Article
Immunology
Stanzin Dawa, Dilip Menon, Prabhakar Arumugam, Akash Kumar Bhaskar, Moumita Mondal, Vivek Rao, Sheetal Gandotra
Summary: Lipid metabolism plays a crucial role in the interaction between host and pathogen during Mycobacterium tuberculosis infection. The accumulation of triglyceride in necrotic granulomas is important for the success of the pathogen, and manipulating lipid droplet homeostasis may potentially offer a new approach for host-directed therapy in Tuberculosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Amanda N. N. Samuels, Erin R. R. Wang, Gregory A. A. Harrison, Joy C. C. Valenta, Christina L. L. Stallings
Summary: This article discusses the impact of bacterial central carbon metabolism on Mtb drug tolerance and proposes that these metabolic pathways could be potential drug targets. By better understanding the physiological state of Mtb in the host, we can hope to treat tuberculosis more effectively.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nala Kachour, Abrianna Beever, James Owens, Ruoqiong Cao, Afsal Kolloli, Ranjeet Kumar, Kayvan Sasaninia, Charles Vaughn, Mohkam Singh, Edward Truong, Christopher Khatchadourian, Christina Sisliyan, Klara Zakery, Wael Khamas, Selvakumar Subbian, Vishwanath Venketaraman
Summary: The supplementation of mice with L-GSH led to increased levels of total GSH, which is associated with reduced oxidative stress, increased levels of granuloma-promoting cytokines, and decreased M. tb burden in the lung.
Article
Immunology
Catarina M. Ferreira, Consuelo Micheli, Palmira Barreira-Silva, Ana Margarida Barbosa, Mariana Resende, Manuel Vilanova, Ricardo Silvestre, Cristina Cunha, Agostinho Carvalho, Fernando Rodrigues, Margarida Correia-Neves, Antonio Gil Castro, Egidio Torrado
Summary: The control of tuberculosis relies on the rapid activation of protective CD4(+) T-cell responses in the lungs. The immunomodulatory cytokine IL-10 hinders this response by impairing the migratory capacity of CD4(+) T cells. However, BCG vaccination can prevent the immunosuppressive effects of IL-10 and accelerate the CD4(+) T-cell response, leading to better control of tuberculosis infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
C. Kanipe, P. M. Boggiatto, E. J. Putz, M. V. Palmer
Summary: The study found that BCG vaccination can reduce the number and size of tuberculosis lesions, decrease necrosis, and increase fibrosis in low-grade lesions. Vaccination has minimal impact on mineralization and density of multinucleated giant cells.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Priyanka Talukdar, Beth F. Junecko, Daniel S. Lane, Pauline Maiello, Joshua T. Mattila
Summary: IFN-λ is expressed in granulomas and may influence myeloid cell function and immunity in tuberculosis. The expression of IFN-λ varies in different granuloma microenvironments, primarily expressed by macrophages and neutrophils, with differences in subcellular localization.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Suresh Kumar, Mehak Zahoor Khan, Neha Khandelwal, Chen Chongtham, Biplab Singha, Ankita Dabla, Debashree Behera, Archana Singh, Balasubramanian Gopal, G. Aneeshkumar Arimbasseri, Siddhesh S. Kamat, Vinay Kumar Nandicoori
Summary: EmbR, a transcription factor, plays crucial roles in modulating cellular morphology, antibiotic resistance, and survival in the host. The study highlights EmbR as a key regulator of the hypoxic response in mycobacterial survival.
Article
Microbiology
Wenping Gong, Yan Liang, Jie Wang, Yinping Liu, Yong Xue, Jie Mi, Pengchuan Li, Xiaoou Wang, Lan Wang, Xueqiong Wu
Summary: This study reports that the combination of Th1 and CTL immunodominant peptides derived from LTBI-RD antigens can distinguish LTBI from ATB in animals and differentiate ATB patients from uninfected individuals. These findings provide a novel insight for the discovery of potential biomarkers for the differential diagnosis of ATB and LTBI in the future.
