Article
Neurosciences
Mario F. Juruena, Martha Bourne, Allan H. Young, Anthony J. Cleare
Summary: Evidence suggests that early life stress can disrupt the functioning of the HPA axis, leading to potential mental health disorders in adulthood. Dysregulation in hormone binding to receptors crucial for maintaining homeostasis may result in illness. The response of the HPA axis to stress plays a critical role in an individual's vulnerability to diseases related to psychological stress.
NEUROSCIENCE LETTERS
(2021)
Review
Endocrinology & Metabolism
You Lee Son, Takayoshi Ubuka, Kazuyoshi Tsutsui
Summary: Under stressful conditions, the GnIH neuropeptide may play a key role in regulating reproductive function. Different types and durations of stress can modulate the GnIH system, impacting the activity of the HPG axis. GnIH appears to be a potential novel mediator responsible for stress-induced reproductive dysfunction.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Agnes Martin, Josiane Castells, Valentine Allibert, Andrea Emerit, Cindy Zolotoff, Victoire Cardot-Ruffino, Yann S. Gallot, Barbara Vernus, Veronique Chauvet, Laurent Bartholin, Laurent Schaeffer, Anne-Cecile Durieux, Christophe Hourde, Francois B. Favier, Laetitia Mazelin, Damien Freyssenet
Summary: This study found that the hypothalamic-pituitary-adrenal-glucocorticoid pathway plays an important role in the transcriptional regulation of skeletal muscle catabolism and hepatic metabolism during cancer cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Review
Chemistry, Medicinal
Mudan Cai, Hee Ra Park, Eun Jin Yang
Summary: Post-traumatic stress disorder (PTSD) is characterized by overwhelming fear and anxiety after exposure to traumatic events. Disturbances in the hypothalamic-pituitary-adrenal (HPA) axis play a role in the development of mood disorders, including anxiety, PTSD, and major depressive disorders. The HPA axis regulates the immune system, fear memory, and neurotransmission. Currently, selective serotonin reuptake inhibitors (SSRIs) are the only approved drugs for PTSD treatment. However, SSRIs have limitations in terms of treatment duration and response rates, necessitating additional pharmacological interventions. Complementary and alternative medicine therapies can ameliorate HPA axis disturbances by regulating gut dysbiosis, insomnia, chronic stress, and depression.
Article
Biochemistry & Molecular Biology
Feiye Wu, Jing Zhu, Yang Wan, Subinuer Kurexi, Jia Zhou, Ke Wang, Tongyu Chen
Summary: This study aimed to investigate the effects of electroacupuncture (EA) on the hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and its potential mechanisms. The results showed that EA treatment effectively inhibited the hyperactivity of the HPA axis and promoted postoperative recovery by activating the oxytocin/oxytocin receptor (OXT/OXTR) signaling pathway.
NEUROCHEMICAL RESEARCH
(2023)
Article
Neurosciences
David E. Ehichioya, S. K. Tahajjul Taufique, Chikodi N. Anigbogu, Smith Jaja
Summary: Poor maternal sleep quality during different phases of pregnancy can impact fetal development. This study found that maternal sleep deprivation in early and late pregnancy can have adverse effects on the hypothalamic-pituitary-adrenal (HPA) axis in female offspring.
Article
Allergy
Wisdom Alemya Akurugu, Carel Jacobus Van Heerden, Nicola Mulder, Ekkehard Werner Zollner
Summary: This study found that some SNPs of the CRHR1 and NR3C1 genes are associated with HPAS in asthmatic children, with the C allele of rs41423247 potentially having a protective effect on HPAS, and the CC genotype being associated with the highest PMTP ACTH response.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Jody A. Rusch, Brian T. Layden, Lara R. Dugas
Summary: Cognitive function in humans relies on the complex interplay between multiple body systems, including the HPA axis. The gut microbiota, which outnumbers human cells and has a greater genetic potential, plays a crucial role through the MGB axis, a bidirectional communication pathway. Stress can affect the MGB axis through the HPA axis and other pathways, and animal research has contributed to a paradigm shift in understanding the influence of microbiota on human health and disease. Preclinical and human trials are currently investigating the applicability of these findings in humans.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Martin Werdermann, Ilona Berger, Laura D. Scriba, Alice Santambrogio, Pia Schlinkert, Heike Brendel, Henning Morawietz, Andreas Schedl, Mirko Peitzsch, Aileen J. F. King, Cynthia L. Andoniadou, Stefan R. Bornstein, Charlotte Steenblock
Summary: This study investigated the impact of metabolic diseases on progenitor cells in the hypothalamic-pituitary-adrenal axis, showing that insulin enhances proliferation and differentiation of these cells, while chronic metabolic stress leads to hyperactivation of the axis. This suggests a potential link between early life stress and the development of metabolic syndrome in adulthood.
