Article
Biochemistry & Molecular Biology
Alexander Mordhorst, Priyavathi Dhandapani, Susann Matthes, Valentina Mosienko, Michael Rothe, Mihail Todiras, Julie Self, Wolf-Hagen Schunck, Anja Schutz, Michael Bader, Natalia Alenina
Summary: Serotonin synthesis involves the hydroxylation of tryptophan, with most vertebrates having two known enzymes for this step. However, even in animals lacking these two enzymes, there is still some serotonin production, suggesting the presence of a third enzyme. The study found evidence that phenylalanine hydroxylase (PAH) may act as a third tryptophan hydroxylase in mammals, contributing to serotonin levels in the blood and potentially serving as a local source of serotonin in organs where other TPHs are not expressed.
Article
Biochemistry & Molecular Biology
Giulia Sbrini, Sabrina I. Hanswijk, Paola Brivio, Anthonieke Middelman, Michael Bader, Fabio Fumagalli, Natalia Alenina, Judith R. Homberg, Francesca Calabrese
Summary: Peripheral serotonin levels have an influence on brain functions under basal and dynamic situations. The lack of peripheral serotonin can reduce anxiety-like behavior, as well as neuronal activation and the expression of brain plasticity-related genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Kyoko Kajimoto, Chie Hisada, Suzuko Ochi, Eri Yoshikawa, Ayumi Suzuki, Hiroko Tsugane, Jiahe Zhang, Mitsuo Iinuma, Kin-ya Kubo, Kagaku Azuma
Summary: The study demonstrated that prenatal stress had negative effects on the behavior and brain pathways of mouse offspring, while maternal chewing behavior could alleviate these effects to some extent.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Parasitology
Michaela Herz, Klaus Brehm
Summary: The study reveals the important role of serotonin in E. multilocularis development and proliferation, with evidence that serotonin is crucial for parasite integrity and survival. Serotonin also stimulates parasite metacestode development and proliferation, potentially contributing to parasite formation and growth in the liver.
PARASITES & VECTORS
(2021)
Article
Endocrinology & Metabolism
Zhenya Zhu, Xiaolong Chen, Shuang Chen, Chenmin Hu, Rui Guo, Yuhao Wu, Ziyu Liu, Xiaoli Shu, Mizu Jiang
Summary: In this study, the effects of GsMTx4 on 5-HT secretion in QGP-1 cells were explored. It was found that GsMTx4 increased 5-HT levels in QGP-1 cells and affected the expression of Piezo1/2 ion channels, TPH1 enzyme, and p38 signaling pathway. GsMTx4 also influenced mouse intestinal motility and blocked the response of QGP-1 cells to ultrasound.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Neurosciences
Mariana Angoa-Perez, Branislava Zagorac, Dina M. Francescutti, Kevin R. Theis, Donald M. Kuhn
Summary: Neuronal 5HT plays a significant role in stress-related responses, including influencing food intake, body weight, CORT levels, and the gut microbiome, but has minimal effects on the brain and adrenal responses induced by CORT.
Article
Biochemistry & Molecular Biology
Valentina S. Evsiukova, Alla B. Arefieva, Ivan E. Sorokin, Alexander V. Kulikov
Summary: This study investigated the levels of serotonin and its main metabolite, 5-hydroxyindoleacetic acid, as well as the activities of the key enzymes involved in their synthesis and degradation in the brains of male and female turquoise killifish at different ages. The results showed that age had a significant effect on body mass, serotonin level, and enzyme activities in the killifish brain. The level of serotonin decreased with age, and there were age-related alterations in the activities of tryptophan hydroxylases and monoamine oxidase. These findings highlight the suitability of N. furzeri as a model organism for studying age-related changes in the serotonin system in the brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Bo Hyun Lee, Bertil Hille, Duk-Su Koh
Summary: The pineal gland secretes melatonin at night, regulated by sympathetic nerve terminals. The secretion of 5-HT is primarily through a specific transporter, and activation of receptors on pinealocytes affects melatonin release.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Alla B. Arefieva, Polina D. Komleva, Vladimir S. Naumenko, Nikita V. Khotskin, Alexander V. Kulikov
Summary: This study investigated the effects of the pharmacological chaperone BH4 on the mutant TPH2 enzyme. The results showed that although BH4 demonstrated chaperone effects in vitro, it was unable to increase the activity of mutant TPH2 in vivo.
