The BLM dissolvasome in DNA replication and repair

A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells

(2013) Giang Huong Nguyen et al.   CHEMISTRY & BIOLOGY

FANCM and FAAP24 Maintain Genome Stability via Cooperative as Well as Unique Functions

(2013) Yucai Wang et al.   MOLECULAR CELL

Replication fork dynamics and the DNA damage response

(2012) Rebecca M. Jones et al.   BIOCHEMICAL JOURNAL

Physical and Functional Interactions of Caenorhabditis elegansWRN-1 Helicase with RPA-1

(2012) Moonjung Hyun et al.   BIOCHEMISTRY

DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network

(2012) Kenneth K. Karanja et al.   CELL CYCLE

An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks

(2012) Anna Maria Hegnauer et al.   EMBO JOURNAL

Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway

(2012) H. Kim et al.   GENES & DEVELOPMENT

The DNA translocase activity of FANCM protects stalled replication forks

(2012) Andrew N. Blackford et al.   HUMAN MOLECULAR GENETICS

RMI1 Promotes DNA Replication Fork Progression and Recovery from Replication Fork Stress

(2012) J. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Multimeric BLM is dissociated upon ATP hydrolysis and functions as monomers in resolving DNA structures

(2012) Ya-Nan Xu et al.   NUCLEIC ACIDS RESEARCH

Bloom’s Syndrome and PICH Helicases Cooperate with Topoisomerase IIα in Centromere Disjunction before Anaphase

(2012) Sébastien Rouzeau et al.   PLoS One

Defining the molecular interface that connects the Fanconi anemia protein FANCM to the Bloom syndrome dissolvasome

(2012) K. A. Hoadley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Chromosome Breakage Is Regulated by the Interaction of the BLM Helicase and Topoisomerase IIα

(2011) Beatriz Russell et al.   CANCER RESEARCH

PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution

(2011) Yuwen Ke et al.   EMBO JOURNAL

Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome

(2011) Avvaru N Suhasini et al.   EMBO JOURNAL

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

(2011) A. V. Nimonkar et al.   GENES & DEVELOPMENT

Replication stress induces 53BP1-containing OPT domains in G1 cells

(2011) Jeanine A. Harrigan et al.   JOURNAL OF CELL BIOLOGY

Failure of Origin Activation in Response to Fork Stalling Leads to Chromosomal Instability at Fragile Sites

(2011) Efrat Ozeri-Galai et al.   MOLECULAR CELL

Aberrant chromosome morphology in human cells defective for Holliday junction resolution

(2011) Thomas Wechsler et al.   NATURE

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

(2011) Anne Letessier et al.   NATURE

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

Homology-directed Fanconi anemia pathway cross-link repair is dependent on DNA replication

(2011) Koji Nakanishi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA

(2011) Peter Sarkies et al.   NUCLEIC ACIDS RESEARCH

Interhomolog recombination and loss of heterozygosity in wild-type and Bloom syndrome helicase (BLM)-deficient mammalian cells

(2011) J. R. LaRocque et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New insights into the formation and resolution of ultra-fine anaphase bridges

(2011) Kok Lung Chan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Fanconi anemia and Bloom's syndrome crosstalk through FANCJ–BLM helicase interaction

(2011) Avvaru N. Suhasini et al.   TRENDS IN GENETICS

Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication

(2010) Dongyi Xu et al.   EMBO JOURNAL

ATR activation and replication fork restart are defective in FANCM-deficient cells

(2010) Rebekka A Schwab et al.   EMBO JOURNAL

Expanded roles of the Fanconi anemia pathway in preserving genomic stability

(2010) Y. Kee et al.   GENES & DEVELOPMENT

Solution structure of the HRDC domain of human Bloom syndrome protein BLM

(2010) Akiko Sato et al.   JOURNAL OF BIOCHEMISTRY

Molecular Cooperation between the Werner Syndrome Protein and Replication Protein A in Relation to Replication Fork Blockage

(2010) Amrita Machwe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Topoisomerase IIIα Is a Single-stranded DNA Decatenase That Is Stimulated by BLM and RMI1

(2010) Jay Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Full-length Saccharomyces cerevisiae Sgs1 Protein Is a Vigorous DNA Helicase That Preferentially Unwinds Holliday Junctions

(2010) Petr Cejka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytokinesis failure occurs in Fanconi anemia pathway–deficient murine and human bone marrow hematopoietic cells

(2010) Patrizia Vinciguerra et al.   JOURNAL OF CLINICAL INVESTIGATION

MHF1-MHF2, a Histone-Fold-Containing Protein Complex, Participates in the Fanconi Anemia Pathway via FANCM

(2010) Thiyam Ramsing Singh et al.   MOLECULAR CELL

BACH1/FANCJ Acts with TopBP1 and Participates Early in DNA Replication Checkpoint Control

(2010) Zihua Gong et al.   MOLECULAR CELL

A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability

(2010) Zhijiang Yan et al.   MOLECULAR CELL

Preventing Nonhomologous End Joining Suppresses DNA Repair Defects of Fanconi Anemia

(2010) Adele Adamo et al.   MOLECULAR CELL

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

(2010) Hengyao Niu et al.   NATURE

DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2

(2010) Petr Cejka et al.   NATURE

Pathways of mammalian replication fork restart

(2010) Eva Petermann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ku70 Corrupts DNA Repair in the Absence of the Fanconi Anemia Pathway

