Allosteric function and dysfunction of the prion protein

Fibrillar Aβ1-42 Enhances NMDA Receptor Sensitivity via the Integrin Signaling Pathway

(2017) Gábor Juhász et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-  Peptide Oligomers Disrupt Axonal Transport through an NMDA Receptor-Dependent Mechanism That Is Mediated by Glycogen Synthase Kinase 3  in Primary Cultured Hippocampal Neurons

(2013) H. Decker et al.   JOURNAL OF NEUROSCIENCE

Adenosine receptor containing oligomers: Their role in the control of dopamine and glutamate neurotransmission in the brain

(2011) Francisco Ciruela et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Homomeric and heteromeric complexes among TGF-β and BMP receptors and their roles in signaling

(2011) Marcelo Ehrlich et al.   CELLULAR SIGNALLING

Amyloid-β42 Interacts Mainly with Insoluble Prion Protein in the Alzheimer Brain

(2011) Wen-Quan Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anomalous diffusion of oligomerized transmembrane proteins

(2011) Ulrich Schmidt et al.   JOURNAL OF CHEMICAL PHYSICS

Prions and protein-folding diseases

(2011) E. Norrby   JOURNAL OF INTERNAL MEDICINE

Amyloid-beta oligomers increase the localization of prion protein at the cell surface

(2011) Fabiana A. Caetano et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimer's Disease Brain-Derived Amyloid- -Mediated Inhibition of LTP In Vivo Is Prevented by Immunotargeting Cellular Prion Protein

(2011) A. E. Barry et al.   JOURNAL OF NEUROSCIENCE

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Ablation of Cellular Prion Protein Does Not Ameliorate Abnormal Neural Network Activity or Cognitive Dysfunction in the J20 Line of Human Amyloid Precursor Protein Transgenic Mice

(2011) M. Cisse et al.   JOURNAL OF NEUROSCIENCE

Thorough work-up and new diagnostic criteria needed for CJD

(2011) David C. Perry et al.   Nature Reviews Neurology

Unaltered prion protein expression in Alzheimer disease patients

(2011) Eri Saijo et al.   Prion

β-amyloid oligomers and prion protein

(2011) Gianluigi Forloni et al.   Prion

Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information

(2011) M. C. Good et al.   SCIENCE

Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

(2011) Darragh B. Freir et al.   Nature Communications

Highly Efficient Protein Misfolding Cyclic Amplification

(2011) Nuria Gonzalez-Montalban et al.   PLoS Pathogens

Molecular pathology of human prion disease

(2010) Jonathan D. F. Wadsworth et al.   ACTA NEUROPATHOLOGICA

Protein coding of neurodegenerative dementias: the neuropathological basis of biomarker diagnostics

(2010) Gabor G. Kovacs et al.   ACTA NEUROPATHOLOGICA

Phenotypic variability of sporadic human prion disease and its molecular basis: past, present, and future

(2010) Piero Parchi et al.   ACTA NEUROPATHOLOGICA

PrPC, the Cellular Isoform of the Human Prion Protein, Is a Novel Biomarker of HIV-Associated Neurocognitive Impairment and Mediates Neuroinflammation

(2010) Toni K. Roberts et al.   AMERICAN JOURNAL OF PATHOLOGY

Prion protein in Alzheimer's pathogenesis: a hot and controversial issue

(2010) Iryna Benilova et al.   EMBO Molecular Medicine

Prion protein and Aβ-related synaptic toxicity impairment

(2010) Anna Maria Calella et al.   EMBO Molecular Medicine

Heterophilic chemokine receptor interactions in chemokine signaling and biology

(2010) Birgit K. Kramp et al.   EXPERIMENTAL CELL RESEARCH

Binding of amyloid β peptide to β2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity

(2010) Dayong Wang et al.   FASEB JOURNAL

Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin γ1 chain

(2010) Flavio H. Beraldo et al.   FASEB JOURNAL

Copper, endoproteolytic processing of the prion protein and cell signalling

(2010) Cathryn Louise Haigh   Frontiers in Bioscience-Landmark

The binding of the molecular chaperone Hsc70 to the prion protein PrP is modulated by pH and copper

