Article
Microbiology
Manisha Yadav, Md. Naushad Akhtar, Manish Mishra, Sandeep Kumar, Raj Kumar, Anil Nandal, Pradip Sen
Summary: To initiate an antileishmanial adaptive immune response, dendritic cells (DCs) must carry Leishmania antigens from peripheral tissues to local draining lymph nodes. However, L. donovani infection impairs DC migration by decreasing CLEC-2 expression, which is mediated by TGF-beta secretion and c-Src activation. Suppression of c-Src expression improves DC arrival in draining lymph nodes by preventing L. donovani-induced CLEC-2 downregulation.
MICROBIOLOGY SPECTRUM
(2023)
Review
Cell Biology
Xinyue Chen, Qi Cai, Ruikai Liang, Deju Zhang, Xiao Liu, Meiying Zhang, Yan Xiong, Minxuan Xu, Qi Liu, Pengyang Li, Peng Yu, Ao Shi
Summary: Copper is a vital mineral for normal physiological processes, including cardiovascular systems. However, copper-induced cell death has been recognized as an important factor in the pathogenesis and progression of cardiovascular disease. Understanding the mechanisms of copper-induced cell death can help improve cardiovascular disease management. This review explores the relationship between copper homeostasis and pathways related to copper-induced cell death in cardiovascular disease, as well as therapeutic strategies.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Zheng Cao, Duo Xu, Jeffrey Harding, Wenting Chen, Xiangsheng Liu, Zi Wang, Lan Wang, Tong Qi, Shilin Chen, Xinheng Guo, Irvin S. Y. Chen, Jimin Guo, Yunfeng Lu, Jing Wen
Summary: Cancer immunotherapy is limited by tumor immunosuppression caused by excessive lactate production. This study presents a nanocapsule enzyme therapeutic approach based on lactate oxidase, which reduces lactate levels and releases immunostimulatory hydrogen peroxide, improving the efficacy of immune checkpoint blockade treatment.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Dan Huang, Chaoqun Sun, Min Chen, Shuyou Bai, Xuanna Zhao, Weiming Wang, Kang Geng, Wenbo Huang, Tingting Zhao, Bin Wu, Guilin Zhang, Dong Wu, Youhua Xu
Summary: This study found that the SIRT1 agonist bergenin can improve asthma-induced airway inflammation and remodeling by activating SIRT1 and regulating the transcriptional activity of nuclear factor kappa B.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Donghui Bai, Tianxiao Sun, Fang Lu, Yancheng Shen, Yan Zhang, Bo Zhang, Guangli Yu, Haihua Li, Jiejie Hao
Summary: The study showed that Eupatilin can attenuate the inflammatory response in OVA-induced asthma by regulating NF-kappa B, MAPK, and Nrf2 signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Chance M. Nowak, Tyler Quarton, Leonidas Bleris
Summary: The study reveals that cells rapidly become asynchronous after synchronization, and the factors controlling this process are largely unknown. Through experiments and simulations, it is found that the variability in cell cycle duration is the main factor causing cell desynchronization, which provides new insights into cell cycle research.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Immunology
Johanna Maria Hoelken, Katja Friedrich, Marion Merkel, Nelli Blasius, Ursula Engels, Timo Buhl, Karsten Ruediger Mewes, Lars Vierkotten, Nicole Elisabeth Teusch
Summary: In this study, THP-1-derived iDCs were integrated into a human skin model as central mediators of the immune reaction. The researchers found that different treatments of iDCs resulted in changes in proteins and cytokines related to sensitization and anti-sensitization. This provides a new approach for studying sensitizing agents and potential drugs for suppressing sensitization.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuan-ru Zheng, Chun-lin Fan, Ye Chen, Jing-yu Quan, Ling-zhu Shi, Chun-yang Tian, Xiao Shang, Ni-shan Xu, Wen-cai Ye, Lin-zhong Yu, Jun-shan Liu
Summary: This study discovered that dammarane-type triterpenoid saponins from Panax notoginseng have anti-inflammatory, anti-angiogenetic, and anti-dengue virus effects. They may be developed as potential functional foods for treating inflammation, angiogenesis, and dengue-related diseases.