MOLECULAR METABOLISM
(2021)
Article
Environmental Sciences
Cynthia N. Ikeji, Isaac A. Adedara, Ebenezer O. Farombi
Summary: This study investigated the impact of myricetin on atrazine-induced reproductive dysfunction and found that myricetin can alleviate the effects of atrazine on the reproductive axis through anti-inflammatory and antioxidant mechanisms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Bei Zhou, Qilong Xu, Junjie Guo, Qinliang Chen, Qingqing Lv, Kan Xiao, Huiling Zhu, Jiangchao Zhao, Yulan Liu
Summary: This study investigates the role of necroptosis in the activation of the hypothalamic-pituitary-adrenal (HPA) axis in a stress model induced by Escherichia coli lipopolysaccharide (LPS). The findings indicate that necroptosis is present and contributes to HPA axis activation induced by LPS. Necroptosis may serve as a potential intervention target for alleviating HPA axis activation and stress responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Hannah M. Costello, Georgios Krilis, Celine Grenier, David Severs, Alicja Czopek, Jessica R. Ivy, Mark Nixon, Megan C. Holmes, Dawn E. W. Livingstone, Ewout J. Hoorn, Neeraj Dhaun, Matthew A. Bailey
Summary: High salt intake activates the hypothalamic-pituitary-adrenal axis, leading to excess glucocorticoid levels and impacting glucocorticoid biology.
CARDIOVASCULAR RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Mojca Jensterle, Rok Herman, Andrej Janez, Wael Al Mahmeed, Khalid Al-Rasadi, Kamila Al-Alawi, Maciej Banach, Yajnavalka Banerjee, Antonio Ceriello, Mustafa Cesur, Francesco Cosentino, Massimo Galia, Su-Yen Goh, Sanjay Kalra, Peter Kempler, Nader Lessan, Paulo Lotufo, Nikolaos Papanas, Ali A. Rizvi, Raul D. Santos, Anca P. Stoian, Peter P. Toth, Vijay Viswanathan, Manfredi Rizzo
Summary: The article reviews the rationale for glucocorticoid use in COVID-19 and emphasizes the need to be cautious about glucocorticoid-induced adrenal insufficiency. The authors also discuss other mechanisms that may affect HPA axis function and the increased risk and severity of COVID-19 in patients with pre-existing HPA axis disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Pardis Mohammadzadeh, Gregory C. Amberg
Summary: AXL is a receptor tyrosine kinase that is commonly associated with various human cancers. It has been found to play a crucial role in neuroendocrine development and function, along with its ligand Gas6. AXL signaling, triggered by Gas6 binding, affects neuroendocrine structure and function in the brain, pituitary, and gonads. AXL has been identified as an upstream inhibitor of gonadotropin receptor hormone (GnRH) production during development and is also involved in the migration of GnRH neurons. It is implicated in reproductive diseases and spermatogenesis. The research on AXL/Gas6 signaling mechanisms provides valuable insights into neuroendocrine function in health and disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Manxiu Ma, Alyssa A. Brunal, Kareem C. Clark, Carleigh Studtmann, Katelyn Stebbins, Shin-ichi Higashijima, Y. Albert Pan
Summary: The expression of corticotropin-releasing hormone (CRH) in the hypothalamus plays a critical role in regulating the hypothalamic-pituitary-adrenal (HPA) axis, which is involved in the stress response. Through studying zebrafish, researchers identified dscaml1 as an important factor in CRH neuron development and HPA axis function. Mutations in dscaml1 led to increased CRH expression and cell number in hypothalamic CRH neurons, as well as altered stress hormone levels and response to stressors. These findings suggest a role for dscaml1 in stress axis development and its potential contribution to neuropsychiatric disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Xenos Petridis, Evangelia Diamanti, George Ch. Trigas, Demos Kalyvas, Efthymia Kitraki
