期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 70, 期 23, 页码 4463-4477出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-013-1379-0
关键词
Epithelial-to-mesenchymal transition; Tumor progression; Posttranscriptional regulation; RNA-binding proteins
资金
- Conselleria de Economia e Industria [10CSA916023PR]
- Rede Galega de Investigacion Cancro Colorrectal (REGICC) [CN2012/217]
- Secretaria Xeral I + D + I [IPP.08-07]
- Conselleria de Cultura, Educacion e Ordenacion Universitaria [PRE/212/163]
Epithelial-to-mesenchymal transition (EMT), one of the crucial steps for carcinoma cells to acquire invasive capacity, results from the disruption of cell-cell contacts and the acquisition of a motile mesenchymal phenotype. Although the transcriptional events controlling EMT have been extensively studied, in recent years, several posttranscriptional mechanisms have emerged as critical in the regulation of EMT during tumor progression. In this review, we highlight the regulation of posttranscriptional events in EMT by RNA-binding proteins (RBPs). RBPs are responsible for controlling pre-mRNA splicing, capping, and polyadenylation, as well as mRNA export, turnover, localization, and translation. We discuss the most relevant aspects of RBPs controlling the metabolism of EMT-related mRNAs, and describe the implication of novel posttranscriptional mechanisms regulating EMT in response to different signaling pathways. Novel insight into posttranscriptional regulation of EMT by RBPs is uncovering new therapeutic targets in cancer invasion and metastasis.
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