期刊
CELLULAR IMMUNOLOGY
卷 276, 期 1-2, 页码 153-161出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2012.05.002
关键词
Dendritic cells; Toll-like receptor; Adjuvant; Cytotoxic T lymphocytes; Type-1 immunity; Cancer immunotherapy
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) [22300331, 22790370, 22700894]
- JSPS [22-5171, 21-2717]
- Grants-in-Aid for Scientific Research [22790370, 22300331, 22700894] Funding Source: KAKEN
Type-1 immunity plays a crucial role in host defense against various tumors and infectious diseases. Here, we first demonstrated that extract of Larix Leptolepis (ELL), one of the most popular timbers at Hokkaido area in Japan, strongly activated Type-1 immunity. ELL induced production of Type-1 cytokines such as IL-12 and TNF-alpha from bone marrow-derived dendritic cells (BMDCs) in TLR2- and TLR4-dependent manner and remarkably up-regulated the expression of MHC and co-stimulatory molecules. In addition, antigen-specific CTLs were significantly augmented by the combined administration of ELL antigen and BMDCs. Finally, we revealed that combination therapy using ELL antigen and BMDCs significantly inhibited the growth of established tumor in mouse model. Thus, these findings suggested that ELL would be a novel adjuvant for inducing an activation of Type-1-dependent immunity including activation of BMDCs and induction of tumor-specific CTLs, which is applicable to the therapy of cancer and infectious diseases. (C) 2012 Elsevier Inc. All rights reserved.
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