Article
Rheumatology
Aurelie Najm, Iain B. McInnes
Summary: IL-23, a pro-inflammatory cytokine secreted by dendritic cells and macrophages, plays a key role in the pathogenesis of rheumatic diseases by promoting T cell differentiation into Th17 cells. Therapeutic strategies targeting IL-23 have shown efficiency in PsA but not yet in RA.
Article
Multidisciplinary Sciences
Atsushi Sugimoto, Tomoe Numaguchi, Ryota Chihama, Yuto Takenaka, Yuuki Sato
Summary: This study identified a beneficial lactic acid bacteria strain, D279, that exerts health-beneficial effects by regulating innate immunity and shows strong antiviral potency in treating influenza.
Article
Multidisciplinary Sciences
Amelie Cachot, Mariia Bilous, Yen-Cheng Liu, Xiaokang Li, Margaux Saillard, Mara Cenerenti, Georg Alexander Rockinger, Tania Wyss, Philippe Guillaume, Julien Schmidt, Raphael Genolet, Giuseppe Ercolano, Maria Pia Protti, Walter Reith, Kalliopi Ioannidou, Laurence de Leval, Joseph A. Trapani, George Coukos, Alexandre Harari, Daniel E. Speiser, Alexander Mathis, David Gfeller, Hatice Altug, Pedro Romero, Camilla Jandus
Summary: CD4 T cells displaying cytotoxic phenotypes were identified in different human cancers through mining single-cell RNA-seq datasets. Ex vivo confirmation of the cytolytic tumor-specific CD4 T cells was achieved using peptide-MHCII-multimer technology. The cytotoxic activity of these cells, partially dependent on SLAMF7, was demonstrated to have delayed kinetics compared to classical cytotoxic lymphocytes, and agonistic engagement of SLAMF7 enhanced their cytotoxicity, indicating potential synergy with other cancer immunotherapies.
Review
Biochemistry & Molecular Biology
Nur Azizah A. Rahman, Vinod R. M. T. Balasubramaniam, Wei Boon Yap
Summary: The IL-12 family consists of cytokines that play a crucial role in activating host antiviral immunity and preventing excessive immune reactions. IL-12 and IL-23 stimulate T cell proliferation and effector cytokine release, leading to host defense against virus infections. IL-27 and IL-35 have dual functions in regulating cytokine synthesis, T cell proliferation, and viral antigen presentation to enhance virus clearance. The multitasking nature of the IL-12 family makes it a highly important target for antiviral therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Haebeen Jung, Hong-Gu Joo
Summary: The study revealed that DSF did not alter the function of DCs, had low cytotoxicity, and induced differential cytokine production.
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2023)
Article
Cell Biology
Irene Olivera, Elixabet Bolanos, Jose Gonzalez-Gomariz, Sandra Hervas-Stubbs, Karina V. Marino, Carlos Luri-Rey, Inaki Etxeberria, Assunta Cirella, Josune Egea, Javier Glez-Vaz, Saray Garasa, Maite Alvarez, Inaki Eguren-Santamaria, Sonia Guedan, Miguel F. Sanmamed, Pedro Berraondo, Gabriel A. Rabinovich, Alvaro Teijeira, Ignacio Melero
Summary: Engineering tumor-specific CD8 T cells with IL-12 mRNA enhances their therapeutic potency when delivered intratumorally.
CELL REPORTS MEDICINE
(2023)
Article
Oncology
Qingxiang Li, Yuke Li, Yifei Wang, Le Xu, Yuxing Guo, Yixiang Wang, Lin Wang, Chuanbin Guo
Summary: The intestinal microbiota, particularly through the probiotic B. breve, can enhance the efficacy of cancer immunotherapy, promoting tumor cell apoptosis; the mechanism of B. breve may involve the regulation of DC-related chemokines and the promotion of IL-12 secretion; the study suggests that exogenous B. breve can alter the intestinal microbiota and enhance its antitumor effect.
Review
Cardiac & Cardiovascular Systems
Akinori Higaki, Ahmad U. M. Mahmoud, Pierre Paradis, Ernesto L. Schiffrin
Summary: Hypertension is partially mediated by immune mechanisms, with IL-23 and IL-17 playing important roles. The IL-23/IL-17 axis has not been a major therapeutic target for hypertension treatment, but shows potential for targeting therapy.
