Article
Immunology
Martha A. L. Boening, Gerald P. Parzmair, Andreas Jeron, Henning P. Duesedau, Olivia Kershaw, Baolin Xu, Borna Relja, Dirk Schlueter, Ildiko Rita Dunay, Annegret Reinhold, Burkhart Schraven, Dunja Bruder
Summary: Mice lacking the adhesion and degranulation-promoting adaptor protein (ADAP) are highly susceptible to infection by the intracellular pathogen Listeria monocytogenes (Lm), showing enhanced immunopathology and increased infiltration of immune cells. Despite high phagocyte numbers in infected tissues, ADAP-deficient mice struggle to control pathogen growth efficiently, indicating a functional impairment in infection-primed phagocytes. Analysis revealed molecular alterations in pro-inflammatory mediators following activation in ADAP-deficient host, leading to enhanced immunopathology and reduced pathogen elimination capacity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zachary T. T. Morrow, John-Demian Sauer
Summary: This study investigates the impact of two innate immune pathways, type I interferon (IFN) production and inflammasome activation, on CD8(+) T-cell response to L. monocytogenes infection. The results show that mice lacking the type I IFN receptor (IFNAR(-/-)) had the strongest T-cell response, while caspase-1(-/-) mice were not significantly different from wild type. IFNAR(-/-)/caspase-1(-/-) mice had fewer T-cells than IFNAR(-/-) mice, suggesting a role for inflammasome activation in the absence of type I IFN. IFNAR(-/-) mice had more than twice as many memory precursors, promoting enhanced protection from rechallenge.
INFECTION AND IMMUNITY
(2023)
Article
Toxicology
Nga T. Nguyen, David S. Umbaugh, Sawyer Smith, Olamide B. Adelusi, Giselle Sanchez-Guerrero, Anup Ramachandran, Hartmut Jaeschke
Summary: Acetaminophen (APAP) overdose is a major cause of acute liver failure, and the role of neutrophils in APAP-induced liver injury is controversial. This study found that neutrophils, recruited through the neutrophil chemoattractant Cxcl2, have no effect on liver injury after a low dose of APAP (300 mg/kg), but aggravate the injury after a high dose (600 mg/kg). Treating mice with an anti-Cxcl2 antibody reduced neutrophil accumulation and liver injury. These findings suggest that neutrophils play a role in APAP-induced liver injury only at severe overdoses.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Microbiology
Michael G. Dorrington, Clinton J. Bradfield, Justin B. Lack, Bin Lin, Jonathan J. Liang, Tregei Starr, Orna Ernst, Julia L. Gross, Jing Sun, Alexandra H. Miller, Olivia Steele-Mortimer, Iain D. C. Fraser
Summary: This study focuses on how macrophages combat opportunistic bacterial pathogen Burkholderia cenocepacia and highlights the crucial role of interferons in killing these bacteria. The results could help guide anti-Burkholderia treatments in susceptible patients. The study emphasizes the importance of type I interferons in protection against opportunistic pathogens through innate immunity, without the need for damaging inflammatory responses.
Article
Cell Biology
Shanti S. D'Souza, Yuanyue Zhang, Jacob T. Bailey, Ivan T. H. Fung, Marcy L. Kuentzel, Sridar Chittur, Qi Yang
Summary: Research has shown that physiological lung aging leads to increased interferon signaling and elevated chemokine concentrations, which exacerbate monocyte infiltration into the lung parenchyma, including a novel subset dependent on type-1 interferon signaling. Treatment with anti-IFNAR1 neutralizing antibodies can rapidly eradicate this subset of monocytes, reduce airway chemokine concentrations, and suppress the accumulation of monocytes in the aged lung parenchyma.
Review
Biochemistry & Molecular Biology
Ashley A. Stegelmeier, Maedeh Darzianiazizi, Kiersten Hanada, Shayan Sharif, Sarah K. Wootton, Byram W. Bridle, Khalil Karimi
Summary: Interferons play a crucial role in regulating host antiviral response, while neutrophils contribute to antiviral defense as host cells. The complex cross-regulatory talk between interferons and neutrophils is essential for initiating appropriate antiviral immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Jenny Jongstra-Bilen, Kelly Tai, Marwan G. Althagafi, Allan Siu, Corey A. Scipione, Saraf Karim, Chanele K. Polenz, Jiro Ikeda, Sharon J. Hyduk, Myron I. Cybulsky
Summary: This study reveals that CCL5 plays a critical role in monocyte recruitment during early lesion formation in atherosclerosis through the CCR5 signaling pathway. However, CCL5 deficiency does not affect early lesion development, and CCL5-blockade does not impact monocyte recruitment in Ldlr-/- mice.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Immunology
Naoto Sakumura, Tadafumi Yokoyama, Masaaki Usami, Yuiko Hosono, Natsumi Inoue, Yusuke Matsuda, Yuko Tasaki, Taizo Wada
Summary: Measuring the expression of CD169 on monocytes and the levels of soluble CD169 in circulation can be a rapid assessment method for type I IFN status in pediatric inflammatory diseases.
CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Giulia Magagna, Guido Finazzi, Virginia Filipello
Summary: This study presents a new set of primers for sequencing inlA in both lineages. The presence of premature stop-codon mutations in inlA is correlated with attenuated virulence, and lineage I isolates are most frequently associated with clinical cases. Using these newly designed primers, the presence of inlA PMSCs in food, food processing environments, and clinical isolates was assessed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Erika Huijser, Cornelia G. van Helden-Meeuwsen, Dwin G. B. Grashof, Jessica R. Tarn, Zana Brkic, Josje M. A. Huisman, M. Javad Wahadat, Harmen J. G. van de Werken, Ana P. Lopes, Joel A. G. van Roon, Paul L. A. van Daele, Sylvia Kamphuis, Wan-Fai Ng, Siroon Bekkering, Leo A. B. Joosten, Willem A. Dik, Marjan A. Versnel
Summary: Trained immunity is a long-term reprogramming of innate immune cells that is linked to atherosclerosis. This study investigated the link between type I interferons and trained immunity in patients with primary Sjogren's syndrome. The findings suggest that type I interferon induces a trained immunity phenotype in monocytes, while trained immunity also affects the production of type I interferons.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Johannes Steffen, Stefanie Ehrentraut, Ute Bank, Aindrila Biswas, Caio Andreeta Figueiredo, Oliver Hoelsken, Henning Peter Duesedau, Vladyslava Dovhan, Laura Knop, Jacqueline Thode, Silvina Romero-Suarez, Carmen Infante Duarte, Jason Gigley, Chiara Romagnani, Andreas Diefenbach, Christoph S. N. Klose, Thomas Schueler, Ildiko Rita Dunay
Summary: This study reveals that innate lymphoid cells (ILC1) accumulate in the brain during the onset of cerebral Toxoplasma gondii infection and contribute to the production of IFN-g and TNF, initiating a neuroinflammatory response and host defense factors.
Article
Chemistry, Medicinal
Li Li, Jia-Min Dong, He-He Ye, Man-Jing Jiang, Huan-Hua Yang, Lin-Pan Liang, Li-Jun Ning, Ying Wu
Summary: Type I and III interferons play essential roles in the host antiviral innate immune system. Baicalin, a bioactive compound in Scutellariae radix, exhibits antiviral, anti-inflammatory, and immunomodulatory effects. This study demonstrated that baicalin increased the expression of type I and III interferons and their receptors in Poly (I:C)-stimulated A549 cells, and attenuated type I interferon-induced neutrophil inflammation.
JOURNAL OF NATURAL MEDICINES
(2023)
Review
Biochemistry & Molecular Biology
Adeline Peignier, Dane Parker
Summary: This review discusses recent literature that provides new insights into the mechanisms of how type I IFN signaling exerts its effects on the outcome of infection from the host's point of view. The identified mechanisms have been wide and varied between pathogens.
TRENDS IN MICROBIOLOGY
(2021)
Review
Parasitology
Stephanie B. Orchanian, Melissa B. Lodoen
Summary: Monocytes play a crucial role during infection by differentiating into macrophages and dendritic cells, releasing cytokines and chemokines, and shaping the adaptive immune response.
TRENDS IN PARASITOLOGY
(2023)
Article
Biology
Daisy X. Ji, Kristen C. Witt, Dmitri Kotov, Shally R. Margolis, Alexander Louie, Victoria Chevee, Katherine J. Chen, Moritz M. Gaidt, Harmandeep S. Dhaliwal, Angus Y. Lee, Stephen L. Nishimura, Dario S. Zamboni, Igor Kramnik, Daniel A. Portnoy, K. Heran Darwin, Russell E. Vance
Summary: Sp140 is a gene that represses type I IFN transcription during bacterial infections, playing an important role in resistance to bacterial infections. Sp140(-/-) mice are susceptible to Legionella pneumophila and Mycobacterium tuberculosis infections, but susceptibility can be rescued by crosses to mice lacking the type I IFN receptor.
Article
Cell Biology
Jeffrey Maslanka, Gretel Torres, Jennifer Londregan, Naomi Goldman, Daniel Silberman, John Somerville, James E. Riggs
Summary: This study investigates the immunobiology of the peritoneum in ovarian cancer, revealing reduced B1 cells in the ascites and selective loss of B1 and marginal zone B cell subsets in the spleen. These findings suggest a correlation between the depletion of B cell subsets and the influx of myeloid-derived suppressor cells during ovarian cancer.
CELLULAR IMMUNOLOGY
(2024)
