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Biochemistry & Molecular Biology
Yoda Janaina Ikenohuchi, Milena Daniela Souza Silva, Cristina Matiele Alves Rego, Aleff Ferreira Francisco, Sulamita da Silva Setubal, Alex Augusto Ferreira E. Ferreira, Charles Nunes Boeno, Hallison Mota Santana, Katia Paula Felipin, Anderson Maciel de Lima, Marcos Roberto de Mattos Fontes, Mauro Valentino Paloschi, Andreimar Martins Soares, Juliana Pavan Zuliani
Summary: This study aimed to investigate the effects of BjcuL from Brazilian jararacussu snake venom on the activation of NLRP3 inflammasome in PBMCs. The results demonstrated that BjcuL activates NLRP3 inflammasome through interaction with TLR4 and participation of ROS in the release of IL-1β. These findings are important for understanding the development of inflammatory reactions observed in snakebite victims.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Medicine, Research & Experimental
Tzu-Li Lu, Yuh-Pyng Sher, Hui-Chen Chen, Wei-Chung Cheng, Ling-Heng Hsu, Chen-Chen Lee
Summary: This study reveals that the B chain of articulatin can activate mouse bone marrow-derived dendritic cells, inducing antigen-specific T cell immune response. This finding has potential implications for the development of vaccines against pathogens and tumors.
Article
Cell Biology
Frederic Coutant, Jean-Jacques Pin, Pierre Miossec
Summary: Inflammatory monocyte-derived dendritic cells exhibit a distinct phenotype with C-type lectin receptors and intracellular proteins. The interaction between infiltrating monocytes and local mesenchymal cells is crucial for the generation of Mo-DCs in rheumatoid arthritis patients.
Article
Immunology
Nataschja I. Ho, Marcel G. Camps, Juan J. Garcia-Vallejo, Erik Bos, Abraham J. Koster, Martijn Verdoes, Yvette van Kooyk, Ferry Ossendorp
Summary: Dendritic cells have the unique ability to present exogenous antigens through MHC class I molecules, with the antigen being conserved in storage compartments for days. These compartments in DCs lack certain molecules involved in MHC class I processing, and the co-localization of active cathepsin X with protein antigen suggests a novel role for cathepsin X in antigen processing and cross-presentation. These compartments can preserve protein antigens from different uptake routes and contribute to long-lasting antigen cross-presentation.
Article
Medicine, Research & Experimental
Matthew Stephens, Keith Keane, Simon Roizes, Shan Liao, Pierre-Yves Von der Weid
Summary: The article introduces a specific DNA aptamer targeting Mincle and discusses its potential in treating inflammatory bowel disease.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Veterinary Sciences
Hui Nan Hao, Yan Yan Song, Kai Ning Ma, Bo Ning Wang, Shao Rong Long, Ruo Dan Liu, Xi Zhang, Zhong Quan Wang, Jing Cui
Summary: This study investigates a novel type C lectin from Trichinella spiralis and its role in the invasion of intestinal epithelial cells. The lectin, TsCTL, was shown to specifically bind to IECs and promote larval invasion. These findings provide important insights into T. spiralis infection mechanisms and the development of vaccines targeting this lectin.
VETERINARY RESEARCH
(2022)
Article
Medicine, Research & Experimental
Francois Bulteau, Michel Thepaut, Maxime Henry, Amandine Hurbin, Laetitia Vanwonterghem, Corinne Vives, Aline Le Roy, Christine Ebel, Olivier Renaudet, Franck Fieschi, Jean-Luc Coll
Summary: This study found that recombinant MGL fragments can efficiently target Tn-positive human tumors without inducing toxicity, making it a promising candidate for in vivo diagnosis and imaging of human tumors and potentially for therapeutic applications.
MOLECULAR PHARMACEUTICS
(2022)
Article
Entomology
Hao Li, Fang-Fang Liu, Li-Qing Fu, Ze Liu, Wen-Ting Zhang, Qian Wang, Xiang-Jun Rao
Summary: The study identified C-type lectins in the oriental armyworm and investigated their expression patterns in different developmental stages and immune responses, indicating their importance in the immune responses of Mythimna separata.