(2010) Simon Wilkins et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Role of α7 Nicotinic Acetylcholine Receptor in Calcium Signaling Induced by Prion Protein Interaction with Stress-inducible Protein 1

(2010) Flavio H. Beraldo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique Structural Characteristics of the Rabbit Prion Protein

(2010) Yi Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aβ42 Neurotoxicity Is Mediated by Ongoing Nucleated Polymerization Process Rather than by Discrete Aβ42 Species

(2010) Asad Jan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction between Human Prion Protein and Amyloid-β (Aβ) Oligomers

(2010) Shugui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Prion Diseases

(2010) Khalilah Brown et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Structure of a Longitudinal Actin Dimer Assembled by Tandem W Domains: Implications for Actin Filament Nucleation

(2010) Grzegorz Rebowski et al.   JOURNAL OF MOLECULAR BIOLOGY

Horse Prion Protein NMR Structure and Comparisons with Related Variants of the Mouse Prion Protein

(2010) Daniel R. Pérez et al.   JOURNAL OF MOLECULAR BIOLOGY

Crucial Role for Prion Protein Membrane Anchoring in the Neuroinvasion and Neural Spread of Prion Infection

(2010) M. Klingeborn et al.   JOURNAL OF VIROLOGY

The prion protein as a receptor for amyloid-β

(2010) Helmut W. Kessels et al.   NATURE

Protein aggregation diseases: pathogenicity and therapeutic perspectives

(2010) Adriano Aguzzi et al.   NATURE REVIEWS DRUG DISCOVERY

NMR Structure of the Human Prion Protein with the Pathological Q212P Mutation Reveals Unique Structural Features

(2010) Gregor Ilc et al.   PLoS One

Is indeed the prion protein a Harlequin servant of "many" masters?

(2010) M. Catia Sorgato et al.   Prion

Amyloid fibrils of human prion protein are spun and woven from morphologically disordered aggregates

(2010) Karin Almstedt et al.   Prion

Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR

(2010) M. Roffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion disease susceptibility is affected by  -structure folding propensity and local side-chain interactions in PrP

(2010) M. Q. Khan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In silico modeling of pH-optimum of protein-protein binding

(2010) Rooplekha C. Mitra et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Ligand Binding and Hydration in Protein Misfolding: Insights from Studies of Prion and p53 Tumor Suppressor Proteins†

(2009) Jerson L. Silva et al.   ACCOUNTS OF CHEMICAL RESEARCH

Degenerating Synaptic Boutons in Prion Disease

(2009) Zuzana Šišková et al.   AMERICAN JOURNAL OF PATHOLOGY

Getting a Grip on Prions: Oligomers, Amyloids, and Pathological Membrane Interactions

(2009) Byron Caughey et al.   Annual Review of Biochemistry

Prion Diseases and Their Biochemical Mechanisms†

(2009) Nathan J. Cobb et al.   BIOCHEMISTRY

Insight into early events in the aggregation of the prion protein on lipid membranes

(2009) Narinder Sanghera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Enhanced prion protein stability coupled to DNA recognition and milieu acidification

(2009) Adriana F. Marques et al.   BIOPHYSICAL CHEMISTRY

Targeting Generation of Antibodies Specific to Conformational Epitopes of Amyloid β-Derived Neurotoxins

(2009) Mary Lambert et al.   CNS & Neurological Disorders-Drug Targets

Copper Binding Extrinsic to the Octarepeat Region in the Prion Protein

(2009) Eric Walter et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Conformational diversity in prion protein variants influences intermolecular β-sheet formation

(2009) Seungjoo Lee et al.   EMBO JOURNAL

Therapeutic interventions ameliorating prion disease

(2009) Marcus W Brazier et al.   Expert Review of Anti-Infective Therapy

Reciprocal remodeling upon binding of the prion protein to its signaling partner hop/STI1

(2009) Sebastián A. Romano et al.   FASEB JOURNAL

PrP interactions with nucleic acids and glycosaminoglycans in function and disease