(2010) P. Pace et al.   SCIENCE

Structural Basis for DNA Strand Separation by the Unconventional Winged-Helix Domain of RecQ Helicase WRN

(2010) Ken Kitano et al.   STRUCTURE

Crystal Structures of RMI1 and RMI2, Two OB-Fold Regulatory Subunits of the BLM Complex

(2010) Feng Wang et al.   STRUCTURE

Structure and Cellular Roles of the RMI Core Complex from the Bloom Syndrome Dissolvasome

(2010) Kelly A. Hoadley et al.   STRUCTURE

How the Fanconi Anemia Pathway Guards the Genome

(2009) George-Lucian Moldovan et al.   Annual Review of Genetics

Defining replication origin efficiency using DNA fiber assays

(2009) Sandie Tuduri et al.   CHROMOSOME RESEARCH

FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling

(2009) Sarah Luke-Glaser et al.   EMBO JOURNAL

RecQ helicases: Multiple structures for multiple functions?

(2009) Alessandro Vindigni et al.   HFSP Journal

Telomerase-associated Protein 1, HSP90, and Topoisomerase IIα Associate Directly with the BLM Helicase in Immortalized Cells Using ALT and Modulate Its Helicase Activity Using Telomeric DNA Substrates

(2009) Saumitri Bhattacharyya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bloom Syndrome Helicase Stimulates RAD51 DNA Strand Exchange Activity through a Novel Mechanism

(2009) Dmitry V. Bugreev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Replication Protein A Stimulates the Werner Syndrome Protein Branch Migration Activity

(2009) Gregory Sowd et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bloom DNA Helicase Facilitates Homologous Recombination between Diverged Homologous Sequences

(2009) Koji Kikuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the SSB Binding Site on E. coli RecQ Reveals a Conserved Surface for Binding SSB's C Terminus

(2009) Robert D. Shereda et al.   JOURNAL OF MOLECULAR BIOLOGY

FANCM Connects the Genome Instability Disorders Bloom's Syndrome and Fanconi Anemia

(2009) Andrew J. Deans et al.   MOLECULAR CELL

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

(2009) Kok Lung Chan et al.   NATURE CELL BIOLOGY

The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

(2009) Valeria Naim et al.   NATURE CELL BIOLOGY

The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair

(2009) Ivan V. Rosado et al.   NUCLEIC ACIDS RESEARCH

Mechanism of Werner DNA Helicase: POT1 and RPA Stimulates WRN to Unwind beyond Gaps in the Translocating Strand

(2009) Byungchan Ahn et al.   PLoS One

Structure of the human RECQ1 helicase reveals a putative strand-separation pin

(2009) A. C. W. Pike et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

(2009) P. Knipscheer et al.   SCIENCE

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

ATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway function

(2008) N. B. Collins et al.   BLOOD

Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends

(2008) Zhu Zhu et al.   CELL

RecQ helicases: guardian angels of the DNA replication fork

(2008) Csanád Z. Bachrati et al.   CHROMOSOMA

DNA helicases Sgs1 and BLM promote DNA double-strand break resection

(2008) S. Gravel et al.   GENES & DEVELOPMENT

BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome

(2008) T. R. Singh et al.   GENES & DEVELOPMENT

RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability

(2008) D. Xu et al.   GENES & DEVELOPMENT

FANCM of the Fanconi anemia core complex is required for both monoubiquitination and DNA repair

(2008) Yutong Xue et al.   HUMAN MOLECULAR GENETICS

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts

(2008) Timothy B. C. London et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Human RecQ Helicases, BLM and RECQ1, Display Distinct DNA Substrate Specificities

(2008) Venkateswarlu Popuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Werner Syndrome Protein Binds Replication Fork and Holliday Junction DNAs as an Oligomer

(2008) Sarah A. Compton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Role of BLAP75 in BLM-Topoisomerase IIIα-dependent Holliday Junction Processing

(2008) Steven Raynard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases

(2008) Karen J. Ouyang et al.   MECHANISMS OF AGEING AND DEVELOPMENT

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

(2008) Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Resolution of Converging Replication Forks by RecQ and Topoisomerase III

(2008) Catherine Suski et al.   MOLECULAR CELL

The FANCM Ortholog Fml1 Promotes Recombination at Stalled Replication Forks and Limits Crossing Over during DNA Double-Strand Break Repair

(2008) Weili Sun et al.   MOLECULAR CELL

FANCM and FAAP24 Function in ATR-Mediated Checkpoint Signaling Independently of the Fanconi Anemia Core Complex

(2008) Spencer J. Collis et al.   MOLECULAR CELL

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

(2008) Eleni P. Mimitou et al.   NATURE

Identification of Holliday junction resolvases from humans and yeast

(2008) Stephen C. Y. Ip et al.   NATURE

FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway

(2008) Masamichi Ishiai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends

(2008) S. Liao et al.   NUCLEIC ACIDS RESEARCH

The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase  

(2008) N. Selak et al.   NUCLEIC ACIDS RESEARCH

Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair

(2008) A. V. Nimonkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Remodeling of DNA replication structures by the branch point translocase FANCM

(2008) K. Gari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA