Article
Immunology
Xiaohong Su, Wenjing Le, Xiaofeng Zhu, Sai Li, Baoxi Wang, Guillermo Madico, Zhaoyan Yang, Christine E. Chaisson, Robert E. McLaughlin, Sumanth Gandra, Jungwon Yoon, Bo Zheng, Lisa A. Lewis, Sunita Gulati, George W. Reed, Sanjay Ram, Peter A. Rice
Summary: This study compared the exposure of female partners to male gonococcal burdens in infected versus uninfected partners. The findings showed that gonococcal infections in women were more frequent when their partners had higher burdens of infection. Additionally, co-infection with Chlamydia was also associated with increased gonococcal burdens in women.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Sunita Gulati, Andreas Holm Mattsson, Sophie Schussek, Bo Zheng, Rosane B. DeOliveira, Jutamas Shaughnessy, Lisa A. Lewis, Peter A. Rice, Par Comstedt, Sanjay Ram
Summary: A safe and effective vaccine is urgently needed to combat multidrug-resistant Neisseria gonorrhoeae. In this study, a platform called EDEN was used to screen 26 potential vaccine antigens, and their efficacy was tested in a mouse model. The combination of NGO1549 and NGO0265 showed significant reduction in colonization by MDR strains.
Article
Infectious Diseases
Sheeba Santhini Manoharan-Basil, Margaux Balduck, Said Abdellati, Zina Gestels, Tessa de Block, Chris Kenyon
Summary: Antibiotic tolerance is associated with treatment failure, but the molecular mechanisms behind it are poorly understood. In a recent study, researchers induced tolerance to ceftriaxone in N. gonorrhoeae and identified mutations in four genes that may contribute to this tolerance. These findings provide insight into the development of antibiotic tolerance in bacteria.
Article
Immunology
Kathryn A. Matthias, Kristie L. Connolly, Afrin A. Begum, Ann E. Jerse, Andrew N. Macintyre, Gregory D. Sempowski, Margaret C. Bash
Summary: Recent studies have found that Neisseria meningitidis vaccines lacking specific proteins can provide protection against Neisseria gonorrhoeae infections in mice, and the antibodies produced can cross-react with N. gonorrhoeae. This finding supports the development of a cross-protective vaccine against Neisseria infections.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Ana Paula R. Costa-Lourenco, Xiaohong Su, Wenjing Le, Zhaoyan Yang, Gregory J. Patts, Paola Massari, Caroline A. Genco
Summary: This study examined epidemiological and clinical factors associated with gonorrhea in women exposed to men with gonococcal urethritis in China. The findings showed high prevalence of N. gonorrhoeae infections in women, with many experiencing symptoms and inflammatory responses. The study highlights the importance of determining target populations for gonococcal vaccine strategies.
Article
Pharmacology & Pharmacy
Priyal Bagwe, Lotika Bajaj, Ipshita Menon, Keegan Braz Gomes, Akanksha Kale, Smital Patil, Sharon Vijayanand, Rikhav Gala, Martin J. D'Souza, Susu M. Zughaier
Summary: There is a concerning increase in global gonorrhea cases, as the bacteria causing the infection has developed antimicrobial resistance. This study explores the immunogenicity of a potential gonorrhea vaccine in mice using dissolving microneedles. The vaccine formulation showed promising results in inducing humoral, cellular, and protective immune responses against gonococcal infection.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Immunology
Stavros A. Maurakis, Cynthia Nau Cornelissen
Summary: Gonorrhea is a global health concern caused by Neisseria gonorrhoeae, which rapidly develops antimicrobial resistance and does not provide protective immunity post-infection. Efforts to create a successful vaccine for gonorrhea have been hindered by the bacterial envelope's ability to undergo rapid changes, making it difficult for the human immune system to recognize it. Recent advancements in computational epitope identification and prediction methods have led to promising progress in developing a viable gonorrheal vaccine.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Lisa A. Lewis, Sunita Gulati, Wioleta M. Zelek, B. Paul Morgan, Wen-Chao Song, Bo Zheng, Nancy Nowak, Rosane B. DeOliveira, Bryan Sanchez, Leandro DeSouza Silva, Janine Schuurman, Frank Beurskens, Sanjay Ram, Peter A. Rice