Article
Geriatrics & Gerontology
V. D. K. Reddy, Minurani Dalai, M. Sultan Khan, Anita Jagota
Summary: The circadian timing system is synchronized by environmental signals, primarily light, and non-photic cues may play a major role in synchronizing the clock under aging condition. This study investigates the effects of time-restricted feeding (TRF) as a non-photic stimulus on serotonin and its related metabolites in the suprachiasmatic nucleus (SCN) and pineal gland of aging rats. The results show that TRF can synchronize the age-induced desynchronization in serotonin metabolome.
Article
Endocrinology & Metabolism
Shelley R. Winn, Sandra Dudley, Tanja Scherer, Nicole Rimann, Beat Thoeny, Sydney Boutros, Destine Krenik, Jacob Raber, Cary O. Harding
Summary: The study found that lifelong weekly pegvaliase treatment can prevent cognitive deficits associated with hyperphenylalaninemia in mice, particularly with significant improvements in overall growth of the mice with early treatment. However, cognitive deficits may reappear after discontinuation of treatment, especially when treatment is stopped in adulthood.
MOLECULAR GENETICS AND METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Mariana Lapo Pais, Joao Martins, Miguel Castelo-Branco, Joana Goncalves
Summary: Tryptophan is an essential amino acid that plays a role in neuropsychiatric diseases. Women have a higher susceptibility to serotonin alterations due to changes in tryptophan levels, leading to a female sex bias in neuropsychiatric diseases. Further research is needed on the impact of diet and sex steroids on tryptophan metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Cezary Chojnacki, Tomasz Poplawski, Anita Gasiorowska, Jan Chojnacki, Janusz Blasiak
Summary: The levels of serotonin and 5-HIAA, as well as the number of EECs, were found to be higher in LC patients compared to healthy controls. Positive correlations were observed between the levels of serotonin and 5-HIAA, serotonin and EEC number, TPH1 mRNA and EEC number, as well as disease severity and 5-HIAA. Budesonide treatment reduced these levels and restored them to values similar to the control group.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Paula D. Trotter, Sharon A. Smith, David J. Moore, Noreen O'Sullivan, Martyn M. McFarquhar, Francis P. McGlone, Susannah C. Walker
Summary: The present study aimed to investigate the effect of acutely lowering central serotonin levels on perceptions of affective touch. The results showed that after lowering serotonin levels, participants rated affective touch as more pleasant and had increased discrimination of specific velocities that target CT fibers. However, lowered serotonin levels had no effect on tactile or cold pain thresholds, but there was a trend for reduced tolerance to cold pain.
PSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mo Xian Chen, Shu Cheng, Lei Lei, Xiao Fan Zhang, Qiang Liu, Aijin Lin, Chloe U. Wallis, Michael James Lukowicz, Pak C. Sham, Qi Li, Li Juan Ao
Summary: The study found that offspring of mothers exposed to FLX during pregnancy exhibited delayed physical development, increased anxiety-like behavior, and impaired social interaction. Down-regulation of 5-HT and SERT expression in the PFC, as well as decreased NAA/tCr levels, were identified. Additionally, a proteomic study revealed sex-dependent differential protein expression.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Behavioral Sciences
Nashat Abumaria, Wei Li, Yuqiang Liu
BEHAVIOURAL BRAIN RESEARCH
(2018)
Article
Cell Biology
Yuqiang Liu, Cui Chen, Yunlong Liu, Wei Li, Zhihong Wang, Qifeng Sun, Hang Zhou, Xiangjun Chen, Yongchun Yu, Yun Wang, Nashat Abumaria
Article
Neurosciences
Chaoqun Li, Feifei Cao, Shengli Li, Shenglin Huang, Wei Li, Nashat Abumaria
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2018)
Article
Cell Biology
Adema Ribic, Michael C. Crair, Thomas Biederer
Review
Biochemistry & Molecular Biology
Nashat Abumaria, Wei Li, Andrew N. Clarkson
CELLULAR AND MOLECULAR LIFE SCIENCES
(2019)
