms

(2013) Somshuvra Mukhopadhyay et al.   MOLECULAR BIOLOGY OF THE CELL

Immune Boosting Explains Regime-Shifts in Prevaccine-Era Pertussis Dynamics

(2013) Jennie S. Lavine et al.   PLoS One

Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses

(2013) E. J. Gillespie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characteristics of Severe Bordetella pertussis Infection Among Infants

(2013) E. L. Murray et al.   Journal of the Pediatric Infectious Diseases Society

Fc RIIb on Liver Sinusoidal Endothelium Clears Small Immune Complexes

(2012) L. P. Ganesan et al.   JOURNAL OF IMMUNOLOGY

Immunization of Teenagers with a Fifth Dose of Reduced DTaP-IPV Induces High Levels of Pertussis Antibodies with a Significant Increase in Opsonophagocytic Activity

(2011) Audun Aase et al.   Clinical and Vaccine Immunology

Natural immune boosting in pertussis dynamics and the potential for long-term vaccine failure

(2011) J. S. Lavine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Retrograde Transport Protects Mice from Lethal Ricin Challenge

(2010) Bahne Stechmann et al.   CELL

Structure, biological functions and applications of the AB5 toxins

(2010) Travis Beddoe et al.   TRENDS IN BIOCHEMICAL SCIENCES

Characterization of a Key Neutralizing Epitope on Pertussis Toxin Recognized by Monoclonal Antibody 1B7

(2009) Jamie N. Sutherland et al.   BIOCHEMISTRY

Monoclonal Antibody 11E10, Which Neutralizes Shiga Toxin Type 2 (Stx2), Recognizes Three Regions on the Stx2 A Subunit, Blocks the Enzymatic Action of the Toxin In Vitro, and Alters the Overall Cellular Distribution of the Toxin

(2009) M. J. Smith et al.   INFECTION AND IMMUNITY

Rab7 Regulates Late Endocytic Trafficking Downstream of Multivesicular Body Biogenesis and Cargo Sequestration

(2009) Phillip A. Vanlandingham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Engineered Neutralizing Antibody M18 Complexed to Domain 4 of the Anthrax Protective Antigen

(2009) Clinton E. Leysath et al.   JOURNAL OF MOLECULAR BIOLOGY

Pertussis Vaccine

(2009) John B. Robbins et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Retrograde transport of pertussis toxin in the mammalian cell

(2008) Roger D. Plaut et al.   CELLULAR MICROBIOLOGY

Intracellular Neutralization of Shiga Toxin 2 by an A Subunit-Specific Human Monoclonal Antibody

(2008) G. Krautz-Peterson et al.   INFECTION AND IMMUNITY

Pertussis Toxin Inhibits Early Chemokine Production To Delay Neutrophil Recruitment in Response to Bordetella pertussis Respiratory Tract Infection in Mice

(2008) C. Andreasen et al.   INFECTION AND IMMUNITY

Neutralization of Botulinum Neurotoxin by a Human Monoclonal Antibody Specific for the Catalytic Light Chain

(2008) Sharad P. Adekar et al.   PLoS One