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2015)
Article
Cell Biology
Efthymia Kitraki, Ivan Nalvarte, Ali Alavian-Ghavanini, Joelle Rueegg
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2015)
Article
Dentistry, Oral Surgery & Medicine
Anna Poimenova, Efthymia Kitraki, Afroditi Kakaboura, Christos Rahiotis
Article
Dentistry, Oral Surgery & Medicine
E. Diamanti, S. Mathieu, C. Jeanneau, E. Kitraki, P. Panopoulos, G. Spyrou, I. About
INTERNATIONAL ENDODONTIC JOURNAL
(2013)
Article
Endocrinology & Metabolism
Emily Panagiotidou, Sophia Zerva, Dimitra J. Mitsiou, Michael N. Alexis, Efthymia Kitraki
JOURNAL OF ENDOCRINOLOGY
(2014)
Article
Dentistry, Oral Surgery & Medicine
D. Dorotheou, N. Gkantidis, M. Karamolegkou, D. Kalyvas, S. Kiliaridis, E. Kitraki
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2013)
Article
Behavioral Sciences
Konstantina Yfanti, Efthymia Kitraki, Dimitris Emmanouil, Nikolaos Pandis, Lisa Papagiannoulis
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2014)
Article
Multidisciplinary Sciences
Laskarina-Maria Korou, George Agrogiannis, Christos Koros, Efthimia Kitraki, Ioannis S. Vlachos, Irene Tzanetakou, Theodore Karatzas, Vasilios Pergialiotis, Dimitrios Dimitroulis, Despina N. Perrea
SCIENTIFIC REPORTS
(2014)
Article
Multidisciplinary Sciences
Anastasia Repouskou, Emily Panagiotidou, Lydia Panagopoulou, Pernilla Larsdotter Bisting, Astrud R. Tuck, Marcus O. D. Sjoedin, Johan Lindberg, Evangelos Bozas, Joelle Rueegg, Chris Gennings, Carl-Gustaf Bornehag, Pauliina Damdimopoulou, Antonios Stamatakis, Efthymia Kitraki
SCIENTIFIC REPORTS
(2019)
Article
Public, Environmental & Occupational Health
Carl-Gustaf Bornehag, Efthymia Kitraki, Antonios Stamatakis, Emily Panagiotidou, Christina Ruden, Huan Shu, Christian Lindh, Joelle Ruegg, Chris Gennings
Article
Environmental Sciences
Michela Di Criscio, Jennifer Ekholm Lodahl, Antonios Stamatakis, Efthymia Kitraki, Ioannis Bakoyiannis, Anastasia Repouskou, Carl-Gustaf Bornehag, Chris Gennings, Diana Lupu, Joelle Ruegg
Summary: Humans are commonly exposed to endocrine disrupting chemicals (EDCs) that interfere with hormones, especially during early development. A previous study found a link between prenatal co-exposure to a mixture of EDCs (Mixture N1) and language delay in children, indicating a neurodevelopmental effect. This study investigated the epigenetic mechanisms underlying the long-term effects of Mixture N1 on gene expression and behavior. The findings demonstrate that Mixture N1 reduces DNA methylation in male mice at genes involved in the hypothalamus-pituitary-adrenal (HPA) axis, and this methylation decrease is correlated with increased gene expression and behavioral changes.
Meeting Abstract
Cell Biology
A. Kaparou, E. Diamanti, X. Matsioula, S. Zinelis, E. Kitraki
WOUND REPAIR AND REGENERATION
(2012)
Meeting Abstract
Dentistry, Oral Surgery & Medicine
P. P. Argyris, N. G. Nikitakis, E. Kitraki, A. Sklavounou
Meeting Abstract
Clinical Neurology
C. Koros, E. Kitraki
JOURNAL OF NEUROLOGY
(2012)
Article
Toxicology
Christos Koros, Efthymia Kitraki
TOXICOLOGY REPORTS
(2014)