Novel roles for insulin receptor (IR) in adipocytes and skeletal muscle cells via new and unexpected substrates

mTOR inhibition with rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes

(2012) Maria J. Pereira et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Diabetes in Mice With Selective Impairment of Insulin Action in Glut4-Expressing Tissues

(2011) Hua V. Lin et al.   DIABETES

Reconstitution of Insulin Action in Muscle, White Adipose Tissue, and Brain of Insulin Receptor Knock-out Mice Fails to Rescue Diabetes

(2011) Hua V. Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis

(2011) Jenna L. Jewell et al.   JOURNAL OF CELL BIOLOGY

Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction

(2011) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1

(2011) Sara Fröjdö et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

(2010) V. P. Houde et al.   DIABETES

Structural and Biological Properties of theDrosophilaInsulin-like Peptide 5 Show Evolutionary Conservation

(2010) Waseem Sajid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

(2010) B. J. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity

(2009) Ludmila Pawlikowska et al.   AGING CELL

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

(2009) A. A. Soukas et al.   GENES & DEVELOPMENT

Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations

(2009) Yang Li et al.   HUMAN MOLECULAR GENETICS

Density functional computational studies on (E)-2-[(2-Hydroxy-5-nitrophenyl)-iminiomethyl]-4-nitrophenolate

(2009) Hasan Tanak et al.   JOURNAL OF MOLECULAR MODELING

Rapid Insulin-Dependent Endocytosis of the Insulin Receptor by Caveolae in Primary Adipocytes

(2009) Siri Fagerholm et al.   PLoS One

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Lineage-Specific Biology Revealed by a Finished Genome Assembly of the Mouse

(2009) Deanna M. Church et al.   PLOS BIOLOGY

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes

(2008) T. Yoshizaki et al.   MOLECULAR AND CELLULAR BIOLOGY

Fat Tissue and Long Life

(2008) Matthias Blüher   Obesity Facts

Dissection of the insulin signaling pathway via quantitative phosphoproteomics

(2008) M. Kruger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans

(2008) M. C. Wang et al.   SCIENCE

Tyrosine Phosphorylation of Munc18c Regulates Platelet-Derived Growth Factor-Stimulated Glucose Transporter 4 Translocation in 3T3L1 Adipocytes

(2007) Mitsuhiko Umahara et al.   ENDOCRINOLOGY

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

(2007) Colin Selman et al.   FASEB JOURNAL

Nonimmunosuppressive effects of mammalian target of rapamycin inhibitors

(2007) Josep M. Cruzado   Transplantation Reviews