Article
Biochemistry & Molecular Biology
Yu-Han Gao, Yuan Zhang, Yu-Xin Guo, Jia-Qi Wang, Meng-Yuan Gao, Zhuo-Hua Zhao, Rui Gao, Ya-Nan Sun, Li-Bin Wang, Xing Li
Summary: Anacardic acid (AA), a phenolic acid extract, exhibits a wide range of biological activities. This study demonstrated that AA effectively alleviated EAE, a classical mouse model of multiple sclerosis, and showed a potential anti-inflammatory therapeutic effect.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Ying Yu, Bing Liu, Siyan Chen, Jianxun Wang, Feng Chen, Tian Liu, Nan Jiang, Wensi Chen, Shengbei Weng, Xiaoxiao Cai, Daoman Xiang
Summary: TSA inhibits the maturation of DCs by down-regulating NF-kappa B (p65) pathway, leading to inhibition of T cell proliferation and cytokine secretion.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Cell Biology
Wei Kiat Jonathan Wee, Zun Siong Low, Chin Kiat Ooi, Benjamin Patrana Henategala, Zhi Guang Ridley Lim, Yun Sheng Yip, Marcus Ivan Gerard Vos, William Wei Ren Tan, Hong Sheng Cheng, Nguan Soon Tan
Summary: The study found that Angptl4 protein regulates monocyte differentiation and coordinates neutrophil clearance and inflammation resolution during wound healing through the modulation of ifi202b expression. This finding contributes to a better understanding of the immune cell mechanisms in wound healing.
CELL DEATH & DISEASE
(2022)
Article
Mathematics, Applied
Y. Yang, F. Z. Nian, J. S. Liu
Summary: In this paper, the evolutionary characteristics and laws of group networks under information dissemination are studied from the perspective of network groups and based on the feedback mechanism. A feedback-based model of information dissemination in group networks is developed, taking into account the differences between same-group and cross-group dissemination of information. The experimental results show that the main factor affecting the final evolutionary results of each group size in the small-world network is group positivity, and the main factor affecting the average degree of each group in the scale-free network is also group positivity.
Article
Medicine, Research & Experimental
Bee Kee Ooi, Su Wen Phang, Phelim Voon Chen Yong, Dinesh Kumar Chellappan, Kamal Dua, Kooi-Yeong Khaw, Bey Hing Goh, Priyia Pusparajah, Wei Hsum Yap
Summary: The study aimed to investigate the role of Nrf2 in the anti-inflammatory effects of MA in atheroma pathogenesis. Opposing effects of MA on Nrf2 expression were observed in HUVECs and THP-1 macrophages. Combined effects of MA and Nrf2 inhibitor ML385 suppressed the expression of MCP-1, VCAM-1, and SR-A.
Article
Immunology
Shailendra Chauhan, Deepak Kumar Rathore, Shilpa Sachan, Sebastien Lacroix-Desmazes, Nimesh Gupta, Amit Awasthi, Sudhanshu Vrati, Manjula Kalia
Summary: The study focuses on describing the human immune response to the mosquito-borne Japanese encephalitis virus (JEV) through analyzing the gene regulatory circuit of JEV infection in human monocyte-derived dendritic cells (moDCs) and its functional validation. It was observed that JEV infection in moDCs leads to robust transcriptional activation of antiviral and inflammatory pathways, along with DC maturation and release of pro-inflammatory cytokines.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Meng Zhang, Qianying Yu, Wei Tang, Yujiao Wu, JiaJia Lv, Lin Sun, Guochao Shi, Min Wu, Jieming Qu, Caixia Di, Zhenwei Xia
Summary: The study revealed that HDM-AEC-EXOs facilitate recruitment, proliferation, migration, and activation of DCs, with CNTN1 playing a critical role. Notch2 receptor is necessary for relaying the CNTN1 signal to activate TH2 cell/TH17 cell immune response. Studies of patients with asthma support the existence of the CNTN1-Notch2 axis observed in cell and mouse models.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Cell Biology
Jeffrey Maslanka, Gretel Torres, Jennifer Londregan, Naomi Goldman, Daniel Silberman, John Somerville, James E. Riggs
Summary: This study investigates the immunobiology of the peritoneum in ovarian cancer, revealing reduced B1 cells in the ascites and selective loss of B1 and marginal zone B cell subsets in the spleen. These findings suggest a correlation between the depletion of B cell subsets and the influx of myeloid-derived suppressor cells during ovarian cancer.
CELLULAR IMMUNOLOGY
(2024)