Article
Peripheral Vascular Disease
Mohammad Shafid, Kumaravelu Jagavelu, Hina Iqbal, Pankaj Yadav, Debabrata Chanda, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: MK2 plays a significant role in pulmonary hypertension, and its inhibition may be a novel target for PH treatment. Inhibition of MK2 alleviated right ventricle pressure and hypertrophy in PH rats, improved cardiac function, reversed pulmonary vascular remodeling, and enhanced pulmonary vascular relaxation.
Article
Gastroenterology & Hepatology
Vincenzo Dinallo, Davide Di Fusco, Antonio Di Grazia, Federica Laudisi, Edoardo Troncone, Giulia Di Maggio, Eleonora Franze, Irene Marafini, Alfredo Colantoni, Angela Ortenzi, Carmine Stolfi, Nicola Di Daniele, Ivan Monteleone, Giovanni Monteleone
Summary: The study found that OTUD5 is overexpressed in both Crohn's disease and ulcerative colitis, suggesting its involvement in amplifying the aberrant cytokine response in inflammatory bowel disease.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Cell Biology
Armando Jesus Perez-Diaz, Beatriz Vazquez-Marin, Jero Vicente-Soler, Francisco Prieto-Ruiz, Teresa Soto, Alejandro Franco, Jose Cansado, Marisa Madrid
Summary: The autophagy pathway in yeast is regulated differently in response to glucose limitation, indicating evolutionary variations in the signaling pathways that govern autophagy during glucose shortage or starvation.
Article
Clinical Neurology
Aina Calls, Abel Torres-Espin, Marc Tormo, Laura Martinez-Escardo, Nuria Bonet, Ferran Casals, Xavier Navarro, Victor J. Yuste, Esther Udina, Jordi Bruna
Summary: This study used single-cell RNA sequencing to analyze the transcriptomic profiles of sensory neurons and satellite glial cells in a mouse model of oxaliplatin neurotoxicity. The results showed that the inflammatory processes were modulated in response to oxaliplatin treatment. Increased levels of NF-kB p65 protein, pro-inflammatory cytokines, and immune cell infiltration were observed in the DRGs and peripheral nerves of the mice, accompanied by mechanical allodynia and decrease in sensory nerve amplitudes.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Damian Jacenik, Eric J. Lebish, Ellen J. Beswick
Summary: The study demonstrates the important role of MK2 in PNETs, with its inhibition improving survival rates in mice and preventing disease progression. MK2 was also found to play a crucial role in regulating tumor metabolism and immune response, providing a new target for PNETs treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Qian Wang, Ci Xu, Qiang Fan, Haihua Yuan, Xin Zhang, Biying Chen, Renjie Cai, Yanjie Zhang, Moubin Lin, Ming Xu
Summary: This study reveals novel insights into p38 alpha-SUMOylation and its association with the intracellular oxidative stress response, which is closely related to the processes of gastric cancer. Furthermore, the PIASx alpha/p38 alpha-SUMOylation/MK2 cis-axis may serve as a desirable therapeutic target in gastric cancer as targeting PIASx alpha, MK2, or a specific peptide region of p38 alpha may reconcile the aberrant oxidative stress response in gastric cancer cells.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Lucia Suarez-Lopez, Bing Shui, Douglas K. Brubaker, Marza Hill, Alexander Bergendorf, Paul S. Changelian, Aisha Laguna, Alina Starchenko, Douglas A. Lauffenburger, Kevin M. Haigis
Summary: Inflammatory bowel diseases (IBDs) are genetically complex and exhibit significant inter-patient heterogeneity. Mouse models of IBD show varied responses to MK2 inhibition, with MK2 suppressing inflammation by targeting inflammatory cells. Using a computational approach, researchers identified IBD patient subgroups predicted to respond to MK2 inhibition, which can aid in identifying which patients will benefit from new therapies.
