Updating the mechanisms of common fragile site instability: how to reconcile the different views?

A selected group of large common fragile site genes have decreased expression in oropharyngeal squamous cell carcinomas

(2014) Ge Gao et al.   GENES CHROMOSOMES & CANCER

Causes of Genome Instability

(2013) Andrés Aguilera et al.   Annual Review of Genetics

Instability at the FRA8I common fragile site disrupts the genomic integrity of the KIAA0146, CEBPD and PRKDC genes in colorectal cancer

(2013) Lena M. Brueckner et al.   CANCER LETTERS

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

(2013) Jacqueline H. Barlow et al.   CELL

Genetic and epigenetic determinants of DNA replication origins, position and activation

(2013) Marcel Méchali et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Common chromosome fragile sites in human and murine epithelial cells andFHIT/FRA3Bloss-induced global genome instability

(2013) Seyed Ali Hosseini et al.   GENES CHROMOSOMES & CANCER

The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability

(2013) Jennifer M. Mason et al.   HUMAN MOLECULAR GENETICS

Role of DNA secondary structures in fragile site breakage along human chromosome 10

(2013) Laura W. Dillon et al.   HUMAN MOLECULAR GENETICS

DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis

(2013) Valérie Bergoglio et al.   JOURNAL OF CELL BIOLOGY

The Human Specialized DNA Polymerases and Non-B DNA: Vital Relationships to Preserve Genome Integrity

(2013) Anne-Sophie Boyer et al.   JOURNAL OF MOLECULAR BIOLOGY

ERCC1 and MUS81–EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis

(2013) Valeria Naim et al.   NATURE CELL BIOLOGY

MUS81 promotes common fragile site expression

(2013) Songmin Ying et al.   NATURE CELL BIOLOGY

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Rev3, the catalytic subunit of Polζ, is required for maintaining fragile site stability in human cells

(2013) Audesh Bhat et al.   NUCLEIC ACIDS RESEARCH

Common Fragile Site Profiling in Epithelial and Erythroid Cells Reveals that Most Recurrent Cancer Deletions Lie in Fragile Sites Hosting Large Genes

(2013) Benoît Le Tallec et al.   Cell Reports

Stepwise Activation of the ATR Signaling Pathway upon Increasing Replication Stress Impacts Fragile Site Integrity

(2013) Stéphane Koundrioukoff et al.   PLoS Genetics

A genome-wide analysis of common fragile sites: What features determine chromosomal instability in the human genome?

(2012) Arkarachai Fungtammasan et al.   GENOME RESEARCH

Landscape of transcription in human cells

(2012) Sarah Djebali et al.   NATURE

Rescue of replication failure by Fanconi anaemia proteins

(2011) Angelos Constantinou   CHROMOSOMA

Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes

(2011) Anne Helmrich et al.   MOLECULAR CELL

Failure of Origin Activation in Response to Fork Stalling Leads to Chromosomal Instability at Fragile Sites

(2011) Efrat Ozeri-Galai et al.   MOLECULAR CELL

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

(2011) Anne Letessier et al.   NATURE

Molecular profiling of common fragile sites in human fibroblasts

(2011) Benoî Le Tallec et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Common fragile sites: mechanisms of instability revisited

(2011) Michelle Debatisse et al.   TRENDS IN GENETICS

Replication dynamics at common fragile site FRA6E

(2010) Elisa Palumbo et al.   CHROMOSOMA

Signatures of mutation and selection in the cancer genome

(2010) Graham R. Bignell et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites

(2009) Allison A Burrow et al.   BMC GENOMICS

Sequencing newly replicated DNA reveals widespread plasticity in human replication timing

(2009) R. S. Hansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA