Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical application

The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation

(2011) S. Patel-Hett et al.   BLOOD

Anti-CD45 pretargeted radioimmunotherapy using bismuth-213: high rates of complete remission and long-term survival in a mouse myeloid leukemia xenograft model

(2011) J. M. Pagel et al.   BLOOD

Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice

(2011) Shi-Jiang Lu et al.   CELL RESEARCH

Congenital amegakaryocytic thrombocytopenia

(2011) Amy E. Geddis   PEDIATRIC BLOOD & CANCER

Induced pluripotent stem cell–derived human platelets: one step closer to the clinic: Figure 1.

(2010) Christos Gekas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transient activation ofc-MYCexpression is critical for efficient platelet generation from human induced pluripotent stem cells

(2010) Naoya Takayama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis

(2009) C. Gekas et al.   BLOOD

c-Myc-mediated control of cell fate in megakaryocyte-erythrocyte progenitors

(2009) Y. Guo et al.   BLOOD

A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell-derived primitive hematopoiesis

(2009) O. Klimchenko et al.   BLOOD

Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo

(2009) Hitoshi Takizawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors

(2008) N. Takayama et al.   BLOOD

Disease-Specific Induced Pluripotent Stem Cells

(2008) In-Hyun Park et al.   CELL

Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells

(2008) Hidekazu Nishikii et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The ground state of embryonic stem cell self-renewal

(2008) Qi-Long Ying et al.   NATURE