期刊
CELLULAR AND MOLECULAR NEUROBIOLOGY
卷 33, 期 5, 页码 681-688出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10571-013-9934-7
关键词
Angiotensin II; AT(1) receptor; Satellite glial cells; Neuronal injury; Dorsal root ganglia; Neuropathic pain
资金
- VEGA from the Slovak Academy of Sciences [2/0203/10, 2/0191/13]
- APVV from the Slovak Academy of Sciences [0314-06]
- CE NOREG from the Slovak Academy of Sciences
- Research & Development Operational Programme [ITMS 26220220127]
- ERDF
To clarify the role of angiotensin II (Ang II) in the regulation of sensory signaling, we studied the effect of subpressor dose (150 ng/kg/min) of Ang II on pain-related behavior in relation with neuronal injury and activation of satellite glial cells (SGCs) in the dorsal root ganglia (DRGs) after chronic constriction injury (CCI). Systemic continuous delivery of Ang II induced the tactile, heat and cold hyperlagesia, when measured at 7 days ofpost-injury. Blockade of the AT(1) receptor with losartan (2.5 mg/kg/day) prevented tactile hyperalgesia and attenuated cold hyperalgesia, but did not affect the response to noxious heat stimulus. A marked increase of large-sized injured primary afferent neurons, detected by ATF3 immunolabeling, was seen in lower lumbar DRGs on ipsilateral side after Ang II treatment. Subpressor dose of Ang II induced an increase of activated SGCs (detected by GFAP immunolabeling) enveloping large-diameter neurons. Our results suggested that Ang II through the AT(1) receptor activation is an important regulatory factor in neuropathic pain perception and plays an important role in the injury of large-sized primary afferent neurons and activation of SGCs elicited by the CCI.
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