期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 71, 期 10, 页码 1829-1837出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-013-1522-y
关键词
Bat-3; Scythe; NKp30 ligand; Natural killer cell; Natural cytotoxicity receptor; Immune regulation; Protein quality control
资金
- Georg-Speyer-Haus
- LOEWE Center for Cell and Gene Therapy Frankfurt
- Hessisches Ministerium fur Wissenschaft und Kunst (HMWK) [III L 4-518/17.004]
- Wilhelm-Sander Stiftung [2010.104.1]
- German Federal Ministry of Health (BMG)
- Ministry of Higher Education, Research and the Arts of the State of Hessen (HMWK)
BCL2-associated athanogene 6 (BAG-6) (also Bat-3/Scythe) was discovered as a gene product of the major histocompatibility complex class III locus. The Xenopus ortholog Scythe was first identified to act as an anti-apoptotic protein. Subsequent studies unraveled that the large BAG-6 protein contributes to a number of cellular processes, including apoptosis, gene regulation, protein synthesis, protein quality control, and protein degradation. In this context, BAG-6 acts as a multifunctional chaperone, which interacts with its target proteins for shuttling to distinct destinations. Nonetheless, as anticipated from its genomic localization, BAG-6 is involved in a variety of immunological pathways such as macrophage function and T(H)1 response. Most recently, BAG-6 was identified on the plasma membrane of dendritic cells and malignantly transformed cells where it serves as cellular ligand for the activating natural killer (NK) cell receptor NKp30 triggering NK cell cytotoxicity. Moreover, target cells were found to secrete soluble variants of BAG-6 and release BAG-6 on the surface of exosomes, which inhibit or activate NK cell cytotoxicity, respectively. These data suggest that the BAG-6 antigen is an important target to shape a directed immune response or to overcome tumor-immune escape strategies established by soluble BAG-6. This review summarizes the currently known functions of BAG-6, a fascinating multicompetent protein, in health and disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据