CARDIOVASCULAR RESEARCH
(2021)
Review
Immunology
Dan Yang, Xinning Guo, Tingxuan Huang, Chuntao Liu
Summary: Innate lymphoid cells play a crucial role in maintaining mucosal homeostasis and protecting against pathogens, with ILC3s emerging as key mediators of mucosal protection and repair through producing IL-17 and IL-22. Further research is needed to understand the role of pulmonary ILC3s in respiratory infections and chronic pulmonary inflammatory diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Helen Loo Yau, Emma Bell, Ilias Ettayebi, Felipe Campos de Almeida, Giselle M. Boukhaled, Shu Yi Shen, David Allard, Beatriz Morancho, Sajid A. Marhon, Charles A. Ishak, Isabela M. Gonzaga, Tiago da Silva Medina, Rajat Singhania, Ankur Chakravarthy, Raymond Chen, Parinaz Mehdipour, Sandra Pommey, Christian Klein, Gustavo P. Amarante-Mendes, David Roulois, Joaquin Arribas, John Stagg, David G. Brooks, Daniel D. De Carvalho
Summary: The study demonstrates that DNA hypomethylating agents directly modulate the anti-tumor response and effector function of CD8(+) T cells, promoting tumor infiltration and suppressing growth. This effect is achieved through the regulation of T cell activation-related transcriptional networks, ultimately enhancing the immune response against tumors.
Article
Immunology
Debby Reuveni, Miriam R. Brezis, Eli Brazowski, Philip Vinestock, Patrick S. C. Leung, Paresh Thakker, M. Eric Gershwin, Ehud Zigmond
Summary: IL-23 plays a crucial role in the pathogenesis of PBC, with IL-23 derived from hepatic monocyte-derived macrophages being particularly significant. Studies using a murine model showed that IL-23 produced by specific MNPs contributes to the severity of PBC, suggesting potential for new immune-based therapies for PBC patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Lisa U. U. Teufel, Dennis M. M. de Graaf, Mihai G. G. Netea, Charles A. A. Dinarello, Leo A. B. Joosten, Rob J. W. Arts
Summary: IL-38 is a newly discovered member of the interleukin-1 family with anti-inflammatory properties. Studies have shown associations between IL-38 concentrations and certain diseases, but establishing a reference range in healthy adults is challenging. This study aims to collect data on IL-38 concentrations in healthy adults and assess factors that may affect its measurements.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Evelyn Kelemen, Renata Bozo, Gergely Groma, Zsuzsanna Bata-Csorgo, Lajos Kemeny, Judit Danis, Marta Szell
Summary: In the last two decades, large-scale gene-expression studies on psoriatic skin samples have revealed molecular differences in nonlesional skin compared to healthy skin, which were originally thought to be susceptibility factors for plaque formation. However, immune regulation and structural alteration specific to nonlesional skin serve as protective factors against plaque formation and contribute to maintaining the nonlesional phenotype.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yutaka Enomoto, Peng Li, Lisa M. Jenkins, Dimitrios Anastasakis, Gaelyn C. Lyons, Markus Hafner, Warren J. Leonard
Summary: NK-EVs derived from IL-15 + IL-21 stimulated NK-92 cells show enhanced cytotoxic capacity against tumor cells, with CD226 playing a key role. However, enrichment of cytolytic granules granzyme B and granzyme H is not the key factor contributing to the enhanced cytotoxic activity.
CANCER GENE THERAPY
(2022)
Review
Immunology
Hongmin Kim, Sung Jae Shin
Summary: Dendritic cells play a crucial role in tuberculosis infection by interacting with immune cells and Mycobacterium tuberculosis, enhancing or inhibiting host defense mechanisms. Understanding the immune responses initiated by dendritic cells is essential for developing anti-tuberculosis control measures.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cell Biology
Jeffrey Maslanka, Gretel Torres, Jennifer Londregan, Naomi Goldman, Daniel Silberman, John Somerville, James E. Riggs
Summary: This study investigates the immunobiology of the peritoneum in ovarian cancer, revealing reduced B1 cells in the ascites and selective loss of B1 and marginal zone B cell subsets in the spleen. These findings suggest a correlation between the depletion of B cell subsets and the influx of myeloid-derived suppressor cells during ovarian cancer.
CELLULAR IMMUNOLOGY
(2024)