Review
Neurosciences
Josh Houlton, Nashat Abumaria, Simon F. R. Hinkley, Andrew N. Clarkson
FRONTIERS IN NEUROSCIENCE
(2019)
Review
Neurosciences
Adema Ribic, Thomas Biederer
Article
Neurosciences
Lin Luo, Mateusz C. Ambrozkiewicz, Fritz Benseler, Cui Chen, Emilie Dumontier, Susanne Falkner, Elisabetta Furlanis, Andrea M. Gomez, Naosuke Hoshina, Wei-Hsiang Huang, Mary Anne Hutchison, Yu Itoh-Maruoka, Laura A. Lavery, Wei Li, Tomohiko Maruo, Junko Motohashi, Emily Ling-Lin Pai, Kenneth A. Pelkey, Ariane Pereira, Thomas Philips, Jennifer L. Sinclair, Jeff A. Stogsdill, Lisa Traunmueller, Jiexin Wang, Joke Wortel, Wenjia You, Nashat Abumaria, Kevin T. Beier, Nils Brose, Harold A. Burgess, Constance L. Cepko, Jean-Francois Cloutier, Cagla Eroglu, Sandra Goebbels, Pascal S. Kaeser, Jeremy N. Kay, Wei Lu, Liqun Luo, Kenji Mandai, Chris J. McBain, Klaus-Armin Nave, Marco A. M. Prado, Vania F. Prado, Jeffrey Rothstein, John L. R. Rubenstein, Gesine Saher, Kenji Sakimura, Joshua R. Sanes, Peter Scheiffele, Yoshimi Takai, Hisashi Umemori, Matthijs Verhage, Michisuke Yuzaki, Huda Yahya Zoghbi, Hiroshi Kawabe, Ann Marie Craig
Letter
Neurosciences
Yan Gao, Wei Li, Bo Sui, Nashat Abumaria
NEUROSCIENCE BULLETIN
(2020)
Article
Cell Biology
Pengju Zhang, Wei Li, Yaan Liu, Yanqin Gao, Nashat Abumaria
Summary: In brain ischemia, suppressing TRPM7 can reduce neuronal death, tissue damage and motor deficits. This study found that deleting TRPM7 in PVB neurons has stronger neuroprotective effects than doing so in CaMKII neurons.
Article
Multidisciplinary Sciences
Karen Perez de Arce, Adema Ribic, Dhrubajyoti Chowdhury, Katherine Watters, Garth J. J. Thompson, Basavaraju G. G. Sanganahalli, Elizabeth T. C. Lippard, Astrid Rohlmann, Stephen M. M. Strittmatter, Markus Missler, Fahmeed Hyder, Thomas Biederer
Summary: LRRTM1 is a post synaptic adhesion protein that promotes synaptic transmission. The authors found that LRRTM1 and SynCAM 1 work together to organize synapses in the prefrontal cortex, affecting cognitive function in mice. The study highlights the roles of LRRTM1 and SynCAM 1 in synaptic, network, and behavioral domains.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Zhuqing Xie, Nashat Abumaria
Summary: In this study, we constructed TRPM7 clones and investigated the effects of truncating TRPM7 at different locations on ion channel activity. Truncating the kinase domain reduced channel activity, while further truncations did not have a significant effect. Truncated clones lacking the TRP or melastatin domains had a nonfunctional channel, likely due to disrupted protein stability. Adding the TRP domain to the truncated structure increased channel activity.
Article
Neurosciences
Chaoqun Li, Tianping Sun, Yimu Zhang, Yan Gao, Zhou Sun, Wei Li, Heping Cheng, Yu Gu, Nashat Abumaria
Summary: Persistence in the face of failure helps overcome challenges, but adjusting behavior or giving up in uncontrollable situations has advantages. The mechanism of behavioral switch in response to uncontrollability in the mammalian brain remains unclear. Using mouse models, researchers found that noradrenergic neurons in the orbitofrontal cortex play a key role in regulating this behavior.
Letter
Neurosciences
Junzhuang Chang, Cui Chen, Wei Li, Nashat Abumaria
NEUROSCIENCE BULLETIN
(2023)
Article
Multidisciplinary Sciences
Junzhuang Chang, Bingqing Guo, Yan Gao, Wei Li, Xiaoyu Tong, Yi Feng, Nashat Abumaria
Summary: Studies have confirmed the presence of a functional network of meningeal lymphatic vessels in the brain. This study aimed to investigate whether lymphatic vessels also extend deep into the brain parenchyma and whether they are regulated by stressful life events. Through various imaging techniques, the researchers demonstrated the existence of lymphatic vessels deep in the brain parenchyma and characterized their features in different brain regions. They also found that chronic stress and corticosterone treatment could regulate the length, area, and diameter of these lymphatic vessels in specific brain areas.