A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels

SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression

(2012) Kristi Muldoon Jacobs et al.   International Journal of Biological Sciences

Mitochondrial DNA mutations in disease and aging

(2011) Chan Bae Park et al.   JOURNAL OF CELL BIOLOGY

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

The AMPK-FoxO3A axis as a target for cancer treatment

(2010) Fulvio Chiacchiera et al.   CELL CYCLE

Calorie restriction: what recent results suggest for the future of ageing research

(2010) Daniel L. Smith et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

p38α Is Required for Ovarian Cancer Cell Metabolism and Survival

(2010) Antonio Matrone et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity

(2009) Ludmila Pawlikowska et al.   AGING CELL

Oxaloacetate supplementation increases lifespan inCaenorhabditis elegansthrough an AMPK/FOXO-dependent pathway

(2009) David S. Williams et al.   AGING CELL

AMP-activated Protein Kinase and FoxO Transcription Factors in Dietary Restriction-induced Longevity

(2009) Eric L. Greer et al.   Annals of the New York Academy of Sciences

Inhibition of p38α unveils an AMPK-FoxO3A axis linking autophagy to cancer-specific metabolism

(2009) Fulvio Chiacchiera et al.   Autophagy

p38α blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1α- to FoxO-dependent transcription

(2009) F Chiacchiera et al.   CELL DEATH AND DIFFERENTIATION

Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression

(2009) Yuanyuan Li et al.   FASEB JOURNAL

Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations

(2009) Yang Li et al.   HUMAN MOLECULAR GENETICS

Association ofFOXO3Avariation with human longevity confirmed in German centenarians

(2009) Friederike Flachsbart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of the FOXO3A Locus with Extreme Longevity in a Southern Italian Centenarian Study

(2009) Chiara Viviani Anselmi et al.   REJUVENATION RESEARCH

Evaluating the glucose tolerance test in mice

(2008) Sofianos Andrikopoulos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL

Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?

(2008) Leonard Guarente   CELL

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

FOXO3A genotype is strongly associated with human longevity

(2008) B. J. Willcox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear receptors and other nuclear transcription factors in mitochondria: Regulatory molecules in a new environment

(2007) Anna-Maria G. Psarra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH