Epigenetic identification of receptor tyrosine kinase-like orphan receptor 2 as a functional tumor suppressor inhibiting β-catenin and AKT signaling but frequently methylated in common carcinomas

NKX2-1/TITF1/TTF-1-Induced ROR1 Is Required to Sustain EGFR Survival Signaling in Lung Adenocarcinoma

(2012) Tomoya Yamaguchi et al.   CANCER CELL

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis

(2012) Kazuhiro Maeda et al.   NATURE MEDICINE

ROR1 Is Expressed in Human Breast Cancer and Associated with Enhanced Tumor-Cell Growth

(2012) Suping Zhang et al.   PLoS One

Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis

(2012) H.-Y. H. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Wnt5a and Ror2 protein in hepatocellular carcinoma associated with poor prognosis

(2012) Ming Geng   WORLD JOURNAL OF GASTROENTEROLOGY

Cancer Stem Cells and Chemosensitivity

(2011) M. Maugeri-Sacca et al.   CLINICAL CANCER RESEARCH

Wnt Signaling Gradients Establish Planar Cell Polarity by Inducing Vangl2 Phosphorylation through Ror2

(2011) Bo Gao et al.   DEVELOPMENTAL CELL

Critical role of Wnt5a-Ror2 signaling in motility and invasiveness of carcinoma cells following Snail-mediated epithelial-mesenchymal transition

(2011) Dayong Ren et al.   GENES TO CELLS

ROR1 is expressed on hematogones (non-neoplastic human B-lymphocyte precursors) and a minority of precursor-B acute lymphoblastic leukemia

(2011) H. Elizabeth Broome et al.   LEUKEMIA RESEARCH

Epigenetic inactivation of paired box gene 5, a novel tumor suppressor gene, through direct upregulation of p53 is associated with prognosis in gastric cancer patients

(2011) X Li et al.   ONCOGENE

The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/β-catenin signaling and silenced in common carcinomas

(2011) L Li et al.   ONCOGENE

WNT5A antagonizes WNT/β-catenin signaling and is frequently silenced by promoter CpG methylation in esophageal squamous cell carcinoma

(2010) Jisheng Li et al.   CANCER BIOLOGY & THERAPY

Anterior neural development requires Del1, a matrix-associated protein that attenuates canonical Wnt signaling via the Ror2 pathway

(2010) A. Takai et al.   DEVELOPMENT

Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors

(2010) L. Grumolato et al.   GENES & DEVELOPMENT

Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer

(2010) Ester Lara et al.   Molecular Cancer

Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase

(2010) H Yamamoto et al.   ONCOGENE

CMTM3, Located at the Critical Tumor Suppressor Locus 16q22.1, Is Silenced by CpG Methylation in Carcinomas and Inhibits Tumor Cell Growth through Inducing Apoptosis

(2009) Y. Wang et al.   CANCER RESEARCH

Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma

(2009) Kazuhito Morioka et al.   CANCER SCIENCE

Ror2 Receptor Requires Tyrosine Kinase Activity to Mediate Wnt5A Signaling

(2009) Amanda Mikels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma

(2009) T M Wright et al.   ONCOGENE

The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma

(2009) M P O’Connell et al.   ONCOGENE

Phospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer

(2009) X -T Hu et al.   ONCOGENE

WNT5A Exhibits Tumor-Suppressive Activity through Antagonizing the Wnt/ -Catenin Signaling, and Is Frequently Methylated in Colorectal Cancer

(2008) J. Ying et al.   CLINICAL CANCER RESEARCH

Cthrc1 Selectively Activates the Planar Cell Polarity Pathway of Wnt Signaling by Stabilizing the Wnt-Receptor Complex

(2008) Shinji Yamamoto et al.   DEVELOPMENTAL CELL

The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle

(2008) Guo-Hua Qiu et al.   JOURNAL OF HEPATOLOGY

Ror receptor tyrosine kinases: orphans no more

(2008) Jennifer L. Green et al.   TRENDS IN CELL BIOLOGY