Review
Immunology
Ricarda Cortes-Vieyra, Octavio Silva-Garcia, Anel Gomez-Garcia, Sergio Gutierrez-Castellanos, Cleto Alvarez-Aguilar, Victor M. Baizabal-Aguirre
Summary: Understanding the regulation of GSK3 beta activity in inflammatory responses caused by pathogenic microorganisms is crucial for controlling the intensity of inflammation. Recent studies have shown that regulating GSK3 beta activity can reduce the detrimental effects of the inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
David A. Montero, Richard Garcia-Betancourt, Roberto M. Vidal, Juliana Velasco, Pablo A. Palacios, Daniela Schneider, Carolina Vega, Leonardo Gomez, Hernan Montecinos, Rodrigo Soto-Shara, Angel Onate, Leandro J. Carreno
Summary: Researchers have developed a chimeric protein-based vaccine targeting seven virulence factors of Shiga toxin-producing Escherichia coli (STEC), which elicited significant immune responses in mice and provided protection against infection. However, further improvement is needed to enhance the vaccine's efficacy and explore other potential mechanisms of protection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Alyson R. Warr, Carole J. Kuehl, Matthew K. Waldor
Summary: The study demonstrates that the Shiga toxin (Stx) released by Enterohemorrhagic Escherichia coli (EHEC) markedly remodels how epithelial cells respond to infection, particularly in terms of the intestinal innate immune response.
Article
Plant Sciences
Soongon Jeong, Chae Woo Lim, Sung Chul Lee
Summary: This study examined the role of the phytohormone abscisic acid (ABA) in plant growth and development, particularly in response to drought stress. It was found that CaMEKK23 interacts with CaSnRK2.6 and has kinase activity. The findings suggest that CaMEKK23 plays a positive regulatory role in ABA-mediated drought stress responses in pepper plants.
Article
Oncology
Jayoung Song, Jinha Yu, Lak Shin Jeong, Sang Kook Lee
Summary: 2'-fluoro-4'-seleno-ara-C, a new generation of cytarabine analogs, exhibits potent antitumor activity against p53-deficient prostate cancer cells by targeting MK2 to induce apoptosis. Combining F-Se-Ara-C with other anticancer drugs can enhance its antitumor activity in p53-deficient prostate cancer cells.
Article
Biotechnology & Applied Microbiology
Xiaozhu Wu, Chenghua Zhou, Xiaofang Li, Jingyi Lin, Luis Carlos Ramos Aguila, Feng Wen, Liande Wang
Summary: In this study, 19 MAPK cascade gene family members were identified in E. grisescens and their evolutionary characteristics and expression patterns were investigated. The results showed uneven distribution of these genes on chromosomes and most of them were induced or constitutively expressed upon M. anisopliae infection. These findings may contribute to the development of new eco-friendly biological insecticides for tea tree protection.
Article
Multidisciplinary Sciences
Sucharit Ray, Robyn Roth, Peter A. Keyel
Summary: Following membrane damage by bacterial cholesterol-dependent cytolysins, calcium influx activates mixed lineage kinase 3, which coordinates microvesicle shedding critical for cellular survival.
Article
Cell Biology
Di Wang, Qiliang Shang, Jianxin Mao, Chu Gao, Jie Wang, Dong Wang, Han Wang, Haoruo Jia, Pandi Peng, Mu Du, Zhuojing Luo, Liu Yang
Summary: Excessive mechanical load is a key factor in the development of mechano stress-induced pathologies such as intervertebral disc degeneration (IDD). This study demonstrates that conditional knockout of Krt8 within nucleus pulposus cells exacerbates load-induced IDD, while overexpression of Krt8 enhances the cells' resistance to overloading-induced apoptosis and degeneration. Additionally, the study reveals that the phosphorylation of KRT8 plays a crucial role in inhibiting the trafficking of RAB33B and suppressing autophagosome initiation, contributing to IDD.