Summary: This study found that an experimental gonococcal peptide vaccine, TMCP2, has a good effect on multidrug-resistant gonorrhea. In the mouse vaginal colonization model, TMCP2, when used in combination with adjuvants, can produce bactericidal immunoglobulin G and promote the clearance of gonococci. At the same time, the study also found that the effectiveness of TMCP2 requires the participation of the terminal complement pathway.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Shuaijie Song, Shuyi Wang, Xiaoyun Jiang, Fan Yang, Shuai Gao, Xu'ai Lin, Hao Cheng, Stijn van der Veen
Summary: The study found that CpG1826 is the optimal Th1-polarizing adjuvant and when combined with MtrE and Loop2 as vaccine antigens, it can generate strong Th1-polarized and bactericidal antibody responses. The vaccine can provide protection against gonococcal infections and accelerate the clearance of already established infections.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Immunology
Eric C. Tang, Kelly A. Johnson, Lizzete Alvarado, Nicole O. Burghardt, Cindy Hernandez, Edwin Lopez, Tazima Jenkins-Barnes, Bryan Hughes, Krysta L. Salas, Kathleen R. Jacobson
Summary: A total of 149 cases of disseminated gonococcal infection (DGI) were identified in California, with most cases occurring in individuals aged 40 years and older, heterosexual individuals, or individuals without urogenital symptoms. All tested isolates were susceptible to both ceftriaxone and cefixime. Expanding gonorrhea screening may be effective in preventing DGI.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Rheumatology
Aurore Moussiegt, Claire Francois, Olivier Belmonte, Julien Jaubert, Nicolas Traversier, Sandrine Picot, Francoise Josse, Xavier Guillot, Patrice Poubeau, Marie-Pierre Moiton, Antoine Bertolotti, Loic Raffray
Summary: Gonococcal arthritis (GA) is rare but important to diagnose early and treat promptly to prevent joint destruction. Use of PCR in joint puncture is useful in cases with negative culture.
CLINICAL RHEUMATOLOGY
(2022)
Article
Microbiology
Lucy K. Shewell, Christopher J. Day, Xavier De Bisscop, Jennifer L. Edwards, Michael P. Jennings
Summary: Neisseria gonorrhoeae has developed resistance to previous antibiotics, necessitating the development of novel antimicrobials. Carbamazepine has been shown to block the interaction between gonococcal pili and human complement receptor 3, as well as effectively clear established gonococcal infections. Concentrations of carbamazepine in vaginal fluid from women taking the drug were found to be sufficient to significantly reduce the number of viable gonococci recovered from cervical cell infections. These findings support the further development of carbamazepine as a host-targeted therapy for gonococcal cervicitis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Wen-Qi Xu, Xiao-li Zheng, Jing-Wei Liu, Qian Zhou, Xiao-Yu Zhu, Jin Zhane, Yan Han, Kai Chen, Shao-Chun Chen, Xiang-Sheng Chen, Yue-Ping Yin
Summary: The study aimed to determine the minimum inhibitory concentrations (MICs) of ertapenem on Neisseria gonorrhoeae collected from eight Chinese provinces in 2018. The results suggest that ertapenem has satisfactory susceptibility in isolates from China, making it a promising treatment option for resistant gonococcal infections.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Infectious Diseases
Maartje Visser, Hannelore M. Gotz, Alje P. van Dam, Birgit Hb van Benthem
Summary: This study investigated the trends and regional variation of gonococcal azithromycin resistance and ceftriaxone decreased susceptibility in the Netherlands from 2013 to 2019. Azithromycin resistance appeared to increase while ceftriaxone decreased susceptibility seemed to decrease. Individual characteristics, sexually transmitted infection diagnoses, and resistance testing results were associated with resistance and decreased susceptibility.
Article
Microbiology
Julio C. Ayala, Matthew W. Schmerer, Ellen N. Kersh, Magnus Unemo, William M. Shafer
Summary: We report the frequent appearance of a novel SNP in the gdhR gene possessed by Neisseria gonorrhoeae, which results in enhanced expression of a virulence gene and is associated with a mutation in the promoter of a repressor gene. This frequent association suggests a link between virulence and antibiotic resistance properties in contemporary gonococcal strains.
Article
Immunology
Karen V. Swanson, Robert D. Junkins, Cathryn J. Kurkjian, Elizabeth Holley-Guthrie, Avani A. Pendse, Rachid El Morabiti, Alex Petrucelli, Glen N. Barber, Chris A. Benedict, Jenny P. -Y. Ting
JOURNAL OF EXPERIMENTAL MEDICINE
(2017)
Article
Microbiology
Liang-Chun Wang, Qian Yu, Vonetta Edwards, Brian Lin, Jessica Qiu, Jerrold R. Turner, Daniel C. Stein, Wenxia Song
Review
Immunology
Constance M. John, Nancy J. Phillips, Daniel C. Stein, Gary A. Jarvis
PATHOGENS AND DISEASE
(2017)
Article
Chemistry, Multidisciplinary
Amanda Mahle, Neeraja Dashaputre, Philip DeShong, Daniel C. Stein
ADVANCED FUNCTIONAL MATERIALS
(2018)
Article
Microbiology
Tonya N. Watkins, Teclegiorgis Gebremariam, Marc Swidergall, Amol C. Shetty, Karen T. Graf, Abdullah Alqarihi, Sondus Alkhazraji, Abrar I. Alsaadi, Vonetta L. Edwards, Scott G. Filler, Ashraf S. Ibrahim, Vincent M. Bruno
Article
Multidisciplinary Sciences
Liang-Chun Wang, Jacob Wagner, Annabelle Capino, Elizabeth Nesbit, Wenxia Song, Daniel C. Stein
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Microbiology
Vonetta L. Edwards, Steven B. Smith, Elias J. McComb, Jeanne Tamarelle, Bing Ma, Michael S. Humphrys, Pawel Gajer, Kathleen Gwilliam, Alison M. Schaefer, Samuel K. Lai, Mishka Terplan, Katrina S. Mark, Rebecca M. Brotman, Larry J. Forney, Patrik M. Bavoil, Jacques Ravel
Review
Dentistry, Oral Surgery & Medicine
Julie T. Marchesan, Mustafa Saadat Girnary, Kevin Moss, Eugenia Timofeev Monaghan, Grant Joseph Egnatz, Yizu Jiao, Shaoping Zhang, Jim Beck, Karen V. Swanson
PERIODONTOLOGY 2000
(2020)
Article
Microbiology
Qian Yu, Liang-Chun Wang, Sofia Di Benigno, Scott D. Gray-Owen, Daniel C. Stein, Wenxia Song
Article
Multidisciplinary Sciences
Kevin L. McKnight, Karen Swanson, Kathryn Austgen, Cindy Richards, Jonathan K. Mitchell, David R. McGivern, Ethan Fritch, John Johnson, Katja Remlinger, Michal Magid-Slav, Maryna Kapustina, Shihyun You, Stanley M. Lemon
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Dentistry, Oral Surgery & Medicine
Karen Swanson, Mustafa Girnary, Tomaz Alves, Jenny P. Y. Ting, Kimon Divaris, Jim Beck, Carolina Maschietto Pucinelli, Raquel Assed Bezerra da Silva, Dilek Uyan, Justin E. Wilson, William T. Seaman, Jennifer Webster-Cyriaque, Nishma Vias, Yizu Jiao, Lloyd Cantley, Arnaud Marlier, Roland R. Arnold, Julie T. Marchesan
Summary: This study experimentally validated the association between IFI16 and AIM2 with periodontitis and demonstrated IFI16's role in regulating inflammatory cell trafficking to the periodontium, protecting against bone loss and potentially serving as targets for the development of new periodontal disease biomarkers and therapeutics.
JOURNAL OF PERIODONTOLOGY
(2022)
Review
Immunology
Karen V. Swanson, Meng Deng, Jenny P. -Y. Ting
NATURE REVIEWS IMMUNOLOGY
(2019)
Meeting Abstract
Infectious Diseases
Steven Smith, Mike Humphrys, Pawel Gajer, Shaikh Iqbal, Vonetta Edwards, Jacques Ravel
SEXUALLY TRANSMITTED INFECTIONS
(2017)
Meeting Abstract
Infectious Diseases
Vonetta Edwards, Elias Mccomb, Steven Smith, Patrik Bavoil, Jacques Ravel
SEXUALLY TRANSMITTED INFECTIONS
(2017)
Article
Infectious Diseases
Liang-Chun Wang, Madeline Litwin, Zahraossadat Sahiholnasab, Wenxia Song, Daniel C. Stein