MICROBIOLOGY SPECTRUM
(2022)
Article
Veterinary Sciences
Mitchell V. Palmer, Tyler C. Thacker, Carly Kanipe, Paola M. Boggiatto
Summary: The study found that bacterial burdens within individual granulomas examined 30 days after infection were greater and more heterogenous compared to those examined 90 to 270 days after infection. Granuloma stage had modest positive and negative correlations with TNF-alpha and IL-10, respectively. However, heterogeneity and mean expression of IFN-gamma, IL-10 and TNF-alpha did not differ significantly over time.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Claudio Pigoli, Vito Tranquillo, Lucia Rita Gibelli, Alessandra Gaffuri, Giovanni Loris Alborali, Maria Pacciarini, Mariagrazia Zanoni, Maria Beatrice Boniotti, Giuseppe Sironi, Mario Caniatti, Valeria Grieco
Summary: This study investigated natural Mycobacterium microti (Mm) infection in European wild boars in Lombardy and Emilia Romagna Italian regions. The results suggest that granuloma maturation plays a role in containing Mm infection in wild boars, indicating that intra-species transmission of the disease may be unlikely.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Fernanda Larenas-Munoz, Ines Ruedas-Torres, Laura Hunter, Alison Bird, Irene Agullo-Ros, Rebecca Winsbury, Simon Clark, Emma Rayner, Francisco J. Salguero
Summary: Tuberculosis remains a significant infectious disease worldwide, requiring the development of new vaccines and therapies. Guinea pigs are a valuable animal model for studying TB, as their granulomatous lesions resemble those observed in humans.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Nicole Poladian, Davit Orujyan, William Narinyan, Armani K. Oganyan, Inesa Navasardyan, Prathosh Velpuri, Abraham Chorbajian, Vishwanath Venketaraman
Summary: Mycobacterium tuberculosis (M. tb) causes tuberculosis infection in humans globally, especially in immunocompromised populations and areas with limited tuberculosis treatment resources. The interaction between M. tb and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) plays a crucial role in the immune response, where NF-kappa B promotes pro-inflammatory cytokines and assists in maintaining granulomas and controlling bacterial load. Understanding the dynamics of M. tb and NF-kappa B interaction is essential for better comprehension of the immune response and potential therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Jess A. Millar, J. Russell Butler, Stephanie Evans, Joshua T. Mattila, Jennifer J. Linderman, JoAnne L. Flynn, Denise E. Kirschner
Summary: Tuberculosis is a global health issue, and understanding the immune response to Mycobacterium tuberculosis infection is crucial for successful interventions. Research suggests that the structural organization of lung granulomas and recruitment of non-specific T cells may contribute to reduced T cell responsiveness in TB infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Nicole L. Grant, Kristen Kelly, Pauline Maiello, Helena Abbott, Shelby O'Connor, Philana Ling Lin, Charles A. Scanga, JoAnne L. Flynn
Summary: Despite research focus on CD4 T cells in Mtb infections, little is known about Mtb-specific T cells within lung granulomas. We identified immunodominant epitopes for two Mtb proteins using a macaque model, facilitating the identification of Mtb-specific cells. Granulomas were found to be enriched sites for Mtb-specific cells, which expressed activation markers and transcription factors. Our data highlighted the importance of activated, polarized Mtb-specific cells for controlling Mtb in lung granulomas.
Article
Immunology
William P. Lafuse, Qian Wu, Naresh Kumar, Noushin Saljoughian, Shrayes Sunkum, Omar Santiagonunez Ahumada, Joanne Turner, Murugesan V. S. Rajaram
Summary: Age is a major risk factor for chronic infections, including tuberculosis (TB). Elderly TB patients also suffer from elevated levels of psychological stress. This study found that psychological stress suppresses lung inflammation in old mice and increases susceptibility to TB infection by promoting differentiation of IL-10 secreting regulatory T cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Immunology
Kamlesh Bhatt, Sheetal Verma, Jerrold J. Ellner, Padmini Salgame
CLINICAL AND VACCINE IMMUNOLOGY
(2015)
Article
Microbiology
Nichole Goodsmith, Xinzheng V. Guo, Omar H. Vandal, Julien Vaubourgeix, Ruojun Wang, Helene Botella, Shuang Song, Kamlesh Bhatt, Amir Liba, Padmini Salgame, Dirk Schnappinger, Sabine Ehrt
Article
Immunology
Jill Konowich, Archana Gopalakrishnan, Jillian Dietzold, Sheetal Verma, Kamlesh Bhatt, Wasiulla Rafi, Padmini Salgame
JOURNAL OF IMMUNOLOGY
(2017)
Article
Multidisciplinary Sciences
Kamlesh Bhatt, Wasiulla Rafi, Neel Shah, Sylvia Christakos, Padmini Salgame
SCIENTIFIC REPORTS
(2016)
Article
Immunology
Kamlesh Bhatt, Aleksandra Uzelac, Sanjeev Mathur, Amanda McBride, Julius Potian, Padmini Salgame
JOURNAL OF IMMUNOLOGY
(2009)
Article
Microbiology
Sheetal Verma, Kamlesh Bhatt, Arianne Lovey, Rodrigo Ribeiro-Rodrigues, Joan Durbin, Edward C. Jones-Lopez, Moises Palaci, Solange A. Vinhas, David Alland, Reynaldo Dietze, Jerrold J. Ellner, Padmini Salgame
Article
Cell Biology
Kamlesh Bhatt, Madhuri Bhagavathula, Sheetal Verma, Graham S. Timmins, Vojo P. Deretic, Jerrold J. Ellner, Padmini Salgame
Summary: The study found that rapamycin may be a candidate adjunct therapy for tuberculosis treatment, reducing infection-induced lung inflammation and the number and size of granulomas. The results suggest the potential use of rapamycin and its analogs as adjunct TB therapies.
DISEASE MODELS & MECHANISMS
(2021)
Review
Immunology
Kamlesh Bhatt, Padmini Salgame
JOURNAL OF CLINICAL IMMUNOLOGY
(2007)
Article
Biochemistry & Molecular Biology
K Bhatt, SK Banerjee, PK Chakraborti
EUROPEAN JOURNAL OF BIOCHEMISTRY
(2000)
Article
Cell Biology
Jeffrey Maslanka, Gretel Torres, Jennifer Londregan, Naomi Goldman, Daniel Silberman, John Somerville, James E. Riggs
Summary: This study investigates the immunobiology of the peritoneum in ovarian cancer, revealing reduced B1 cells in the ascites and selective loss of B1 and marginal zone B cell subsets in the spleen. These findings suggest a correlation between the depletion of B cell subsets and the influx of myeloid-derived suppressor cells during ovarian cancer.
CELLULAR IMMUNOLOGY
(2024)