Key role of ERK1/2 molecular scaffolds in heart pathology

Evidence for FHL1 as a novel disease gene for isolated hypertrophic cardiomyopathy

(2012) Felix W. Friedrich et al.   HUMAN MOLECULAR GENETICS

A Novel Mechanism Involving Four-and-a-half LIM Domain Protein-1 and Extracellular Signal-regulated Kinase-2 Regulates Titin Phosphorylation and Mechanics

(2012) Anna Raskin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced expression of DYRK1A in cardiomyocytes inhibits acute NFAT activation but does not prevent hypertrophy in vivo

(2011) Cornelia Grebe et al.   CARDIOVASCULAR RESEARCH

IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload

(2011) Mauro Sbroggiò et al.   CARDIOVASCULAR RESEARCH

ERK dimers and scaffold proteins: Unexpected partners for a forgotten (cytoplasmic) task

(2011) Berta Casar et al.   CELL CYCLE

Morgana and melusin: Two fairies chaperoning signal transduction

(2011) Roberta Ferretti et al.   CELL CYCLE

G Protein–Dependent and G Protein–Independent Signaling Pathways and Their Impact on Cardiac Function

(2011) Douglas G. Tilley   CIRCULATION RESEARCH

ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1

(2011) M. Sbroggio et al.   JOURNAL OF CELL SCIENCE

MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1L613V mutation

(2011) Xue Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

G protein coupled receptor kinase 2 interacting protein 1 (GIT1) is a novel regulator of mitochondrial biogenesis in heart

(2011) Jinjiang Pang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections

(2011) Yang Zhang et al.   NATURE MEDICINE

Four and a half LIM protein 1 gene mutations cause four distinct human myopathies: A comprehensive review of the clinical, histological and pathological features

(2011) Belinda S. Cowling et al.   NEUROMUSCULAR DISORDERS

Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information

(2011) M. C. Good et al.   SCIENCE

Extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in cardiac hypertrophy

(2010) Izhak Kehat et al.   Annals of the New York Academy of Sciences

The Ras-ERK pathway: Understanding site-specific signaling provides hope of new anti-tumor therapies

(2010) Fernando Calvo et al.   BIOESSAYS

Mitogen-Activated Protein Kinase Inhibitors Improve Heart Function and Prevent Fibrosis in Cardiomyopathy Caused by Mutation in Lamin A/C Gene

(2010) Wei Wu et al.   CIRCULATION

IQGAP1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation by Akt activation

(2010) Feng Chen et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

β-Arrestin: A signaling molecule and potential therapeutic target for heart failure

(2010) Nabila Noor et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling

(2010) Paula A. da Costa Martins et al.   NATURE CELL BIOLOGY

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitogen-Activated Protein Kinase Signaling in the Heart: Angels Versus Demons in a Heart-Breaking Tale

(2010) Beth A. Rose et al.   PHYSIOLOGICAL REVIEWS

Cardiac hypertrophy: Targeting Raf/MEK/ERK1/2-signaling

(2009) Kristina Lorenz et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

DYRK1A Is a Novel Negative Regulator of Cardiomyocyte Hypertrophy

(2009) Christian Kuhn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beta-Arrestin-Mediated Signaling in the Heart

(2008) Priyesh A. Patel et al.   CIRCULATION JOURNAL

Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins

(2008) A. Muchir et al.   HUMAN MOLECULAR GENETICS

The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders

(2008) Yoko Aoki et al.   HUMAN MUTATION

An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice

(2008) Farah Sheikh et al.   JOURNAL OF CLINICAL INVESTIGATION

A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy

(2008) Kristina Lorenz et al.   NATURE MEDICINE