Article
Veterinary Sciences
Zhen Wang, Qi Qi Lu, Min Min Weng, Yang Li Li, Lu Lu Han, Yan Yan Song, Yu Long Shi, Ruo Dan Liu, Jing Cui, Zhong Quan Wang
Summary: This study found that rTsCTL interacts directly with SDC-1 on Caco-2 cells. The binding of rTsCTL to SDC-1 increases the expression of SDC-1 and claudin-2, and decreases the expression of occludin and claudin- 1 through the STAT3 pathway. Inhibiting SDC-1 synthesis and the STAT3 pathway can impede the binding of rTsCTL to syndecan-1 and the activation of the STAT3 pathway, thereby weakening larval invasion.
VETERINARY RESEARCH
(2023)
Article
Fisheries
Zhiqiang Zhang, Xinchao Liu, Qi Li, Miao Xie, Yongxiong Huang, Baijian Jiang, Xing Li, Yu Huang, Jichang Jian
Summary: This study identified a hepatic lectin molecule from Nile tilapia and uncovered its functions in the tilapia immune response to bacteria. The hepatic lectin plays a crucial role in recognizing and agglutinating pathogens, and it is primarily expressed in nonspecific cytotoxic cells and monocytes/macrophages. Blocking hepatic lectin significantly affects the antibacterial immune responses in tilapia.
Article
Biochemistry & Molecular Biology
Ronit Vogt Sionov, Chrystelle Lamagna, Zvi Granot
Summary: This study identifies the mechanism of interaction between neutrophils and tumor cells, showing that the interaction between Cathepsin G on neutrophil surface and tumor RAGE, as well as the involvement of C-type lectin receptors, contribute to neutrophil-mediated cytotoxicity towards tumor cells.
Article
Immunology
Grace A. Snyder, Shir Eliachar, Michael T. Connelly, Shani Talice, Uzi Hadad, Orly Gershoni-Yahalom, William E. Browne, Caroline V. Palmer, Benyamin Rosental, Nikki Traylor-Knowles
Summary: This study identified and characterized phagocytes from coral and sea anemones, demonstrating their role in engulfing bacteria, fungi, beads, as well as self and damaged cells. The findings also showed that phagocytic cells target antigens localize to low pH phagolysosomes, and the inhibition of actin filament rearrangement interferes with efficient particle phagocytosis. Additionally, cellular markers for lysolitic vesicles and reactive oxygen species were found to correlate with hexacorallian phagocytes, laying a foundation for better understanding of their immune cell biology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Mark H. T. Stappers, Christina Nikolakopoulou, Darin L. Wiesner, Raif Yuecel, Bruce S. Klein, Janet A. Willment, Gordon D. Brown
Summary: Our data shows that the choice of enzymes in generating single cell suspensions from murine tissues can affect the detection of surface expression of antifungal CLRs. Utilizing a method that best preserves receptor expression, we found that non-myeloid expression of antifungal CLRs is confined to MelLec on endothelial cells in murine mucosal tissues.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Fisheries
Yonglei Zhang, Ping Zhang, Runnan Yu, Bin Li
Summary: This study cloned and characterized the C-type lectin S group (CTL-S) TcCTL1 gene in Tribolium castaneum, and functional analysis showed that TcCTL1 can recognize and agglutinate pathogens, activate immune signaling pathways, and also play a crucial role in embryogenesis.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Immunology
Rajan Singh, Anshul Anand, Arun K. Rawat, Shashi Saini, Baishakhi Mahapatra, Naveen K. Singh, Alok K. Mishra, Samer Singh, Nisha Singh, Dhiraj Kishore, Vinod Kumar, Pradeep Das, Rakesh K. Singh
Summary: Leishmania parasites upregulate the expression of immune inhibitory receptor CD300a on host antigen presenting and phagocytic cells to dampen their effector functions. Blocking CD300a signals enhances the immune response, reduces parasitic uptake, and promotes the conversion of CD4(+) T cells to memory cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Jeffrey Maslanka, Gretel Torres, Jennifer Londregan, Naomi Goldman, Daniel Silberman, John Somerville, James E. Riggs
Summary: This study investigates the immunobiology of the peritoneum in ovarian cancer, revealing reduced B1 cells in the ascites and selective loss of B1 and marginal zone B cell subsets in the spleen. These findings suggest a correlation between the depletion of B cell subsets and the influx of myeloid-derived suppressor cells during ovarian cancer.
CELLULAR IMMUNOLOGY
(2024)