期刊
CELLULAR IMMUNOLOGY
卷 283, 期 1-2, 页码 51-60出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2013.06.008
关键词
Peritoneal and tumor-associated macrophages; Tumor microenvironment; Inflammation; Immunosuppression
资金
- National Institutes of Health [R21 CA153172, KO1 CA101926]
- NATIONAL CANCER INSTITUTE [R21CA153172, K01CA101926] Funding Source: NIH RePORTER
Macrophages are key players in the inflammatory response. In this study, we tested the hypothesis that although all macrophage subpopulations in tumor hosts are affected by the disease, it is the close proximity to the tumor that induces major alterations in these cells. We compared tumor-associated macrophages (TAMs) with peritoneal macrophages from mice bearing D1-DMBA-3 mammary tumors (T-PEMs). Our results show that TAMs downregulate IL-12p70 but upregulate IL-12p40, IL-23, IL-6 and IL-10. Some NF kappa B and C/EBP transcription factors family members are decreased in TAMs; however NF kappa Bp50 homodimers, STAT1/pSTAT1 and STAT3/pSTAT3 are overexpressed. Furthermore, while TAMs block T-cell proliferation and are more prone to apoptosis compared to T-PEMs, both types of macrophages have an impaired phagocytic capacity. Moreover,. TAMs constitutively express iNOS and produce nitric oxide but do not express arginase and are Gr-1(high) and CD11b(low). Collectively, our analysis of two spatially distinct macrophage subpopulations in tumor-bearing mice revealed that the tumor modulates them differently into two molecularly and functionally dissimilar macrophage subpopulations. (C) 2013 Elsevier Inc. All rights reserved.
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