(2009) Jerson et al.   Frontiers in Bioscience-Landmark

Prion protein and its ligand stress inducible protein 1 regulate astrocyte development

(2009) Camila Arantes et al.   GLIA

Structure of the Flexible Amino-Terminal Domain of Prion Protein Bound to a Sulfated Glycan

(2009) Lara M. Taubner et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Dynamics Study of the Cu2+Binding-Induced “Structuring” of the N-Terminal Domain of Human Prion Protein

(2009) Gianni Valensin et al.   JOURNAL OF PHYSICAL CHEMISTRY B

G-protein-coupled receptor oligomers: two or more for what? Lessons from mGlu and GABABreceptors

(2009) J.-P. Pin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Impact of Quaternary Organization on the Antigenic Structure of the Tick-Borne Encephalitis Virus Envelope Glycoprotein E

(2009) S. Kiermayr et al.   JOURNAL OF VIROLOGY

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Selective presynaptic degeneration in the synaptopathy associated with ME7-induced hippocampal pathology

(2009) Bryony C. Gray et al.   NEUROBIOLOGY OF DISEASE

Prions: Protein Aggregation and Infectious Diseases

(2009) Adriano Aguzzi et al.   PHYSIOLOGICAL REVIEWS

The Comprehensive Native Interactome of a Fully Functional Tagged Prion Protein

(2009) Dorothea Rutishauser et al.   PLoS One

Folding kinetics of the human prion protein probed by temperature jump

(2009) T. Hart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

Regulation of Embryonic Cell Adhesion by the Prion Protein

(2009) Edward Málaga-Trillo et al.   PLOS BIOLOGY

Interactome Analyses Identify Ties of PrPC and Its Mammalian Paralogs to Oligomannosidic N-Glycans and Endoplasmic Reticulum-Derived Chaperones

(2009) Joel C. Watts et al.   PLoS Pathogens

The Prion's Elusive Reason for Being

(2008) Adriano Aguzzi et al.   Annual Review of Neuroscience

Protein Misfolding and Neurodegeneration

(2008) Claudio Soto et al.   ARCHIVES OF NEUROLOGY

The chemistry of copper binding to PrP: is there sufficient evidence to elucidate a role for copper in protein function?

(2008) Paul Davies et al.   BIOCHEMICAL JOURNAL

Copper and the structural biology of the prion protein

(2008) John H. Viles et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Prion Protein Complexed to N2a Cellular RNAs through Its N-terminal Domain Forms Aggregates and Is Toxic to Murine Neuroblastoma Cells

(2008) Mariana P. B. Gomes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein

(2008) C. J. Parkyn et al.   JOURNAL OF CELL SCIENCE

Evidence for Stepwise Formation of Amyloid Fibrils by the Mouse Prion Protein

(2008) Shweta Jain et al.   JOURNAL OF MOLECULAR BIOLOGY

Endocytosis of Prion Protein Is Required for ERK1/2 Signaling Induced by Stress-Inducible Protein 1

(2008) F. A. Caetano et al.   JOURNAL OF NEUROSCIENCE

Aggregated, Wild-Type Prion Protein Causes Neurological Dysfunction and Synaptic Abnormalities

(2008) R. Chiesa et al.   JOURNAL OF NEUROSCIENCE

Cooperativity and biological complexity

(2008) Adrian Whitty   Nature Chemical Biology

Systematic review of therapeutic interventions in human prion disease

(2008) L. A. Stewart et al.   NEUROLOGY

Structural effects of Cu(ii)-coordination in the octapeptide region of the human prion protein

(2008) Eva-Stina Riihimäki et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Physiology of the Prion Protein

(2008) Rafael Linden et al.   PHYSIOLOGICAL REVIEWS

Intriguing nucleic-acid-binding features of mammalian prion protein

(2008) Jerson L. Silva et al.   TRENDS IN BIOCHEMICAL SCIENCES

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL

Aβ1–42 modulation of Akt phosphorylation via α7 nAChR and NMDA receptors

(2007) Jonathan J. Abbott et al.   NEUROBIOLOGY OF AGING